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Annual Report 2018

Division of Cohort Consortium Research

Shoichiro Tsugane, Manami Inoue, Motoki Iwasaki, Osamu Henmi, Jun Umezawa, Ryoko Katagiri, Ryuhei Osanai, Ayako Toyama

Introduction

The Division of Cohort Consortium Research aims to create evidence for the prevention of cancer and other diseases and extending the healthy life expectancy of Japanese. It does this by conducting epidemiological research using a domestic epidemiological research network.

Research activities

1) The Collaborative Epidemiological Research Network Project of the Six National Centers for Advanced and Specialized Medical Care (6NC Project).

The 6NC Project is a core research project of the Division of Cohort Consortium Research. The main aim of the 6NC Project is to establish the 6NC Epidemiological Research Collaboration Platform, which will be used to conduct pooled analyses and mutual data analysis by exchange and cooperation among researchers at the six national centers. As part of this project we have established an analysis platform which offers both onsite and remote access with information security protection. We have also launched an initiative working group to make recommendations to extend the healthy life expectancy of Japanese, and for comprehensive disease prevention. This project started in 2017.

2) Promotion of collaborative research among six NCs using on-going cohort studies in the NCC

Using data from the JPHC study, we proposed two research protocols of dementia assessed by the long-term care insurance system in collaboration with National Center for Geriatrics and Gerontology and one research protocol of depression in collaboration with National Center of Neurology and Psychiatry. Regarding collaborative studies using data from the JPHC-NEXT study, we have four on-going studies proposed by the National Center of Neurology and Psychiatry and National Center for Child Health and Development, respectively, and we have analyzed data after obtaining IRB approval.

Regarding practical use of electronic medical information in cohort studies, we have collected information on health insurance claims and diagnosis procedure combinations (DPC) in the JPHC-NEXT study and conducted a validation study for diagnosis of cancer and diabetes through this information.

Future prospects

As well as creating scientific evidence, we will expand and strengthen research collaboration networks aiming to extend the healthy life expectancy of Japanese, and for comprehensive disease prevention.

List of papers published in 2018

Journal

1. Nanri A, Mizoue T, Noda M, Goto A, Sawada N, Tsugane S. Menstrual and reproductive factors and type 2 diabetes risk: The Japan Public Health Center-based Prospective Study. J Diabetes Investig, 10:147-153, 2019

2. Svensson T, Sawada N, Mimura M, Nozaki S, Shikimoto R, Tsugane S. The association between midlife serum high-density lipoprotein and mild cognitive impairment and dementia after 19 years of follow-up. Transl Psychiatry, 9:26, 2019

3. Travis RC, Perez-Cornago A, Appleby PN, Albanes D, Joshu CE, Lutsey PL, Mondul AM, Platz EA, Weinstein SJ, Layne TM, Helzlsouer KJ, Visvanathan K, Palli D, Peeters PH, Bueno-de-Mesquita B, Trichopoulou A, Gunter MJ, Tsilidis KK, Sanchez MJ, Olsen A, Brenner H, Schottker B, Perna L, Holleczek B, Knekt P, Rissanen H, Yeap BB, Flicker L, Almeida OP, Wong YYE, Chan JM, Giovannucci EL, Stampfer MJ, Ursin G, Gislefoss RE, Bjorge T, Meyer HE, Blomhoff R, Tsugane S, Sawada N, English DR, Eyles DW, Heath AK, Williamson EJ, Manjer J, Malm J, Almquist M, Marchand LL, Haiman CA, Wilkens LR, Schenk JM, Tangen CM, Black A, Cook MB, Huang WY, Ziegler RG, Martin RM, Hamdy FC, Donovan JL, Neal DE, Touvier M, Hercberg S, Galan P, Deschasaux M, Key TJ, Allen NE. A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk. Cancer Res, 79:274-285, 2019

