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国立がん研究センター 中央病院

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Department of Diagnostic Pathology

Chief: Yasushi Yatabe
Assistant Chief: Nobuyoshi Hiraoka, Taisuke Mori, Akihiko Yoshida
Staff pathologist: Masayuki Yoshida, Akiko Maeshima, Hiroshi Yoshida, Taiki Hashimoto, Junpei Kashima, Hirokazu Sugino, Satsuki Kishikawa
Staff resident: Naoko Abeto, Shogo Nishino, Yuto Kaimi, Ayaka Mitsui, Keishi Makita, Yumi Asai
Resident: Ayumi Sugitani

Introduction

The Department of Diagnostic Pathology is responsible for histological and cytological diagnoses and autopsies in the National Cancer Center Hospital. In 2023, the department consisted of 12 staff pathologists, 7 residents, and 14 pathology technologists, including 13 cytotechnologists. We made diagnoses of a total of 23,775 histological and 11,043 cytological samples (Table 1). This included 1,789 intraoperative frozen sections and 294 intraoperative cytological diagnoses. We also provided a total of 857 pathology diagnoses to the outpatient clinic via the pathology consultation system.

The Team and What We Do

Accurate and precise histological and cytological diagnoses play a key role in the management of cancer in the hospital. This is based on gross observation and conventional haematoxylin and eosin staining of specimens, but we also actively use immunohistochemical techniques. In recent years, the detection of genetic abnormalities and the expression of specific molecules has become increasingly important in clinical practice, as some of these alterations have been used to select patients for molecularly targeted therapy, treatment with immune checkpoint inhibitors, and to predict clinical outcomes. Although the number of pathological autopsies has remained stable in recent years, the evaluation of the cause of death, the biological basis of disease and the therapeutic effects in autopsy specimens is essential to contribute to and improve the quality of medical care at our hospital. This year, 23,775 biopsy and surgical specimens, including 19,066 biopsy and 4,709 surgically resected specimens, 11,043 cytological diagnoses and 14 autopsies were obtained (Table 1). As a member of a multidisciplinary team, we believe that communication with clinicians is essential. Therefore, in addition to regular intradepartmental conferences and autopsy reviews, joint conferences are held on a regular basis. We also commit to research, i.e. studies aimed at improving pathological diagnosis, elucidating the biological/oncological characteristics of tumors and providing insights into the selection of therapeutic options.
Table 1. Numbers of specimens diagnosed in the department in 2023

Clinical department

Histology

Cytology

Autopsy

Brain surgery

355

48

0

Head and neck surgery

2,138

353

0

Breast surgery

2,663

358

0

Thoracic surgery

2,158

2,029

3

Gastrointestinal surgery

6,772

406

1

Hepatobiliary and pancreatic surgery

1,685

1,690

2

Urologic surgery

705

1,753

1

Gynecologic surgery

1,145

3,159

1

Bone and soft tissue surgery

837

43

0

Dermatologic surgery

859

17

0

Hematologic malignancies

1,654

305

1

Radiation oncology

86

43

0

Medical checkup

1,342

0

0

Others

1,426

839

5

Total

23,775

11,043

14

Research activities

Our department covers a wide range of pathologic research from basic to clinical aspects, which are conducted by the individual organ-based units, led by Drs. N. Hiraoka (hepatobiliary and pancreatic malignancies), A. Maeshima (hematology), T. Mori (head and neck malignancies), H. Sugino (brain tumors), T. Hashimoto (gastrointestinal tract), Y. Yatabe (thoracic malignancies), A. Yoshida (bone and soft tissue malignancies), H. Yoshida (gynecology) and M. Yoshida (breast malignancies).

Education

We have been actively recruiting pathology residents and clinical fellows for pathology training and have produced many pathologists throughout the country. At present, six fellows and one trainee for board certification are enrolled in our programme. 

Prospects

Our goal is to provide pathological diagnosis that is closely related to clinical practice, with medical safety being the highest priority. We also try to train pathologists, who are in short supply in Japan, and provide training in pathology for tumor diagnosis. It is also important for us to develop research activities in collaboration with clinical departments in the hospital and the NCC Research Institute adjacent to the hospital, and to apply biological abnormalities in tumors to diagnosis.

