Annual Report 2019
Division of Screening Technology
Takahisa Matsuda, Masau Sekiguchi, Kazuya Inoki, Tomi Abe, Noriko Abeshima, Orie Kitamura, Mio Shimamura, Mika Mori
Introduction
The Division of Screening Technology works as a part of the Screening Research Group in the Center for Public Health Sciences. The Screening Research Group is divided into two divisions (Division of Screening Assessment and Management / Division of Screening Technology). The Division of Screening Technology consists of two staff medical doctors, five special research assistants and one visiting researcher.
The Team and What We Do
In the Division of Screening Technology, we aim to develop new diagnostic techniques that can be applied to cancer screening, as well as researching existing diagnostic methods that can be applied to medical examinations. We are also assessing a new close examination method in cancer screening. In addition, we also work on research aiming at risk stratification of people to be screened.
Research activities
Examinations are ongoing for the cancer detection rate of each screening modality (e.g. Chest CT, upper/lower GI Endoscopy, MMG/Tomosynthesis and Breast Ultrasonography, FDG-PETCT/MRI, CT colonography), the characteristics of the detected cancer, and the false positive rate for all individuals who underwent cancer screening during the 15 years from the establishment our center in 2004. In addition, we aim to clarify the relationship between cancer screening and cancer death from long-term (prognosis survey) results. Moreover, the following research is ongoing: 1) Field construction for verification of diagnostic tools for colorectal cancer and precancerous lesions using biomarkers (Oshima Study), 2) Japan Polyp Study: multicenter prospective cohort study to elucidate the preventive effect of colorectal cancer caused by polypectomy, 3) Development of an endoscope system for early detection of pancreatic cancer, 4) Study on establishment and effectiveness assessment of screening model using colonoscopy (Aomori Project), 5) Multicenter clinical research for accuracy evaluation and standardization of CT colonography, 6) Cost-effectiveness analysis on GI screening and surveillance using endoscope, 7) Prospective study on colorectal cancer risk in first-degree relatives of colorectal cancer patients. In addition, the amino index (AICS) study has received plasma samples from 8,111 screening individuals, and comprehensive amino acid analysis has been completed. Now, the analysis data will be collated with clinical data. Among these, the following six papers were published in this period. 1) Sekiguchi M, Matsuda T, et al., Cost-effectiveness analysis of postpolypectomy colonoscopy surveillance using Japanese data (Dig Endosc. 2019), 2) Sekiguchi M, Matsuda T, et al., Incidence of advanced colorectal neoplasia in individuals with untreated diminutive colorectal adenomas diagnosed by magnifying image-enhanced endoscopy (Am J Gastroenterol 2019), 3) Sekiguchi M, Matsuda T, et al., Feasibility of observational screening colonoscopy followed by deferred polypectomy (J Gastroenterol Hepatol 2020), 4) Sekiguchi M, Matsuda T, et al., Family history of colorectal cancer and prevalence of advanced colorectal neoplasia in asymptomatic screened populations in different age groups (Gastrointest Endosc. 2020), 5) Sekiguchi M, Matsuda T, et al., Cost-effectiveness analysis of colorectal cancer screening using colonoscopy, fecal immunochemical test, and risk score (J Gastroenterol Hepatol 2020), 6) Kakinuma R, Matsuda T, et al., Low-dose CT lung cancer screening in never-smokers and smokers: results of an eight-year observational study (Transl Lung Cancer Res 2020).
Other research: We are collaborating with external researchers using 1,325 stool samples collected from the Oshima Study. (Research on colibactin-producing bacteria as fecal biomarkers, bacteria and bacterial flora as fecal biomarkers and their functions). In addition, 26 English articles were published, focusing on the diagnosis, treatment, and screening of colorectal cancer and gastric cancer.
Future prospects
We will promote screening development research to gather evidence.