4. McCullough ML, Zoltick ES, Weinstein SJ, Fedirko V, Wang M, Cook NR, Eliassen AH, Zeleniuch-Jacquotte A, Agnoli C, Albanes D, Barnett MJ, Buring JE, Campbell PT, Clendenen TV, Freedman ND, Gapstur SM, Giovannucci EL, Goodman GG, Haiman CA, Ho GYF, Horst RL, Hou T, Huang WY, Jenab M, Jones ME, Joshu CE, Krogh V, Lee IM, Lee JE, Mannisto S, Le Marchand L, Mondul AM, Neuhouser ML, Platz EA, Purdue MP, Riboli E, Robsahm TE, Rohan TE, Sasazuki S, Schoemaker MJ, Sieri S, Stampfer MJ, Swerdlow AJ, Thomson CA, Tretli S, Tsugane S, Ursin G, Visvanathan K, White KK, Wu K, Yaun SS, Zhang X, Willett WC, Gail MH, Ziegler RG, Smith-Warner SA. Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts. J Natl Cancer Inst, 111:158-169, 2019

5. Schmit SL, Edlund CK, Schumacher FR, Gong J, Harrison TA, Huyghe JR, Qu C, Melas M, Van Den Berg DJ, Wang H, Tring S, Plummer SJ, Albanes D, Alonso MH, Amos CI, Anton K, Aragaki AK, Arndt V, Barry EL, Berndt SI, Bezieau S, Bien S, Bloomer A, Boehm J, Boutron-Ruault MC, Brenner H, Brezina S, Buchanan DD, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Castelao JE, Chan AT, Chang-Claude J, Chanock SJ, Cheng I, Cheng YW, Chin LS, Church JM, Church T, Coetzee GA, Cotterchio M, Cruz Correa M, Curtis KR, Duggan D, Easton DF, English D, Feskens EJM, Fischer R, FitzGerald LM, Fortini BK, Fritsche LG, Fuchs CS, Gago-Dominguez M, Gala M, Gallinger SJ, Gauderman WJ, Giles GG, Giovannucci EL, Gogarten SM, Gonzalez-Villalpando C, Gonzalez-Villalpando EM, Grady WM, Greenson JK, Gsur A, Gunter M, Haiman CA, Hampe J, Harlid S, Harju JF, Hayes RB, Hofer P, Hoffmeister M, Hopper JL, Huang SC, Huerta JM, Hudson TJ, Hunter DJ, Idos GE, Iwasaki M, Jackson RD, Jacobs EJ, Jee SH, Jenkins MA, Jia WH, Jiao S, Joshi AD, Kolonel LN, Kono S, Kooperberg C, Krogh V, Kuehn T, Kury S, LaCroix A, Laurie CA, Lejbkowicz F, Lemire M, Lenz HJ, Levine D, Li CI, Li L, Lieb W, Lin Y, Lindor NM, Liu YR, Loupakis F, Lu Y, Luh F, Ma J, Mancao C, Manion FJ, Markowitz SD, Martin V, Matsuda K, Matsuo K, McDonnell KJ, McNeil CE, Milne R, Molina AJ, Mukherjee B, Murphy N, Newcomb PA, Offit K, Omichessan H, Palli D, Cotore JPP, Perez-Mayoral J, Pharoah PD, Potter JD, Qu C, Raskin L, Rennert G, Rennert HS, Riggs BM, Schafmayer C, Schoen RE, Sellers TA, Seminara D, Severi G, Shi W, Shibata D, Shu XO, Siegel EM, Slattery ML, Southey M, Stadler ZK, Stern MC, Stintzing S, Taverna D, Thibodeau SN, Thomas DC, Trichopoulou A, Tsugane S, Ulrich CM, van Duijnhoven FJB, van Guelpan B, Vijai J, Virtamo J, Weinstein SJ, White E, Win AK, Wolk A, Woods M, Wu AH, Wu K, Xiang YB, Yen Y, Zanke BW, Zeng YX, Zhang B, Zubair N, Kweon SS, Figueiredo JC, Zheng W, Marchand LL, Lindblom A, Moreno V, Peters U, Casey G, Hsu L, Conti DV, Gruber SB. Novel Common Genetic Susceptibility Loci for Colorectal Cancer. J Natl Cancer Inst, 111:146-157, 2019

