Annual Report 2019
NEXT Medical Device Innovation Center
Masaru Konishi, Masaaki Ito, Tomonori Yano, Yusuke Yoda, Nobuyoshi Takeshita, Hiro Hasegawa, Takahiro Igaki, Daichi Kitaguchi, Shigehiro Kojima, Yoshito Shibusawa, Yumi Kinebuchi, Akihiro Hirao, Daisuke Sato, Yuki Furusawa, Kazuyuki Hayashi, Shigekazu Nagashima, Hiroki Matsuzaki, Masato Murata, Yoichi Ninomiya, Atsushi Yamada, Toru Fujino, Mika Makari, Tomoko Ohe, Yuko Hitomi, Yukari Nagatsuma, Yuka Takahashi, Reria Sato, Megumi Kawakami, Machiko Kakihara, Ryuko Shimoda, Maruko Kikuta, Yoko Furuichi, Kumi Suzuki, Yoko Hatanaka, Emi Konno, Kazue Ando, Miwa Sako, Ryo Sekiguchi, Ibuki Watanabe, Norio Yamamoto, Yuko Tanabe, Yuka Mitsuke
Introduction
The Center for New Surgical and Endoscopic Development for Exploratory Technology (NEXT) was founded in the National Cancer Center Hospital East on May 8, 2017. It provides state-of-the-art medical care to patients and develops medical devices and technologies, especially in surgical and endoscopic fields with the following aims:
- Providing currently available state-of-the-art medical care.
- Developing next-generation medical devices and technologies based on clinical needs.
- Introducing developed medical devices and technologies to clinical practice.
- Developing the next generation of leaders in the cancer-care field.
The NEXT Medical Device Innovation Center is included in the NEXT and develops next-generation medical devices and technologies based on clinical needs.
The Team and What We Do
The NEXT Medical Device Innovation Center undertakes research and development on innovative medical devices in exploratory technology based on clinical needs in industry-academia-government and medical-engineering collaboration. Especially, we target instruments and devices used in/around the endoscopic and laparoscopic surgery fields. We promote device development in partnership with medical device businesses, “monozukuri” (manufacturing) companies, academia, and the Chiba area. Furthermore, we support clinical trials and act as an advanced incubation facility providing training for surgeons and disseminating information.
Research activities
The NEXT Medical Device Innovation Center has undertaken more than 19 research and development collaborations with industry and academia partners. Especially, we have developed artificial intelligence (AI) applications for the medical field. Two activate projects about the medical applications of AI technology research and development have been adopted by the Japan Agency for Medical Research and Development (AMED) as a funding support program, and we have started a project to develop a medical device that supports surgery and to create a database of surgical images of endoscopic surgery for the purpose of improving the efficiency and safety of surgery. We also have developed AI applications for endoscopic diagnosis. We have also developed AI technology applications for endoscopic diagnosis, surgical support robots, oxygen saturation imaging endoscopes, and surgical and endoscopic procedure training devices. In recognition of these efforts in medical device development, our hospital was adopted as one of the 14 medical device development bases nationwide in AMED's “Support Program on Collaborative Innovation Networks for Medical Device” (FY2019-2023). nbsp;
Furthermore, we have promoted collaboration with venture companies in the development of medical devices from the idea of matching clinical needs and engineering seeds. To accelerate the matching and collaboration with venture companies, we held the “Medical Device Innovation in Kashiwanoha” symposiums on September 19 as well as last year.
Clinical trials
1) Clinical evaluation trial about prediction of treatment effect of chemotherapy or chemoradiotherapy for gastrointestinal cancer using oxygen saturation imaging endoscopy.
2) Clinical trial of biodegradable stent (BD-stent) for patients with refractory benign esophageal stricture.
Education
We held training seminars on the latest endoscopic surgeries such as transanal total mesorectal excision (taTME) once a month to improve surgeon's surgical techniques. We also cooperated with the “NEXT Medical-Engineering Collaboration Introductory Seminar” sponsored by Chiba Prefecture. Furthermore, in our clinical field observation program, 38 people from 4 institutions have visited the operating room and intensive care unit (ICU) in our hospital in order to collect information on clinical needs.
