Annual Report 2019
Division of Health Care Research
Yutaka Matsuoka, Maiko Fujimori, Akiko Hanai, Katsunori Tsuji, Ayako Sato, Tomomi Narisawa, Miyuki Odawara, Akiko Mitsuim Masako Okamura, Tempei Miyaji, Tomoe Mashiko, Hiroko Noguchi, Saki Harashima, Keisuke Inoue, Eisuke Ochi, Ryo Okubo, Masanori Mori, Miyuki Kanamaru, Kyoko Akutsu, Sayaka Jinno, Maki Minemura, Asami Satake, Kotone Hata, Miyuki Kurosaki, Kinjiro Hirayama, Ayumi Mitsuyama, Ryo Soga, Rumiko Sugihara, Umehashi, Tomomi Akiyama, Kana Serizawa, Kumiko Shinozaki
Introduction
The Division of Health Care Research was established in January 2016 by the National Cancer Center to acknowledge the numerous individuals surviving cancer for extended periods and reflect the need to study their unmet healthcare needs. Our division works to enhance the quality and healthy life expectancy of all persons diagnosed with cancer and solve the late and long-term psychological effects experienced during their remaining lifetime. Our division supports clinical research that examines the effectiveness of supportive, palliative and psychosocial care among cancer survivors and their families.
The Team and What We Do
We have two teams: one for original research and one for clinical research support. Our division focuses on epidemiological, interventional and behavioral and public health translational research on cancer survivorship to enhance survival and psychosocial wellbeing among all persons diagnosed with cancer and their family caregivers. Our division initiates an interdisciplinary research program ranging from basic bio-behavioral science to the development, testing and delivery of psychosocial, behavioral and survivorship care and also manages J-SUPPORT as a central support office.
Research activities
Health promotion research
We have begun a randomized controlled trial to examine the effect of high-intensity, intermittent training using patients' own body weight on cardiorespiratory fitness for sedentary breast cancer survivors. A survey was conducted to determine the extent to which recommendations of breast cancer guidelines for physical activity are recognized and practiced by medical professionals engaged in breast cancer care.
Patient-physician communication research
A randomized controlled trial was conducted and participants’ enrollment was continued. The trial aims to examine the effectiveness of communication support interventions in patients with advanced pancreatic cancer, their care givers, and physicians to promote their shared decision-making on treatment and care after standard chemotherapy. Another randomized controlled trial (UMIN000034379) was conducted to examine the feasibility of a shared decision-making support program for patients with advanced colorectal cancer. An experimental investigation was continued in order for cancer screening examinees to examine the relationship between cognitive, physiological, and behavioral responses during interviews with physicians. A survey protocol was developed to evaluate the psychological distress and quality of life of advanced cancer patients undergoing genetic panel testing.
Developing cancer survivorship guidelines
We developed the panel’s consensus on the definition of survivorship, the aim and target users of the guidelines, and 11 clinical issues as a compass for the development of comprehensive cancer survivorship guidelines in Japan.
Suicide prevention research
We have conducted the nationwide population-based study using data from the National Cancer Registry to investigate the suicide risk among cancer patients in Japan and identify the patient subgroups and time periods associated with higher risk. We have released a guide for suicide countermeasures in oncology (1st edition).
Supportive care clinical research
In consultation with medical device manufacturers regarding cooling therapy to reduce chemotherapy-induced peripheral neuropathy, we made a clinical research protocol.
Clinical trials
Feasibility study on development of patient question asking support program to prepare for the time of the anti-cancer agent therapy discontinuation (UMIN000034379)
A randomized controlled trial of integrated empathic communication support program to promote end of life discussion among rapidly progressive cancer patient, caregiver and physician (UMIN000033612)
Effect of home-based high-intensity interval training and behavioral modification using information and communication technology on cardiorespiratory fitness and exercise habits among sedentary breast cancer survivors: a randomized controlled trial (UMIN000036400)
Education
Dr. Diogo Sampaio Barros Viana from the Portuguese Ministry of Health, Portugal
Dr. Yuri Ishino from the Jikei University School of Medicine
Ms. Hina Ikeda from Musashino University
Mr. Kuniaki Tokitou from Kitasato University
Future prospects
We will release cancer survivorship guidelines for Japan. We plan to promote behavioral research for bridging the evidence-practice gap in the field of cancer survivorship and we will continue to provide consultation on research design and statistical analysis and support clinical trials in terms of quality management.