List of papers published in 2019
Journal
1. Inoki K, Kakugawa Y, Takamaru H, Sekiguchi M, Matsumoto M, Matsuda T, Ito A, Tanaka T, Inamoto Y, Fuji S, Kurosawa S, Kim SW, Fukuda T, Ohe Y, Saito Y. Capsule Endoscopy after Hematopoietic Stem Cell Transplantation Can Predict Transplant-Related Mortality. Digestion, 101:198-207, 2020
2. Sekiguchi M, Kakugawa Y, Nakamura K, Matsumoto M, Takamaru H, Yamada M, Sakamoto T, Saito Y, Matsuda T. Feasibility of observational screening colonoscopy followed by deferred polypectomy. J Gastroenterol Hepatol, 35:263-270, 2020
3. Sekiguchi M, Kakugawa Y, Nakamura K, Matsumoto M, Tomizawa Y, Murakami Y, Saito Y, Matsuda T. Family history of colorectal cancer and prevalence of advanced colorectal neoplasia in asymptomatic screened populations in different age groups. Gastrointest Endosc, 91:1361-1370, 2020
4. Sekiguchi M, Igarashi A, Sakamoto T, Saito Y, Esaki M, Matsuda T. Cost-effectiveness analysis of colorectal cancer screening using colonoscopy, fecal immunochemical test, and risk score. J Gastroenterol Hepatol, 2020
5. Mori Y, Kudo SE, East JE, Rastogi A, Bretthauer M, Misawa M, Sekiguchi M, Matsuda T, Saito Y, Ikematsu H, Hotta K, Ohtsuka K, Kudo T, Mori K. Cost savings in colonoscopy with artificial intelligence-aided polyp diagnosis: an add-on analysis of a clinical trial (with video). Gastrointest Endosc, S0016-5107(20)34034-7, 2020
6. Abe S, Saito Y, Tanaka Y, Ego M, Yanagisawa F, Kawashima K, Takamaru H, Sekiguchi M, Yamada M, Sakamoto T, Matsuda T, Goto O, Yahagi N. A novel endoscopic hand-suturing technique for defect closure after colorectal endoscopic submucosal dissection: a pilot study. Endoscopy, doi: 10.1055/a-1120-8533, 2020
7. Abe S, Wu SYS, Ego M, Takamaru H, Sekiguchi M, Yamada M, Nonaka S, Sakamoto T, Suzuki H, Yoshinaga S, Matsuda T, Oda I, Saito Y. Efficacy of Current Traction Techniques for Endoscopic Submucosal Dissection. Gut Liver, 2020
8. Yachida S, Mizutani S, Shiroma H, Shiba S, Nakajima T, Sakamoto T, Watanabe H, Masuda K, Nishimoto Y, Kubo M, Hosoda F, Rokutan H, Matsumoto M, Takamaru H, Yamada M, Matsuda T, Iwasaki M, Yamaji T, Yachida T, Soga T, Kurokawa K, Toyoda A, Ogura Y, Hayashi T, Hatakeyama M, Nakagama H, Saito Y, Fukuda S, Shibata T, Yamada T. Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer. Nat Med, 25:968-976, 2019
9. Katada C, Horimatsu T, Muto M, Tanaka K, Matsuda K, Fujishiro M, Saito Y, Ohtsuka K, Oda I, Kato M, Kida M, Kobayashi K, Hoteya S, Kodashima S, Matsuda T, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Kato M, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Tajiri H. Current status of esophageal endoscopy including the evaluation of smoking and alcohol consumption in Japan: an analysis based on the Japan endoscopy database. Esophagus, 16:174-179, 2019
10. Wong JCT, Chiu HM, Kim HS, Byeon JS, Matsuda T, Kobayashi N, Wu DC, Ong DE, Sung JJY. Adenoma detection rates in colonoscopies for positive fecal immunochemical tests versus direct screening colonoscopies. Gastrointest Endosc, 89:607-613.e1, 2019
11. Takeuchi Y, Sawaya M, Oka S, Tamai N, Kawamura T, Uraoka T, Ikematsu H, Moriyama T, Arao M, Ishikawa H, Ito Y, Matsuda T. Efficacy of autofluorescence imaging for flat neoplasm detection: a multicenter randomized controlled trial (A-FLAT trial). Gastrointest Endosc, 89:460-469, 2019
12. Niikura R, Yamada A, Fujishiro M, Tanaka K, Matsuda K, Saito Y, Ohtsuka K, Oda I, Katada C, Kato M, Kida M, Kobayashi K, Hoteya S, Horimatsu T, Kodashima S, Matsuda T, Muto M, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Kato M, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Shinozaki T, Tajiri H, Koike K. The Effects of Direct Oral Anticoagulants, Warfarin, Aspirin and Thienopyridine on the Performance of Immunochemical, Faecal, Occult Blood Tests. Digestion, 100:117-126, 2019