6. Suzuki K, Akiyama M, Ishigaki K, Kanai M, Hosoe J, Shojima N, Hozawa A, Kadota A, Kuriki K, Naito M, Tanno K, Ishigaki Y, Hirata M, Matsuda K, Iwata N, Ikeda M, Sawada N, Yamaji T, Iwasaki M, Ikegawa S, Maeda S, Murakami Y, Wakai K, Tsugane S, Sasaki M, Yamamoto M, Okada Y, Kubo M, Kamatani Y, Horikoshi M, Yamauchi T, Kadowaki T. Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population. Nat Genet, 51:379-386, 2019

7. Ferro A, Morais S, Pelucchi C, Dierssen-Sotos T, Martin V, Lopez- Carrillo L, Malekzadeh R, Tsugane S, Hamada GS, Hidaka A, Hernandez-Ramirez RU, Lopez-Cervantes M, Zaridze D, Maximovitch D, Pourfarzi F, Zhang ZF, Yu GP, Pakseresht M, Ye W, Plymoth A, Leja M, Gasenko E, Derakhshan MH, Negri E, La Vecchia C, Peleteiro B, Lunet N. Sex differences in the prevalence of Helicobacter pylori infection: an individual participant data pooled analysis (StoP Project). Eur J Gastroenterol Hepatol, 31:593-598, 2019

8. Yamaguchi M, Okamura S, Yamaji T, Iwasaki M, Tsugane S, Shetty V, Koizumi T. Plasma cytokine levels and the presence of colorectal cancer. PLoS ONE, 14:e0213602, 2019

9. Bertuccio P, Alicandro G, Rota M, Pelucchi C, Bonzi R, Galeone C, Bravi F, Johnson KC, Hu J, Palli D, Ferraroni M, Lopez-Carrillo L, Lunet N, Ferro A, Malekzadeh R, Zaridze D, Maximovitch D, Vioque J, Navarrete-Munoz EM, Pakseresht M, Hernandez- Ramirez RU, Lopez-Cervantes M, Ward M, Pourfarzi F, Tsugane S, Hidaka A, Zhang ZF, Kurtz RC, Lagiou P, Lagiou A, Boffetta P, Boccia S, Negri E, La Vecchia C. Citrus fruit intake and gastric cancer: The stomach cancer pooling (StoP) project consortium. Int J Cancer, 144:2936-2944, 2019

10. Hayashi R, Iso H, Yamagishi K, Yatsuya H, Saito I, Kokubo Y, Eshak ES, Sawada N, Tsugane S. Working Hours and Risk of Acute Myocardial Infarction and Stroke Among Middle-Aged Japanese Men- The Japan Public Health Center-Based Prospective Study Cohort II. Circ J, 83:1072-1079, 2019

11. Kabasawa K, Tanaka J, Nakamura K, Ito Y, Yoshida K, Takachi R, Sawada N, Tsugane S, Narita I. Study Design and Baseline Profiles of Participants in the Uonuma CKD Cohort Study in Niigata, Japan. J Epidemiol, 2019

