Annual Report 2019
Division of Prevention
Manami Inoue, Taichi Shimazu, Michihiro Mutoh, Junko Saito, Sarah K. Abe, Md. Rashedul Islam, Aki Otsuki, Ayami Ono, Yingyan Gong, Masami Sakano, Shiori Tanaka, Takumi Narita, Mayo Hirabayashi, Nagisa Mori, Akiko Yaguchi, Yoko Yamagiwa, Yasuko Iba, Michiko Okajima, Hanako Saito, Ayako Toyama, Yoko Hirose
Introduction
The Division of Prevention has planned and conducted studies on cancer prevention.
The Team and What We Do
The Division of Prevention focuses on prevention research to investigate and develop prevention methods (lifestyle, chemoprevention, molecular markers, etc.), risk prediction, risk stratification models, and evidence-based cancer prevention guidelines.
Research activities
1. Evaluation of cancer prevention strategies in Japan and cancer prevention guidelines
To develop an evidence-based cancer prevention strategy in Japan, systematic reviews, meta-analyses, and pooled analyses of Japanese epidemiological research were conducted.
2. Asia Cohort Consortium (ACC)
The ACC is a collaborative effort which seeks to understand the relationship between genetics, environmental exposures and the etiology of disease through the establishment of a consortium of cohort studies with healthy individuals throughout Asian countries. Our division serves as the coordinating center and data center of the ACC, and directs many of its ongoing projects.
3. The effectiveness of Helicobacter pylori (H. pylori) eradication on gastric cancer prevention
This study aims to assess whether H. pylori eradication prevents the subsequent development of gastric cancer by pooled analysis of large-scale epidemiological studies with information on H. pylori infection status (JPHC-NEXT in the Yokote, Saku and Chikusei areas; the Yamagata Cohort; and the Tokyo Gastric Cancer Screening Study). This project started in 2017.
4. Attributable Causes of Cancer (JAPAN PAF PROJECT)
We conducted a systematic assessment to estimate the current burden of cancer attributable to known preventable risk factors in Japan. The first estimation was conducted for cancer incidence and mortality in the year 2005. The estimation is currently being updated for the year 2015.
5. Development of prevention measures based on interventional research.
We have completed a double-blind, randomized clinical trial of aspirin and mesalazine to see if these drugs suppress the occurrence of new adenomas in patients with a history of multiple colorectal adenomas. Now, we are planning a new clinical trial aimed at clinical use of aspirin. Another clinical research project aiming to develop colorectal cancer chemopreventive drugs is in progress.
6. Effectiveness of personalized advice using a cancer risk prediction tool on modifying lifestyle habits: a randomized controlled trial
We conducted a randomized controlled trial among healthy individuals to evaluate the effectiveness of giving personalized advice. We used a probability calculated by a prediction model of cumulative cancer risk based on lifestyle factors on lifestyle modification. Personalized advice is then compared to standard advice for the prevention of cancer not using risk probability.
7. National survey on access to and use of cancer- and health-related information, and cancer risk behaviors
We plan to conduct a nationally representative cross-sectional survey on access to, knowledge of, attitudes towards and use of cancer- and health-related information and cancer risk behaviors in Japan. Randomly selected Japanese people aged 20 years or older will be asked to respond to a self-administered questionnaire by mail.
Education
We supervised the research of domestic and international Master and PhD students. We serve as Coordinate Department of Cancer Epidemiology, Graduate School of Medicine, The University of Tokyo. We accepted guest researchers and trainees from overseas.
Future prospects
We focus on research for the development of effective cancer prevention strategies. Research to find an effective tool to support behavior modification for promoting health will be planned.
