Annual Report 2017

Takahisa Matsuda, Koichi Nagata, Masau Sekiguchi, Tomi Abe, Noriko Abeshima, Orie Kitamura, Masae Omaru, Mika Mori, (Visiting Researcher) Masaki Matsuoka, Hiroshi Matsumoto, Noriaki Takahashi, Ken Takabayashi, Takaaki Yasuda, Kayoko Kasuya, Hidenori Kanazawa, Shogo Endo, Kazutomo Togashi

Introduction

 The Division of Screening Technology works as a part of the Screening Research Group in the Center for Public Health Sciences. The Screening Research Group is divided into two divisions (Division of Screening Assessment and Management/ Division of Screening Technology). The Division of Screening Technology consists of three staff medical doctors, five special research assistants, and nine visiting researchers.

Our team and what we do

 In the Division of Screening Technology, we aim to develop new diagnostic techniques that can be applied to cancer screening, and research existing diagnostic methods that can be applied to medical examinations. We are also assessing a new close examination method in cancer screening. In addition, we also work on research aiming at risk stratification of people to be screened.

Research activities

1) We are examining the cancer detection rate of each screening modality (e.g. Chest CT, upper/ lower GI Endoscopy, MMG/ Tomosynthesis and Breast Ultrasonography, FDG-PET, CT-colonography), the characteristics of the detected cancer, and the false positive rate for all medical examiners who underwent cancer screening during 10 years from the establishment of our center (Center for Public Health Sciences) in 2004. In addition, we aim to clarify the relationship between cancer screening and cancer death from long-term (prognosis survey) results. In this period (January 2017 - March 2018), we published a total of three papers as follows: 1: A large-scale analysis of diagnostic sensitivity of PET-CT for esophageal cancer, 2: Association of plasma C-reactive protein level with the prevalence of colorectal adenoma, 3: A scoring model for predicting advanced colorectal neoplasia in a screened population of asymptomatic Japanese individuals.

2) Field construction for verification of diagnostic tools for colorectal cancer and precancerous lesions using biomarkers (Oshima study) is ongoing.

3) Japan Polyp Study: multicenter prospective cohort study to elucidate the preventive effect of colorectal cancer caused by polypectomy is ongoing.

4) Development of an endoscope system for early detection of pancreatic cancer is ongoing.

5) Study on establishment and effectiveness assessment of screening model using colonoscopy (Aomori Project) is ongoing.

6) Multicenter clinical research for accuracy evaluation and standardization of CT colonography is ongoing.

7) Cost-effectiveness analysis on GI screening and surveillance using endoscope is ongoing.

8) Prospective study on colorectal cancer risk in first-degree relatives of colorectal cancer patients is ongoing.

Future prospects

 We will promote screening development research leading to the creation of evidence.

List of papers published in January 2017 - March 2018

Journal

 1. Nakamura F, Saito Y, Haruyama S, Sekiguchi M, Yamada M, Sakamoto T, Nakajima T, Yamamoto S, Murakami Y, Ishikawa H, Matsuda T. Short-term Prospective Questionnaire Study of Early Postoperative Quality of Life After Colorectal Endoscopic Submucosal Dissection. Dig Dis Sci, 62:3325-3335, 2017

 2. Saito Y, Bhatt A, Matsuda T. Colorectal endoscopic submucosal dissection and its journey to the West. Gastrointest Endosc, 86:90-92, 2017

 3. Nagata K, Takabayashi K, Yasuda T, Hirayama M, Endo S, Nozaki R, Shimada T, Kanazawa H, Fujiwara M, Shimizu N, Iwatsuki T, Iwano T, Saito H. Adverse events during CT colonography for screening, diagnosis and preoperative staging of colorectal cancer: a Japanese national survey. Eur Radiol, 27:4970-4978, 2017

