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Annual Report 2017

Division of Science and Technology for Endoscopy (Tsukiji Campus)

Ichiro Oda, Yutaka Saito, Haruhisa Suzuki, Satoru Nonaka, Taku Sakamoto, Masayoshi Yamada, Yasuo Kakugawa, Shigetaka Yoshinaga, Seiichiro Abe, Hiroyuki Takamaru, Keiko Nakamura

Introduction

 Remarkable progress has been made on not only endoscopic diagnosis but also endoscopic treatment. Our efforts will be focused on the developments of new endoscopic diagnosis (e.g. molecular imaging) and treatment (e.g. full thickness resection), as well as an effective training system with industry-academia collaboration (Figure 1).

Figure 1. The research and developmenton new endoscopic diagnostic, therapeuticand training equipments in collaborationwith companies and academia
Figure 1. The research and developmenton new endoscopic diagnostic, therapeuticand training equipments in collaborationwith companies and academia

Figure 1. The research and developmenton new endoscopic diagnostic, therapeuticand training equipments in collaborationwith companies and academia
Figure 1. The research and developmenton new endoscopic diagnostic, therapeuticand training equipments in collaborationwith companies and academia(Full Size)

Our team and what we do

 In fiscal year 2017, in the Division of Science and Technology for Endoscopy of the Exploratory Oncology Research & Clinical Trial Center (EPOC) at the National Cancer Center (NCC) - Tsukiji Campus, four teams were organized (Diagnosis team, Treatment team, Training team, AI team) to develop the innovative endoscopic diagnosis, treatment and training system. We have searched clinical needs, and then set up development themes for each team.

Diagnosis team; Taku Sakamoto, Haruhisa Suzuki, Satoru Nonaka, Masayoshi Yamada

Treatment team; Satoru Nonaka, Taku Sakamoto, Seiichiro Abe, Hiroyuki Takamaru

Training team; Haruhisa Suzuki, Yasuo Kakugawa, Shigetaka Yoshinaga, Taku Sakamoto, Keiko Nakamura

Artificial intelligence (AI) team; Masayoshi Yamada, Ichiro Oda

Supervisors; Ichiro Oda, Yutaka Saito

Research activities

1) In collaboration with Olympus Corporation, we have started the development of new endoscopic diagnostic, therapeutic and training equipments at Olympus Lab in the National Cancer Center Research Institute (NCCRI). Although details are currently confidential, each team is involved in three or four research and development themes.

2) In collaboration with the Artificial Intelligence Research Center (AIRC), the National Institute of Advanced Industrial Science and Technology (AIST) (Professor Jun Sese), the NCCRI (Professor Ryuji Hamamoto), and the Division of Science and Technology for Endoscopy of the EPOC (Kashiwa Campus: Professor Hiroaki Ikematsu), we have started the research and development of an endoscopic diagnosis support system on tumor invasion of gastrointestinal cancer using AI.

Education

 We have invited residents from the Department of Endoscopy of the National Cancer Center Hospital (NCCH) to our meetings and experiments of each development team, and educated them to be the leaders of the next generation in the research and development on the endoscopic science and technology.

Future prospects

 We are working on the research and development of new endoscopic diagnostic, therapeutic and training equipments in collaboration with companies and academia. In the future, we would like to disseminate our new equipments to the world.

List of papers published in January 2017 - March 2018

Journal

 1. Tanabe S, Ishido K, Matsumoto T, Kosaka T, Oda I, Suzuki H, Fujisaki J, Ono H, Kawata N, Oyama T, Takahashi A, Doyama H, Kobayashi M, Uedo N, Hamada K, Toyonaga T, Kawara F, Tanaka S, Yoshifuku Y. Long-term outcomes of endoscopic submucosal dissection for early gastric cancer: a multicenter collaborative study. Gastric cancer, 20:45-52, 2017