List of papers published in 2019
Journal
1. Wong JYY, Zhang H, Hsiung CA, Shiraishi K, Yu K, Matsuo K, Wong MP, Hong YC, Wang J, Seow WJ, Wang Z, Song M, Kim HN, Chang IS, Chatterjee N, Hu W, Wu C, Mitsudomi T, Zheng W, Kim JH, Seow A, Caporaso NE, Shin MH, Chung LP, An SJ, Wang P, Yang Y, Zheng H, Yatabe Y, Zhang XC, Kim YT, Cai Q, Yin Z, Kim YC, Bassig BA, Chang J, Ho JCM, Ji BT, Daigo Y, Ito H, Momozawa Y, Ashikawa K, Kamatani Y, Honda T, Hosgood HD, Sakamoto H, Kunitoh H, Tsuta K, Watanabe SI, Kubo M, Miyagi Y, Nakayama H, Matsumoto S, Tsuboi M, Goto K, Shi J, Song L, Hua X, Takahashi A, Goto A, Minamiya Y, Shimizu K, Tanaka K, Wei F, Matsuda F, Su J, Kim YH, Oh IJ, Song F, Su WC, Chen YM, Chang GC, Chen KY, Huang MS, Chien LH, Xiang YB, Park JY, Kweon SS, Chen CJ, Lee KM, Blechter B, Li H, Gao YT, Qian B, Lu D, Liu J, Jeon HS, Hsiao CF, Sung JS, Tsai YH, Jung YJ, Guo H, Hu Z, Wang WC, Chung CC, Burdett L, Yeager M, Hutchinson A, Berndt SI, Wu W, Pang H, Li Y, Choi JE, Park KH, Sung SW, Liu L, Kang CH, Zhu M, Chen CH, Yang TY, Xu J, Guan P, Tan W, Wang CL, Hsin M, Sit KY, Ho J, Chen Y, Choi YY, Hung JY, Kim JS, Yoon HI, Lin CC, Park IK, Xu P, Wang Y, He Q, Perng RP, Chen CY, Vermeulen R, Wu J, Lim WY, Chen KC, Li YJ, Li J, Chen H, Yu CJ, Jin L, Chen TY, Jiang SS, Liu J, Yamaji T, Hicks B, Wyatt K, Li SA, Dai J, Ma H, Jin G, Song B, Wang Z, Cheng S, Li X, Ren Y, Cui P, Iwasaki M, Shimazu T, Tsugane S, Zhu J, Chen Y, Yang K, Jiang G, Fei K, Wu G, Lin HC, Chen HL, Fang YH, Tsai FY, Hsieh WS, Yu J, Stevens VL, Laird-Offringa IA, Marconett CN, Rieswijk L, Chao A, Yang PC, Shu XO, Wu T, Wu YL, Lin D, Chen K, Zhou B, Huang YC, Kohno T, Shen H, Chanock SJ, Rothman N, Lan Q. Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women. Genomics, 112:1223-1232, 2020
2. Adachi S, Hamoya T, Fujii G, Narita T, Komiya M, Miyamoto S, Kurokawa Y, Takahashi M, Takayama T, Ishikawa H, Tashiro K, Mutoh M. Theracurmin inhibits intestinal polyp development in Apc-mutant mice by inhibiting inflammation-related factors. Cancer Sci, 111:1367-1374, 2020
3. Matsuoka YJ, Okubo R, Shimizu Y, Tsuji K, Narisawa T, Sasaki J, Sasai H, Akashi-Tanaka S, Hamaguchi T, Iwasa T, Iwata S, Kato T, Kurotani K, Maruyama D, Mori A, Ogawa A, Sakurai N, Shimazu T, Shimizu C, Tabuchi T, Takahashi M, Takano T, Tatematsu N, Uchitomi Y, Watanabe C, Fukui T. Developing the structure of Japan's cancer survivorship guidelines using an expert panel and modified Delphi method. J Cancer Surviv, 14:273-283, 2020
4. Shimizu Y, Tsuji K, Ochi E, Arai H, Okubo R, Kuchiba A, Shimazu T, Sakurai N, Narisawa T, Ueno T, Iwata H, Matsuoka Y. Study protocol for a nationwide questionnaire survey of physical activity among breast cancer survivors in Japan. BMJ Open, 10:e032871, 2020
5. Hanyuda A, Sawada N, Uchino M, Kawashima M, Yuki K, Tsubota K, Yamagishi K, Iso H, Yasuda N, Saito I, Kato T, Abe Y, Arima K, Tanno K, Sakata K, Shimazu T, Yamaji T, Goto A, Inoue M, Iwasaki M, Tsugane S. Physical inactivity, prolonged sedentary behaviors, and use of visual display terminals as potential risk factors for dry eye disease: JPHC-NEXT study. Ocul Surf, 18:56-63, 2020