 4. Inoki K, Sakamoto T, Takamaru H, Sekiguchi M, Yamada M, Nakajima T, Matsuda T, Taniguchi H, Sekine S, Kanemitsu Y, Ohe Y, Saito Y. Predictive relevance of lymphovascular invasion in T1 colorectal cancer before endoscopic treatment. Endoscopy international open, 5:E1278-E1283, 2017

 5. Hiraoka K, Inagaki A, Kato Y, Huang TT, Mitchell LA, Kamijima S, Takahashi M, Matsumoto H, Hacke K, Kruse CA, Ostertag D, Robbins JM, Gruber HE, Jolly DJ, Kasahara N. Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity. Neuro Oncol, 19:918-929, 2017

 6. Tamai N, Saito Y, Sakamoto T, Nakajima T, Matsuda T, Sumiyama K, Tajiri H, Koyama R, Kido S. Effectiveness of computer-aided diagnosis of colorectal lesions using novel software for magnifying narrow-band imaging: a pilot study. Endoscopy international open, 5:E690-E694, 2017

 7. Sekiguchi M, Oda I. High miss rate for gastric superficial cancers at endoscopy: what is necessary for gastric cancer screening and surveillance using endoscopy? Endoscopy international open, 5:E727-E728, 2017

 8. Oka S, Uraoka T, Tamai N, Ikematsu H, Chino A, Okamoto K, Takeuchi Y, Imai K, Ohata K, Shiga H, Raftopoulos S, Lee BI, Matsuda T. Standardization of endoscopic resection for colorectal tumors larger than 10 mm in diameter. Dig Endosc, 29 Suppl 2:40-44, 2017

 9. Ishii M, Tarumi KI, Shiotani A, Kamada T, Fujita M, Matsumoto H, Murao T, Manabe N, Kusunoki H, Hata J, Haruma K. Early Intervention with Infliximab Prevents Reoperation in Crohn's Disease: A Single-Center Retrospective Analysis. Digestion, 96:158-165, 2017

10. Sekiguchi M, Oda I, Suzuki H, Abe S, Nonaka S, Yoshinaga S, Taniguchi H, Sekine S, Saito Y. Clinical outcomes and prognostic factors in gastric cancer patients aged >/=85 years undergoing endoscopic submucosal dissection. Gastrointest Endosc, 85:963-972, 2017

11. Matsuda T, Ono A, Sekiguchi M, Fujii T, Saito Y. Advances in image enhancement in colonoscopy for detection of adenomas. Nat Rev Gastroenterol Hepatol, 14:305-314, 2017

12. Yamada M, Saito Y, Takamaru H, Sasaki H, Yokota T, Matsuyama Y, Sato Y, Sakamoto T, Nakajima T, Taniguchi H, Sekine S, Matsuda T. Long-term clinical outcomes of endoscopic submucosal dissection for colorectal neoplasms in 423 cases: a retrospective study. Endoscopy, 49:233-242, 2017

13. Sekiguchi M, Matsuda T, Saito Y. What is the optimal colorectal cancer screening program for an average-risk population? Translational gastroenterology and hepatology, 2:17, 2017

14. Hotta K, Matsuda T, Kakugawa Y, Ikematsu H, Kobayashi N, Kushima R, Hozawa A, Nakajima T, Sakamoto T, Mori M, Fujii T, Saito Y. Regional colorectal cancer screening program using colonoscopy on an island: a prospective Nii-jima study. Jpn J Clin Oncol, 47:118-122, 2017

15. Suzuki H, Oda I, Abe S, Sekiguchi M, Nonaka S, Yoshinaga S, Saito Y, Fukagawa T, Katai H. Clinical outcomes of early gastric cancer patients after noncurative endoscopic submucosal dissection in a large consecutive patient series. Gastric Cancer, 20:679-689, 2017