List of papers published in 2019

  1. Yoshida A, Arai Y, Hama N, Chikuta H, Bando Y, Nakano S, Kobayashi E, Shibahara J, Fukuhara H, Komiyama M, Watanabe SI, Tamura K, Kawai A, Shibata Expanding the clinicopathologic and molecular spectrum of BCOR-associated sarcomas in adults. Histopathology, 76:509-520, 2020
  1. Wong JYY, Zhang H, Hsiung CA, Shiraishi K, Yu K, Matsuo K, Wong MP, Hong YC, Wang J, Seow WJ, Wang Z, Song M, Kim HN, Chang IS, Chatterjee N, Hu W, Wu C, Mitsudomi T, Zheng W, Kim JH, Seow A, Caporaso NE, Shin MH, Chung LP, An SJ, Wang P, Yang Y, Zheng H, Yatabe Y, Zhang XC, Kim YT, Cai Q, Yin Z, Kim YC, Bassig BA, Chang J, Ho JCM, Ji BT, Daigo Y, Ito H, Momozawa Y, Ashikawa K, Kamatani Y, Honda T, Hosgood HD, Sakamoto H, Kunitoh H, Tsuta K, Watanabe SI, Kubo M, Miyagi Y, Nakayama H, Matsumoto S, Tsuboi M, Goto K, Shi  J, Song L, Hua X, Takahashi A, Goto A, Minamiya Y, Shimizu K, Tanaka K, Wei F, Matsuda F, Su J, Kim YH, Oh IJ, Song F, Su WC, Chen YM, Chang GC, Chen KY, Huang MS, Chien LH, Xiang YB, Park JY, Kweon SS, Chen CJ, Lee KM, Blechter B, Li H, Gao YT, Qian B, Lu D, Liu J, Jeon HS, Hsiao CF, Sung JS, Tsai YH, Jung YJ, Guo H, Hu Z, Wang WC, Chung CC, Burdett L, Yeager M, Hutchinson A, Berndt SI, Wu W, Pang H, Li Y, Choi JE, Park KH, Sung SW, Liu L, Kang CH, Zhu M, Chen CH, Yang TY, Xu J, Guan P, Tan W, Wang CL, Hsin M, Sit KY, Ho J, Chen Y, Choi YY, Hung JY, Kim JS, Yoon HI, Lin CC, Park IK, Xu P, Wang Y, He Q, Perng RP, Chen CY, Vermeulen R, Wu J, Lim WY, Chen KC, Li YJ, Li J, Chen H, Yu CJ, Jin L, Chen TY, Jiang SS, Liu J, Yamaji T, Hicks B, Wyatt K, Li SA, Dai J, Ma H, Jin G, Song B, Wang Z, Cheng S, Li X, Ren Y, Cui P, Iwasaki M, Shimazu T, Tsugane S, Zhu J, Chen Y, Yang K, Jiang G, Fei K, Wu G, Lin HC, Chen HL, Fang YH, Tsai FY, Hsieh WS, Yu J, Stevens VL, Laird-Offringa IA, Marconett CN, Rieswijk L, Chao A, Yang PC, Shu XO, Wu T, Wu YL, Lin D, Chen K, Zhou B, Huang YC, Kohno T, Shen H, Chanock SJ, Rothman N, Lan Q. Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome- wide association study data from never-smoking Asian women. Genomics, 112時12分23-1232, 2020
  1. Hirose S, Murakami N, Takahashi K, Kuno I, Takayanagi D, Asami Y, Matsuda M, Shimada Y, Yamano S, Sunami K, Yoshida K, Honda T, Nakahara T, Watanabe T, Komatsu M, Hamamoto R, Kato MK, Matsumoto K, Okuma K, Kuroda T, Okamoto A, Itami J, Kohno T, Kato T, Shiraishi K, Yoshida H. Genomic alterations in STK11 can predict clinical outcomes in cervical cancer patients. Gynecol Oncol, 156:203-210, 2020
  1. Sudo K, Kato K, Matsuzaki J, Takizawa S, Aoki Y, Shoji H, Iwasa S, Honma Y, Takashima A, Sakamoto H, Naka T, Sekine S, Boku N, Ochiya Identification of serum microRNAs predicting the response of esophageal squamous-cell carcinoma to nivolumab. Jpn J Clin Oncol, 50:114-121, 2020
  1. Murakami N, Mori T, Kubo Y, Yoshimoto S, Ito K, Honma Y, Ueno T, Kobayashi K, Okamoto H, Boku N, Takahashi K, Inaba K, Okuma K, Igaki H, Nakayama Y, Itami Prognostic impact of immunohistopathologic features in definitive radiation therapy for nasopharyngeal cancer patients. J Radiat Res, 61:161-168, 2020
  1. Kakinuma R, Muramatsu Y, Asamura H, Watanabe SI, Kusumoto M, Tsuchida T, Kaneko M, Tsuta K, Maeshima AM, Ishii G, Nagai K, Yamaji T, Matsuda T, Moriyama N. Low-dose CT lung cancer screening in never-smokers and smokers: results of an eight-year observational Transl Lung Cancer Res, 9時10分-22, 2020
  1. Shiino S, Yoshida M, Tokura M, Watase C, Murata T, Jimbo K, Takayama S, Suto A, Satomi K, Miyagi Maeshima A, Kikuchi M, Uchiyama N, Kinoshita Locally advanced triple negative breast cancer arising from fibroadenoma with complete response to neoadjuvant chemotherapy: A case report. Int J Surg Case Rep, 68:234-238, 2020
  1. Ushigusa T, Yoshida H, Kuno I, Kojima N, Ishikawa M, Kato
    T. Characteristics and prognostic significance of incidentally detected cancer cells in uterine specimens of patients with pelvic high-grade serous carcinoma. Cytopathology, 31:122- 129, 2020
  1. Edwards JG, Chansky K, Van Schil P, Nicholson AG, Boubia S, Brambilla E, Donington J, Galateau-Sallé F, Hoffmann H, Infante M, Marino M, Marom EM, Nakajima J, Ostrowski M, Travis WD, Tsao MS, Yatabe Y, Giroux DJ, Shemanski L, Crowley J, Krasnik M, Asamura H, Rami-Porta R. The IASLC Lung Cancer Staging Project: Analysis of Resection Margin Status and Proposals for Residual Tumor Descriptors for Non-Small Cell Lung Cancer. J Thorac Oncol, 15時34分4-359, 2020
  1. Mishima S, Taniguchi H, Akagi K, Baba E, Fujiwara Y, Hirasawa A, Ikeda M, Maeda O, Muro K, Nishihara H, Nishiyama H, Takano T, Tsuchihara K, Yatabe Y, Kodera Y, Yoshino Japan Society of Clinical Oncology provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA m
  2. Naito Y, Mishima S, Akagi K, Igarashi A, Ikeda M, Okano S, Kato S, Takano T, Tsuchihara K, Terashima K, Nishihara H, Nishiyama H, Hiyama E, Hirasawa A, Hosoi H, Maeda O, Yatabe Y, Okamoto W, Ono S, Kajiyama H, Nagashima F, Hatanaka Y, Miyachi M, Kodera Y, Yoshino T, Taniguchi H. Japan society of clinical oncology/Japanese society of medical oncology- led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion- positive advanced solid tumors, cooperated by the Japanese society of pediatric hematology/oncology. Int J Clin Oncol, 25:403-417, 2020
  1. Maeda M, Takeshima H, Iida N, Hattori N, Yamashita S, Moro H, Yasukawa Y, Nishiyama K, Hashimoto T, Sekine S, Ishii G, Ochiai A, Fukagawa T, Katai H, Sakai Y, Ushijima Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3. Gut, 69:243-251, 2020