12. Nishiyama T, Nakatochi M, Goto A, Iwasaki M, Hachiya T, Sutoh Y, Shimizu A, Wang C, Tanaka H, Watanabe M, Hosono A, Tamai Y, Yamada T, Yamaji T, Sawada N, Fukumoto K, Otsuka K, Tanno K, Tomita H, Kojima K, Nagasaki M, Hozawa A, Hishida A, Sasakabe T, Nishida Y, Hara M, Ito H, Oze I, Nakamura Y, Mikami H, Ibusuki R, Takezaki T, Koyama T, Kuriyama N, Endoh K, Kuriki K, Turin TC, Naoyuki T, Katsuura-Kamano S, Uemura H, Okada R, Kawai S, Naito M, Momozawa Y, Kubo M, Sasaki M, Yamamoto M, Tsugane S, Wakai K, Suzuki S. Genome-wide association List of papers published in 2018 Journal Center for Public Health Sciences 525 meta-analysis and Mendelian randomization analysis confirm ALDH2 influencing on sleep duration in the Japanese population. Sleep, 2019

13. Rota M, Alicandro G, Pelucchi C, Bonzi R, Bertuccio P, Hu J, Zhang ZF, Johnson KC, Palli D, Ferraroni M, Yu GP, Galeone C, Lopez-Carrillo L, Muscat J, Lunet N, Ferro A, Ye W, Plymoth A, Malekzadeh R, Zaridze D, Maximovitch D, Kogevinas M, Fernandez de Larrea N, Vioque J, Navarrete-Munoz EM, Tsugane S, Hamada GS, Hidaka A, Pakseresht M, Wolk A, Hakansson N, Hernandez-Ramirez RU, Lopez-Cervantes M, Ward M, Pourfarzi F, Mu L, Kurtz RC, Lagiou A, Lagiou P, Boffetta P, Boccia S, Negri E, La Vecchia C. Education and gastric cancer risk-An individual participant data meta-analysis in the StoP project consortium. Int J Cancer, 2019

14. Tanikawa C, Kamatani Y, Terao C, Usami M, Takahashi A, Momozawa Y, Suzuki K, Ogishima S, Shimizu A, Satoh M, Matsuo K, Mikami H, Naito M, Wakai K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Kohri K, Yu ASL, Yasui T, Murakami Y, Kubo M, Matsuda K. Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese Population. J Am Soc Nephrol, 30:855-864, 2019

15. Viet Vu CH, Uchino M, Kawashima M, Yuki K, Tsubota K, Nishi A, German CA, Sakata K, Tanno K, Iso H, Yamagishi K, Yasuda N, Saito I, Kato T, Arima K, Tomita Y, Shimazu T, Yamaji T, Goto A, Inoue M, Iwasaki M, Sawada N, Tsugane S. Lack of social support and social trust as potential risk factors for dry eye disease: JPHC-NEXT study. Ocul Surf, 17:278-284, 2019

16. Yoshizaki T, Ishihara J, Kotemori A, Yamamoto J, Kokubo Y, Saito I, Yatsuya H, Yamagishi K, Sawada N, Iwasaki M, Iso H, Tsugane S. Association of vegetable, fruit, and Okinawan vegetable consumption with incident stroke and coronary heart disease. J Epidemiol, 2019

17. Zha L, Sobue T, Kitamura T, Kitamura Y, Sawada N, Iwasaki M, Sasazuki S, Yamaji T, Shimazu T, Tsugane S. Changes in Smoking Status and Mortality From All Causes and Lung Cancer: A Longitudinal Analysis of a Population-based Study in Japan. J Epidemiol, 29:11-17, 2019

18. Sugawara Y, Tsuji I, Mizoue T, Inoue M, Sawada N, Matsuo K, Ito H, Naito M, Nagata C, Kitamura Y, Sadakane A, Tanaka K, Tamakoshi A, Tsugane S, Shimazu T. Cigarette smoking and cervical cancer risk: an evaluation based on a systematic review and meta- analysis among Japanese women. Jpn J Clin Oncol, 49:77-86, 2019

19. Hidaka A, Budhathoki S, Yamaji T, Sawada N, Tanaka-Mizuno S, Kuchiba A, Charvat H, Goto A, Shimazu T, Inoue M, Noda M, Tsugane S, Iwasaki M. Plasma C-peptide and glycated albumin and subsequent risk of cancer: From a large prospective case-cohort study in Japan. Int J Cancer, 144:718-729, 2019