 2. Hotta K, Matsuda T, Kakugawa Y, Ikematsu H, Kobayashi N, Kushima R, Hozawa A, Nakajima T, Sakamoto T, Mori M, Fujii T, Saito Y. Regional colorectal cancer screening program using colonoscopy on an island: a prospective Nii-jima study. Jpn J Clin Oncol, 47:118-122, 2017

 3. Yamada M, Saito Y, Takamaru H, Sasaki H, Yokota T, Matsuyama Y, Sato Y, Sakamoto T, Nakajima T, Taniguchi H, Sekine S, Matsuda T. Long-term clinical outcomes of endoscopic submucosal dissection for colorectal neoplasms in 423 cases: a retrospective study. Endoscopy, 49:233-242, 2017

 4. Abe S, Minagawa T, Tanaka H, Oda I, Saito Y. Successful endoscopic closure using over-the-scope clip for delayed stomach perforation caused by nasogastric tube after endoscopic submucosal dissection. Endoscopy, 49:E56-E57, 2017

 5. Nakamura K, Nonaka S, Nakajima T, Yachida T, Abe S, Sakamoto T, Suzuki H, Yoshinaga S, Oda I, Matsuda T, Sekine S, Kanemitsu Y, Katai H, Saito Y, Hirota S. Clinical outcomes of gastric polyps and neoplasms in patients with familial adenomatous polyposis. Endosc Int Open, 5:E137-E145, 2017

 6. Nishiumi S, Kobayashi T, Kawana S, Unno Y, Sakai T, Okamoto K, Yamada Y, Sudo K, Yamaji T, Saito Y, Kanemitsu Y, Okita NT, Saito H, Tsugane S, Azuma T, Ojima N, Yoshida M. Investigations in the possibility of early detection of colorectal cancer by gas chromatography/triple-quadrupole mass spectrometry. Oncotarget, 8:17115-17126, 2017

 7. Sekiguchi M, Oda I, Suzuki H, Abe S, Nonaka S, Yoshinaga S, Taniguchi H, Sekine S, Saito Y. Clinical outcomes and prognostic factors in gastric cancer patients aged >/=85 years undergoing endoscopic submucosal dissection. Gastrointest Endosc, 85:963-972, 2017

 8. Federico Iacopini, Takuji Gotoda,Fabrizio Montagnese, Fabio Andrei, Yutaka Saito. Underwater endoscopic submucosal dissection of a nonpolypoid super?cial tumor spreading into the appendix. VideoGIE, 2:82-84, 2017

 9. Mortagy M, Mehta N, Parsi MA, Abe S, Stevens T, Vargo JJ, Saito Y, Bhatt A. Magnetic anchor guidance for endoscopic submucosal dissection and other endoscopic procedures. World journal of gastroenterology, 23:2883-2890, 2017

10. Abe S, Oda I, Inoki K, Sekiguchi M, Nonaka S, Suzuki H, Yoshinaga S, Ngamruengphong S, Saito Y. Should we perform surveillance endoscopy after endoscopic submucosal dissection of premalignant gastric adenoma? Ann Laparosc Endosc Surg, 2:95, 2017

11. Saito Y, Bhatt A, Matsuda T. Colorectal endoscopic submucosal dissection and its journey to the West. Gastrointest Endosc, 86:90-92, 2017

12. Suzuki H, Oda I, Abe S, Sekiguchi M, Nonaka S, Yoshinaga S, Saito Y, Fukagawa T, Katai H. Clinical outcomes of early gastric cancer patients after noncurative endoscopic submucosal dissection in a large consecutive patient series. Gastric Cancer, 20:679-689, 2017

13. Ishihara R, Oyama T, Abe S, Takahashi H, Ono H, Fujisaki J, Kaise M, Goda K, Kawada K, Koike T, Takeuchi M, Matsuda R, Hirasawa D, Yamada M, Kodaira J, Tanaka M, Omae M, Matsui A, Kanesaka T, Takahashi A, Hirooka S, Saito M, Tsuji Y, Maeda Y, Yamashita H, Oda I, Tomita Y, Matsunaga T, Terai S, Ozawa S, Kawano T, Seto Y. Risk of metastasis in adenocarcinoma of the esophagus: a multicenter retrospective study in a Japanese population. J Gastroenterol, 52:800-808, 2017