  1. Camargo MC, Kim KM, Matsuo K, Torres J, Liao LM, Morgan D, Michel A, Waterboer T, Song M, Gulley ML, Dominguez RL, Yatabe Y, Kim S, Cortes-Martinez G, Lissowska J, Zabaleta J, Pawlita M, Rabkin CS. Circulating Antibodies against Epstein- Barr Virus (EBV) and p53 in EBV-Positive and -Negative Gastric Cancer. Cancer Epidemiol Biomarkers Prev, 29:414-419, 2020
  1. Chatani S, Hasegawa T, Kato S, Murata S, Sato Y, Yamaura H, Yamamoto K, Yatabe Y, Inaba Image-guided core needle biopsy in the diagnosis of malignant lymphoma: comparison with surgical excision biopsy. Eur J Radiol, 127:108990, 2020
  1. Fujiyoshi T, Tajika M, Tanaka T, Ishihara M, Mizuno N, Hara K, Hijioka S, Imaoka H, Yatabe Y, Hirooka Y, Goto H, Yamao K, Niwa Corrigendum to: Comparative evaluation of new and conventional classifications of magnifying endoscopy with narrow band imaging for invasion depth of superficial esophageal squamous cell carcinoma. Dis Esophagus, 33:doaa040. doi: 10.1093/dote/doaa040, 2020
  1. Goto T, Arai Y, Shibata T, Oyama T, Yoshida Sarcoma with MGA-NUTM1 fusion in the lung: an emerging entity. Virchows Arch, 476:317-322, 2020
  1. Hiroshima K, Yoshizawa A, Takenaka A, Haba R, Kawahara K, Minami Y, Kakinuma H, Shibuki Y, Miyake S, Kajio K, Miyamoto K, Nagatomo M, Nishimura S, Mano M, Matsubayashi J, Motoi N, Nagao T, Nakatsuka SI, Yoshida T, Satoh Cytology Reporting System for Lung Cancer from the Japan Lung Cancer Society and Japanese Society of Clinical Cytology: An Interobserver Reproducibility Study and Risk of Malignancy Evaluation on Cytology Specimens. Acta Cytol, 1-11, 2020
  1. Hojo T, Masuda N, Iwamoto T, Niikura N, Anan K, Aogi K, Ohnishi T, Yamauchi C, Yoshida M, Kinoshita T, Masuoka H, Sagara Y, Sakatani T, Kojima Y, Tsuda H, Kumamaru H, Miyata H, Nakamura Taxane-based combinations as adjuvant chemotherapy for node-positive ER-positive breast cancer based on 2004-2009 data from the Breast Cancer Registry of the Japanese Breast Cancer Society. Breast Cancer, 27:85-91, 2020
  1. Ikeda K, Sato S, Chigira H, Shibuki Y, Hiraoka Characterizing the Ef fe c t of A u toma te d C e l l S or t ing S olu t ion s on Cytomorphological Changes. Acta Cytol, 64:232-240, 2020
  1. Lantuejoul S, Sound-Tsao M, Cooper WA, Girard N, Hirsch FR, Roden AC, Lopez-Rios F, Jain D, Chou TY, Motoi N, Kerr KM, Yatabe Y, Brambilla E, Longshore J, Papotti M, Sholl LM, Thunnissen E, Rekhtman N, Borczuk A, Bubendorf L, Minami Y, Beasley MB, Botling J, Chen G, Chung JH, Dacic S, Hwang D, Lin D, Moreira A, Nicholson AG, Noguchi M, Pelosi G, Poleri C, Travis W, Yoshida A, Daigneault JB, Wistuba II, Mino-Kenudson PD-L1 Testing for Lung Cancer in 2019: Perspective From the IASLC Pathology Committee. J Thorac Oncol, 15時49分9-519, 2020
  1. Makiuchi S, Yoshida H, Ishikawa M, Kojima N, Kanai Y, Kato Primary Peritoneal Low-grade Serous Carcinoma in a Patient With Lynch Syndrome: A Case Report. Int J Gynecol Pathol, 39:327-332, 2020
  1. Mikubo M, Seto K, Kitamura A, Nakaguro M, Hattori Y, Maeda N, Miyazaki T, Watanabe K, Murakami H, Tsukamoto T, Yamada T, Fujita S, Masago K, Ramkissoon S, Ross JS, Elvin J, Yatabe
  2. Calculating the Tumor Nuclei Content for Comprehensive Cancer Panel Testing. J Thorac Oncol, 15時13分0-137, 2020
  1. Muto Y, Namikawa K, Fujiwara Y, Mori T, Nakano E, Takahashi A, Yamazaki N. Bullous pemphigoid induced by pembrolizumab in a patient with non-small-cell lung cancer who achieved durable complete response despite treatment cessation and long-term corticosteroid administration: A case report. J Dermatol, 47:e9- e11, 2020
  1. Namikawa K, Takahashi A, Mori T, Tsutsumida A, Suzuki S, Motoi N, Jinnai S, Kage Y, Mizuta H, Muto Y, Nakano E, Yamazaki Nivolumab for patients with metastatic uveal melanoma previously untreated with ipilimumab: a single- institution retrospective study. Melanoma Res, 30:76-84, 2020
  1. Ogasawara R, Hashimoto D, Sugita J, Yamawaki F, Naka T, Mitsuhashi T, Takahashi S, Miyashita N, Okada K, Onozawa M, Matsuno Y, Teshima Loss of nivolumab binding to T cell PD-1 predicts relapse of Hodgkin lymphoma. Int J Hematol, 111時47分5- 479, 2020
  1. Okamura T, Hashimoto T, Naka T, Yoshida T, Tanabe N, Ogawa R, Yamada M, Saito Y, Yatabe Y, Sekine S. Clinicopathologic and Molecular Characteristics of Familial Adenomatous Polyposis-associated Traditional Serrated Am J Surg Pathol, 44:1282-1289, 2020
  1. Onishi Y, Ito K, Motoi N, Morita T, Watanabe SI, Kusumoto M. Ciliated muconodular papillary tumor of the lung: 18F-FDG PET/ CT findings of 15 Ann Nucl Med, 34:448-452, 2020
  1. Onishi Y, Kusumoto M, Motoi N, Watanabe H, Watanabe Ciliated Muconodular Papillary Tumor of the Lung: Thin-Section CT Findings of 16 Cases. AJR Am J Roentgenol, 214:761-765, 2020
  1. Sasaki E, Masago K, Fujita S, Hanai N, Yatabe Frequent KRAS and HRAS mutations in squamous cell papillomas of the head and neck. J Pathol Clin Res, 6時15分4-159, 2020
  1. Seto K, Haneda M, Masago K, Fujita S, Kato S, Sasaki E, Hosoda W, Murakami Y, Kuroda H, Horio Y, Hida T, Okubo K, Yatabe Negative reactions of BRAF mutation-specific immunohistochemistry to non-V600E mutations of BRAF. Pathol Int, 70:253-261, 2020
  1. Tachibana M, Saito M, Kobayashi J, Isono T, Yatabe Y, Tsutsumi
  2. Distal-type bronchiolar adenoma of the lung expressing p16(INK4a) - morphologic, immunohistochemical, ultrastructural and genomic analysis - report of a case and review of the literature. Pathol Int, 70:179-185, 2020
  1. Taniguchi H, Uehara K, Nakayama G, Nakayama H, Aiba T, Hattori N, Kataoka M, Nakano Y, Kawase Y, Okochi O, Matsuoka H, Utsunomiya S, Sakamoto E, Mori Y, Umeda S, Shikano T, Komori K, Tajika M, Kadowaki S, Muro K, Yatabe Tumor Location Is Associated With the Prevalence of Braf And Pik3ca Mutations in Patients with Wild-Type Ras Colorectal Cancer: A Prospective Multi-Center Cohort Study in Japan.Transl Oncol, 13時10分0786, 2020
