Annual Report 2018
Division of Screening Technology
Takahisa Matsuda, Masau Sekiguchi, Kazuya Inoki, Tomi Abe, Noriko Abeshima, Orie Kitamura, Masae Omaru, Mika Mori
Introduction
The Division of Screening Technology works as a part of the Screening Research Group in the Center for Public Health Sciences. The Screening Research Group is divided into two divisions (Division of Screening Assessment and Management/ Division of Screening Technology). The Division of Screening Technology consists of two staff medical doctors, five special research assistants and 1 visiting researcher.
The Team and What We Do
In the Division of Screening Technology, we aim to develop new diagnostic techniques that can be applied to cancer screening, as well as researching existing diagnostic methods that can be applied to medical examinations. We are also assessing a new close examination method in cancer screening. In addition, we also work on research aiming at risk stratification of people to be screened.
Research activities/ Clinical trials
Examinations are on going for the examination of the cancer detection rate of each screening modality (e.g., Chest CT, upper/ lower GI Endoscopy, MMG/ Tomosynthesis and Breast Ultrasonography, FDG-PETCT/MRI, CT-colonography), the characteristics of the detected cancer, and the false positive rate for all individuals who underwent cancer screening during the 14 years from the establishment of our center in 2004. In addition, we aim to clarify the relationship between cancer screening and cancer death from long-term (prognosis survey) results. Moreover, the following research is ongoing.
1) Field construction for verification of diagnostic tools for colorectal cancer and precancerous lesions using biomarkers (Oshima study),
2) Japan Polyp Study: multicenter prospective cohort study to elucidate the preventive effect of colorectal cancer caused by polypectomy,
3) Development of an endoscope system for early detection of pancreatic cancer,
4) Study on establishment and effectiveness assessment of screening model using colonoscopy (Aomori Project),
5) Multicenter clinical research for accuracy evaluation and standardization of CT colonography,
6) Cost-effectiveness analysis on GI screening and surveillance using endoscope, and
7) Prospective study on colorectal cancer risk in first-degree relatives of colorectal cancer patients. In addition, the amino index (AICS) study has received plasma samples from 7,845 screening individuals, and comprehensive amino acid analysis of 6,989 samples collected by the end of 2017 has been completed. From now on, the analysis data will be collated with clinical data.
Among them, the following two papers were published in this period.
1) Sekiguchi M, et al. A scoring model for predicting advanced colorectal neoplasia in a screened population of asymptomatic Japanese individuals (J Gastroenterol 2018),
2) Kakinuma R, et al. Evaluation of the 95% limits of agreement of the volumes of 5-year clinically stable solid nodules for the development of a follow-up system for indeterminate solid nodules in CT lung cancer screening (J Thorac Dis 2018).
Other research: We are collaborating with external researchers using 1,325 stool samples collected from the Oshima Study. (Research on colibactin-producing bacteria as fecal biomarkers, bacteria and bacterial flora as fecal biomarkers and their functions). In addition, 16 English articles were published, focusing on the diagnosis, treatment, and screening of colorectal cancer and gastric cancer.
Future prospects
We will promote screening development research to gather evidence.
List of papers published in 2018
Journal
1. Wong JCT, Chiu HM, Kim HS, Byeon JS, Matsuda T, Kobayashi N, Wu DC, Ong DE, Sung JJY. Adenoma detection rates in colonoscopies for positive fecal immunochemical tests versus direct screening colonoscopies. Gastrointest Endosc, 89:607-613.e1, 2019
2. Takeuchi Y, Sawaya M, Oka S, Tamai N, Kawamura T, Uraoka T, Ikematsu H, Moriyama T, Arao M, Ishikawa H, Ito Y, Matsuda T. Efficacy of autofluorescence imaging for flat neoplasm detection: a multicenter randomized controlled trial (A-FLAT trial). Gastrointest Endosc, 89:460-469, 2019
3. Sung JJY, Chiu HM, Jung KW, Jun JK, Sekiguchi M, Matsuda T, Kyaw MH. Increasing Trend in Young-Onset Colorectal Cancer in Asia: More Cancers in Men and More Rectal Cancers. Am J Gastroenterol, 114:322-329, 2019
