Annual Report 2017
Division of BNCT Medical Research
Jun Itami, Hiroshi Igaki, Hiroaki Kurihara, Yoshitaka Narita, Seiichi Yoshimoto, Naoya Yamazaki, Mitsuko Masutani, Hiroyuki Okamoto, Akihisa Wakita, Satoshi Nakamura, Shie Nishioka, Yoshihisa Abe, Masashi Ito, Shouji Imamichi, Kazuma Kobayashi
Introduction
The Division of BNCT Medical Research is developing a proton linear accelerator for boron neutron capture therapy (BNCT) in cooperation with Cancer Intelligence Care Systems, Inc. (CICS) and performing nonclinical experiments. Clinical trials are being planned for clinical implementation of accelerator-based BNCT.
Research activities
The proton linear accelerator for BNCT installed in the National Cancer Center Hospital (NCCH) in the Tsukiji Campus now works stably and continuous neutron irradiation up to eight hours is being performed since the autumn of 2016. Currently, 60% of the final specified neutron flux is obtained and the system can be even used clinically. In this year, preclinical studies of physical as well as biological properties of the system were performed in accordance with the good laboratory practice (GLP) standards to obtain the Pharmaceuticals and Medical Devices Agency (PMDA) approval.
Hiroaki Kurihara et al. are developing F-BPA automatic production system. A clinical trial of 18F-BPA PET/CT was finished with recruitment of 120 patients, and the properties of 18F-BPA PET were investigated.
References
1. Nakamura S, Imamichi S, Masumoto K, Ito M, Wakita A, Okamoto H, Nishioka S, Iijima K, Kobayashi K, Abe Y, Igaki H, Kurita K, Nishio T, Masutani M, Itami J. Evaluation of radioactivity in the bodies of mice induced by neutron exposure from an epi-thermal neutron source of an accelerator-based boron neutron capture therapy system. Proc Jpn Acad Ser B Phys Biol Sci. 2017;93(10):821-831. doi: 10.2183/pjab.93.051.
2. Nakamura S, Wakita A, Ito M, Okamoto H, Nishioka S, Iijima K, Kobayashi K, Nishio T, Igaki H, Itami J. Modeling the detection efficiency of an HP-Ge detector for use in boron neutron capture therapy. Appl Radiat Isot. 2017 Jul;125:80-85. doi: 10.1016/j.apradiso.2017.03.027.
3. Kono Y, Kurihara H, Kawamoto H, Yasui N, Honda N, Igaki H, Itami J. Radiation absorbed dose estimates for 18F-BPA PET. Acta Radiol. 2017 Sep;58(9):1094-1100. doi: 10.1177/0284185116688378.
4. Watanabe Y, Kurihara H, Itami J, Sasaki R, Arai Y, Sugimura K. Relationship between the uptake of 18F-borono-L-phenylalanine and L-[methyl-11C] methionine in head and neck tumors and normal organs. Radiat Oncol. 2017 Jan 14;12(1):17. doi: 10.1186/s13014-017-0763-6.
