Annual Report 2019
Division of Science and Technology for Endoscopy (Tsukiji Campus)
Ichiro Oda, Yutaka Saito, Haruhisa Suzuki, Satoru Nonaka, Taku Sakamoto, Masayoshi Yamada, Yasuo Kakugawa, Shigetaka Yoshinaga, Seiichiro Abe, Hiroyuki Takamaru, Keiko Nakamura
Introduction
Remarkable progress has been made in not only endoscopic diagnosis but also endoscopic treatment. Our efforts will be focused on the developments of new endoscopic diagnosis (e.g. molecular imaging, functional imaging) and treatment (e.g. full thickness resection), as well as an effective training system with industry-academia collaboration (Figure 1).
The Team and What We Do
Since fiscal year 2017, in the Division of Science and Technology for Endoscopy of the Exploratory Oncology Research & Clinical Trial Center (EPOC) at the National Cancer Center (NCC) Tsukiji campus, four teams were organized (diagnosis team, treatment team, training team, AI team) to develop the innovative endoscopic diagnosis, treatment and training system. We searched clinical needs, and then set up development themes for each team.
Diagnosis team: Taku Sakamoto, Haruhisa Suzuki, Satoru Nonaka, Masayoshi Yamada
Treatment team: Satoru Nonaka, Taku Sakamoto, Seiichiro Abe, Hiroyuki Takamaru
Training team: Haruhisa Suzuki, Yasuo Kakugawa, Shigetaka Yoshinaga, Taku Sakamoto, Keiko Nakamura
Artificial intelligence (AI) team: Masayoshi Yamada, Ichiro Oda
Supervisors: Ichiro Oda, Yutaka Saito
Research activities
1. In collaboration with Olympus Corporation, we have started the development of new endoscopic diagnostic, therapeutic and training equipment at Olympus Lab in the National Cancer Center Research Institute (NCCRI). In fiscal year 2019, we continued to develop innovative endoscopic equipment. Although the details are currently confidential, each team is involved in three or four research and development themes and is aiming to publish some of the developments in 2020. The following presentations were actually submitted for consideration.
1. Sakamoto T, et al., The 99th Annual Meeting of the Japan Gastroenterological Endoscopy Society, September 2020, Kyoto, Japan
2. M. Ego, et al., The 111th Annual Meeting of the Japan Gastroenterological Endoscopy Society Kanto Chapter, December 2020, Tokyo, Japan
We also received support from the National Cancer Center Research and Development Fund (31-S-5). We conducted animal experiments on pigs and obtained basic data for future First in Human studies.
2. In collaboration with the Artificial Intelligence Research Center (AIRC), the National Institute of Advanced Industrial Science and Technology (AIST) (Professor Jun Sese), the NCCRI (Professor Ryuji Hamamoto), and the Division of Science and Technology for Endoscopy of the EPOC (Kashiwa campus: Professor Hiroaki Ikematsu), we have started the research and development of an endoscopic diagnosis support system on tumor invasion of gastrointestinal cancer using AI. Preliminary results were submitted for the following presentations.
1. Yamada, M. et al., The 100th Annual Meeting of the Japan Gastroenterological Endoscopy Society, Kobe, Japan, November 2020
Education
We have invited residents from the Department of Endoscopy of the National Cancer Center Hospital (NCCH) to our meetings and experiments of each development team, and educated them to be leaders of the next generation in the research and development of endoscopic science and technology.
Future prospects
We are working on the research and development of new endoscopic diagnostic, therapeutic and training equipment in collaboration with companies and academia. In the future, we would like to disseminate our new equipment to the world.