4. Sekiguchi M, Igarashi A, Sakamoto T, Saito Y, Esaki M, Matsuda T. Cost-effectiveness analysis of postpolypectomy colonoscopy surveillance using Japanese data. Dig Endosc, 31:40-50, 2019
5. Yachida T, Oda I, Abe S, Sekiguchi M, Nonaka S, Suzuki H, Yoshinaga S, Taniguchi H, Sekine S, Masugata H, Masaki T, Daiko H, Saito Y. Risk of Lymph Node Metastasis in Patients with the Superficial Spreading Type of Esophageal Squamous Cell Carcinoma. Digestion, 1-6, 2019
6. Inoki K, Kakugawa Y, Takamaru H, Sekiguchi M, Matsumoto M, Matsuda T, Ito A, Tanaka T, Inamoto Y, Fuji S, Kurosawa S, Kim SW, Fukuda T, Ohe Y, Saito Y. Capsule Endoscopy after Hematopoietic Stem Cell Transplantation Can Predict Transplant-Related Mortality. Digestion, 1-10, 2019
7. Kodashima S, Tanaka K, Matsuda K, Fujishiro M, Saito Y, Ohtsuka K, Oda I, Katada C, Kato M, Kida M, Kobayashi K, Hoteya S, Horimatsu T, Matsuda T, Muto M, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Kato M, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Tajiri H. First progress report on the Japan Endoscopy Database project. Dig Endosc, 30:20-28, 2018
8. Bogie RMM, Veldman MHJ, Snijders LARS, Winkens B, Kaltenbach T, Masclee AAM, Matsuda T, Rondagh EJA, Soetikno R, Tanaka S, Chiu HM, Sanduleanu-Dascalescu S. Endoscopic subtypes of colorectal laterally spreading tumors (LSTs) and the risk of submucosal invasion: a meta-analysis. Endoscopy, 50:263-282, 2018
9. Sakamoto T, Saito Y, Nakamura F, Abe S, Takamaru H, Sekiguchi M, Yamada M, Nakajima T, Matsuda T, Yamagishi H, Kato H. Short-term outcomes following endoscopic submucosal dissection of large protruding colorectal neoplasms. Endoscopy, 50:606-612, 2018
10. Matsuda K, Tanaka K, Fujishiro M, Saito Y, Ohtsuka K, Oda I, Katada C, Kato M, Kida M, Kobayashi K, Hoteya S, Horimatsu T, Kodashima S, Matsuda T, Muto M, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Kato M, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Tajiri H. Design paper: Japan Endoscopy Database (JED): A prospective, large database project related to gastroenterological endoscopy in Japan. Dig Endosc, 30:5-19, 2018
11. Rutter MD, Beintaris I, Valori R, Chiu HM, Corley DA, Cuatrecasas M, Dekker E, Forsberg A, Gore-Booth J, Haug U, Kaminski MF, Matsuda T, Meijer GA, Morris E, Plumb AA, Rabeneck L, Robertson DJ, Schoen RE, Singh H, Tinmouth J, Young GP, Sanduleanu S. World Endoscopy Organization Consensus Statements on Post-Colonoscopy and Post-Imaging Colorectal Cancer. Gastroenterology, 155:909-925.e3, 2018
12. Sekiguchi M, Kakugawa Y, Matsumoto M, Matsuda T. A scoring model for predicting advanced colorectal neoplasia in a screened population of asymptomatic Japanese individuals. J Gastroenterol, 53:1109-1119, 2018
13. Sakamoto T, Nakajima T, Matsuda T, Murakami Y, Ishikawa H, Yao K, Saito Y. Comparison of the diagnostic performance between magnifying chromoendoscopy and magnifying narrow- band imaging for superficial colorectal neoplasms: an online survey. Gastrointest Endosc, 87:1318-1323, 2018
14. Abe S, Oda I, Minagawa T, Sekiguchi M, Nonaka S, Suzuki H, Yoshinaga S, Bhatt A, Saito Y. Metachronous Gastric Cancer Following Curative Endoscopic Resection of Early Gastric Cancer. Clinical endoscopy, 51:253-259, 2018
15. Abe S, Saito Y, Oono Y, Tanaka Y, Sakamoto T, Yamada M, Nakajima T, Matsuda T, Ikematsu H, Yano T, Sekine S, Kojima M, Yamagishi H, Kato H. Pilot study on probe-based confocal laser endomicroscopy for colorectal neoplasms: an initial experience in Japan. Int J Colorectal Dis, 33:1071-1078, 2018
16. Iwatate M, Sano Y, Tanaka S, Kudo SE, Saito S, Matsuda T, Wada Y, Fujii T, Ikematsu H, Uraoka T, Kobayashi N, Nakamura H, Hotta K, Horimatsu T, Sakamoto N, Fu KI, Tsuruta O, Kawano H, Kashida H, Takeuchi Y, Machida H, Kusaka T, Yoshida N, Hirata I, Terai T, Yamano HO, Nakajima T, Sakamoto T, Yamaguchi Y, Tamai N, Nakano N, Hayashi N, Oka S, Ishikawa H, Murakami Y, Yoshida S, Saito Y. Validation study for development of the Japan NBI Expert Team classification of colorectal lesions. Dig Endosc, 30:642-651, 2018
17. Kudo T, Saito Y, Ikematsu H, Hotta K, Takeuchi Y, Shimatani M, Kawakami K, Tamai N, Mori Y, Maeda Y, Yamada M, Sakamoto T, Matsuda T, Imai K, Ito S, Hamada K, Fukata N, Inoue T, Tajiri H, Yoshimura K, Ishikawa H, Kudo SE. New-generation full-spectrum endoscopy versus standard forward-viewing colonoscopy: a multicenter, randomized, tandem colonoscopy trial (J-FUSE Study). Gastrointest Endosc, 88:854-864, 2018