List of papers published in January 2017 - March 2018
Journal
1. Igaki H, Harada K, Umezawa R, Miyakita Y, Ohno M, Takahashi M, Sumi M, Inaba K, Murakami N, Ito Y, Narita Y, Itami J. Outcomes of surgery followed by local brain radiotherapy compared with surgery followed by whole brain radiotherapy for single brain metastasis. Tumori, 103:367-373, 2017
2. Honma Y, Hokamura N, Nagashima K, Sudo K, Shoji H, Iwasa S, Takashima A, Kato K, Hamaguchi T, Boku N, Umezawa R, Ito Y, Itami J, Koyanagi K, Igaki H, Tachimori Y. Clinical Outcomes of Resectable Esophageal Cancer with Supraclavicular Lymph Node Metastases Treated with Curative Intent. Anticancer Res, 37:3741-3749, 2017
3. Yoshioka Y, Kotsuma T, Komiya A, Kariya S, Konishi K, Nonomura N, Ogawa K, Tanaka E, Nishimura K, Fujiuchi Y, Kitamura H, Yamagami T, Yamasaki I, Teshima T, Nakamura K, Itami J. Nationwide, Multicenter, Retrospective Study on High-Dose-Rate Brachytherapy as Monotherapy for Prostate Cancer. Int J Radiat Oncol Biol Phys, 97:952-961, 2017
4. Sekii S, Murakami N, Kato T, Harada K, Kitaguchi M, Takahashi K, Inaba K, Igaki H, Ito Y, Sasaki R, Itami J. Outcomes of salvage high-dose-rate brachytherapy with or without external beam radiotherapy for isolated vaginal recurrence of endometrial cancer. Journal of contemporary brachytherapy, 9:209-215, 2017
5. Okamoto H, Nakamura S, Nishioka S, Iijima K, Wakita A, Abe Y, Tohyama N, Kawamura S, Minemura T, Itami J. Independent assessment of source position for gynecological applicator in high-dose-rate brachytherapy. Journal of contemporary brachytherapy, 9:477-486, 2017
6. Nakamura S, Imamichi S, Masumoto K, Ito M, Wakita A, Okamoto H, Nishioka S, Iijima K, Kobayashi K, Abe Y, Igaki H, Kurita K, Nishio T, Masutani M, Itami J. Evaluation of radioactivity in the bodies of mice induced by neutron exposure from an epi-thermal neutron source of an accelerator-based boron neutron capture therapy system. Proc Jpn Acad Ser B Phys Biol Sci, 93:821-831, 2017
7. Nakamura S, Okamoto H, Wakita A, Umezawa R, Takahashi K, Inaba K, Murakami N, Kato T, Igaki H, Ito Y, Abe Y, Itami J. A management method for the statistical results of patient-specific quality assurance for intensity-modulated radiation therapy. J Radiat Res, 58:572-578, 2017
8. Nakamura S, Wakita A, Ito M, Okamoto H, Nishioka S, Iijima K, Kobayashi K, Nishio T, Igaki H, Itami J. Modeling the detection efficiency of an HP-Ge detector for use in boron neutron capture therapy. Appl Radiat Isot, 125:80-85, 2017
9. Yamaguchi M, Suzuki R, Oguchi M, Asano N, Amaki J, Akiba T, Maeda T, Itasaka S, Kubota N, Saito Y, Kobayashi Y, Itami J, Ueda K, Miyazaki K, Ii N, Tomita N, Sekiguchi N, Takizawa J, Saito B, Murayama T, Ando T, Wada H, Hyo R, Ejima Y, Hasegawa M, Katayama N. Treatments and Outcomes of Patients With Extranodal Natural Killer/T-Cell Lymphoma Diagnosed Between 2000 and 2013: A Cooperative Study in Japan. J Clin Oncol, 35:32-39, 2017
10. Watanabe Y, Kurihara H, Itami J, Sasaki R, Arai Y, Sugimura K. Relationship between the uptake of 18F-borono-L-phenylalanine and L-[methyl-11C] methionine in head and neck tumors and normal organs. Radiat Oncol, 12:17, 2017
11. Kobayashi K, Mori T, Matsumoto F, Murakami N, Teshima M, Fukasawa M, Matsumoto Y, Matsumura S, Itami J, Asai M, Yoshimoto S. Impact of microscopic orbital periosteum invasion in orbital preservation surgery. Jpn J Clin Oncol, 47:321-327, 2017
