Annual Report 2018
Division of Science and Technology for Endoscopy (Tsukiji Campus)
Ichiro Oda, Yutaka Saito, Haruhisa Suzuki, Satoru Nonaka, Taku Sakamoto, Masayoshi Yamada, Yasuo Kakugawa, Shigetaka Yoshinaga, Seiichiro Abe, Hiroyuki Takamaru, Keiko Nakamura
Introduction
Remarkable progress has been made on not only endoscopic diagnosis but also endoscopic treatment. Our efforts will be focused on the developments of new endoscopic diagnosis (e.g., molecular imaging, functional imaging) and treatment (e.g., full thickness resection), as well as an effective training system with industryacademia collaboration (Figure 1).
The Team and What We Do
Since fiscal 2017, in the Division of Science and Technology for Endoscopy of the Exploratory Oncology Research & Clinical Trial Center (EPOC) at the National Cancer Center (NCC) Tsukiji campus, four teams were organized (Diagnosis team, Treatment team, Training team, AI team) to develop the innovative endoscopic diagnosis, treatment and training system. We have searched clinical needs, and then set up development themes for each team.
Diagnosis team: Taku Sakamoto, Haruhisa Suzuki, Satoru Nonaka, Masayoshi Yamada
Treatment team: Satoru Nonaka, Taku Sakamoto, Seiichiro Abe, Hiroyuki Takamaru
Training team: Haruhisa Suzuki, Yasuo Kakugawa, Shigetaka Yoshinaga, Taku Sakamoto, Keiko Nakamura
Artificial intelligence (AI) team: Masayoshi Yamada, Ichiro Oda
Supervisors: Ichiro Oda, Yutaka Saito
Research activities
1) In collaboration with Olympus Corporation, we have started the development of new endoscopic diagnostic, therapeutic and training equipment at Olympus Lab in the National Cancer Center Research Institute (NCCRI). Although details are currently confidential, each team is involved in three or four research and development themes and is aiming to publish some of the developments in 2020.
2) In collaboration with the Artificial Intelligence Research Center (AIRC), the National Institute of Advanced Industrial Science and Technology (AIST) (Professor Jun Sese), the NCCRI (Professor Ryuji Hamamoto), and the Division of Science and Technology for Endoscopy of the EPOC (Kashiwa campus:Professor Hiroaki Ikematsu), we have started the research and development of an endoscopic diagnosis support system on tumor invasion of gastrointestinal cancer using AI.
Education
We have invited residents from the Department of Endoscopy of the National Cancer Center Hospital (NCCH) to our meetings and experiments of each development team, and trained them to be the leaders of the next generation in the research and development in endoscopic science and technology.
Future prospects
We are working on the research and development of new endoscopic diagnostic, therapeutic and training equipment in collaboration with companies and academia. In the future, we would like to disseminate our new equipment throughout the world.
List of papers published in 2018
Journal
1. Hashimoto T, Ogawa R, Yoshida H, Taniguchi H, Kojima M, Saito Y, Sekine S. Acquisition of WNT Pathway Gene Alterations Coincides With the Transition From Precursor Polyps to Traditional Serrated Adenomas. Am J Surg Pathol, 43:132-139, 2019
2. Yachida T, Oda I, Abe S, Sekiguchi M, Nonaka S, Suzuki H, Yoshinaga S, Taniguchi H, Sekine S, Masugata H, Masaki T, Daiko H, Saito Y. Risk of Lymph Node Metastasis in Patients with the Superficial Spreading Type of Esophageal Squamous Cell Carcinoma. Digestion, 1-6, 2019