6. Kobayashi M, Sasazuki S, Shimazu T, Sawada N, Yamaji T, Iwasaki M, Mizoue T, Tsugane S. Association of dietary diversity with total mortality and major causes of mortality in the Japanese population: JPHC study. Eur J Clin Nutr, 74:54-66, 2020
7. Kotemori A, Sawada N, Iwasaki M, Yamaji T, Shivappa N, Hebert JR, Ishihara J, Inoue M, Tsugane S. Validating the dietary inflammatory index using inflammatory biomarkers in a Japanese population: A cross-sectional study of the JPHC-FFQ validation study. Nutrition, 69:110569, 2020
8. Makiuchi T, Sobue T, Kitamura T, Ishihara J, Sawada N, Iwasaki M, Yamaji T, Shimazu T, Tsugane S. Relationship between Meat/Fish Consumption and Biliary Tract Cancer: The Japan Public Health Center-Based Prospective Study. Cancer Epidemiol Biomarkers Prev, 29:95-102, 2020
9. Sawada N, Iwasaki M, Yamaji T, Goto A, Shimazu T, Inoue M, Tanno K, Sakata K, Yamagishi K, Iso H, Yasuda N, Kato T, Saito I, Hasegawa M, Aoyagi K, Tsugane S. The Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT): Study Design and Participants. J Epidemiol, 30:46-54, 2020
10. Goto A, Yamaji T, Sawada N, Momozawa Y, Kamatani Y, Kubo M, Shimazu T, Inoue M, Noda M, Tsugane S, Iwasaki M. Diabetes and cancer risk: A Mendelian randomization study. Int J Cancer, 146:712-719, 2020
11. Inoue M, Sawada N, Goto A, Shimazu T, Yamaji T, Iwasaki M, Tsugane S. High-Negative Anti-Helicobacter pylori IgG Antibody Titers and Long-Term Risk of Gastric Cancer: Results from a Large-Scale Population-Based Cohort Study in Japan. Cancer Epidemiol Biomarkers Prev, 29:420-426, 2020
12. Kito K, Ishihara J, Yamamoto J, Hosoda T, Kotemori A, Takachi R, Nakamura K, Tanaka J, Yamaji T, Shimazu T, Ishii Y, Sawada N, Iwasaki M, Iso H, Sobue T, Tsugane S. Variations in the estimated intake of acrylamide from food in the Japanese population. Nutr J, 19:17, 2020
13. Ono A, Inoue M, Sawada N, Saito E, Yamaji T, Shimazu T, Goto A, Iwasaki M, Tsugane S. Impact of alcohol drinking on cancer risk with consideration of flushing response: The Japan Public Health Center-based Prospective Study Cohort (JPHC study). Prev Med, 133:106026, 2020
14. Yamaji T, Iwasaki M, Sawada N, Shimazu T, Inoue M, Tsugane S. Fat mass and obesity-associated gene polymorphisms, pre-diagnostic plasma adipokine levels and the risk of colorectal cancer: The Japan Public Health Center-based Prospective Study. PLoS One, 15:e0229005, 2020
15. Ihira H, Sawada N, Yamaji T, Goto A, Shimazu T, Kikuchi H, Inoue S, Inoue M, Iwasaki M, Tsugane S. Occupational sitting time and subsequent risk of cancer: The Japan Public Health Center-based Prospective Study. Cancer Sci, 111:974-984, 2020