16. Nakamura K, Nonaka S, Nakajima T, Yachida T, Abe S, Sakamoto T, Suzuki H, Yoshinaga S, Oda I, Matsuda T, Sekine S, Kanemitsu Y, Katai H, Saito Y, Hirota S. Clinical outcomes of gastric polyps and neoplasms in patients with familial adenomatous polyposis. Endosc Int Open, 5:E137-E145, 2017

17. Ikematsu H, Sakamoto T, Togashi K, Yoshida N, Hisabe T, Kiriyama S, Matsuda K, Hayashi Y, Matsuda T, Osera S, Kaneko K, Utano K, Naito Y, Ishihara H, Kato M, Yoshimura K, Ishikawa H, Yamamoto H, Saito Y. Detectability of colorectal neoplastic lesions using a novel endoscopic system with blue laser imaging: a multicenter randomized controlled trial. Gastrointest Endosc, 86:386-394, 2017

18. Budhathoki S, Iwasaki M, Yamaji T, Yamamoto H, Kato Y, Tsugane S. Association of plasma concentrations of branched-chain amino acids with risk of colorectal adenoma in a large Japanese population. Ann Oncol, 28:818-823, 2017

19. Katsumata R, Shiotani A, Murao T, Ishii M, Fujita M, Matsumoto H, Haruma K. Gender Differences in Serotonin Signaling in Patients with Diarrhea-predominant Irritable Bowel Syndrome. Intern Med, 56:993-999, 2017

20. Akagi T, Inomata M, Hasegawa S, Kinjo Y, Ito M, Fukunaga Y, Kanazawa A, Idani H, Yamamoto S, Otsuka K, Endo S, Watanabe M. Japan Society of Laparoscopic Colorectal Surgery. Short- and long-term outcomes following laparoscopic palliative resection for patients with incurable, asymptomatic stage IV colorectal cancer:A multicenter study in Japan. J Anus Rectum Colon, 1:125-130, 2017

21. Sekiguchi M, Terauchi T, Kakugawa Y, Shimada N, Saito Y, Matsuda T. Performance of 18-fluoro-2-deoxyglucose positron emission tomography for esophageal cancer screening. World journal of gastroenterology, 23:2743-2749, 2017

22. Kumamoto K, Endo S, Isohata N, Nirei A, Nemoto D, Utano K, Saito T, Togashi K. Pseudocirrhosis caused by regorafenib in an advanced rectal cancer patient with multiple liver metastases. Molecular and clinical oncology, 6:63-66, 2017

23. Suzuki M, Kanazawa H, Shinozaki T, Sugimoto H. Radiologists need to be aware of secondary central venous stenosis in patients with SAPHO syndrome. Eur Radiol, 27:4532-4537, 2017

24. Fujita M, Manabe N, Murao T, Osawa M, Hirai S, Fukushima S, Shogen Y, Nakato R, Ishii M, Matsumoto H, Hata J, Shiotani A. Differences in the clinical course of 516 Japanese patients with upper gastrointestinal bleeding between weekday and weekend admissions. Scand J Gastroenterol, 52:1365-1370, 2017

25. Togashi K, Nemoto D, Takayanagi D, Koshimizu T, Endo S, Lefor AK. Lidocaine is a novel antispasmodic agent during colonoscopy. Clin. Invest, 7:65-66, 2017

26. Nemoto D, Utano K, Isohata N, Endo S, Kumamoto K, Koshimizu TA, Lefor A, Togashi K. Topical lidocaine inhibits spasm during colonoscopy: a double-blind, randomized controlled trial (with video). Endoscopy international open, 5:E402-E407, 2017

27. Utano K, Nagata K, Honda T, Mitsushima T, Yasuda T, Kato T, Horita S, Asano M, Oda N, Majima K, Kawamura Y, Hirayama M, Watanabe N, Kanazawa H, Lefor AK, Sugimoto H. Diagnostic Performance and Patient Acceptance of Reduced-Laxative CT Colonography for the Detection of Polypoid and Non-Polypoid Neoplasms: A Multicenter Prospective Trial. Radiology, 282:399-407, 2017