3. Inoki K, Kakugawa Y, Takamaru H, Sekiguchi M, Matsumoto M, Matsuda T, Ito A, Tanaka T, Inamoto Y, Fuji S, Kurosawa S, Kim SW, Fukuda T, Ohe Y, Saito Y. Capsule Endoscopy after Hematopoietic Stem Cell Transplantation Can Predict Transplant-Related Mortality. Digestion, 1-10, 2019
4. Oda I, Hoteya S, Fujishiro M. Status of Helicobacter pylori infection and gastric mucosal atrophy in patients with gastric cancer: Analysis based on the Japan Endoscopy Database. Dig Endosc, 31:103, 2019
5. Sakamoto T, Nakajima T, Matsuda T, Murakami Y, Ishikawa H, Yao K, Saito Y. Comparison of the diagnostic performance between magnifying chromoendoscopy and magnifying narrow- band imaging for superficial colorectal neoplasms: an online survey. Gastrointest Endosc, 87:1318-1323, 2018
6. Abe S, Martinez-Alcala A, Baig KKK, Saito Y, Monkemuller K. Oxidized cellulose as hemostatic agent to prevent bleeding after high-risk endoscopic resection of rectal laterally spreading tumor overlying hemorrhoids. Endoscopy, 50:E95-E96, 2018
7. Takahashi Y, Takeuchi T, Kojima Y, Nagami Y, Ominami M, Uedo N, Hamada K, Suzuki H, Oda I, Miyaoka Y, Yamanouchi S, Tokioka S, Tomatsuri N, Yoshida N, Naito Y, Nonaka T, Kodashima S, Ogata S, Hongo Y, Oshima T, Li Z, Shibagaki K, Oikawa T, Tominaga K, Higuchi K. Efficacy and safety of Helicobacter pylori eradication therapy immediately after endoscopic submucosal dissection. J Gastroenterol Hepatol, 33:1341-1346, 2018
8. Abe S, Oda I, Minagawa T, Sekiguchi M, Nonaka S, Suzuki H, Yoshinaga S, Bhatt A, Saito Y. Metachronous Gastric Cancer Following Curative Endoscopic Resection of Early Gastric Cancer. Clinical endoscopy, 51:253-259, 2018
9. Ishihara R, Oyama T, Abe S, Takahashi H, Ono H, Fujisaki J, Kaise M, Goda K, Kawada K, Koike T, Takeuchi M, Matsuda R, Hirasawa D, Yamada M, Kodaira J, Tanaka M, Omae M, Matsui A, Kanesaka T, Takahashi A, Hirooka S, Saito M, Tsuji Y, Maeda Y, Yamashita H, Oda I, Tomita Y, Matsunaga T, Terai S, Ozawa S, Kawano T, Seto Y. Reply to the letter to the editor: Lymph node metastasis of adenocarcinoma and different definitions of sm1 cancer in the esophagus. J Gastroenterol, 53:804-805, 2018
10. Sano Y, Hirata D, Saito Y. Japan NBI Expert Team classification: Narrow-band imaging magnifying endoscopic classification of colorectal tumors. Dig Endosc, 30:543-545, 2018
11. Aadam AA, Abe S. Endoscopic submucosal dissection for superficial esophageal cancer. Dis Esophagus, 31:2018
12. Yamada M, Saito Y, Mojtahed A. Minimally invasive endoscopic surgery for complex colorectal lesions : progress from standard treatments to full thickness resections. Ann Laparos Endosc Surg, 3:56, 2018
13. Maeda M, Yamashita S, Shimazu T, Iida N, Takeshima H, Nakajima T, Oda I, Nanjo S, Kusano C, Mori A, Moro H, Yamada H, Tsugane S, Sugiyama T, Sakai Y, Ushijima T. Novel epigenetic markers for gastric cancer risk stratification in individuals after Helicobacter pylori eradication. Gastric Cancer, 21:745-755, 2018
14. Abe S, Saito Y, Oono Y, Tanaka Y, Sakamoto T, Yamada M, Nakajima T, Matsuda T, Ikematsu H, Yano T, Sekine S, Kojima M, Yamagishi H, Kato H. Pilot study on probe-based confocal laser endomicroscopy for colorectal neoplasms: an initial experience in Japan. Int J Colorectal Dis, 33:1071-1078, 2018
15. Inoki K, Nakajima T, Nonaka S, Abe S, Suzuki H, Yoshinaga S, Oda I, Yamada M, Takatsu M, Yoshida H, Taniguchi H, Sekine S, Ohe Y, Saito Y. Feasibility of endoscopic resection using bipolar snare for nonampullary duodenal tumours in familial adenomatous polyposis patients. Fam Cancer, 17:517-524, 2018