List of papers published in 2019
Journal
1. Matsuoka YJ, Okubo R, Shimizu Y, Tsuji K, Narisawa T, Sasaki J, Sasai H, Akashi-Tanaka S, Hamaguchi T, Iwasa T, Iwata S, Kato T, Kurotani K, Maruyama D, Mori A, Ogawa A, Sakurai N, Shimazu T, Shimizu C, Tabuchi T, Takahashi M, Takano T, Tatematsu N, Uchitomi Y, Watanabe C, Fukui T. Developing the structure of Japan's cancer survivorship guidelines using an expert panel and modified Delphi method. J Cancer Surviv, 14:273-283, 2020
2. Harashima S, Fujimori M. Risk of suicide among adolescents and young adults with cancer and a need for targeted interventions. Ann Transl Med, 8:428, 2020
3. van der Mei WF, Barbano AC, Ratanatharathorn A, Bryant RA, Delahanty DL, deRoon-Cassini TA, Lai BS, Lowe SR, Matsuoka YJ, Olff M, Qi W, Schnyder U, Seedat S, Kessler RC, Koenen KC, Shalev AY. Evaluating a screener to quantify PTSD risk using emergency care information: a proof of concept study. BMC Emerg Med, 20:16, 2020
4. Wada S, Sadahiro R, Matsuoka Y, Uchitomi Y, Shimizu K. The association between postoperative recovery and psychosocial factors in cancer patients. Journal of Surgery, 8:9-15, 2020
5. Shimizu Y, Tsuji K, Ochi E, Arai H, Okubo R, Kuchiba A, Shimazu T, Sakurai N, Narisawa T, Ueno T, Iwata H, Matsuoka Y. Study protocol for a nationwide questionnaire survey of physical activity among breast cancer survivors in Japan. BMJ Open, 10:e032871, 2020
6. Wu Y, Levis B, Sun Y, Krishnan A, He C, Riehm KE, Rice DB, Azar M, Yan XW, Neupane D, Bhandari PM, Imran M, Chiovitti MJ, Saadat N, Boruff JT, Cuijpers P, Gilbody S, McMillan D, Ioannidis JPA, Kloda LA, Patten SB, Shrier I, Ziegelstein RC, Henry M, Ismail Z, Loiselle CG, Mitchell ND, Tonelli M, Al-Adawi S, Beraldi A, Braeken APBM, Büel-Drabe N, Bunevicius A, Carter G, Chen CK, Cheung G, Clover K, Conroy RM, Cukor D, da Rocha E Silva CE, Dabscheck E, Daray FM, Douven E, Downing MG, Feinstein A, Ferentinos PP, Fischer FH, Flint AJ, Fujimori M, Gallagher P, Gandy M, Goebel S, Grassi L, Härter M, Jenewein J, Jetté N, Julião M, Kim JM, Kim SW, Kjærgaard M, Köhler S, Loosman WL, Löwe B, Martin-Santos R, Massardo L, Matsuoka Y, Mehnert A, Michopoulos I, Misery L, Navines R, O'Donnell ML, Öztürk A, Peceliuniene J, Pintor L, Ponsford JL, Quinn TJ, Reme SE, Reuter K, Rooney AG, Sánchez-González R, Schwarzbold ML, Senturk Cankorur V, Shaaban J, Sharpe L, Sharpe M, Simard S, Singer S, Stafford L, Stone J, Sultan S, Teixeira AL, Tiringer I, Turner A, Walker J, Walterfang M, Wang LJ, White J, Wong DK, Benedetti A, Thombs BD. Probability of major depression diagnostic classification based on the SCID, CIDI and MINI diagnostic interviews controlling for Hospital Anxiety and Depression Scale - Depression subscale scores: An individual participant data meta-analysis of 73 primary studies. J Psychosom Res, 129:109892, 2020
7. Lowe SR, Ratanatharathorn A, Lai BS, van der Mei W, Barbano AC, Bryant RA, Delahanty DL, Matsuoka YJ, Olff M, Schnyder U, Laska E, Koenen KC, Shalev AY, Kessler RC. Posttraumatic stress disorder symptom trajectories within the first year following emergency department admissions: pooled results from the International Consortium to predict PTSD. Psychol Med, 1-11, 2020
8. Guu TW, Mischoulon D, Sarris J, Hibbeln J, McNamara RK, Hamazaki K, Freeman MP, Maes M, Matsuoka YJ, Belmaker RH, Marx W, Pariante C, Berk M, Jacka F, Su KP. A multi-national, multi-disciplinary Delphi consensus study on using omega-3 polyunsaturated fatty acids (n-3 PUFAs) for the treatment of major depressive disorder. J Affect Disord, 265:233-238, 2020
9. Okubo R, Matsuoka YJ, Sawada N, Mimura M, Kurotani K, Nozaki S, Shikimoto R, Tsugane S. Diet quality and depression risk in a Japanese population: the Japan Public Health Center (JPHC)-based Prospective Study. Sci Rep, 9:7150, 2019
10. Harashima S, Fujimori M, Akechi T, Matsuda T, Saika K, Hasegawa T, Inoue K, Yoshiuchi K, Miyashiro I, Uchitomi Y, Matsuoka YJ. Suicide, other externally caused injuries and cardiovascular death following a cancer diagnosis: study protocol for a nationwide population-based study in Japan (J-SUPPORT 1902). BMJ Open, 9:e030681, 2019