  1. Travis WD, Dacic S, Wistuba I, Sholl L, Adusumilli P, Bubendorf L, Bunn P, Cascone T, Chaft J, Chen G, Chou TY, Cooper W, Erasmus JJ, Ferreira CG, Goo JM, Heymach J, Hirsch FR, Horinouchi H, Kerr K, Kris M, Jain D, Kim YT, Lopez-Rios F, Lu S, Mitsudomi T, Moreira A, Motoi N, Nicholson AG, Oliveira R, Papotti M, Pastorino U, Paz-Ares L, Pelosi G, Poleri C, Provencio M, Roden AC, Scagliotti G, Swisher SG, Thunnissen E, Tsao MS, Vansteenkiste J, Weder W, Yatabe IASLC Multidisciplinary Recommendations for Pathologic Assessment of Lung Cancer Resection Specimens After Neoadjuvant Therapy. J Thorac Oncol, 15:709-740, 2020
  1. Uehara T, Yoshida H, Fukuhara M, Yoshida M, Motoi N, Sugawara S, Sone M, Arai Y, Tamura K, Uno M, Ishikawa M, Kato Efficacy of ascitic fluid cell block for diagnosing primary ovarian, peritoneal, and tubal cancer in patients with peritoneal carcinomatosis with ascites. Gynecol Oncol, 157:398-404, 2020
  1. Yamazawa E, Ohno M, Satomi K, Yoshida A, Miyakita Y, Takahashi M, Satomi N, Asanome T, Maeshima A, Shiotsuka M, Iwata S, Yamasaki H, Morishima Y, Sugiyama H, Narita First case of human neurocoenurosis caused by Taenia serialis: A case report. Int J Infect Dis, 92:171-174, 2020
  1. Yonemaru J, Takahashi M, Nara S, Ichikawa H, Ishigamori R, Imai T, Hiraoka A yolk sac tumor of the pancreas and derived xenograft model effectively responded to VIP chemotherapy. Pancreatology, 20時55分1-557, 2020
  1. Tsumura K, Arai E, Tian Y, Shibuya A, Nishihara H, Yotani T, Yamada Y, Takahashi Y, Maeshima AM, Fujimoto H, Nakagawa T, Kume H, Homma Y, Yoshida T, Kanai Establishment of permutation for cancer risk estimation in the urothelium based on genome-wide DNA methylation analysis. Carcinogenesis, 40:1308-1319, 2019
  1. Hirata M, Asano N, Katayama K, Yoshida A, Tsuda Y, Sekimizu M, Mitani S, Kobayashi E, Komiyama M, Fujimoto H, Goto T, Iwamoto Y, Naka N, Iwata S, Nishida Y, Hiruma T, Hiraga H, Kawano H, Motoi T, Oda Y, Matsubara D, Fujita M, Shibata T, Nakagawa H, Nakayama R, Kondo T, Imoto S, Miyano S, Kawai A, Yamaguchi R, Ichikawa H, Matsuda K. Integrated exome and RNA sequencing of dedifferentiated liposarcoma. Nat Commun, 10時56分83, 2019
  1. Yoshida T, Hijioka S, Hosoda W, Ueno M, Furukawa M, Kobayashi N, Ikeda M, Ito T, Kodama Y, Morizane C, Notohara K, Taguchi H, Kitano M, Yane K, Tsuchiya Y, Komoto I, Tanaka H, Tsuji A, Hashigo S, Mine T, Kanno A, Murohisa G, Miyabe K, Takagi T, Matayoshi N, Sakaguchi M, Ishii H, Kojima Y, Matsuo K, Yoshitomi H, Nakamori S, Yanagimoto H, Yatabe Y, Furuse J, Mizuno N. Surgery for Pancreatic Neuroendocrine Tumor G3 and Carcinoma G3 Should be Considered Ann Surg Oncol, 26:1385-1393, 2019
  1. Iwaya H, Hijioka S, Mizuno N, Kuwahara T, Okuno N, Tajika M, Tanaka T, Ishihara M, Hirayama Y, Onishi S, Ito A, Kuraoka N, Matsumoto S, Polmanee P, Shimizu Y, Yatabe Y, Niwa Y, Tamada K, Ido A, Hara Usefulness of septal thickness measurement on endoscopic ultrasound as a predictor of malignancy of branched-duct and mixed-type intraductal papillary mucinous neoplasm of the pancreas. Dig Endosc, 31:672-681, 2019
  1. Ikeda C, Maruyama D, Oka H, Fujino T, Maeshima AM, Matsushita Bone marrow involvement by monomorphic epitheliotropic intestinal T-cell lymphoma. Br J Haematol, 187:10, 2019
  1. Sunami K, Ichikawa H, Kubo T, Kato M, Fujiwara Y, Shimomura
    A, Koyama T, Kakishima H, Kitami M, Matsushita H, Furukawa E, Narushima D, Nagai M, Taniguchi H, Motoi N, Sekine S, Maeshima A, Mori T, Watanabe R, Yoshida M, Yoshida A, Yoshida H, Satomi K, Sukeda A, Hashimoto T, Shimizu T, Iwasa S, Yonemori K, Kato K, Morizane C, Ogawa C, Tanabe N, Sugano K, Hiraoka N, Tamura K, Yoshida T, Fujiwara Y, Ochiai A, Yamamoto N, Kohno T. Feasibility and utility of a panel testing for 114 cancer-associated genes in a clinical setting: A hospital- based study. Cancer Sci, 110時14分80-1490, 2019
  1. Sekimizu M, Yoshida A, Mitani S, Asano N, Hirata M, Kubo T, Yamazaki F, Sakamoto H, Kato M, Makise N, Mori T, Yamazaki N, Sekine S, Oda I, Watanabe SI, Hiraga H, Yonemoto T, Kawamoto T, Naka N, Funauchi Y, Nishida Y, Honoki K, Kawano H, Tsuchiya H, Kunisada T, Matsuda K, Inagaki K, Kawai A, Ichikawa H. Frequent mutations of genes encoding vacuolar H+ -ATPase components in granular cell Genes Chromosomes Cancer, 58:373-380, 2019
  1. Hashimoto T, Ogawa R, Tang TY, Yoshida H, Taniguchi H, Katai H, Oda I, Sekine RHOA mutations and CLDN18-ARHGAP fusions in intestinal-type adenocarcinoma with anastomosing glands of the stomach. Mod Pathol, 32:568-575, 2019
  1. Mizuguchi Y, Sakamoto T, Hashimoto T, Tsukamoto S, Iwasa S, Saito Y, Sekine S. Identification of a novel PRR15L-RSPO2 fusion transcript in a sigmoid colon cancer derived from superficially serrated Virchows Arch, 475:659-663, 2019
  1. Kobayashi K, Yoshimoto S, Matsumoto F, Ando M, Murakami N, Omura G, Fukasawa M, Matsumoto Y, Matsumura S, Akamatsu M, Hiraoka N, Eigitsu R, Mori All-Exon TP53 Sequencing and Protein Phenotype Analysis Accurately Predict Clinical Outcome after Surgical Treatment of Head and Neck Squamous Cell Carcinoma. Ann Surg Oncol, 26:2294-2303, 2019
  1. Matsumoto F, Matsumura S, Mori T, Mori A, Omura G, Matsumoto Y, Fukasawa M, Kobayashi K, Yoshimoto Common carotid artery ligation at the proximal side before rupture in patients with ligation or occlusion of the external carotid artery at risk of carotid blowout syndrome. Jpn J Clin Oncol, 49:839-844, 2019