28. Nagata K, Endo S, Honda T, Yasuda T, Hirayama M, Takahashi S, Kato T, Horita S, Furuya K, Kasai K, Matsumoto H, Kimura Y, Utano K, Sugimoto H, Kato H, Yamada R, Yamamichi J, Shimamoto T, Ryu Y, Matsui O, Kondo H, Doi A, Abe T, Yamano H-O, Takeuchi K, Hanai H, Saida Y, Fukuda K, Nappi J, Yoshida H. Accuracy of CT Colonography for Detection of Polypoid and Nonpolypoid Neoplasia by Gastroenterologists and Radiologists: A Nationwide Multicenter Study in Japan. Am J Gastroenterol, 112:163-171, 2017

29. Matsumoto H, Yo S, Fukushima S, Osawa M, Murao T, Ishii M, Fujita M, Shiotani A. Forgotten Kirschner wire passing across the sigmoid colon. Clin J Gastroenterol, 10:154-156, 2017

30. Kanazawa H, Utano K, Kijima S, Sasaki T, Miyakura Y, Horie H, Lefor AK, Sugimoto H. Combined assessment using optical colonoscopy and computed tomographic colonography improves the determination of tumor location and invasion depth. Asian J Endosc Surg, 10:28-34, 2017

31. Matsuoka M, Shimizu N, Nagata K, Saito H. Colon cancer with rapid growth in 16months confirmed by computed tomographic colonography. Arab J Gastroenterol, 19:45-46, 2018

32. Shiotani A, Katsumata R, Gouda K, Fukushima S, Nakato R, Murao T, Ishii M, Fujita M, Matsumoto H, Sakakibara T. Hypergastrinemia in Long-Term Use of Proton Pump Inhibitors. Digestion, 97:154-162, 2018

33. Cho H, Sekine S, Sekiguchi M. Adenocarcinoma of the colon presenting as a submucosal tumor. Dig Endosc, 30:114-115, 2018

34. Kodashima S, Tanaka K, Matsuda K, Fujishiro M, Saito Y, Ohtsuka K, Oda I, Katada C, Kato M, Kida M, Kobayashi K, Hoteya S, Horimatsu T, Matsuda T, Muto M, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Tajiri H. First progress report on the Japan Endoscopy Database project. Dig Endosc, 30:20-28, 2018

35. Matsuda K, Tanaka K, Fujishiro M, Saito Y, Ohtsuka K, Oda I, Katada C, Kato M, Kida M, Kobayashi K, Hoteya S, Horimatsu T, Kodashima S, Matsuda T, Muto M, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Tajiri H. Design paper: Japan Endoscopy Database (JED): A prospective, large database project related to gastroenterological endoscopy in Japan. Dig Endosc, 30:5-19, 2018

36. Abe S, Oda I, Minagawa T, Sekiguchi M, Nonaka S, Suzuki H, Yoshinaga S, Bhatt A, Saito Y. Metachronous Gastric Cancer Following Curative Endoscopic Resection of Early Gastric Cancer. Clin Endosc, 51:253-259, 2018

37. Sakamoto T, Saito Y, Nakamura F, Abe S, Takamaru H, Sekiguchi M, Yamada M, Nakajima T, Matsuda T, Yamagishi H, Kato H. Short-term outcomes following endoscopic submucosal dissection of large protruding colorectal neoplasms. Endoscopy, 50:606-612, 2018

38. Bogie RMM, Veldman MHJ, Snijders LARS, Winkens B, Kaltenbach T, Masclee AAM, Matsuda T, Rondagh EJA, Soetikno R, Tanaka S, Chiu HM, Sanduleanu-Dascalescu S. Correction: Endoscopic subtypes of colorectal laterally spreading tumors (LSTs) and the risk of submucosal invasion: a meta-analysis. Endoscopy, 50:C4, 2018