16. Iwatate M, Sano Y, Tanaka S, Kudo SE, Saito S, Matsuda T, Wada Y, Fujii T, Ikematsu H, Uraoka T, Kobayashi N, Nakamura H, Hotta K, Horimatsu T, Sakamoto N, Fu KI, Tsuruta O, Kawano H, Kashida H, Takeuchi Y, Machida H, Kusaka T, Yoshida N, Hirata I, Terai T, Yamano HO, Nakajima T, Sakamoto T, Yamaguchi Y, Tamai N, Nakano N, Hayashi N, Oka S, Ishikawa H, Murakami Y, Yoshida S, Saito Y. Validation study for development of the Japan NBI Expert Team classification of colorectal lesions. Dig Endosc, 30:642-651, 2018
17. Mori Y, Kudo SE, Misawa M, Saito Y, Ikematsu H, Hotta K, Ohtsuka K, Urushibara F, Kataoka S, Ogawa Y, Maeda Y, Takeda K, Nakamura H, Ichimasa K, Kudo T, Hayashi T, Wakamura K, Ishida F, Inoue H, Itoh H, Oda M, Mori K. Real-Time Use of Artificial Intelligence in Identification of Diminutive Polyps During Colonoscopy: A Prospective Study. Ann Intern Med, 169:357-366, 2018
18. Arantes V, Uedo N, Morita Y, Toyonaga T, Nakano Y, Pedrosa MS, Oda I, Saito Y, Suzuki H, Yamamoto K, Sato Y, Draganov PV. Polypoid nodule scar after gastric endoscopic submucosal dissection: results from a multicenter study. Endosc Int Open, 6:E1198-E1203, 2018
19. Kudo T, Saito Y, Ikematsu H, Hotta K, Takeuchi Y, Shimatani M, Kawakami K, Tamai N, Mori Y, Maeda Y, Yamada M, Sakamoto T, Matsuda T, Imai K, Ito S, Hamada K, Fukata N, Inoue T, Tajiri H, Yoshimura K, Ishikawa H, Kudo SE. New-generation full-spectrum endoscopy versus standard forward-viewing colonoscopy: a multicenter, randomized, tandem colonoscopy trial (J-FUSE Study). Gastrointest Endosc, 88:854-864, 2018
20. Hashimoto T, Tanaka Y, Ogawa R, Mori T, Yoshida H, Taniguchi H, Hiraoka N, Kojima M, Oono Y, Saito Y, Sekine S. Superficially serrated adenoma: a proposal for a novel subtype of colorectal serrated lesion. Mod Pathol, 31:1588-1598, 2018
21. Niikura R, Yamada A, Fujishiro M, Tanaka K, Matsuda K, Saito Y, Ohtsuka K, Oda I, Katada C, Kato M, Kida M, Kobayashi K, Hoteya S, Horimatsu T, Kodashima S, Matsuda T, Muto M, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Kato M, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Shinozaki T, Tajiri H, Koike K. The Effects of Direct Oral Anticoagulants, Warfarin, Aspirin and Thienopyridine on the Performance of Immunochemical, Faecal, Occult Blood Tests. Digestion, 1-10, 2018
22. Sugizaki K, Tari A, Kitadai Y, Oda I, Nakamura S, Yoshino T, Sugiyama T. Anti-Helicobacter pylori therapy in localized gastric mucosa-associated lymphoid tissue lymphoma: A prospective, nationwide, multicenter study in Japan. Helicobacter, 23:e12474, 2018
23. Hijioka S, Sakamoto Y, Ohba A, Maruki Y, Chan JCY, Okusaka T, Saito Y. Novel simultaneous endoscopic ultrasound-guided hepaticoduodenostomy and hepaticogastrostomy for recurrent hepatic hilar obstruction. Endoscopy, 50:E320-E322, 2018
24. Hijioka S, Arai Y, Sone M, Yoshinaga S, Chan J, Sakamoto Y, Okusaka T, Saito Y. Novel forward-viewing EUS-guided ileoureterostomy technique for recurrent pyelonephritis caused by ureteral stenosis. VideoGIE, 3:281-283, 2018
Book
1. Abe S, Catalano F, Saito Y. Endoscopic Resections:EMR and ESD. In: Galloro G (ed), Revisiting Barrett's Esophagus, Switzerland, Springer International Publishing, pp 147-158, 2019
2. Yamada M, Saito Y, Sansone S, Takamaru H, Sakamoto T. Endoscopic Resection of Early Colorectal Cancer. In: Ishida H, Koda K (eds), Recent Advances in the Treatment of Colorectal Cancer, Singapore, Springer Singapore, pp 3-15, 2019