16. Masaoka H, Matsuo K, Oze I, Ito H, Naito M, Wada K, Nagata C, Nakayama T, Kitamura Y, Sadakane A, Tamakoshi A, Tsuji I, Sugawara Y, Sawada N, Mizoue T, Inoue M, Tanaka K, Tsugane S, Shimazu T. Alcohol Drinking and Bladder Cancer Risk From a Pooled Analysis of Ten Cohort Studies in Japan. J Epidemiol, 30:309-313, 2020
17. Aversa J, Song M, Shimazu T, Inoue M, Charvat H, Yamaji T, Sawada N, Pfeiffer RM, Karimi P, Dawsey SM, Rabkin CS, Tsugane S, Camargo MC. Prediagnostic circulating inflammation biomarkers and esophageal squamous cell carcinoma: A case-cohort study in Japan. Int J Cancer, 147:686-691, 2020
18. Hidaka A, Sawada N, Svensson T, Goto A, Yamaji T, Shimazu T, Iwasaki M, Inoue M, Tsugane S. Family history of cancer and subsequent risk of cancer: A large-scale population-based prospective study in Japan. Int J Cancer, 147:331-337, 2020
19. Jang J, Wang T, Cai H, Ye F, Murphy G, Shimazu T, Taylor PR, Qiao YL, Yoo KY, Jee SH, Kim J, Chen SC, Abnet CC, Tsugane S, Zheng W, Shu XO, Pawlita M, Park SK, Epplein M. The U-shaped association between body mass index and gastric cancer risk in the Helicobacter pylori Biomarker Cohort Consortium: A nested case-control study from eight East Asian cohort studies. Int J Cancer, 147:777-784, 2020
20. Saito I, Yamagishi K, Kokubo Y, Yatsuya H, Iso H, Sawada N, Inoue M, Tsugane S. Non-High-Density Lipoprotein Cholesterol and Risk of Stroke Subtypes and Coronary Heart Disease: The Japan Public Health Center-Based Prospective (JPHC) Study. J Atheroscler Thromb, 27:363-374, 2020
21. Svensson T, Inoue M, Saito E, Sawada N, Iso H, Mizoue T, Goto A, Yamaji T, Shimazu T, Iwasaki M, Tsugane S. The association between habitual sleep duration and mortality according to sex and age: the Japan Public Health Center-based Prospective Study. J Epidemiol, 2020
22. Kurokawa Y, Fujii G, Tomono S, Miyamoto S, Hamoya T, Takahashi M, Narita T, Komiya M, Kobayashi M, Higami Y, Mutoh M. The Radical Scavenger NZ-419 Suppresses Intestinal Polyp Development in Apc-Mutant Mice. J Clin Med, 9:270, 2020
23. Cabasag CJ, Arnold M, Butler J, Inoue M, Trabert B, Webb PM, Bray F, Soerjomataram I. The influence of birth cohort and calendar period on global trends in ovarian cancer incidence. Int J Cancer, 146:749-758, 2020
24. Nolen LD, Vindigni SM, Parsonnet J. Combating Gastric Cancer in Alaska Native People: An Expert and Community Symposium. Gastroenterology, 158:1197-1201, 2020
25. Miyamoto S, Narita T, Komiya M, Fujii G, Hamoya T, Nakanishi R, Tamura S, Kurokawa Y, Takahashi M, Mutoh M. Novel screening system revealed that intracellular cholesterol trafficking can be a good target for colon cancer prevention. Sci Rep, 9:6192, 2019
26. Ishikawa H, Mutoh M, Abe T, Nakajima T, Takeuchi Y, Ezoe Y, Wakabayashi K, Doyama H, Sakai T. Utility of Mesalazine in Familial Adenomatous Polyposis: Clinical Report of Reduction of Polyp Size in Patients with Ulcerative Colitis, and Safety Examination in Familial Adenomatous Polyposis Patients. Pharmacology, 104:51-56, 2019