20. Ihira H, Sawada N, Yamaji T, Goto A, Shimazu T, Inoue M, Iwasaki M, Tsugane S. Physical activity and subsequent risk of kidney, bladder and upper urinary tract cancer in the Japanese population: the Japan Public Health Centre-based Prospective Study. Br J Cancer, 120:571-574, 2019

21. Abe SK, Saito E, Sawada N, Tsugane S, Ito H, Lin Y, Tamakoshi A, Sado J, Kitamura Y, Sugawara Y, Tsuji I, Nagata C, Sadakane A, Shimazu T, Mizoue T, Matsuo K, Naito M, Tanaka K, Inoue M. Coffee consumption and mortality in Japanese men and women: A pooled analysis of eight population-based cohort studies in Japan (Japan Cohort Consortium). Prev Med, 123:270-277, 2019

22. Yang JJ, Yu D, Wen W, Shu XO, Saito E, Rahman S, Gupta PC, He J, Tsugane S, Xiang YB, Gao YT, Koh WP, Tamakoshi A, Irie F, Sadakane A, Tsuji I, Kanemura S, Matsuo K, Nagata C, Chen CJ, Yuan JM, Shin MH, Park SK, Pan WH, Qiao YL, Pednekar MS, Gu D, Sawada N, Li HL, Gao J, Cai H, Grant E, Tomata Y, Sugawara Y, Ito H, Wada K, Shen CY, Wang R, Ahn YO, You SL, Yoo KY, Ashan H, Chia KS, Boffetta P, Inoue M, Kang D, Potter JD, Zheng W. Tobacco Smoking and Mortality in Asia: A Pooled Meta-analysis. JAMA Netw Open, 2:e191474, 2019

23. Camargo MC, Song M, Shimazu T, Charvat H, Yamaji T, Sawada N, Kemp TJ, Pfeiffer RM, Hildesheim A, Pinto LA, Tsugane S, Rabkin CS. Circulating Inflammation Markers and Risk of Gastric and Esophageal Cancers: A Case-Cohort Study Within the Japan Public Health Center-Based Prospective Study. Cancer Epidemiol Biomarkers Prev, 28:829-832, 2019

24. Mori N, Shimazu T, Charvat H, Mutoh M, Sawada N, Iwasaki M, Yamaji T, Inoue M, Goto A, Takachi R, Ishihara J, Noda M, Iso H, Tsugane S. Cruciferous vegetable intake and mortality in middle- aged adults: A prospective cohort study. Clin Nutr, 38:631- 643, 2019

25. Tanaka S, Sawada N, Yamaji T, Shimazu T, Goto A, Iwasaki M, Inoue M, Tsugane S. Female reproductive factors and risk of lymphoid neoplasm: The Japan Public Health Center-based Prospective Study. Cancer Sci, 110:1442-1452, 2019

26. Yamagiwa Y, Sawada N, Shimazu T, Yamaji T, Goto A, Takachi R, Ishihara J, Iwasaki M, Inoue M, Tsugane S. Fruit and vegetable intake and pancreatic cancer risk in a population-based cohort study in Japan. Int J Cancer, 144:1858-1866, 2019

27. Kawachi A, Shimazu T, Budhathoki S, Sawada N, Yamaji T, Iwasaki M, Inoue M, Tsugane S. Association of BMI and height with the risk of endometrial cancer, overall and by histological subtype: a population-based prospective cohort study in Japan. Eur J Cancer Prev, 28:196-202, 2019

28. Goto A, Yamaji T, Sawada N, Momozawa Y, Kamatani Y, Kubo M, Shimazu T, Inoue M, Noda M, Tsugane S, Iwasaki M. Diabetes and cancer risk: A Mendelian randomization study. Int J Cancer, 2019

29. Inoue M, Tsugane S. Coffee Drinking and Reduced Risk of Liver Cancer: Update on Epidemiological Findings and Potential Mechanisms. Curr Nutr Rep, 2019