  1. Kawajiri A, Kitano S, Maeshima AM, Inamoto Y, Tajima K, Takemura T, Tanaka T, Ito A, Okinaka K, Kurosawa S, Kim SW, Taniguchi H, Ogawa C, Izutsu K, Yamamoto N, Fukuda Association of CD204+ macrophages with poor outcomes of malignant lymphomas not in remission treated by allogeneic HCT. Eur J Haematol, 13時57分8-587, 2019
  1. Naito T, Udagawa H, Sato J, Horinouchi H, Murakami S, Goto Y, Kanda S, Fujiwara Y, Yamamoto N, Zenke Y, Kirita K, Matsumoto S, Yoh K, Niho S, Motoi N, Ohe Y, Ishii G, Goto
  2. A Minimum Of 100 Tumor Cells in a Single Biopsy Sample Is Required to Assess Programmed Cell Death Ligand 1 Expression in Predicting Patient Response to Nivolumab Treatment in Nonsquamous Non-Small Cell Lung Carcinoma. J Thorac Oncol, 14時18分18-1827, 2019
  1. Sato J, Shimoi T, Shimomura A, Noguchi E, Kodaira M, Yunokawa M, Yonemori K, Shimizu C, Fujiwara Y, Yoshida M, Tamura The Incidence of Nonmalignant Diseases among Patients with Suspected Carcinoma of Unknown Primary Site. Intern Med, 58:1423-1428, 2019
  1. Shibaki R, Murakami S, Matsumoto Y, Goto Y, Kanda S, Horinouchi H, Fujiwara Y, Yamamoto N, Motoi N, Kusumoto M, Yamamoto N, Ohe Tumor expression and usefulness as a biomarker of programmed death ligand 1 in advanced non- small cell lung cancer patients with preexisting interstitial lung disease. Med Oncol, 36:49, 2019
  1. Shibaki R, Murakami S, Shinno Y, Matsumoto Y, Goto Y, Kanda S, Horinouchi H, Fujiwara Y, Motoi N, Yamamoto N, Ohe Malignant pleural effusion as a predictor of the efficacy of anti-PD-1 antibody in patients with non-small cell lung cancer. Thorac Cancer, 10:815-822, 2019
  1. Shimomura A, Yonemori K, Yoshida M, Yoshida T, Yasojima H, Masuda N, Aogi K, Takahashi M, Naito Y, Shimizu S, Nakamura R, Hamada A, Michimae H, Hashimoto J, Yamamoto H, Kawachi A, Shimizu C, Fujiwara Y, Tamura K. Gene Alterations in Triple-Negative Breast Cancer Patients in a Phase I/II Study of Eribulin and Olaparib Combination Transl Oncol, 12時13分86-1394, 2019
  1. Kuroda T, Ogiwara H, Sasaki M, Takahashi K, Yoshida H, Kiyokawa T, Sudo K, Tamura K, Kato T, Okamoto A, Kohno Therapeutic preferability of gemcitabine for ARID1A-deficient ovarian clear cell carcinoma. Gynecol Oncol, 155:489-498, 2019
  1. Murakami N, Mori T, Nakamura S, Yoshimoto S, Honma Y, Ueno T, Kobayashi K, Kashihara T, Takahashi K, Inaba K, Okuma K, Igaki H, Nakayama Y, Itami Prognostic value of the expression of epithelial cell adhesion molecules in head and neck squamous cell carcinoma treated by definitive radiotherapy. J Radiat Res, 60:803-811, 2019
  1. Ghani FI, Dendo K, Watanabe R, Yamada K, Yoshimatsu Y, Yugawa T, Nakahara T, Tanaka K, Yoshida H, Yoshida M, Ishikawa M, Goshima N, Kato T, Kiyono An Ex-Vivo Culture System of Ovarian Cancer Faithfully Recapitulating the Pathological Features of Primary Tumors. Cells, 8:644, 2019
  1. Kojima N, Yoshida H, Kuno I, Uehara T, Uno M, Ishikawa M, Kato Prognostic impact of intraoperative peritoneal cytology in interval debulking surgery for pelvic high-grade serous carcinoma. Cancer Med, 8時45分98-4604, 2019
  1. Yoshida A, Wakai S, Ryo E, Miyata K, Miyazawa M, Yoshida KI, Motoi T, Ogawa C, Iwata S, Kobayashi E, Watanabe SI, Kawai A, Mori Expanding the Phenotypic Spectrum of Mesenchymal Tumors Harboring the EWSR1-CREM Fusion. Am J Surg Pathol, 43:1622-1630, 2019
  1. Ohashi-Nakatani K, Shibuki Y, Fujima M, Watanabe R, Yoshida A, Yoshida H, Matsumoto Y, Tsuchida T, Watanabe SI, Motoi
  2. Primary pulmonary meningioma: A rare case report of aspiration cytological features and immunohistochemical assessment. Diagn Cytopathol, 47:330-333, 2019
  1. Hiraoka N, Toue S, Okamoto C, Kikuchi S, Ino Y, Yamazaki- Itoh R, Esaki M, Nara S, Kishi Y, Imaizumi A, Ono N, Shimada
  2. Tissue amino acid profiles are characteristic of tumor type, malignant phenotype, and tumor progression in pancreatic tumors. Sci Rep, 9:9816, 2019
  1. Iwasaki T, Hiraoka N, Ino Y, Nakajima K, Kishi Y, Nara S, Esaki M, Shimada K, Katai Reduction of intrapancreatic neural density in cancer tissue predicts poorer outcome in pancreatic ductal carcinoma. Cancer Sci, 110時14分91-1502, 2019
  1. Hashimoto T, Ogawa R, Yoshida H, Taniguchi H, Kojima M, Saito Y, Sekine S. EIF3E-RSPO2 and PIEZO1-RSPO2 fusions in colorectal traditional serrated Histopathology, 75:266-273, 2019
  1. Ito Y, Makita S, Maeshima AM, Hatta S, Yuda S, Suzuki T, Fukuhara S, Munakata W, Taniguchi H, Suzuki T, Maruyama D, Izutsu K. EBV-encoded RNA1-positive cells in the bone marrow specimens of patients with EBV-negative lymphomas and
    sarcomas. Pathol Int, 69:392-397, 2019
  1. Nakamura N, Maruyama D, Maeshima AM, Saito Y, Fujino T, Ito Y, Hatta S, Makita S, Fukuhara S, Munakata W, Suzuki  T, Fujimoto H, Izutsu K. Multiple myeloma with IGH-FGFR3 rearrangement progressing as testicular plasmacytoma during carfilzomib treatment. Ann Hematol, 98:2463-2465, 2019
  1. Nakai R, Fukuhara S, Maeshima AM, Kim SW, Ito Y, Hatta S, Suzuki T, Yuda S, Makita S, Munakata W, Suzuki T, Maruyama D, Izutsu Alectinib, an anaplastic lymphoma kinase (ALK) inhibitor, as a bridge to allogeneic stem cell transplantation in  a patient with ALK-positive anaplastic large-cell lymphoma refractory to chemotherapy and brentuximab vedotin. Clin Case Rep, 7時25分00-2504, 2019
  1. Maeshima AM, Taniguchi H, Ito Y, Hatta S, Suzuki T, Yuda S, Makita S, Fukuhara S, Munakata W, Suzuki T, Maruyama D, Izutsu Clinicopathological characteristics of diffuse large B-cell lymphoma involving small and large intestines: an analysis of 126 patients. Int J Hematol, 110時34分0-346, 2019
