Annual Report 2017

Satoshi Iwata, Mika Shiotsuka, Sayuri Hara

Introduction

 The Department of Infectious Diseases is a new department which was established in April 2017. We support the clinical practice in relation to infectious diseases in the National Cancer Center Hospital (NCCH) in cooperation with the Office of Infection Control and Prevention in the Department of Safety Management. We also conduct research activities for infectious diseases and vaccines in cooperation with other clinical departments inside/outside of the hospital.

 Our department consists of infectious disease specialists and an office clerk.

Our team and what we do

• Advising on the infection control and prevention, especially focusing on healthcare-associated infections, problematic pathogens including multidrug-resistant bacteria, and occupational infections
• Consulting with physicians on appropriate diagnosis of and treatment for infectious diseases
• Implementing antimicrobial stewardship strategy based on the local data from our hospital and the current clinical evidence
• Taking weekly ward rounds to monitor the environmental maintenance and compliance with the Infection Prevention and Control Manual
• Conducting surveillance for healthcare-associated infections and drug-resistant bacteria
• Providing education for the staff on standard practices regarding infection control and prevention with up-to-date evidence
• Checking for immunization status of the hospital staff and vaccinate those with insufficient protective immunity
• Advising on building and refurbishment projects from the aspect of infection control
• Holding conferences or mutual site visits with other regional hospitals to promote improvement in the infection control and prevention practices of one another

Research activities

• Effective education of infection control practice, especially medical device management
• Appropriate dosing of antimicrobial drugs in cancer patients
• The ideal system of infection control for cancer center in Japanese medical care system
• Mechanism of antimicrobial resistance of multi-drug resistant strain of Enterobacteriaceae isolated from cancer patient
• Genetic analysis for novel strain of non-tuberculous mycobacteria isolated from cancer patient
• Molecular epidemiology of Streptococci and Mycoplasma pneumoniae
• Epidemiology of bacterial meningitis in Japan

Education

 We conducted training for physicians and medical personnel on infection control and management of infectious diseases.

Future prospects

 Our final goal is to establish an ideal and feasible model of an infection control system for cancer centers in Japan and to develop human resources for management of infectious diseases, infection control, or appropriate use of antimicrobial agents.

List of papers published in January 2017 - March 2018

Journal

 1. Uwamino Y, Sugita K, Hasegawa N, Nishimura T, Fujiwara H, Iwata S. Rapid Detection and Typing of Carbapenemase Genes from Carbapenem-Resistant Enterobacteriaceae Isolates Collected in a Japanese Hospital Using the Xpert Carba-R Assay. Jpn J Infect Dis, 70:124-125, 2017

 2. Iwata S, Murata S, Rong Han S, Wakana A, Sawata M, Tanaka Y. Safety and Immunogenicity of a 9-Valent Human Papillomavirus Vaccine Administered to 9- to 15-Year-Old Japanese Girls. Jpn J Infect Dis, 70:368-373, 2017

 3. Sakata H, Kuroki H, Ouchi K, Tajima T, Iwata S. Pediatric community-acquired pneumonia treated with a three-day course of tebipenem pivoxil. J Infect Chemother, 23:307-311, 2017

 4. Ebara Y, Morozumi M, Sato M, Moritoki N, Toyofuku M, Takata M, Murata M, Ubukata K, Iwata S. Enhancement of bactericidal activity against group B streptococci with reduced penicillin susceptibility by uptake of gentamicin into cells resulting from combination with beta-lactam antibiotics. J Infect Chemother, 23:312-318, 2017