List of papers published in 2019
Journal
1. Hashiguchi Y, Muro K, Saito Y, Ito Y, Ajioka Y, Hamaguchi T, Hasegawa K, Hotta K, Ishida H, Ishiguro M, Ishihara S, Kanemitsu Y, Kinugasa Y, Murofushi K, Nakajima TE, Oka S, Tanaka T, Taniguchi H, Tsuji A, Uehara K, Ueno H, Yamanaka T, Yamazaki K, Yoshida M, Yoshino T, Itabashi M, Sakamaki K, Sano K, Shimada Y, Tanaka S, Uetake H, Yamaguchi S, Yamaguchi N, Kobayashi H, Matsuda K, Kotake K, Sugihara K. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer. Int J Clin Oncol, 25:1-42, 2020
2. Yoshinaga S, Itoi T, Yamao K, Yasuda I, Irisawa A, Imaoka H, Tsuchiya T, Doi S, Yamabe A, Murakami Y, Ishikawa H, Saito Y. Safety and efficacy of endoscopic ultrasound-guided fine needle aspiration for pancreatic masses: A prospective multicenter study. Dig Endosc, 32:114-126, 2020
3. Kasuga K, Saito Y, Wu SYS, Takamaru H, Sakamoto T, Sekine S, Uraoka T. Impact of endoscopic submucosal dissection of an anal squamous intraepithelial lesion with indistinct border. Endoscopy, 52:E75-E77, 2020
4. Tanaka S, Kashida H, Saito Y, Yahagi N, Yamano H, Saito S, Hisabe T, Yao T, Watanabe M, Yoshida M, Saitoh Y, Tsuruta O, Sugihara KI, Igarashi M, Toyonaga T, Ajioka Y, Kusunoki M, Koike K, Fujimoto K, Tajiri H. Japan Gastroenterological Endoscopy Society guidelines for colorectal endoscopic submucosal dissection/endoscopic mucosal resection. Dig Endosc, 32:219-239, 2020
5. Inoki K, Kakugawa Y, Takamaru H, Sekiguchi M, Matsumoto M, Matsuda T, Ito A, Tanaka T, Inamoto Y, Fuji S, Kurosawa S, Kim SW, Fukuda T, Ohe Y, Saito Y. Capsule Endoscopy after Hematopoietic Stem Cell Transplantation Can Predict Transplant-Related Mortality. Digestion, 101:198-207, 2020
6. Kobayashi K, Tanaka S, Murakami Y, Ishikawa H, Sada M, Oka S, Saito Y, Iishi H, Kudo SE, Ikematsu H, Igarashi M, Saitoh Y, Inoue Y, Hisabe T, Tsuruta O, Sano Y, Yamano H, Shimizu S, Yahagi N, Matsuda K, Nakamura H, Fujii T, Sugihara K. Predictors of invasive cancer of large laterally spreading colorectal tumors: A multicenter study in Japan. JGH Open, 4:83-89, 2020
7. Nunobe S, Oda I, Ishikawa T, Akazawa K, Katai H, Isobe Y, Miyashiro I, Tsujitani S, Ono H, Tanabe S, Fukagawa T, Suzuki S, Kakeji Y. Surgical outcomes of elderly patients with Stage I gastric cancer from the nationwide registry of the Japanese Gastric Cancer Association. Gastric Cancer, 23:328-338, 2020
8. Yachida T, Oda I, Abe S, Sekiguchi M, Nonaka S, Suzuki H, Yoshinaga S, Taniguchi H, Sekine S, Masugata H, Masaki T, Daiko H, Saito Y. Risk of Lymph Node Metastasis in Patients with the Superficial Spreading Type of Esophageal Squamous Cell Carcinoma. Digestion, 101:239-244, 2020
9. Yoshida M, Takizawa K, Nonaka S, Shichijo S, Suzuki S, Sato C, Komori H, Minagawa T, Oda I, Uedo N, Hirasawa K, Matsumoto K, Sumiyoshi T, Mori K, Gotoda T, Ono H. Conventional versus traction-assisted endoscopic submucosal dissection for large esophageal cancers: a multicenter, randomized controlled trial (with video). Gastrointest Endosc, 91:55-65.e2.doi: 10.1016/j.gie.2019.08.014, 2020
10. Sekimizu M, Yoshida A, Mitani S, Asano N, Hirata M, Kubo T, Yamazaki F, Sakamoto H, Kato M, Makise N, Mori T, Yamazaki N, Sekine S, Oda I, Watanabe SI, Hiraga H, Yonemoto T, Kawamoto T, Naka N, Funauchi Y, Nishida Y, Honoki K, Kawano H, Tsuchiya H, Kunisada T, Matsuda K, Inagaki K, Kawai A, Ichikawa H. Frequent mutations of genes encoding vacuolar H+ -ATPase components in granular cell tumors. Genes Chromosomes Cancer, 58:373-380, 2019