  1. Takahashi-Shishido N, Morimura S, Tomita Y, Miyagi-Maeshima A, Fukuhara S, Izutsu K, Sugaya Case of follicular lymphoma presenting with nodules and plaques on the face. J Dermatol, 46:e380-e381, 2019
  1. Nakano MH, Udagawa C, Shimo A, Kojima Y, Yoshie R, Zaha H, Abe N, Motonari T, Unesoko M, Tamura K, Shimoi T, Yoshida M, Yoshida T, Sakamoto H, Kato K, Mushiroda T, Tsugawa K, Zembutsu H. A Genome-Wide Association Study Identifies Five Novel Genetic Markers for Trastuzumab-Induced Cardiotoxicity in Japanese Biol Pharm Bull, 42:2045-2053, 2019
  1. Cho H, Yamada M, Tanabe N, Yoshida T, Sugano K, Hashimoto T, Hijioka S. Argon Plasma Coagulation With Cholangioscopy as Additional Treatment for Residual Ampullary Tumor in a Young Familial Adenomatous Polyposis ACG Case Rep J, 6:e00202, 2019
  1. Cohen PA, Powell A, Böhm S, Gilks CB, Stewart CJR, Meniawy TM, Bulsara M, Avril S, Brockbank EC, Bosse T, de Azevedo Focchi GR, Ganesan R, Glasspool RM, Howitt BE, Kim HS, Lee JY, Le ND, Lockley M, Manchanda R, Mandalia T, McCluggage WG, McNeish I, Midha D, Srinivasan R, Tan YY, van der Griend R, Yunokawa M, Zannoni GF, Singh Pathological chemotherapy response score is prognostic in tubo-ovarian high-grade serous carcinoma: A systematic review and meta- analysis of individual patient data. Gynecol Oncol, 154:441-448, 2019
  1. Hakiri S, Fukui T, Mori S, Kawaguchi K, Nakamura S, Ozeki N, Kato T, Goto M, Yatabe Y, Yokoi Clinicopathologic Features of Thymoma With the Expression of Programmed Death Ligand 1. Ann Thorac Surg, 17時41分8-424, 2019
  1. Hijioka S, Sakuma K, Aoki M, Mizuno N, Kuwahara T, Okuno N, Hara K, Yatabe Clinical and in vitro studies of the correlation between MGMT and the effect of streptozocin in pancreatic NET. Cancer Chemother Pharmacol, 83:43-52, 2019
  1. Hironaka-Mitsuhashi A, Tsuda H, Yoshida M, Shimizu C, Asaga S, Hojo T, Tamura K, Kinoshita T, Ushijima T, Hiraoka N, Fujiwara Invasive breast cancers in adolescent and young adult women show more aggressive immunohistochemical and clinical features than those in women aged 40-44 years. Breast Cancer, 26:386-396, 2019
  1. Honda K, Kadowaki S, Kato K, Hanai N, Hasegawa Y, Yatabe Y, Muro Durable response to the ALK inhibitor alectinib in inflammatory myofibroblastic tumor of the head and neck with a novel SQSTM1-ALK fusion: a case report. Invest New Drugs,37:791-795, 2019
  1. Horio Y, Mizuno T, Sakao Y, Inaba Y, Yatabe Y, Hida Successful salvage surgery following multimodal therapy in a patient who harboured ALK-rearranged advanced lung adenocarcinoma with multiple organ metastases. Respirol Case Rep, 7:e00451, 2019
  1. Inoue S, Hirota Y, Ueno T, Fukui Y, Yoshida E, Hayashi T, Kojima S, Takeyama R, Hashimoto T, Kiyono T, Ikemura M, Taguchi A, Tanaka T, Tanaka Y, Sakata S, Takeuchi K, Muraoka A, Osuka S, Saito T, Oda K, Osuga Y, Terao Y, Kawazu M, Mano H. Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations. Nat Commun, 10時57分85, 2019
  1. Ishikura N, Usui Y, Ito H, Kasugai Y, Oze I, Kato S, Yatabe Y, Nakamura S, Matsuo Helicobacter pylori (HP) infection alone, but not HP-induced atrophic gastritis, increases the risk of gastric lymphoma: a case-control study in Japan. Ann Hematol, 98:1981-1987, 2019
  1. Ito A, Nakanishi H, Yoshimura M, Ito S, Sakao Y, Kodera Y, Yatabe Y, Kaneda Dynamics of Circulating Tumor Cells Early After Targeting Therapy to Human EGFR-mutated Lung Cancers and HER2 Gene-amplified Gastric Cancers in Mice. Anticancer Res, 39:4711-4720, 2019
  1. Iwata Y, Kinoshita T, Kimura K, Komori K, Hayashi D, Akazawa T, Shigeyoshi I, Tsutsuyama M, Kawakami J, Ouchi A, Natsume S, Uemura N, Ito Y, Misawa K, Senda Y, Abe T, Ito S, Tajika M, Yatabe Y, Yoshida K, Shimizu A long-term survival case of Sister Mary Joseph's nodule caused by colon cancer and treated with a multidisciplinary approach. Nagoya J Med Sci, 81:325-329, 2019
  1. Jain D, Nambirajan A, Borczuk A, Chen G, Minami Y, Moreira AL, Motoi N, Papotti M, Rekhtman N, Russell PA, Savic Prince S, Yatabe Y, Bubendorf L. Immunocytochemistry for predictive biomarker testing in lung cancer cytology. Cancer Cytopathol, 127:325-339, 2019
  1. Kataoka A, Sawaki M, Okumura S, Onishi S, Iwase M, Sugino K, Ishiguro J, Gondo N, Kotani H, Yoshimura A, Hattori M, Sasaki E, Yatabe Y, Yoshimura K, Omi K, Iwata H. Prediction of pathological margin status using preoperative contrast- enhanced MRI in patients with early breast cancer who underwent skin-sparing Breast J, 25:202-206, 2019
  1. Kobayashi K, Matsumoto Y, Matsumoto F, Sato T, Mori T, Tsuchida T, Omura G, Matsumura S, Ikeda A, Sakai A, Eguchi K, Yoshimoto S. A surgical approach to schwannomas originating from the esophageal branch of the recurrent laryngeal nerve: Pictorial essay. Head Neck, 41:4054-4059, 2019
  1. Koide Y, Sasaki E, Masago K, Fujita S, Beppu S, Nishikawa D, Suzuki H, Hasegawa Y, Yatabe Y, Hanai Epithelioid hemangioendothelioma of the parotid gland: a case report. Int Cancer Conf J, 8時39分-42, 2019
  1. Kojima N, Yoshida H, Uehara T, Ushigusa T, Asami Y, Shiraishi K, Kato Primary Clear Cell Adenocarcinoma of the Vulva: A Case Study With Mutation Analysis and Literature Review. Int J Surg Pathol, 27:792-797, 2019
  1. Kondoh C, Horio Y, Hayashi Y, Ebi H, Hida T, Hasegawa Y, Yatabe Anaplastic lymphoma kinase expression in small-cell lung cancer. Histopathology, 75:20-28, 2019
  1. Kosaka T, Yajima T, Yamaki E, Nakazawa S, Tomizawa K, Onozato R, Yamazaki A, Hirato J, Yatabe Y, Shimizu K, Mogi A, Shirabe Long-term complete response in a patient withpostoperative recurrent ALK-rearranged lung adenocarcinoma treated with crizotinib: A case report. Mol Clin Oncol, 11時30分9- 312, 2019