12. Kono Y, Kurihara H, Kawamoto H, Yasui N, Honda N, Igaki H, Itami J. Radiation absorbed dose estimates for 18F-BPA PET. Acta Radiol, 58:1094-1100, 2017
13. Yoden E, Nose T, Otani Y, Asahi S, Tsukiyama I, Dokiya T, Saeki T, Fukuda I, Sekine H, Shikama N, Kumazaki Y, Takahashi T, Yoshida K, Kotsuma T, Masuda N, Nakashima K, Matsumura T, Nakagawa S, Tachiiri S, Moriguchi Y, Itami J, Oguchi M. Uncertainty of cosmetic evaluation after accelerated partial breast irradiation: interim analysis of a Japanese prospective multi-institutional feasibility study. Jpn J Radiol, 35:381-388, 2017
14. Iwata T, Ueno H, Itami J, Ito Y, Inaba K, Morizane C, Kondo S, Sakamoto Y, Shiba S, Sasaki M, Koga F, Okusaka T. Efficacy of radiotherapy for primary tumor in patients with unresectable pancreatic neuroendocrine tumors. Jpn J Clin Oncol, 47:826-831, 2017
15. Ishiyama H, Kamitani N, Kawamura H, Kato S, Aoki M, Kariya S, Matsumura T, Kaidu M, Yoshida K, Hashimoto Y, Noda Y, Lim KHC, Kawase T, Takahashi T, Inaba K, Kumano M, Yoshikawa N, Yoshioka Y, Nakamura K, Hiratsuka J, Itami J, Hayakawa K. Nationwide multi-institutional retrospective analysis of high-dose-rate brachytherapy combined with external beam radiotherapy for localized prostate cancer: An Asian Prostate HDR-BT Consortium. Brachytherapy, 16:503-510, 2017
16. Sudo K, Kato K, Kuwabara H, Sasaki Y, Takahashi N, Shoji H, Iwasa S, Honma Y, Okita NT, Takashima A, Hamaguchi T, Yamada Y, Ito Y, Itami J, Fukuda T, Tobinai K, Boku N. Patterns of Relapse after Definitive Chemoradiotherapy in Stage II/III (Non-T4) Esophageal Squamous Cell Carcinoma. Oncology, 94:47-54, 2018
17. Umezawa R, Murakami N, Nakamura S, Wakita A, Okamoto H, Tsuchida K, Kashihara T, Kobayashi K, Harada K, Takahashi K, Inaba K, Ito Y, Igaki H, Masui K, Yoshida K, Jingu K, Tselis N, Itami J. Image-guided interstitial high-dose-rate brachytherapy for locally recurrent uterine cervical cancer: A single-institution study. Brachytherapy, 17:368-376, 2018
18. Morita T, Kurihara H, Hiroi K, Honda N, Igaki H, Hatazawa J, Arai Y, Itami J. Dynamic changes in 18F-borono-L-phenylalanine uptake in unresectable, advanced, or recurrent squamous cell carcinoma of the head and neck and malignant melanoma during boron neutron capture therapy patient selection. Radiat Oncol, 13:4, 2018
19. Okamoto H, Murakami N, Carvajal CC, Miura Y, Wakita A, Nakamura S, Nishioka S, Iijima K, Inaba K, Ito Y, Kato T, Toita T, Itami J. Positional uncertainty of vaginal cuff and feasibility of implementing portable bladder scanner in postoperative cervical cancer patients. Phys Med, 45:1-5, 2018
20. Kashihara T, Nakamura S, Wakita A, Okamoto H, Inaba K, Umezawa R, Shima S, Tsuchida K, Kobayashi K, Takahashi K, Murakami N, Ito Y, Igaki H, Fujimoto H, Uno T, Itami J. Importance of the site of positive surgical margin in salvage external beam radiation therapy for biochemical recurrence of prostate cancer after radical prostatectomy. Cancer Med, 7:1723-1730, 2018
21. Umezawa R, Inaba K, Nakamura S, Wakita A, Okamoto H, Shima S, Tsuchida K, Kashihara T, Kobayashi K, Harada K, Takahashi K, Murakami N, Ito Y, Igaki H, Jingu K, Itami J. Long-term Results of External Beam Radiotherapy for Prostate Cancer with Prostate-specific Antigen of More Than 50 ng/ml and Without Evidence of Lymph Node or Distant Metastasis. Anticancer Res, 38:2303-2309, 2018
Book
1. Itami J. Pyothorax-Associated Lymphoma. In: Sasai K., Oguchi M (ed), Radiation Therapy for Extranodal Lymphomas, pp 45-54, 2017