27. Mawaribuchi S, Onuma Y, Aiki Y, Kuriyama Y, Mutoh M, Fujii G, Ito Y. The rBC2LCN-positive subpopulation of PC-3 cells exhibits cancer stem-like properties. Biochem Biophys Res Commun, 515:176-182, 2019
28. Takahashi M, Fujii G, Hamoya T, Kurokawa Y, Matsuzawa Y, Miki K, Komiya M, Narita T, Mutoh M. Activation of NF-E2 p45-related factor-2 transcription and inhibition of intestinal tumor development by AHCC, a standardized extract of cultured Lentinula edodes mycelia. J Clin Biochem Nutr, 65:203-208, 2019
29. Nakamura T, Ishikawa H, Sakai T, Ayabe M, Wakabayashi K, Mutoh M, Matsuura N. Effect of physical fitness on colorectal tumor development in patients with familial adenomatous polyposis. Medicine (Baltimore), 98:e17076, 2019
30. Totsuka Y, Lin Y, He Y, Ishino K, Sato H, Kato M, Nagai M, Elzawahry A, Totoki Y, Nakamura H, Hosoda F, Shibata T, Matsuda T, Matsushima Y, Song G, Meng F, Li D, Liu J, Qiao Y, Wei W, Inoue M, Kikuchi S, Nakagama H, Shan B. DNA Adductome Analysis Identifies N-Nitrosopiperidine Involved in the Etiology of Esophageal Cancer in Cixian, China. Chem Res Toxicol, 32:1515-1527, 2019
31. Tsuji K, Ochi E, Okubo R, Shimizu Y, Kuchiba A, Ueno T, Shimazu T, Kinoshita T, Sakurai N, Matsuoka Y. Effect of home-based high-intensity interval training and behavioural modification using information and communication technology on cardiorespiratory fitness and exercise habits among sedentary breast cancer survivors: habit-B study protocol for a randomised controlled trial. BMJ Open, 9:e030911, 2019
32. Fujiwara M, Inagaki M, Shimazu T, Kodama M, So R, Matsushita T, Yoshimura Y, Horii S, Fujimori M, Takahashi H, Nakaya N, Kakeda K, Miyaji T, Hinotsu S, Harada K, Okada H, Uchitomi Y, Yamada N. A randomised controlled trial of a case management approach to encourage participation in colorectal cancer screening for people with schizophrenia in psychiatric outpatient clinics: study protocol for the J-SUPPORT 1901 (ACCESS) study. BMJ Open, 9:e032955, 2019
33. Camargo MC, Song M, Shimazu T, Charvat H, Yamaji T, Sawada N, Kemp TJ, Pfeiffer RM, Hildesheim A, Pinto LA, Tsugane S, Rabkin CS. Circulating Inflammation Markers and Risk of Gastric and Esophageal Cancers: A Case-Cohort Study Within the Japan Public Health Center-Based Prospective Study. Cancer Epidemiol Biomarkers Prev, 28:829-832, 2019
34. Hirabayashi M, Inoue M, Sawada N, Saito E, Abe SK, Hidaka A, Iwasaki M, Yamaji T, Shimazu T, Tsugane S. Helicobacter pylori infection, atrophic gastritis, and risk of pancreatic cancer: A population-based cohort study in a large Japanese population: the JPHC Study. Sci Rep, 9:6099, 2019
35. Mori N, Shimazu T, Charvat H, Mutoh M, Sawada N, Iwasaki M, Yamaji T, Inoue M, Goto A, Takachi R, Ishihara J, Noda M, Iso H, Tsugane S. Cruciferous vegetable intake and mortality in middle-aged adults: A prospective cohort study. Clin Nutr, 38:631-643, 2019
36. Tanaka S, Sawada N, Yamaji T, Shimazu T, Goto A, Iwasaki M, Inoue M, Tsugane S. Female reproductive factors and risk of lymphoid neoplasm: The Japan Public Health Center-based Prospective Study. Cancer Sci, 110:1442-1452, 2019