  1. Koshikawa T, Fujita N, Ueda N, Ota Y, Sasaki E, Murakami Y, Hosoda W, Yatabe Y, Hanai N, Higuchi M, Hirokawa M, Miyauchi A. Important cytological findings for distinction between follicular variant and conventional papillary thyroid carcinoma, including noninvasive follicular thyroid tumors with papillary-like nuclear features. Endocr J, 66:475-483, 2019
  1. Kosugi A, Kasahara M, Yang L, Nakamura-Takahashi A, Shibahara T, Mori Method for diagnosing neoplastic lesions by quantitative fluorescence value. Sci Rep, 9:7833, 2019
  1. Kubo M, Kawai M, Kumamaru H, Miyata H, Tamura K, Yoshida M, Ogo E, Nagahashi M, Asaga S, Kojima Y, Kadoya T, Aogi K, Niikura N, Miyashita M, Iijima K, Hayashi N, Yamamoto Y, Imoto S, Jinno H. A population-based recurrence risk management study of patients with pT1 node-negative HER2+ breast cancer: a National Clinical Database study. Breast Cancer Res Treat, 178:647-656, 2019
  1. Kubota Y, Arakawa Y, Sekiguchi M, Watanabe K, Hiwatari M, Kishimoto H, Nakazawa A, Yoshida A, Ogawa S, Hanada R, Oka A, Takita J, Koh A case of malignant rhabdoid tumor mimicking yolk sac tumor. Pediatr Blood Cancer, 66:e27784, 2019
  1. Kuno I, Yoshida H, Kohno T, Ochiai A, Kato Endometrial cancer arising after complete remission of uterine malignant lymphoma: A case report and mutation analysis. Gynecol Oncol Rep, 28:50-53, 2019
  1. Kuroda H, Sugita Y, Ohya Y, Yoshida T, Arimura T, Sakakura N, Hida T, Yatabe Y, Sakao Importance of avoiding surgery delays after initial discovery of suspected non-small-cell lung cancer in clinical stage IA patients. Cancer Manag Res, 11時10分7- 115, 2019
  1. Kurozumi K, Nakano Y, Ishida J, Tanaka T, Doi M, Hirato J, Yoshida A, Washio K, Shimada A, Kohno T, Ichimura K, Yanai H, Date I. High-grade glioneuronal tumor with an ARHGEF2- NTRK1 fusion gene. Brain Tumor Pathol, 36:121-128, 2019
  1. Makise N, Sekimizu M, Kobayashi E, Yoshida H, Fukayama M, Kato T, Kawai A, Ichikawa H, Yoshida Low-grade endometrial stromal sarcoma with a novel MEAF6-SUZ12 fusion. Virchows Arch, 475:527-531, 2019
  1. Mitani S, Taniguchi H, Sugiyama K, Masuishi T, Honda K, Narita Y, Kadowaki S, Ura T, Ando M, Tajika M, Yatabe Y, Muro The impact of the Glasgow Prognostic Score on survival in second-line chemotherapy for metastatic colorectal cancer patients with BRAF V600E mutation. Ther Adv Med Oncol, 11時17分58835918820298, 2019
  1. Mori T, Kobayashi K, Yoshimoto S. ASO Author Reflections: Precise p53 Analysis in Formalin-Fixed Paraffin-Embedded Specimens Can Predict Head and Neck Squamous Cell Carcinoma Outcomes. Ann Surg Oncol, 26:614-615, 2019
  1. Naito T, Umemura S, Nakamura H, Zenke Y, Udagawa H, Kirita K, Matsumoto S, Yoh K, Niho S, Motoi N, Aokage K, Tsuboi M, Ishii G, Goto Successful treatment with nivolumab for SMARCA4-deficient non-small cell lung carcinoma with a high tumor mutation burden: A case report. Thorac Cancer, 10時12分85- 1288, 2019
  1. Nakai T, Matsumoto Y, Sasada S, Tanaka M, Tsuchida T, Ohe Y, Motoi N. Cryobiopsy during flex-rigid pleuroscopy: an emerging alternative biopsy method in malignant pleural mesothelioma. A comparative study of pathology. Jpn J Clin Oncol, 49:559-566, 2019
  1. Nakanishi K, Mizuno T, Sakakura N, Kuroda H, Shimizu J, Hida T, Yatabe Y, Sakao Salvage surgery for small cell lung cancer after chemoradiotherapy. Jpn J Clin Oncol, 49:389-392, 2019
  1. Nakano Y, Yamasaki K, Sakamoto H, Matsusaka Y, Kunihiro N, Fukushima H, Inoue T, Honda-Kitahara M, Hara J, Yoshida A, Ichimura K. A long-term survivor of pediatric midline glioma with H3F3A K27M and BRAF V600E double mutations. Brain Tumor Pathol, 36:162-168, 2019
  1. Narumi K, Miyakawa R, Shibasaki C, Henmi M, Mizoguchi Y, Ueda R, Hashimoto H, Hiraoka N, Yoshida T, Aoki K. Local Administration of GITR Agonistic Antibody Induces a Stronger Antitumor Immunity than Systemic Delivery. Sci Rep, 9時55分62, 2019
  1. Onishi S, Sawaki M, Ishiguro J, Kataoka A, Iwase M, Sugino K, Adachi Y, Gondo N, Kotani H, Yoshimura A, Hattori M, Matsuo K, Yatabe Y, Iwata H. The overall survival of breast cancer patients without adjuvant therapy. Surg Today, 49:610-620, 2019
  1. Osawa T, Shimamura T, Saito K, Hasegawa Y, Ishii N, Nishida M, Ando R, Kondo A, Anwar M, Tsuchida R, Hino S, Sakamoto A, Igarashi K, Saitoh K, Kato K, Endo K, Yamano S, Kanki Y, Matsumura Y, Minami T, Tanaka T, Anai M, Wada Y, Wanibuchi H, Hayashi M, Hamada A, Yoshida M, Yachida S, Nakao M, Sakai J, Aburatani H, Shibuya M, Hanada K, Miyano S, Soga T, Kodama Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2. Cell Rep, 29:89-103.e7, 2019
  1. Saito Y, Muramatsu T, Kanai Y, Ojima H, Sukeda A, Hiraoka N, Arai E, Sugiyama Y, Matsuzaki J, Uchida R, Yoshikawa N, Furukawa R, Saito Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma. Cell Rep, 27:1265-1276.e4, 2019
  1. Sekine S, Kiyono T, Ryo E, Ogawa R, Wakai S, Ichikawa H, Suzuki K, Arai S, Tsuta K, Ishida M, Sasajima Y, Goshima N, Yamazaki N, Mori Recurrent YAP1-MAML2 and YAP1- NUTM1 fusions in poroma and porocarcinoma. J Clin Invest, 129:3827-3832, 2019
  1. Shiino S, Matsuzaki J, Shimomura A, Kawauchi J, Takizawa S, Sakamoto H, Aoki Y, Yoshida M, Tamura K, Kato K, Kinoshita T, Kitagawa Y, Ochiya Serum miRNA-based Prediction of Axillary Lymph Node Metastasis in Breast Cancer. Clin Cancer Res, 25:1817-1827, 2019
  1. Shiino S, Yoshida M, Jimbo K, Asaga S, Takayama S, Maeshima A, Tsuda H, Kinoshita T, Hiraoka Two rare cases of endosalpingiosis in the axillary sentinel lymph nodes: evaluation of immunohistochemical staining and one-step nucleic acid amplification (OSNA) assay in patients with breast cancer. Virchows Arch, 474:633-638, 2019