30. Kobayashi M, Sasazuki S, Shimazu T, Sawada N, Yamaji T, Iwasaki M, Mizoue T, Tsugane S. Association of dietary diversity with total mortality and major causes of mortality in the Japanese population: JPHC study. Eur J Clin Nutr, 2019

31. Makiuchi T, Sobue T, Kitamura T, Sawada N, Iwasaki M, Yamaji T, Shimazu T, Inoue M, Tsugane S. Smoking, Alcohol Consumption, and Risks for Biliary Tract Cancer and Intrahepatic Bile Duct Cancer. J Epidemiol, 29:180-186, 2019

32. Sawada N, Iwasaki M, Yamaji T, Goto A, Shimazu T, Inoue M, Tanno K, Sakata K, Yamagishi K, Iso H, Yasuda N, Kato T, Saito I, Hasegawa M, Aoyagi K, Tsugane S. The Japan Public Health Center-based Prospective Study for the Next Generation (JPHCNEXT): Study design and participants. J Epidemiol, 2019

33. Shimizu Y, Sawada N, Nakamura K, Watanabe Y, Kitamura K, Iwasaki M, Tsugane S. Menstrual and reproductive factors and risk of vertebral fractures in Japanese women: the Japan Public Health Center-based prospective (JPHC) study. Osteoporos Int, 29:2791-2801, 2018

34. Tanikawa C, Kamatani Y, Toyoshima O, Sakamoto H, Ito H, Takahashi A, Momozawa Y, Hirata M, Fuse N, Takai-Igarashi T, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Hishida A, Wakai K, Furusyo N, Murakami Y, Nakamura Y, Imoto I, Inazawa J, Oze I, Sato N, Tanioka F, Sugimura H, Hirose H, Yoshida T, Matsuo K, Kubo M, Matsuda K. Genome-wide association study identifies gastric cancer susceptibility loci at 12q2411-12 and 20q1121. Cancer Sci, 109:4015-4024, 2018

35. Takahashi A, Kitamura K, Watanabe Y, Kobayashi R, Saito T, Takachi R, Kabasawa K, Oshiki R, Tsugane S, Iki M, Sasaki A, Yamazaki O, Nakamura K. Epidemiological profiles of chronic low back and knee pain in middle-aged and elderly Japanese from the Murakami cohort. J Pain Res, 11:3161-3169, 2018

36. Yodsurang V, Tang Y, Takahashi Y, Tanikawa C, Kamatani Y, Takahashi A, Momozawa Y, Fuse N, Sugawara J, Shimizu A, Fukushima A, Hishida A, Furusyo N, Naito M, Wakai K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Hirata M, Murakami Y, Kubo M, Matsuda K. Genome-wide association study (GWAS) of ovarian cancer in Japanese predicted regulatory variants in 22q131. PLoS ONE, 13:e0209096, 2018

37. Otsuki S, Saito E, Sawada N, Abe SK, Hidaka A, Yamaji T, Shimazu T, Goto A, Iwasaki M, Iso H, Mizoue T, Shibuya K, Inoue M, Tsugane S. Female reproductive factors and risk of all-cause and cause-specific mortality among women: The Japan Public Health Center-based Prospective Study (JPHC study). Ann Epidemiol, 28:597-604.e6, 2018

38. Shin S, Saito E, Sawada N, Ishihara J, Takachi R, Nanri A, Shimazu T, Yamaji T, Iwasaki M, Sasazuki S, Inoue M, Tsugane S. Dietary patterns and prostate cancer risk in Japanese: the Japan Public Health Center-based Prospective Study (JPHC Study). Cancer Causes Control, 29:589-600, 2018

39. Narita S, Saito E, Sawada N, Shimazu T, Yamaji T, Iwasaki M, Ishihara J, Takachi R, Shibuya K, Inoue M, Tsugane S. Dietary consumption of antioxidant vitamins and subsequent lung cancer risk: The Japan Public Health Center-based prospective study. Int J Cancer, 142:2441-2460, 2018