11. Katada C, Horimatsu T, Muto M, Tanaka K, Matsuda K, Fujishiro M, Saito Y, Ohtsuka K, Oda I, Kato M, Kida M, Kobayashi K, Hoteya S, Kodashima S, Matsuda T, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Kato M, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Tajiri H. Current status of esophageal endoscopy including the evaluation of smoking and alcohol consumption in Japan: an analysis based on the Japan endoscopy database. Esophagus, 16:174-179, 2019
12. Hashimoto T, Ogawa R, Tang TY, Yoshida H, Taniguchi H, Katai H, Oda I, Sekine S. RHOA mutations and CLDN18-ARHGAP fusions in intestinal-type adenocarcinoma with anastomosing glands of the stomach. Mod Pathol, 32:568-575, 2019
13. Kuwabara H, Abe S, Nonaka S, Suzuki H, Yoshinaga S, Oda I, Saito Y. Clinical feasibility of endoscopic submucosal dissection with minimum lateral margin of superficial esophageal squamous cell carcinoma. Endosc Int Open, 7:E396-E402, 2019
14. Abe S. Post ESD bleeding prevention: Are polyglycolic acid sheets here to stay? Endoscopy, 51:613-614, 2019
15. Yachida S, Mizutani S, Shiroma H, Shiba S, Nakajima T, Sakamoto T, Watanabe H, Masuda K, Nishimoto Y, Kubo M, Hosoda F, Rokutan H, Matsumoto M, Takamaru H, Yamada M, Matsuda T, Iwasaki M, Yamaji T, Yachida T, Soga T, Kurokawa K, Toyoda A, Ogura Y, Hayashi T, Hatakeyama M, Nakagama H, Saito Y, Fukuda S, Shibata T, Yamada T. Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer. Nat Med, 25:968-976, 2019
16. Kobayashi S, Nonaka S, Oda I, Abe S, Suzuki H, Yoshinaga S, Taniguchi H, Sekine S, Igarashi Y, Saito Y. A case of mixed-type early gastric cancer with recurrence following curative endoscopic submucosal dissection for expanded indication. Endosc Int Open, 7:E841-E845, 2019
17. Sakamoto T, Inoki K, Takamaru H, Sekiguchi M, Yamada M, Nakajima T, Matsuda T, Saito Y. Efficacy of linked colour imaging in magnifying chromoendoscopy with crystal violet staining: a pilot study. Int J Colorectal Dis, 34:1341-1344, 2019
18. Chen HY, Yamada M, Saito Y. Successful removal of a serrated lesion involving the appendiceal orifice using a traction device. Dig Endosc, 31:333, 2019
19. Jimenez-Garcia VA, Yamada M, Ikematsu H, Takamaru H, Abe S, Sakamoto T, Nakajima T, Matsuda T, Saito Y. Endoscopic submucosal dissection in management of colorectal tumors near or involving a diverticulum: a retrospective case series. Endosc Int Open, 7:E664-E671, 2019
20. Saito Y, Sylvia Wu SY, Ego M, Abe S. Colorectal endoscopic submucosal dissection with use of a bipolar and insulated tip knife. VideoGIE, 4:314-318, 2019
21. Niikura R, Yamada A, Fujishiro M, Tanaka K, Matsuda K, Saito Y, Ohtsuka K, Oda I, Katada C, Kato M, Kida M, Kobayashi K, Hoteya S, Horimatsu T, Kodashima S, Matsuda T, Muto M, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Kato M, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Shinozaki T, Tajiri H, Koike K. The Effects of Direct Oral Anticoagulants, Warfarin, Aspirin and Thienopyridine on the Performance of Immunochemical, Faecal, Occult Blood Tests. Digestion, 100:117-126, 2019
22. Kobayashi S, Yamada M, Takamaru H, Sakamoto T, Matsuda T, Sekine S, Igarashi Y, Saito Y. Diagnostic yield of the Japan NBI Expert Team (JNET) classification for endoscopic diagnosis of superficial colorectal neoplasms in a large-scale clinical practice database. United European Gastroenterol J, 7:914-923, 2019
23. Inoki K, Yamada M, Kuwabara H, Takamaru H, Sekiguchi M, Sakamoto T, Matsuda T, Saito Y. Newly-developed colonoscope (PCF-PQ260L) is useful for patients with difficult colons. Turk J Gastroenterol, 30:630-635, 2019
24. Yamada M, Saito Y, Imaoka H, Saiko M, Yamada S, Kondo H, Takamaru H, Sakamoto T, Sese J, Kuchiba A, Shibata T, Hamamoto R. Development of a real-time endoscopic image diagnosis support system using deep learning technology in colonoscopy. Sci Rep, 9:14465, 2019