In order to develop human resources of creating innovative medical devices in our hospital, we held the “NEXT seminar” four times. The “NEXT seminar” has given information related to medical device development to participants.
Future prospects
We will promote the development of medical devices more and more supported by AMED in the “Support Program on Collaborative Innovation Networks for Medical Device”. In particular, we will establish a system for clinical field observation programs, support obtaining POC through animal tests, and further promote cooperation with venture companies that possess innovative technology solutions.
List of papers published in 2019
Journal
1. Hasegawa H, Tsukada Y, Wakabayashi M, Nomura S, Sasaki T, Nishizawa Y, Ikeda K, Akimoto T, Ito M. Impact of intraoperative indocyanine green fluorescence angiography on anastomotic leakage after laparoscopic sphincter-sparing surgery for malignant rectal tumors. Int J Colorectal Dis, 35:471-480, 2020
2. Sato D, Motegi A, Kadota T, Kojima T, Bando H, Shinmura K, Hori K, Yoda Y, Oono Y, Zenda S, Ikematsu H, Akimoto T, Yano T. Therapeutic results of proton beam therapy with concurrent chemotherapy for cT1 esophageal cancer and salvage endoscopic therapy for local recurrence. Esophagus, 17:305-311, 2020
3. Minamide T, Yoda Y, Hori K, Shinmura K, Oono Y, Ikematsu H, Yano T. Advantages of salvage photodynamic therapy using talaporfin sodium for local failure after chemoradiotherapy or radiotherapy for esophageal cancer. Surg Endosc, 34:899-906, 2020
4. Yano T, Wang KK. Photodynamic Therapy for Gastrointestinal Cancer. Photochem Photobiol, 96:517-523, 2020
5. Kitaguchi D, Takeshita N, Matsuzaki H, Takano H, Owada Y, Enomoto T, Oda T, Miura H, Yamanashi T, Watanabe M, Sato D, Sugomori Y, Hara S, Ito M. Real-time automatic surgical phase recognition in laparoscopic sigmoidectomy using the convolutional neural network-based deep learning approach. Surg Endosc, 2019
6. Okamoto N, Morimoto H, Yamamoto Y, Kanda K, Nankinzan R, Kasamatsu S, Yoshimura S, Kan M, Nakano A, Hosaka S, Watanabe Y, Arahata K, Toyama Y, Okamura A, Yamaguchi T, Yano T. Skill-up study of systemic endoscopic examination technique using narrow band imaging of the head and neck region of patients with esophageal squamous cell carcinoma: Prospective multicenter study. Dig Endosc, 31:653-661, 2019
7. Yamamoto Y, Shinmura K, Yano T. Two cases of early gastric and esophageal cancers treated by endoscopic submucosal dissection in three-dimensional endoscopy. Dig Endosc, 31:e120-e121, 2019
8. Kondo A, Nishizawa Y, Horikiri Y, Amemori H, Tsukada Y, Sasaki T, Kawai T, Daiko H, Ito M. A novel device designed to improve the operability of energy devices with foot pedals in endoscopic surgery: the Foot-Site Monitor. Surg Today, 49:965-970, 2019
9. Masatake A, Kawai T, Han S, Nishizawa Yuji, Ito M, Sasaki T, Tsukada Y, Ikeda K, Hasegawa H. 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12-15 June 2019. Surg Endosc, 33:485-781, 2019
10. Wu H, Minamide T, Yano T. Role of photodynamic therapy in the treatment of esophageal cancer. Dig Endosc, 31:508-516, 2019
11. Kumahara K, Ikematsu H, Shinmura K, Murano T, Inaba A, Okumura K, Nishihara K, Sunakawa H, Furue Y, Ito R, Sato D, Minamide T, Okamoto N, Yamamoto Y, Suyama M, Takashima K, Nakajo K, Yoda Y, Hori K, Oono Y, Yano T. Objective evaluation of the visibility of colorectal lesions using eye tracking. Dig Endosc, 31:552-557, 2019