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Annual Report 2018

Department of Infectious Diseases

Satoshi Iwata, Mika Shiotsuka, Sayuri Hara

Introduction

 The Department of Infectious Diseases was established in April 2017. We support clinical practice in relation to infectious diseases in the National Cancer Center Hospital in cooperation with the Office of Infection Control and Prevention. We also conduct research activities for infectious diseases and vaccines in cooperation with other departments inside/outside of the hospital.

 Our department consists of infectious disease specialists and an office clerk.

The Team and What We Do

  • Advise on infection control and prevention, especially focusing on healthcare-associated infections, problematic pathogens including multidrug-resistant bacteria, and occupational infections.
  • Consult with physicians on appropriate diagnosis of and treatment for infectious diseases.
  • Implement antimicrobial stewardship strategy based on local data from our hospital and current clinical evidence.
  • Take weekly rounds in the wards to monitor environmental maintenance and compliance with the Infection Prevention and Control Manual.
  • Conduct surveillance for healthcare-associated infections and drug-resistant bacteria.
  • Provide education for the staff on standard practices regarding infection control and prevention with up-to-date evidence.
  • Check for immunization status of the hospital staff and vaccinate those with insufficient protective immunity.
  • Advise on building and refurbishment projects from the aspect of infection control.
  • Hold conferences or mutual site visits with other regional hospitals to promote improvement in infection control and prevention practices.

Research activities

  • Effective education of infection control practice, especially medical device management.
  • Appropriate dosing of antimicrobial drugs in cancer patients.
  • Ideal system of infection control for cancer center in Japanese medical care system.
  • Mechanism of antimicrobial resistance of multi drug-resistant strain of Enterobacteriaceae isolated from cancer patients.
  • Molecular epidemiology of Streptococci and Mycoplasma pneumoniae.
  • Epidemiology of bacterial meningitis in Japan.
  • Case-report for a first case of human neurocoenurosis caused by Taenia serialis.

Education

  • Training for infection control and management of infectious diseases in physicians and medical personnel.

Future prospects

 Our final goal is to establish an ideal and feasible model of an infection control system for cancer centers in Japan and to develop human resources for management of infectious diseases and infection control or appropriate use of antimicrobial agents.

List of papers published in 2018

Journal

 1. Sakata H, Watanabe A, Iwata S, Sato Y, Suzuki K, Miyashita N, Hori S, Yamaguchi Y, Odajima M, Katakuse Y, Hasegawa T, Maki N, Wada K. Surveillance on susceptibility of strains isolated from pediatric infections. J Infect Chemother, 25:163-169, 2019

 2. Namkoong H, Ishii M, Fujii H, Yagi K, Asami T, Asakura T, Suzuki S, Hegab AE, Kamata H, Tasaka S, Atarashi K, Nakamoto N, Iwata S, Honda K, Kanai T, Hasegawa N, Koyasu S, Betsuyaku T. Clarithromycin expands CD11b+ Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia. PLoS Pathog, 14:e1006955, 2018

 3. Natori Y, Shiotsuka M, Slomovic J, Hoschler K, Ferreira V, Ashton P, Rotstein C, Lilly L, Schiff J, Singer L, Humar A, Kumar D. A Double-Blind, Randomized Trial of High-Dose vs Standard-Dose Influenza Vaccine in Adult Solid-Organ Transplant Recipients. Clin Infect Dis, 66:1698-1704, 2018

 4. Ubukata K, Morozumi M, Sakuma M, Takata M, Mokuno E, Tajima T, Iwata S. Etiology of Acute Otitis Media and Characterization of Pneumococcal Isolates After Introduction of 13-Valent Pneumococcal Conjugate Vaccine in Japanese Children. Pediatr Infect Dis J, 37:598-604, 2018

 5. Takesue Y, Kusachi S, Mikamo H, Sato J, Watanabe A, Kiyota H, Iwata S, Kaku M, Hanaki H, Sumiyama Y, Kitagawa Y, Nakajima K, Ueda T, Uchino M, Mizuguchi T, Ambo Y, Konosu M, Ishibashi K, Matsuda A, Hase K, Harihara Y, Okabayashi K, Seki S, Hara T, Matsui K, Matsuo Y, Kobayashi M, Kubo S, Uchiyama K, Shimizu J, Kawabata R, Ohge H, Akagi S, Oka M, Wakatsuki T, Suzuki K, Okamoto K, Yanagihara K. Corrigendum to "Antimicrobial susceptibility of common pathogens isolated from postoperative intra-abdominal infections in Japan" [J Infect Chemother 24 (2018) 330-340]. J Infect Chemother, 24:592-595, 2018

 6. Ando M, Morozumi M, Adachi Y, Ubukata K, Iwata S. Multilocus Sequence Typing of Mycoplasma pneumoniae, Japan, 2002- 2016. Emerging Infect Dis, 24:1895-1901, 2018

 7. Kubota H, Uwamino Y, Matsui M, Sekizuka T, Suzuki Y, Okuno R, Uchitani Y, Ariyoshi T, Aoki W, Suzuki S, Kuroda M, Shinkai T, Yokoyama K, Sadamasu K, Funakoshi T, Murata M, Hasegawa N, Iwata S. FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan. J Antimicrob Chemother, 73:2969-2972, 2018

 8. Ubukata K, Takata M, Morozumi M, Chiba N, Wajima T, Hanada S, Shouji M, Sakuma M, Iwata S. Effects of Pneumococcal Conjugate Vaccine on Genotypic Penicillin Resistance and Serotype Changes, Japan, 2010-2017. Emerging Infect Dis, 24:2010-2020, 2018