37. Viet Vu CH, Uchino M, Kawashima M, Yuki K, Tsubota K, Nishi A, German CA, Sakata K, Tanno K, Iso H, Yamagishi K, Yasuda N, Saito I, Kato T, Arima K, Tomita Y, Shimazu T, Yamaji T, Goto A, Inoue M, Iwasaki M, Sawada N, Tsugane S. Lack of social support and social trust as potential risk factors for dry eye disease: JPHC-NEXT study. Ocul Surf, 17:278-284, 2019
38. Yamagiwa Y, Sawada N, Shimazu T, Yamaji T, Goto A, Takachi R, Ishihara J, Iwasaki M, Inoue M, Tsugane S. Fruit and vegetable intake and pancreatic cancer risk in a population-based cohort study in Japan. Int J Cancer, 144:1858-1866, 2019
39. Yang JJ, Yu D, Wen W, Saito E, Rahman S, Shu XO, Chen Y, Gupta PC, Gu D, Tsugane S, Xiang YB, Gao YT, Yuan JM, Tamakoshi A, Irie F, Sadakane A, Tomata Y, Kanemura S, Tsuji I, Matsuo K, Nagata C, Chen CJ, Koh WP, Shin MH, Park SK, Wu PE, Qiao YL, Pednekar MS, He J, Sawada N, Li HL, Gao J, Cai H, Wang R, Sairenchi T, Grant E, Sugawara Y, Zhang S, Ito H, Wada K, Shen CY, Pan WH, Ahn YO, You SL, Fan JH, Yoo KY, Ashan H, Chia KS, Boffetta P, Inoue M, Kang D, Potter JD, Zheng W. Association of Diabetes With All-Cause and Cause-Specific Mortality in Asia: A Pooled Analysis of More Than 1 Million Participants. JAMA Netw Open, 2:e192696, 2019
40. Kawachi A, Shimazu T, Budhathoki S, Sawada N, Yamaji T, Iwasaki M, Inoue M, Tsugane S. Association of BMI and height with the risk of endometrial cancer, overall and by histological subtype: a population-based prospective cohort study in Japan. Eur J Cancer Prev, 28:196-202, 2019
41. Makiuchi T, Sobue T, Kitamura T, Sawada N, Iwasaki M, Yamaji T, Shimazu T, Inoue M, Tsugane S. Smoking, Alcohol Consumption, and Risks for Biliary Tract Cancer and Intrahepatic Bile Duct Cancer. J Epidemiol, 29:180-186, 2019
42. Abe SK, Saito E, Sawada N, Tsugane S, Ito H, Lin Y, Tamakoshi A, Sado J, Kitamura Y, Sugawara Y, Tsuji I, Nagata C, Sadakane A, Shimazu T, Mizoue T, Matsuo K, Naito M, Tanaka K, Inoue M. Coffee consumption and mortality in Japanese men and women: A pooled analysis of eight population-based cohort studies in Japan (Japan Cohort Consortium). Prev Med, 123:270-277, 2019
43. Maruyama K, Ikeda A, Ishihara J, Takachi R, Sawada N, Shimazu T, Nakamura K, Tanaka J, Yamaji T, Iwasaki M, Iso H, Tsugane S. Food frequency questionnaire reproducibility for middle-aged and elderly Japanese. Asia Pac J Clin Nutr, 28:362-370, 2019
44. Koyanagi YN, Ito H, Matsuo K, Sugawara Y, Hidaka A, Sawada N, Wada K, Nagata C, Tamakoshi A, Lin Y, Takeuchi T, Kitamura Y, Utada M, Sadakane A, Mizoue T, Naito M, Tanaka K, Shimazu T, Tsugane S, Inoue M. Smoking and Pancreatic Cancer Incidence: A Pooled Analysis of 10 Population-Based Cohort Studies in Japan. Cancer Epidemiol Biomarkers Prev, 28:1370-1378, 2019