 5. Takesue Y, Kusachi S, Mikamo H, Sato J, Watanabe A, Kiyota H, Iwata S, Kaku M, Hanaki H, Sumiyama Y, Kitagawa Y, Mizuguchi T, Ambo Y, Konosu M, Ishibashi K, Matsuda A, Hase K, Harihara Y, Okabayashi K, Seki S, Hara T, Matsui K, Matsuo Y, Kobayashi M, Kubo S, Uchiyama K, Shimizu J, Kawabata R, Ohge H, Akagi S, Oka M, Wakatsuki T, Suzuki K, Okamoto K, Yanagihara K. Antimicrobial susceptibility of pathogens isolated from surgical site infections in Japan: Comparison of data from nationwide surveillance studies conducted in 2010 and 2014-2015. J Infect Chemother, 23:339-348, 2017

 6. Shinjoh M, Yamaguchi Y, Iwata S. Pediatric bacterial meningitis in Japan, 2013-2015 - 3-5 years after the wide use of Haemophilus influenzae type b and Streptococcus pneumoniae conjugated vaccines. J Infect Chemother, 23:427-438, 2017

 7. Morozumi M, Okada T, Tajima T, Ubukata K, Iwata S. Killing kinetics of minocycline, doxycycline and tosufloxacin against macrolide-resistant Mycoplasma pneumoniae. Int J Antimicrob Agents, 50:255-257, 2017

 8. Chiba N, Murayama SY, Morozumi M, Iwata S, Ubukata K. Genome Evolution to Penicillin Resistance in Serotype 3 Streptococcus pneumoniae by Capsular Switching. Antimicrob Agents Chemother, 61:e00478-17, 2017

 9. Watanabe S, Ohnishi T, Yuasa A, Kiyota H, Iwata S, Kaku M, Watanabe A, Sato J, Hanaki H, Manabe M, Suzuki T, Otsuka F, Aihara M, Iozumi K, Tamaki T, Funada Y, Shinozaki M, Kobayashi M, Okuda M, Kikyo G, Kikuchi K, Okada Y, Takeshima M, Kaneko O, Ogawa N, Ito R, Okuyama R, Shimada S, Shimizu T, Hatta N, Manabu M, Tsutsui K, Tanaka T, Miyachi Y, Asada H, Furukawa F, Kurokawa I, Iwatsuki K, Hide M, Muto M, Yamamoto O, Niihara H, Takagaki K, Kubota Y, Sayama K, Sano S, Furue M, Kanekura T. The first nationwide surveillance of antibacterial susceptibility patterns of pathogens isolated from skin and soft-tissue infections in dermatology departments in Japan. J Infect Chemother, 23:503-511, 2017

10. Yanagihara K, Watanabe A, Aoki N, Matsumoto T, Yoshida M, Sato J, Wakamura T, Sunakawa K, Kadota J, Kiyota H, Iwata S, Kaku M, Hanaki H, Ohsaki Y, Fujiuchi S, Takahashi M, Takeuchi K, Takeda H, Ikeda H, Miki M, Nakanowatari S, Takahashi H, Utagawa M, Nishiya H, Kawakami S, Morino E, Takasaki J, Mezaki K, Chonabayashi N, Tanaka C, Sugiura H, Goto H, Saraya T, Kurai D, Katono Y, Inose R, Niki Y, Takuma T, Kudo M, Ehara S, Sato Y, Tsukada H, Watabe N, Honma Y, Mikamo H, Yamagishi Y, Nakamura A, Ohashi M, Seki M, Hamaguchi S, Toyokawa M, Fujikawa Y, Mitsuno N, Ukimura A, Miyara T, Nakamura T, Mikasa K, Kasahara K, Ui K, Fukuda S, Morimura M, Yamashita M, Takesue Y, Wada Y, Sugimoto K, Kusano N, Nose M, Mihara E, Kuwabara M, Doi M, Watanabe Y, Tokuyasu H, Hino S, Negayama K, Mukae H, Kawanami T, Ota T, Fujita M, Honda J, Hiramatsu K, Aoki Y, Fukuoka M, Magarifuchi H, Nagasawa Z, Kaku N, Fujita J, Higa F, Tateyama M. Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2012: General view of the pathogens' antibacterial susceptibility. J Infect Chemother, 23:587-597, 2017