25. Sakamoto T, Tomizawa Y, Cho H, Takamaru H, Sekiguchi M, Yamada M, Matsuda T, Murakami Y, Saito Y. Additional value of linked color imaging in colonoscopy: a retrospective study. Endosc Int Open, 7:E1448-E1454, 2019
26. Abe S, Oda I, Suzuki H, Yoshinaga S, Saito Y. A challenging case of gastric endoscopic submucosal dissection: removal of a sizable cancer through altering patient's position and multiple clip-line traction. VideoGIE, 4:558-560, 2019
27. Atkinson NSS, Ket S, Bassett P, Aponte D, De Aguiar S, Gupta N, Horimatsu T, Ikematsu H, Inoue T, Kaltenbach T, Leung WK, Matsuda T, Paggi S, Radaelli F, Rastogi A, Rex DK, Sabbagh LC, Saito Y, Sano Y, Saracco GM, Saunders BP, Senore C, Soetikno R, Vemulapalli KC, Jairath V, East JE. Narrow-Band Imaging for Detection of Neoplasia at Colonoscopy: A Meta-analysis of Data From Individual Patients in Randomized Controlled Trials. Gastroenterology, 157:462-471, 2019
28. Abe S, Ishihara R, Takahashi H, Ono H, Fujisaki J, Matsui A, Takahashi A, Goda K, Kawada K, Koike T, Takeuchi M, Tsuji Y, Hirasawa D, Oyama T. Long-term outcomes of endoscopic resection and metachronous cancer after endoscopic resection for adenocarcinoma of the esophagogastric junction in Japan. Gastrointest Endosc, 89:1120-1128, 2019
29. Saito Y, Nonaka S. ESD as first-intent resection method: also for the duodenum? Endosc Int Open, 7:E1761-E1762, 2019
30. Mizuguchi Y, Sakamoto T, Hashimoto T, Tsukamoto S, Iwasa S, Saito Y, Sekine S. Identification of a novel PRR15L-RSPO2 fusion transcript in a sigmoid colon cancer derived from superficially serrated adenoma. Virchows Arch, 475:659-663, 2019
31. Iwabu J, Yamashita S, Takeshima H, Kishino T, Takahashi T, Oda I, Koyanagi K, Igaki H, Tachimori Y, Daiko H, Nakazato H, Nishiyama K, Lee YC, Hanazaki K, Ushijima T. FGF5 methylation is a sensitivity marker of esophageal squamous cell carcinoma to definitive chemoradiotherapy. Sci Rep, 9:13347, 2019
32. Nakajo K, Abe S, Oda I, Ishihara R, Tanaka M, Yoshio T, Katada C, Yano T. Impact of the Charlson Comorbidity Index on the treatment strategy and survival in elderly patients after non-curative endoscopic submucosal dissection for esophageal squamous cell carcinoma: a multicenter retrospective study. J Gastroenterol, 54:871-880, 2019
33. Minashi K, Nihei K, Mizusawa J, Takizawa K, Yano T, Ezoe Y, Tsuchida T, Ono H, Iizuka T, Hanaoka N, Oda I, Morita Y, Tajika M, Fujiwara J, Yamamoto Y, Katada C, Hori S, Doyama H, Oyama T, Nebiki H, Amagai K, Kubota Y, Nishimura K, Kobayashi N, Suzuki T, Hirasawa K, Takeuchi T, Fukuda H, Muto M. Efficacy of Endoscopic Resection and Selective Chemoradiotherapy for Stage I Esophageal Squamous Cell Carcinoma. Gastroenterology, 157:382-390.e3, 2019
34. Uemura N, Oda I, Saito Y, Ono H, Fujisaki J, Matsuhashi N, Ohata K, Yahagi N, Yada T, Satoh M, Tajiri H, Inomata M, Kitano S. Efficacy and safety of 0.6% sodium alginate solution in endoscopic submucosal dissection for esophageal and gastric neoplastic lesion: A randomized controlled study. Dig Endosc, 31:396-404, 2019
Book
1. Saito Y, Takamaru H, Ono A, Sakamoto T,Yamada M, Sekiguchi M, Abe S, Sekine S, Matsuda T. Chapter 10. Endoscopic Submucosal Dissection for T1 Colorectal Cancer. In: Endoscopic Management of Colorectal T1(SM) Carcinoma, Singapore, Springer Singapore, pp 77-86, 2019
2. Abe S, Catalano F, Saito Y. Endoscopic Resections: EMR and ESD. In: Galloro G (ed), Revisiting Barrett’s Esophagus, Switzerland, Springer Switzerland, pp 147-158, 2019