14. Ngamruengphong S, Abe S, Oda I. Endoscopic Management of Early Gastric Adenocarcinoma and Preinvasive Gastric Lesions. Surg Clin North Am, 97:371-385, 2017

15. Ikematsu H, Sakamoto T, Togashi K, Yoshida N, Hisabe T, Kiriyama S, Matsuda K, Hayashi Y, Matsuda T, Osera S, Kaneko K, Utano K, Naito Y, Ishihara H, Kato M, Yoshimura K, Ishikawa H, Yamamoto H, Saito Y. Detectability of colorectal neoplastic lesions using a novel endoscopic system with blue laser imaging: a multicenter randomized controlled trial. Gastrointest Endosc, 86:386-394, 2017

16. Maeda M, Nakajima T, Oda I, Shimazu T, Yamamichi N, Maekita T, Asada K, Yokoi C, Ando T, Yoshida T, Nanjo S, Fujishiro M, Gotoda T, Ichinose M, Ushijima T. High impact of methylation accumulation on metachronous gastric cancer: 5-year follow-up of a multicentre prospective cohort study. Gut, 66:1721-1723, 2017

17. Tamai N, Saito Y, Sakamoto T, Nakajima T, Matsuda T, Sumiyama K, Tajiri H, Koyama R, Kido S. Effectiveness of computer-aided diagnosis of colorectal lesions using novel software for magnifying narrow-band imaging: a pilot study. Endoscopy international open, 5:E690-E694, 2017

18. Saito Y, Sumiyama K, Chiu PW. Robot assisted tumor resection devices. Expert Rev Med Devices, 14:657-662, 2017

19. Mejia-Perez LK, Abe S, Stevens T, Parsi MA, Jang SN, Oda I, Vargo JJ, Saito Y, Bhatt A. A minimally invasive treatment for early GI cancers. Cleve Clin J Med, 84:707-717, 2017

20. Iacopini F, Saito Y, Bella A, Gotoda T, Rigato P, Elisei W, Montagnese F, Iacopini G, Costamagna G. Colorectal endoscopic submucosal dissection: predictors and neoplasm-related gradients of difficulty. Endoscopy international open, 5:E839-E846, 2017

21. Spychalski M, Skulimowski A, Dziki A, Saito Y. Colorectal endoscopic submucosal dissection (ESD) in the West - when can satisfactory results be obtained? A single-operator learning curve analysis. Scand J Gastroenterol, 52:1442-1452, 2017

22. Abe S, Iyer PG, Oda I, Kanai N, Saito Y. Approaches for stricture prevention after esophageal endoscopic resection. Gastrointest Endosc, 86:779-791, 2017

23. Nakamura F, Saito Y, Haruyama S, Sekiguchi M, Yamada M, Sakamoto T, Nakajima T, Yamamoto S, Murakami Y, Ishikawa H, Matsuda T. Short-term Prospective Questionnaire Study of Early Postoperative Quality of Life After Colorectal Endoscopic Submucosal Dissection. Dig Dis Sci, 62:3325-3335, 2017

24. Abe S, Oda I, Suzuki H, Yoshinaga S, Saito Y. Insulated tip knife tunneling technique with clip line traction for safe endoscopic submucosal dissection of large circumferential esophageal cancer. VIDEOGIE, 2:342-345, 2017

25. Shichijo S, Uedo N, Saito Y. Report of the international symposiums at the 93rd Congress of Japan Gastroenterological Endoscopy Society in Osaka, 2017. Dig Endosc, 29:761-764, 2017

26. Yachida T, Nakajima T, Nonaka S, Nakamura K, Suzuki H, Yoshinaga S, Oda I, Moriya Y, Masaki T, Saito Y. Characteristics and Clinical Outcomes of Duodenal Neoplasia in Japanese Patients With Familial Adenomatous Polyposis. J Clin Gastroenterol, 2016