11. Nishikawa-Nakamura N, Okada T, Nishimura K, Iwai T, Ubukata K, Iwata S, Iwai A. An infant with concurrent serotype 6C invasive pneumococcal disease and infectious mononucleosis. J Infect Chemother, 23:785-787, 2017

12. Sakai J, Maeda T, Tarumoto N, Misawa K, Tamura S, Imai K, Yamaguchi T, Iwata S, Murakami T, Maesaki S. A novel detection procedure for mutations in the 23S rRNA gene of Mycoplasma pneumoniae with peptide nucleic acid-mediated loop-mediated isothermal amplification assay. J Microbiol Methods, 141:90-96, 2017

13. Nishimura T, Tamizu E, Uno S, Uwamino Y, Fujiwara H, Nishio K, Nakano Y, Shiono H, Namkoong H, Hoshino Y, Iwata S, Hasegawa N. hsa-miR-346 is a potential serum biomarker of Mycobacterium avium complex pulmonary disease activity. J Infect Chemother, 23:703-708, 2017

14. Toyofuku M, Morozumi M, Hida M, Satoh Y, Sakata H, Shiro H, Ubukata K, Murata M, Iwata S. Effects of Intrapartum Antibiotic Prophylaxis on Neonatal Acquisition of Group B Streptococci. J Pediatr, 190:169-173.e1, 2017

15. Sakai J, Maeda T, Tarumoto N, Misawa K, Tamura S, Imai K, Yamaguchi T, Iwata S, Murakami T, Maesaki S. Corrigendum to "A novel detection procedure for mutations in the 23S rRNA gene of Mycoplasma pneumoniae with peptide nucleic acid-mediated loop-mediated isothermal amplification assay" [J. Microbiol. Methods 141 (2017) 90-96]. J Microbiol Methods, 144:192, 2018

16. Takesue Y, Kusachi S, Mikamo H, Sato J, Watanabe A, Kiyota H, Iwata S, Kaku M, Hanaki H, Sumiyama Y, Kitagawa Y, Mizuguchi T, Ambo Y, Konosu M, Ishibashi K, Matsuda A, Hase K, Harihara Y, Okabayashi K, Seki S, Hara T, Matsui K, Matsuo Y, Kobayashi M, Kubo S, Uchiyama K, Shimizu J, Kawabata R, Ohge H, Akagi S, Oka M, Wakatsuki T, Suzuki K, Okamoto K, Yanagihara K. Corrigendum to 'Antimicrobial susceptibility of pathogens isolated from surgical site infections in Japan: Comparison of data from nationwide surveillance studies conducted in 2010 and 2014-2015' [J Infect Chemother 23 (2017) 339-348]. J Infect Chemother, 24:156-157, 2018

17. Shoji H, Masayuki M, Takuma T, Iwata S, Mikamo H, Fujita J, Okada K, Niki Y. Corrigendum to "Serotype distribution of Streptococcus pneumoniae isolated from adult respiratory tract infections in nationwide Japanese surveillances from 2006 to 2014" [J Infect Chemother 23 (2017) 538-544]. J Infect Chemother, 24:236, 2018

18. Aoki K, Harada S, Yahara K, Ishii Y, Motooka D, Nakamura S, Akeda Y, Iida T, Tomono K, Iwata S, Moriya K, Tateda K. Molecular Characterization of IMP-1-Producing Enterobacter cloacae Complex Isolates in Tokyo. 62:e02091-17, 2018

19. Natori Y, Shiotsuka M, Slomovic J, Hoschler K, Ferreira V, Ashton P, Rotstein C, Lilly L, Schiff J, Singer L, Humar A, Kumar D. A Double-Blind, Randomized Trial of High-Dose vs Standard-Dose Influenza Vaccine in Adult Solid-Organ Transplant Recipients. Clin Infect Dis, 66:1698-1704, 2018