Division of Boron Neutron Capture Therapy

Jun Itami, Hiroshi Igaki, Hiroaki Kurihara, Yoshitaka Narita, Seiichi Yoshimoto, Naoya Yamazaki, Mitsuko Masutani, Hiroyuki Okamoto, Akihisa Wakita, Satoshi Nakamura, Shie Nishioka, Yoshihisa Abe, Masashi Ito, Shouji Imamichi, Kazuma Kobayashi

Introduction

The Division of Boron Neutron Capture Therapy is developing a proton linear accelerator for the boron neutron capture therapy (BNCT) in cooperation with Cancer Intelligence Care Systems, Inc. (CICS) and performing nonclinical experiments. Clinical trials are being planned for clinical implementation of accelerator-based BNCT.

Research activities

The proton linear accelerator for BNCT installed in the National Cancer Center Hospital (NCCH) in Tsukiji Campus currently works stably and continuous neutron irradiation up to eight hours has been performing since the autumn of 2016. Currently, 60% of the final specified neutron flux is obtained and the system can be even used clinically. Parallel to the accelerator development, various new instrumentations, including sintered LiF for covering glass dosimeter were developed to measure neutron flux and gamma ray contamination. Using such newly developed instruments, physical evaluation of the neutron fields is under way, with the measurements of neutron flux, neutron spectrum, and field flatness. For launching biological experiments in the neutron area, the extent of radioactivation of mice in the neutron fields was evaluated. The main radionuclide produced in the mice after neutron exposure was Na-24, which turned out to be within the Basic Safety Standards (BSS). Therefore, irradiated mice can be brought out of the controlled area. To elucidate biological property of neutron fields, cell radiation and mice radiation experiments are being performed which will give the relative biological effectiveness of neutrons. Further experiments using boronophenylalanine (BPA) will be performed soon.

Hiroaki Kurihara et al. are developing F-BPA automatic production system. Clinical trial of F-BPA PET/CT was finished with the recruitment of 120 patients, and the property of F-BPA PET was investigated.

List of papers published in 2016

Journal

1.Kobayashi K, Matsumoto F, Kodaira M, Mori T, Murakami N, Yoshida A, Maki D, Teshima M, Fukasawa M, Itami J, Asai M, Yoshimoto S. Significance of delayed primary excision in localized nonmetastatic adult head and neck rhabdomyosarcoma. Cancer Med, 5:2708-2714, 2016

2.Okamoto H, Wakita A, Nakamura S, Nishioka S, Aikawa A, Kato T, Abe Y, Kobayashi K, Inaba K, Murakami N, Itami J. Dosimetric impact of an air passage on intraluminal brachytherapy for bronchus cancer. J Radiat Res, 57:637-645, 2016

3.Murakami N, Kato S, Nakano T, Uno T, Yamanaka T, Sakurai H, Yoshimura R, Hiratsuka J, Kuroda Y, Yoshio K, Itami J. A phase I/II clinical trial for the hybrid of intracavitary and interstitial brachytherapy for locally advanced cervical cancer. BMC Cancer, 16:640, 2016

4.Kobayashi K, Murakami N, Inaba K, Wakita A, Nakamura S, Okamoto H, Sato J, Umezawa R, Takahashi K, Igaki H, Ito Y, Shigematsu N, Itami J. Dose reconstruction technique using non-rigid registration to evaluate spatial correspondence between high-dose region and late radiation toxicity: a case of tracheobronchial stenosis after external beam radiotherapy combined with endotracheal brachytherapy for tracheal cancer. J Contemp Brachytherapy, 8:156-163, 2016

5.Inaba K, Okamoto H, Wakita A, Tsuchida K, Kashihara T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Umezawa R, Takahashi K, Murakami N, Ito Y, Igaki H, Uno T, Itami J. Long-term observations of radiation-induced creatinine clearance reduction and renal parenchymal volume atrophy. Radiother Oncol, 120:145-149, 2016