27. Purchiaroni F, Nakajima T, Sakamoto T, Abe S, Saito Y. Over-The-Scope-Clip pre-mounted onto a double balloon enteroscope for fast and successful closure of post-EMR jejunal perforation: case report. BMC Gastroenterol, 17:152, 2017

28. Yokoyama A, Katada C, Yokoyama T, Yano T, Kaneko K, Oda I, Shimizu Y, Doyama H, Koike T, Takizawa K, Hirao M, Okada H, Yoshii T, Konishi K, Yamanouchi T, Tsuda T, Omori T, Kobayashi N, Suzuki H, Tanabe S, Hori K, Nakayama N, Kawakubo H, Ishikawa H, Muto M. Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer. PLoS One, 12:e0175182, 2017

29. Yano T, Yoda Y, Nomura S, Toyosaki K, Hasegawa H, Ono H, Tanaka M, Morimoto H, Horimatsu T, Nonaka S, Kaneko K, Sato A. Prospective trial of biodegradable stents for refractory benign esophageal strictures after curative treatment of esophageal cancer. Gastrointest Endosc, 86:492-499, 2017

30. Yamada M, Oda I, Tanaka H, Abe S, Nonaka S, Suzuki H, Yoshinaga S, Kuchiba A, Koyanagi K, Igaki H, Taniguchi H, Sekine S, Saito Y, Tachimori Y. Tumor location is a risk factor for lymph node metastasis in superficial Barrett's adenocarcinoma. Endoscopy international open, 5:E868-E874, 2017

31. Nakanishi H, Doyama H, Ishikawa H, Uedo N, Gotoda T, Kato M, Nagao S, Nagami Y, Aoyagi H, Imagawa A, Kodaira J, Mitsui S, Kobayashi N, Muto M, Takatori H, Abe T, Tsujii M, Watari J, Ishiyama S, Oda I, Ono H, Kaneko K, Yokoi C, Ueo T, Uchita K, Matsumoto K, Kanesaka T, Morita Y, Katsuki S, Nishikawa J, Inamura K, Kinjo T, Yamamoto K, Yoshimura D, Araki H, Kashida H, Hosokawa A, Mori H, Yamashita H, Motohashi O, Kobayashi K, Hirayama M, Kobayashi H, Endo M, Yamano H, Murakami K, Koike T, Hirasawa K, Miyaoka Y, Hamamoto H, Hikichi T, Hanabata N, Shimoda R, Hori S, Sato T, Kodashima S, Okada H, Mannami T, Yamamoto S, Niwa Y, Yashima K, Tanabe S, Satoh H, Sasaki F, Yamazato T, Ikeda Y, Nishisaki H, Nakagawa M, Matsuda A, Tamura F, Nishiyama H, Arita K, Kawasaki K, Hoppo K, Oka M, Ishihara S, Mukasa M, Minamino H, Yao K. Evaluation of an e-learning system for diagnosis of gastric lesions using magnifying narrow-band imaging: a multicenter randomized controlled study. Endoscopy, 49:957-967, 2017

32. Tanabe S, Hirabayashi S, Oda I, Ono H, Nashimoto A, Isobe Y, Miyashiro I, Tsujitani S, Seto Y, Fukagawa T, Nunobe S, Furukawa H, Kodera Y, Kaminishi M, Katai H. Gastric cancer treated by endoscopic submucosal dissection or endoscopic mucosal resection in Japan from 2004 through 2006: JGCA nationwide registry conducted in 2013. Gastric cancer, 20:834-842, 2017

33. Sekiguchi M, Oda I. High miss rate for gastric superficial cancers at endoscopy: what is necessary for gastric cancer screening and surveillance using endoscopy? Endoscopy international open, 5:E727-E728, 2017

34. Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2016 for the Clinical Practice of Hereditary Colorectal Cancer (Translated Version). J Anus Rectum Colon, 2:S1-S51, 2018