45. Yamagishi K, Iso H, Shimazu T, Tamakoshi A, Sawada N, Matsuo K, Ito H, Wakai K, Nakayama T, Kitamura Y, Sado J, Tsuji I, Sugawara Y, Mizoue T, Inoue M, Nagata C, Sadakane A, Tanaka K, Tsugane S, Sasazuki S. Fish intake and risk of mortality due to aortic dissection and aneurysm: A pooled analysis of the Japan cohort consortium. Clin Nutr, 38:1678-1683, 2019
46. Yang K, Zhang Y, Saito E, Rahman MS, Gupta PC, Sawada N, Tamakoshi A, Gao YT, Koh WP, Shu XO, Tsuji I, Sadakane A, Nagata C, You SL, Yuan JM, Shin MH, Chen Y, Pan WH, Pednekar MS, Tsugane S, Cai H, Xiang YB, Ozasa K, Tomata Y, Kanemura S, Sugawara Y, Wada K, Wang R, Ahn YO, Yoo KY, Ahsan H, Chia KS, Boffetta P, Kang D, Potter JD, Inoue M, Zheng W, Nan H. Association between educational level and total and cause-specific mortality: a pooled analysis of over 694 000 individuals in the Asia Cohort Consortium. BMJ Open, 9:e026225, 2019
47. Yuwaki K, Shimazu T, Yamagiwa Y, Inoue M, Goto A, Yamaji T, Iwasaki M, Sawada N, Tsugane S. Association between serum liver enzymes and all-cause mortality: The Japan Public Health Center-based Prospective Study. Liver Int, 39:1566-1576, 2019
48. Mori N, Sawada N, Iwasaki M, Yamaji T, Goto A, Shimazu T, Inoue M, Murphy N, Gunter MJ, Tsugane S. Circulating sex hormone levels and colorectal cancer risk in Japanese postmenopausal women: The JPHC nested case-control study. Int J Cancer, 145:1238-1244, 2019
49. Mori N, Sawada N, Shimazu T, Yamaji T, Goto A, Takachi R, Ishihara J, Iwasaki M, Inoue M, Tsugane S. Cruciferous vegetable intake and colorectal cancer risk: Japan public health center-based prospective study. Eur J Cancer Prev, 28:420-427, 2019
50. Abe SK, Saito E, Sawada N, Tsugane S, Ito H, Lin Y, Tamakoshi A, Sado J, Kitamura Y, Sugawara Y, Tsuji I, Nagata C, Sadakane A, Shimazu T, Mizoue T, Matsuo K, Naito M, Tanaka K, Inoue M. Green tea consumption and mortality in Japanese men and women: a pooled analysis of eight population-based cohort studies in Japan. Eur J Epidemiol, 34:917-926, 2019
51. Butt J, Varga MG, Wang T, Tsugane S, Shimazu T, Zheng W, Abnet CC, Yoo KY, Park SK, Kim J, Jee SH, Qiao YL, Shu XO, Waterboer T, Pawlita M, Epplein M. Smoking, Helicobacter Pylori Serology, and Gastric Cancer Risk in Prospective Studies from China, Japan, and Korea. Cancer Prev Res (Phila), 12:667-674, 2019
52. Kashino I, Serafini M, Kurotani K, Akter S, Mizoue T, Ishihara J, Kotemori A, Sawada N, Inoue M, Iwasaki M, Noda M, Tsugane S. Relationship between dietary non-enzymatic antioxidant capacity and type 2 diabetes risk in the Japan Public Health Center-based Prospective Study. Nutrition, 66:62-69, 2019
53. Oze I, Charvat H, Matsuo K, Ito H, Tamakoshi A, Nagata C, Wada K, Sugawara Y, Sawada N, Yamaji T, Naito M, Tanaka K, Shimazu T, Mizoue T, Tsugane S, Inoue M. Revisit of an unanswered question by pooled analysis of eight cohort studies in Japan: Does cigarette smoking and alcohol drinking have interaction for the risk of esophageal cancer? Cancer Med, 8:6414-6425, 2019