6.Kobayashi K, Kurihara H, Watanabe Y, Murakami N, Inaba K, Nakamura S, Wakita A, Okamoto H, Umezawa R, Takahashi K, Igaki H, Ito Y, Yoshimoto S, Shigematsu N, Itami J. In vivo spatial correlation between 18F-BPA and 18F-FDG uptakes in head and neck cancer. Appl Radiat Isot, 115:138-146, 2016

7.Kawajiri A, Maruyama D, Maeshima AM, Nomoto J, Makita S, Kitahara H, Miyamoto KI, Fukuhara S, Suzuki T, Munakata W, Tajima K, Itami J, Taniguchi H, Kobayashi Y, Tobinai K. Impact of the double expression of MYC and BCL2 on outcomes of localized primary gastric diffuse large B-cell lymphoma patients in the rituximab era. Blood Cancer J, 6:e477, 2016

8.Murakami N, Kato T, Miyamoto Y, Nakamura S, Wakita A, Okamoto H, Tsuchida K, Kashihara T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Takahashi K, Umezawa R, Inaba K, Ito Y, Igaki H, Itami J. Salvage High-dose-rate Interstitial Brachytherapy for Pelvic Recurrent Cervical Carcinoma After Hysterectomy. Anticancer Res, 36:2413-2421, 2016

9.Murakami N, Kobayashi K, Kato T, Nakamura S, Wakita A, Okamoto H, Shima S, Tsuchida K, Kashihara T, Harada K, Takahashi K, Umezawa R, Inaba K, Ito Y, Igaki H, Itami J. The role of interstitial brachytherapy in the management of primary radiation therapy for uterine cervical cancer. J Contemp Brachytherapy, 8:391-398, 2016

10.Murakami N, Matsumoto F, Yoshimoto S, Ito Y, Mori T, Ueno T, Tuchida K, Kashihara T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Umezawa R, Takahashi K, Inaba K, Igaki H, Itami J. Patterns of recurrence after selective postoperative radiation therapy for patients with head and neck squamous cell carcinoma. BMC Cancer, 16:192, 2016

11.Nakamura S, Murakami N, Inaba K, Wakita A, Kobayashi K, Takahashi K, Okamoto H, Umezawa R, Morota M, Sumi M, Igaki H, Ito Y, Itami J. After low and high dose-rate interstitial brachytherapy followed by IMRT radiotherapy for intermediate and high risk prostate cancer. BMC Cancer, 16:296, 2016

12.Okamoto H, Hamada M, Sakamoto E, Wakita A, Nakamura S, Kato T, Abe Y, Takahashi K, Igaki H, Itami J. Log-file analysis of accuracy of beam localization for brain tumor treatment by CyberKnife. Pract Radiat Oncol, 6:e361-e367, 2016

13.Takahashi K, Morota M, Kagami Y, Okamoto H, Sekii S, Inaba K, Murakami N, Igaki H, Ito Y, Uno T, Itami J. Prospective study of postoperative whole breast radiotherapy for Japanese large-breasted women: a clinical and dosimetric comparisons between supine and prone positions and a dose measurement using a breast phantom. BMC Cancer, 16:757, 2016

14.Inaba K, Nakamura S, Okamoto H, Kashihara T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Takahashi K, Murakami N, Ito Y, Igaki H, Uno T, Itami J. Early-onset dropped head syndrome after radiotherapy for head and neck cancer: dose constraints for neck extensor muscles. J Radiat Res, 57:169-173, 2016

15.Nose T, Otani Y, Asahi S, Tsukiyama I, Dokiya T, Saeki T, Fukuda I, Sekine H, Shikama N, Kumazaki Y, Takahashi T, Yoshida K, Kotsuma T, Masuda N, Yoden E, Nakashima K, Matsumura T, Nakagawa S, Tachiiri S, Moriguchi Y, Itami J, Oguchi M. A Japanese prospective multi-institutional feasibility study on accelerated partial breast irradiation using interstitial brachytherapy: clinical results with a median follow-up of 26 months. Breast Cancer, 23:861-868, 2016