11. Sadahiro R, Sawada N, Matsuoka YJ, Mimura M, Nozaki S, Shikimoto R, Goto A, Tsugane S. Midlife cancer/diabetes and risk of dementia and mild cognitive impairment: A population-based prospective cohort study in Japan. Psychiatry Clin Neurosci, 73:597-599, 2019
12. Noguchi H, Okubo R, Hamazaki K, Yamashita A, Narisawa T, Matsuoka YJ. Serum polyunsaturated fatty acids and risk of psychiatric disorder at 6 months after acute coronary syndrome: A prospective cohort study. Prostaglandins Leukot Essent Fatty Acids, 149:18-23, 2019
13. Horigome A, Okubo R, Hamazaki K, Kinoshita T, Katsumata N, Uezono Y, Xiao JZ, Matsuoka YJ. Association between blood omega-3 polyunsaturated fatty acids and the gut microbiota among breast cancer survivors. Benef Microbes, 10:751-758, 2019
14. Mori M, Fujimori M, Ishiki H, Nishi T, Hamano J, Otani H, Uneno Y, Oba A, Morita T, Uchitomi Y. The Effects of Adding Reassurance Statements: Cancer Patients' Preferences for Phrases in End-of-Life Discussions. J Pain Symptom Manage, 57:1121-1129, 2019
15. Mori M, Fujimori M, Ishiki H, Nishi T, Hamano J, Otani H, Uneno Y, Oba A, Morita T, Uchitomi Y. Adding a Wider Range and “Hope for the Best, and Prepare for the Worst” Statement: Preferences of Patients with Cancer for Prognostic Communication. Oncologist, 24:e943-e952, 2019
16. Watanabe N, Horikoshi M, Shinmei I, Oe Y, Narisawa T, Kumachi M, Matsuoka Y, Hamazaki K, Furukawa TA. Brief mindfulness-based stress management program for a better mental state in working populations - Happy Nurse Project: A randomized controlled trial(☆☆). J Affect Disord, 251:186-194, 2019
17. Barbano AC, van der Mei WF, deRoon-Cassini TA, Grauer E, Lowe SR, Matsuoka YJ, O'Donnell M, Olff M, Qi W, Ratanatharathorn A, Schnyder U, Seedat S, Kessler RC, Koenen KC, Shalev AY. Differentiating PTSD from anxiety and depression: Lessons from the ICD-11 PTSD diagnostic criteria. Depress Anxiety, 36:490-498, 2019
18. Mori M, Fujimori M, van Vliet LM, Yamaguchi T, Shimizu C, Kinoshita T, Morishita-Kawahara M, Inoue A, Inoguchi H, Matsuoka Y, Bruera E, Morita T, Uchitomi Y. Explicit prognostic disclosure to Asian women with breast cancer: A randomized, scripted video-vignette study (J-SUPPORT1601). Cancer, 125:3320-3329, 2019
19. Tsuji K, Ochi E, Okubo R, Shimizu Y, Kuchiba A, Ueno T, Shimazu T, Kinoshita T, Sakurai N, Matsuoka Y. Effect of home-based high-intensity interval training and behavioural modification using information and communication technology on cardiorespiratory fitness and exercise habits among sedentary breast cancer survivors: habit-B study protocol for a randomised controlled trial. BMJ Open, 9:e030911, 2019
20. Fujiwara M, Inagaki M, Shimazu T, Kodama M, So R, Matsushita T, Yoshimura Y, Horii S, Fujimori M, Takahashi H, Nakaya N, Kakeda K, Miyaji T, Hinotsu S, Harada K, Okada H, Uchitomi Y, Yamada N. A randomised controlled trial of a case management approach to encourage participation in colorectal cancer screening for people with schizophrenia in psychiatric outpatient clinics: study protocol for the J-SUPPORT 1901 (ACCESS) study. BMJ Open, 9:e032955, 2019
21. Okubo R, Wada S, Shimizu Y, Tsuji K, Hanai A, Imai K, Uchitomi Y, Fujiwara Y, Tsugane S, Matsuoka YJ. Expectations of and recommendations for a cancer survivorship guideline in Japan: a literature review of guidelines for cancer survivorship. Jpn J Clin Oncol, 49:812-822, 2019
22. Guu TW, Mischoulon D, Sarris J, Hibbeln J, McNamara RK, Hamazaki K, Freeman MP, Maes M, Matsuoka YJ, Belmaker RH, Jacka F, Pariante C, Berk M, Marx W, Su KP. International Society for Nutritional Psychiatry Research Practice Guidelines for Omega-3 Fatty Acids in the Treatment of Major Depressive Disorder. Psychother Psychosom, 88:263-273, 2019
23. Higuchi Y, Fujiwara M, Nakaya N, Fujimori M, Hayashibara C, So R, Shinkawa I, Sato K, Yada Y, Kodama M, Takenaka H, Kishi Y, Kakeda K, Uchitomi Y, Yamada N, Inagaki M. Change in smoking cessation stage over 1 year in patients with schizophrenia: a follow up study in Japan. BMC Psychiatry, 19:367, 2019
24. Hayashibara C, Inagaki M, Fujimori M, Higuchi Y, Fujiwara M, Terada S, Okamura H, Uchitomi Y, Yamada N. Confidence in communicating with patients with cancer mediates the relationship between rehabilitation therapists' autistic-like traits and perceived difficulty in communication. Palliat Support Care, 17:186-194, 2019