40. Narita S, Saito E, Sawada N, Shimazu T, Yamaji T, Iwasaki M, Sasazuki S, Noda M, Inoue M, Tsugane S. Coffee Consumption and Lung Cancer Risk: The Japan Public Health Center-Based Prospective Study. J Epidemiol, 28:207-213, 2018

41. Ferro A, Morais S, Pelucchi C, Aragones N, Kogevinas M, Lopez- Carrillo L, Malekzadeh R, Tsugane S, Hamada GS, Hidaka A, Hernandez-Ramirez RU, Lopez-Cervantes M, Zaridze D, Maximovitch D, Pourfarzi F, Zhang ZF, Yu GP, Pakseresht M, Ye W, Plymoth A, Leja M, Gasenko E, Derakhshan MH, Negri E, La Vecchia C, Peleteiro B, Lunet N. Smoking and Helicobacter pylori infection: an individual participant pooled analysis (Stomach Cancer Pooling- StoP Project). Eur J Cancer Prev, 2018

42. Li Y, Yatsuya H, Iso H, Yamagishi K, Saito I, Kokubo Y, Sawada N, Tsugane S. Body Mass Index and Risks of Incident Ischemic Stroke Subtypes: The Japan Public Health Center-Based Prospective (JPHC) Study. J Epidemiol, 2018

43. Maeda M, Yamashita S, Shimazu T, Iida N, Takeshima H, Nakajima T, Oda I, Nanjo S, Kusano C, Mori A, Moro H, Yamada H, Tsugane S, Sugiyama T, Sakai Y, Ushijima T. Novel epigenetic markers for gastric cancer risk stratification in individuals after Helicobacter pylori eradication. Gastric Cancer, 21:745-755, 2018

44. Kikuchi H, Inoue S, Lee IM, Odagiri Y, Sawada N, Inoue M, Tsugane S. Impact of Moderate-Intensity and Vigorous-Intensity Physical Activity on Mortality. Med Sci Sports Exerc, 50:715-721, 2018

45. Koyanagi YN, Matsuo K, Ito H, Tamakoshi A, Sugawara Y, Hidaka A, Wada K, Oze I, Kitamura Y, Liu R, Mizoue T, Sawada N, Nagata C, Wakai K, Nakayama T, Sadakane A, Tanaka K, Inoue M, Tsugane S, Sasazuki S. Body-Mass Index and Pancreatic Cancer Incidence: A Pooled Analysis of Nine Population-Based Cohort Studies With More Than 340,000 Japanese Subjects. J Epidemiol, 28:245-252, 2018

46. Goto A, Noda M, Goto M, Yasuda K, Mizoue T, Yamaji T, Sawada N, Iwasaki M, Inoue M, Tsugane S. Predictive performance of a genetic risk score using 11 susceptibility alleles for the incidence of Type 2 diabetes in a general Japanese population: a nested case-control study. Diabet Med, 35:602-611, 2018

47. Ueno M, Shimazu T, Sawada N, Tsugane S, Kawaguchi Y. Validity of self-reported tooth counts and masticatory status study of a Japanese adult population. J Oral Rehabil, 45:393-398, 2018

48. Sado J, Kitamura T, Sobue T, Sawada N, Iwasaki M, Sasazuki S, Yamaji T, Shimazu T, Tsugane S. Risk of thyroid cancer in relation to height, weight, and body mass index in Japanese individuals: a population-based cohort study. Cancer Med, 7:2200-2210, 2018

49. Nakagawa T, Kobayashi T, Nishiumi S, Hidaka A, Yamaji T, Sawada N, Hirata Y, Yamanaka K, Azuma T, Goto A, Shimazu T, Inoue M, Iwasaki M, Yoshida M, Tsugane S. Metabolome analysis for pancreatic cancer risk in nested case-control study: Japan Public Health Center-based prospective Study. Cancer Sci, 109:1672- 1681, 2018