  1. Sivakumar S, San Lucas FA, Jakubek YA, McDowell TL, Lang W, Kallsen N, Peyton S, Davies GE, Fukuoka J, Yatabe Y, Zhang J, Futreal PA, Fowler J, Fujimoto J, Ehli EA, Hawk ET, Wistuba II, Kadara H, Scheet Genomic landscape of allelic imbalance in premalignant atypical adenomatous hyperplasias of the lung. EBioMedicine, 42:296-303, 2019
  1. Suzuki T, Yamazaki H, Honda K, Ryo E, Kaneko A, Ota Y, Mori Altered DNA methylation is associated with aberrant stemness gene expression in early?stage HNSCC. Int J Oncol, 55:915-924, 2019
  2. Tajika M, Tanaka T, Ishihara M, Hirayama Y, Oonishi S, Mizuno N, Kuwahara T, Okuno N, Matsumoto S, Ooshiro T, Kinoshita T, Komori K, Bhatia V, Hara K, Yatabe Y, Niwa Long-term outcomes of metachronous neoplasms in the ileal pouch and rectum after surgical treatment in patients with familial adenomatous polyposis. Endosc Int Open, 7:E691-E698, 2019
  1. Takayama S, Satomi K, Yoshida M, Watase C, Murata T, Shiino S, Jimbo K, Suto Spontaneous regression of occult breast cancer with axillary lymph node metastasis: A case report. Int J Surg Case Rep, 63:75-79, 2019
  1. Tomita T, Mori T, Onishi β-Arrestin 1 (ARRB1) serves as a molecular marker of the peripheral circadian rhythm. Int J Oral Sci, 11時32分, 2019
  1. Toyoda K, Maeshima AM, Nomoto J, Suzuki T, Yuda S, Yamauchi N, Taniguchi H, Makita S, Fukuhara S, Munakata W, Maruyama D, Tobinai K, Kobayashi Mucosa-associated lymphoid tissue lymphoma with t(11;18)(q21;q21) translocation: long-term follow-up results. Ann Hematol, 98:1675-1687, 2019
  1. Tsao MS, Yatabe Old Soldiers Never Die: Is There Still a Role for Immunohistochemistry in the Era of Next-Generation Sequencing Panel Testing? J Thorac Oncol, 14時20分35-2038, 2019
  1. Tsukada T, Yoshida H, Ishikawa M, Asami Y, Shiraishi K, Kato Malignant struma ovarii presenting with follicular carcinoma: A case report with molecular analysis. Gynecol Oncol Rep, 30:100498, 2019
  1. Tsutsuyama M, Nakanishi H, Yoshimura M, Oshiro T, Kinoshita T, Komori K, Shimizu Y, Ichinosawa Y, Kinuta S, Wajima K, Sakakibara Y, Yatabe Y, Ito S, Kodera Detection of circulating tumor cells in drainage venous blood from colorectal cancer patients using a new filtration and cytology- based automated platform. PLoS One, 14:e0212221, 2019
  1. Uehara T, Yoshida H, Tate K, Kato Metachronous occurrence of two different histological subtypes of endometriosis-related neoplasms. Gynecol Oncol Rep, 27:42- 45, 2019
  1. Watari J, Mitani S, Ito C, Tozawa K, Tomita T, Oshima T, Fukui H, Kadowaki S, Natsume S, Senda Y, Tajika M, Hara K, Yatabe Y, Shimizu Y, Muro K, Morimoto T, Hirota S, Das KM, Miwa Molecular alterations and PD-L1 expression in non-ampullary duodenal adenocarcinoma: Associations among clinicopathological, immunophenotypic and molecular features. Sci Rep, 9時10分526, 2019
  1. Yamazaki F, Nakatani F, Asano N, Wakai S, Sekimizu M, Mitani S, Kubo T, Kawai A, Ichikawa H, Yoshida Novel NTRK3 Fusions in Fibrosarcomas of Adults. Am J Surg Pathol, 43:523-530, 2019
  1. Yamazawa E, Honma Y, Satomi K, Taniguchi H, Takahashi M, Yoshida A, Tominaga K, Miyakita Y, Ohno M, Asanome T, Satomi N, Narita A rare case of brain metastasis from poorly differentiated small bowel adenocarcinoma. Surg Neurol Int, 10時25分6, 2019
  1. Yatabe Y, Dacic S, Borczuk AC, Warth A, Russell PA, Lantuejoul S, Beasley MB, Thunnissen E, Pelosi G, Rekhtman N, Bubendorf L, Mino-Kenudson M, Yoshida A, Geisinger KR, Noguchi M, Chirieac LR, Bolting J, Chung JH, Chou TY, Chen G, Poleri C, Lopez-Rios F, Papotti M, Sholl LM, Roden AC, Travis WD, Hirsch FR, Kerr KM, Tsao MS, Nicholson AG, Wistuba I, Moreira Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer. J Thorac Oncol, 14時37分7-407, 2019
  1. Yoshida A, Arai Y, Tanzawa Y, Wakai S, Hama N, Kawai A, Shibata KMT2A (MLL) fusions in aggressive sarcomas in young adults. Histopathology, 75:508-516, 2019
  1. Yoshida KI, Nakano Y, Honda-Kitahara M, Wakai S, Motoi T, Ogura K, Sano N, Shibata T, Okuma T, Iwata S,  Kawai A, Ichimura K, Yoshida Absence of H3F3A mutation in a subset of malignant giant cell tumor of bone. Mod Pathol, 32:1751-1761, 2019
  1. Yoshida H, Yokota H, Singh R, Kiyuna T, Yamaguchi M, Kikuchi S, Yagi Y, Ochiai Meeting Report: The International Workshop on Harmonization and Standardization of Digital Pathology Image, Held on April 4, 2019 in Tokyo. Pathobiology, 86:322-324, 2019
  1. Yoshioka H, Shimokawa M, Seto T, Morita S, Yatabe Y, Okamoto I, Tsurutani J, Satouchi M, Hirashima T, Atagi S, Shibata K, Saito H, Toyooka S, Yamamoto N, Nakagawa K, Mitsudomi Final overall survival results of WJTOG3405, a randomized phase III trial comparing gefitinib versus cisplatin with docetaxel as the first-line treatment for patients with stage IIIB/IV or postoperative recurrent EGFR mutation- positive non-small-cell lung cancer. Ann Oncol, 30:1978-1984, 2019
  1. Yuda S, Shimizu C, Yoshida M, Shiino S, Kinoshita T, Maeshima AM, Tamura Biomarker discordance between primary breast cancer and bone or bone marrow metastases. Jpn J Clin Oncol, 49:426-430, 2019

Book

  1. Singhi AD, Adsay NV, Hiraoka N, Terris Acinar cystic transformation of the pancreas. In: WHO classification of Tumours (ed), Digestive System Tumours WHO Classification of Tumours, 5th Edition, Lyon, IARC, pp 300-302, 2019
  2. Singhi AD, Adsay NV, Hiraoka N, Terris B. Serous neoplasms of the pancreas. In: WHO classification of Tumours (ed), Digestive System Tumours WHO Classification of Tumours, 5th Edition, Lyon, IARC, pp 303-306, 2019