54. Tanaka K, Tamakoshi A, Sugawara Y, Mizoue T, Inoue M, Sawada N, Matsuo K, Ito H, Naito M, Nagata C, Kitamura Y, Sadakane A, Tsugane S, Shimazu T. Coffee, green tea and liver cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol, 49:972-984, 2019
55. Tanaka S, Abe SK, Sawada N, Yamaji T, Shimazu T, Goto A, Iwasaki M, Iso H, Mizoue T, Inoue M, Tsugane S. Female reproductive factors and risk of external causes of death among women: The Japan Public Health Center-based Prospective Study (JPHC Study). Sci Rep, 9:14329, 2019
56. Islam Z, Akter S, Kashino I, Mizoue T, Sawada N, Mori N, Yamagiwa Y, Tsugane S, Naito M, Tamakoshi A, Wada K, Nagata C, Sugawara Y, Tsuji I, Matsuo K, Ito H, Lin Y, Kitamura Y, Sadakane A, Tanaka K, Shimazu T, Inoue M. Meat subtypes and colorectal cancer risk: A pooled analysis of 6 cohort studies in Japan. Cancer Sci, 110:3603-3614, 2019
57. Ugai T, Ito H, Oze I, Saito E, Rahman MS, Boffetta P, Gupta PC, Sawada N, Tamakoshi A, Shu XO, Koh WP, Gao YT, Sadakane A, Tsuji I, Park SK, Nagata C, You SL, Pednekar MS, Tsugane S, Cai H, Yuan JM, Xiang YB, Ozasa K, Tomata Y, Kanemura S, Sugawara Y, Wada K, Chen CJ, Yoo KY, Chia KS, Ahsan H, Zheng W, Inoue M, Kang D, Potter J, Matsuo K. Association of BMI, Smoking, and Alcohol with Multiple Myeloma Mortality in Asians: A Pooled Analysis of More than 800,000 Participants in the Asia Cohort Consortium. Cancer Epidemiol Biomarkers Prev, 28:1861-1867, 2019
58. Hirabayashi M, Inoue M, Sawada N, Saito E, Abe SK, Hidaka A, Iwasaki M, Yamaji T, Shimazu T, Shibuya K, Tsugane S. Effect of body-mass index on the risk of gastric cancer: A population-based cohort study in A Japanese population. Cancer Epidemiol, 63:101622, 2019
59. Murai U, Yamagishi K, Sata M, Kokubo Y, Saito I, Yatsuya H, Ishihara J, Inoue M, Sawada N, Iso H, Tsugane S. Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study. Am J Clin Nutr, 110:1449-1455, 2019
60. Honjo K, Iso H, Ikeda A, Yamagishi K, Saito I, Kato T, Yasuda N, Aoyagi K, Arima K, Sakata K, Tanno K, Inoue M, Iwasaki M, Shimazu T, Goto A, Yamaji T, Sawada N, Tsugane S. Cross-sectional association between employment status and self-rated health among middle-aged Japanese women: The influence of socioeconomic conditions and work-life conflict. J Epidemiol, 2019
61. Hirayama Y, Tsunematsu Y, Yoshikawa Y, Tamafune R, Matsuzaki N, Iwashita Y, Ohnishi I, Tanioka F, Sato M, Miyoshi N, Mutoh M, Ishikawa H, Sugimura H, Wakabayashi K, Watanabe K. Activity-Based Probe for Screening of High-Colibactin Producers from Clinical Samples. Org Lett, 21:4490-4494, 2019
62. Hosgood HD 3rd, Klugman M, Matsuo K, White AJ, Sadakane A, Shu XO, Lopez-Ridaura R, Shin A, Tsuji I, Malekzadeh R, Noisel N, Bhatti P, Yang G, Saito E, Rahman S, Hu W, Bassig B, Downward G, Vermeulen R, Xue X, Rohan T, Abe SK, Broët P, Grant EJ, Dummer TJB, Rothman N, Inoue M, Lajous M, Yoo KY, Ito H, Sandler DP, Ashan H, Zheng W, Boffetta P, Lan Q. The establishment of the Household Air Pollution Consortium (HAPCO). Atmosphere (Basel), 10:422, 2019
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