50. Shin S, Saito E, Sawada N, Ishihara J, Takachi R, Nanri A, Shimazu T, Yamaji T, Iwasaki M, Sasazuki S, Inoue M, Tsugane S. Dietary patterns and colorectal cancer risk in middle-aged adults: A large population-based prospective cohort study. Clin Nutr, 37:1019-1026, 2018

51. Sasazuki S, Inoue M, Shimazu T, Wakai K, Naito M, Nagata C, Tanaka K, Tsuji I, Sugawara Y, Mizoue T, Matsuo K, Ito H, Tamakoshi A, Sawada N, Nakayama T, Kitamura Y, Sadakane A, Tsugane S. Evidence-based cancer prevention recommendations for Japanese. Jpn J Clin Oncol, 48:576-586, 2018

52. Shin S, Sawada N, Saito E, Yamaji T, Iwasaki M, Shimazu T, Sasazuki S, Inoue M, Tsugane S. Menstrual and reproductive factors in the risk of thyroid cancer in Japanese women: the Japan Public Health Center-Based Prospective Study. Eur J Cancer Prev, 27:361-369, 2018

53. Kashino I, Akter S, Mizoue T, Sawada N, Kotemori A, Matsuo K, Oze I, Ito H, Naito M, Nakayama T, Kitamura Y, Tamakoshi A, Tsuji I, Sugawara Y, Inoue M, Nagata C, Sadakane A, Tanaka K, Tsugane S, Shimazu T. Coffee drinking and colorectal cancer and its subsites: A pooled analysis of 8 cohort studies in Japan. Int J Cancer, 143:307-316, 2018

54. Kiyabu GY, Sawada N, Iwasaki M, Yamaji T, Shimazu T, Sasazuki S, Inoue M, Tsugane S. The association between plasma C-peptide concentration and the risk of prostate cancer: a nested case-control study within a Japanese population-based prospective study. Eur J Cancer Prev, 27:461-467, 2018

55. Kokubo Y, Saito I, Iso H, Yamagishi K, Yatsuya H, Ishihara J, Maruyama K, Inoue M, Sawada N, Tsugane S. Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study. Clin Nutr, 37:1602-1608, 2018

56. Varga MG, Cai H, Waterboer T, Murphy G, Shimazu T, Taylor PR, Qiao YL, Park SK, Yoo KY, Jee SH, Cho ER, Kim J, Abnet CC, Tsugane S, Cai Q, Zheng W, Pawlita M, Shu XO, Epplein M. Epstein- Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia. Dig Dis Sci, 63:2765-2772, 2018

57. Ikeda A, Iso H, Yamagishi K, Iwasaki M, Yamaji T, Miura T, Sawada N, Inoue M, Tsugane S. Plasma tea catechins and risk of cardiovascular disease in middle-aged Japanese subjects: The JPHC study. Atherosclerosis, 277:90-97, 2018

58. Kashino I, Serafini M, Ishihara J, Mizoue T, Sunami A, Maruyama K, Sawada N, Inoue M, Nanri A, Kurotani K, Akter S, Iwasaki M, Tsugane S. The Validity and Reproducibility of Dietary Non-enzymatic Antioxidant Capacity Estimated by Self-administered Food Frequency Questionnaires. J Epidemiol, 28:428-436, 2018

59. Katagiri R, Goto A, Nakagawa T, Nishiumi S, Kobayashi T, Hidaka A, Budhathoki S, Yamaji T, Sawada N, Shimazu T, Inoue M, Iwasaki M, Yoshida M, Tsugane S. Increased Levels of Branched- Chain Amino Acid Associated With Increased Risk of Pancreatic Cancer in a Prospective Case-Control Study of a Large Cohort. Gastroenterology, 155:1474-1482.e1, 2018

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