13. Sekiguchi M, Igarashi A, Sakamoto T, Saito Y, Esaki M, Matsuda T. Cost-effectiveness analysis of postpolypectomy colonoscopy surveillance using Japanese data. Dig Endosc, 31:40-50, 2019
14. Sung JJY, Chiu HM, Jung KW, Jun JK, Sekiguchi M, Matsuda T, Kyaw MH. Increasing Trend in Young-Onset Colorectal Cancer in Asia: More Cancers in Men and More Rectal Cancers. Am J Gastroenterol, 114:322-329, 2019
15. Sakamoto T, Ramaraj R, Tomizawa Y, Cho H, Matsuda T, Saito Y. Clinical significance of colorectal polyp detection on colonoscopy insertion. United European Gastroenterol J, 7:125-129, 2019
16. Lee BI, Matsuda T. Estimation of Invasion Depth: The First Key to Successful Colorectal ESD. Clin Endosc, 52:100-106, 2019
17. Atkinson NSS, Ket S, Bassett P, Aponte D, De Aguiar S, Gupta N, Horimatsu T, Ikematsu H, Inoue T, Kaltenbach T, Leung WK, Matsuda T, Paggi S, Radaelli F, Rastogi A, Rex DK, Sabbagh LC, Saito Y, Sano Y, Saracco GM, Saunders BP, Senore C, Soetikno R, Vemulapalli KC, Jairath V, East JE. Narrow-Band Imaging for Detection of Neoplasia at Colonoscopy: A Meta-analysis of Data From Individual Patients in Randomized Controlled Trials. Gastroenterology, 157:462-471, 2019
18. Jimenez-Garcia VA, Yamada M, Ikematsu H, Takamaru H, Abe S, Sakamoto T, Nakajima T, Matsuda T, Saito Y. Endoscopic submucosal dissection in management of colorectal tumors near or involving a diverticulum: a retrospective case series. Endosc Int Open, 7:E664-E671, 2019
19. Sekiguchi M, Otake Y, Kakugawa Y, Matsumoto M, Tomizawa Y, Saito Y, Matsuda T. Incidence of Advanced Colorectal Neoplasia in Individuals With Untreated Diminutive Colorectal Adenomas Diagnosed by Magnifying Image-Enhanced Endoscopy. Am J Gastroenterol, 114:964-973, 2019
20. Sakamoto T, Inoki K, Takamaru H, Sekiguchi M, Yamada M, Nakajima T, Matsuda T, Saito Y. Efficacy of linked colour imaging in magnifying chromoendoscopy with crystal violet staining: a pilot study. Int J Colorectal Dis, 34:1341-1344, 2019
21. Inoki K, Yamada M, Kuwabara H, Takamaru H, Sekiguchi M, Sakamoto T, Matsuda T, Saito Y. Newly-developed colonoscope (PCF-PQ260L) is useful for patients with difficult colons. Turk J Gastroenterol, 30:630-635, 2019
22. Ichijima R, Abe S, Kobayashi S, Minagawa T, Tagawa T, Nakajima T, Yamada M, Takamaru H, Sekiguchi M, Sakamoto T, Oda I, Matsuda T, Saito Y, Gotoda T. Efficacy of Full-Spectrum Endoscopy to Visualize the Major Duodenal Papilla in Patients with Familial Adenomatous Polyposis. Digestion, 1-8, 2019
23. Inoki K, Sakamoto T, Takamaru H, Sekiguchi M, Yamada M, Matsuda T, Saito Y. The Diagnostic Performance for Colorectal Neoplasms Using Magnified Endoscopy Differs between Experts and Novice Endoscopists: A Post Hoc Analysis. Digestion, 1-8, 2019
24. Sakamoto T, Takamaru H, Sekiguchi M, Yamada M, Matsuda T, Saito Y. Reliability of Japan Narrow-Band Imaging Expert Team Classification for the Diagnosis of Colorectal Neoplasms: A Pilot Study. Digestion, 1-6, 2019
25. Kobayashi S, Yamada M, Takamaru H, Sakamoto T, Matsuda T, Sekine S, Igarashi Y, Saito Y. Diagnostic yield of the Japan NBI Expert Team (JNET) classification for endoscopic diagnosis of superficial colorectal neoplasms in a large-scale clinical practice database. United European Gastroenterol J, 7:914-923, 2019
26. Sakamoto T, Tomizawa Y, Cho H, Takamaru H, Sekiguchi M, Yamada M, Matsuda T, Murakami Y, Saito Y. Additional value of linked color imaging in colonoscopy: a retrospective study. Endosc Int Open, 7:E1448-E1454, 2019