35. Watanabe T, Muro K, Ajioka Y, Hashiguchi Y, Ito Y, Saito Y, Hamaguchi T, Ishida H, Ishiguro M, Ishihara S, Kanemitsu Y, Kawano H, Kinugasa Y, Kokudo N, Murofushi K, Nakajima T, Oka S, Sakai Y, Tsuji A, Uehara K, Ueno H, Yamazaki K, Yoshida M, Yoshino T, Boku N, Fujimori T, Itabashi M, Koinuma N, Morita T, Nishimura G, Sakata Y, Shimada Y, Takahashi K, Tanaka S, Tsuruta O, Yamaguchi T, Yamaguchi N, Tanaka T, Kotake K, Sugihara K. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer. Int J Clin Oncol, 23:1-34, 2018

36. Kodashima S, Tanaka K, Matsuda K, Fujishiro M, Saito Y, Ohtsuka K, Oda I, Katada C, Kato M, Kida M, Kobayashi K, Hoteya S, Horimatsu T, Matsuda T, Muto M, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Tajiri H. First progress report on the Japan Endoscopy Database project. Dig Endosc, 30:20-28, 2018

37. Matsuda K, Tanaka K, Fujishiro M, Saito Y, Ohtsuka K, Oda I, Katada C, Kato M, Kida M, Kobayashi K, Hoteya S, Horimatsu T, Kodashima S, Matsuda T, Muto M, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Tajiri H. Design paper: Japan Endoscopy Database (JED): A prospective, large database project related to gastroenterological endoscopy in Japan. Dig Endosc, 30:5-19, 2018

38. Kanesaka T, Uedo N, Yao K, Ezoe Y, Doyama H, Oda I, Kaneko K, Kawahara Y, Yokoi C, Sugiura Y, Ishikawa H, Takeuchi Y, Arao M, Iwatsubo T, Iwagami H, Matsuno K, Muto M, Saito Y, Tomita Y. Multiple convex demarcation line for prediction of benign depressed gastric lesions in magnifying narrow-band imaging. Endosc Int Open, 6:E145-E155, 2018

39. Morita S, Arai Y, Sugawara S, Sone M, Sakamoto Y, Okusaka T, Yoshinaga S, Saito Y, Terai S. Antireflux Metal Stent for Initial Treatment of Malignant Distal Biliary Obstruction. Gastroenterol Res Pract, 2018:3805173, 2018

40. Yamashita S, Kishino T, Takahashi T, Shimazu T, Charvat H, Kakugawa Y, Nakajima T, Lee YC, Iida N, Maeda M, Hattori N, Takeshima H, Nagano R, Oda I, Tsugane S, Wu MS, Ushijima T. Genetic and epigenetic alterations in normal tissues have differential impacts on cancer risk among tissues. Proc Natl Acad Sci U S A, 115:1328-1333, 2018

41. Katai H, Ishikawa T, Akazawa K, Isobe Y, Miyashiro I, Oda I, Tsujitani S, Ono H, Tanabe S, Fukagawa T, Nunobe S, Kakeji Y, Nashimoto A. Five-year survival analysis of surgically resected gastric cancer cases in Japan: a retrospective analysis of more than 100,000 patients from the nationwide registry of the Japanese Gastric Cancer Association (2001-2007). Gastric Cancer, 21:144-154, 2018

42. Hasuike N, Ono H, Boku N, Mizusawa J, Takizawa K, Fukuda H, Oda I, Doyama H, Kaneko K, Hori S, Iishi H, Kurokawa Y, Muto M. A non-randomized confirmatory trial of an expanded indication for endoscopic submucosal dissection for intestinal-type gastric cancer (cT1a): the Japan Clinical Oncology Group study (JCOG0607). Gastric Cancer, 21:114-123, 2018

Book

 1. Iacopini F, Saito Y. Colorectal Endoscopic Submucosal Dissection. In: Facciorusso, Antonio, Muscatiello, Nicola (eds), Colon Polypectomy, pp 73-88, 2018