Annual Report 2020
Division of Epidemiology
Motoki Iwasaki, Taiki Yamaji, Ryoko Katagiri, Kayo Ohashi, Eriko Kanehara, Yoko Shimizu, Shiori Suzuki, Miyuki Hori, CHEI Choy Lye, Maki Igarashi, Akiko Hanyuda, Aya Morishita
Introduction
Research is being conducted to construct evidence for the development of cancer prevention by clarifying the causes of human cancer using a study base of a large-scale cohort study and other studies of local residents.
Research activities
1) Traditional molecular epidemiologic studies to investigate the causes of cancer
We have conducted several traditional molecular epidemiologic studies to investigate the causes of cancer. By using genetic information obtained from the Japan Public Health Center (JPHC)-based prospective study, we constructed a risk prediction model for upper aero-digestive tract cancer. The 10-year absolute risk for developing upper aero-digestive tract cancer varied by risk factor profile, from 0.09% for the lowest risk group (<50 years of age, non-smoking, and moderate drinking or less) to 6.05% for the highest risk group (≥60 years of age, current smoking, heavy drinking along with Lys alteration in ALDH2). The c-index for the gene-environment interaction model (0.71) was slightly higher than that for the environmental model (0.67). The addition of a gene-environment interaction to a lifestyle-based model might improve the performance to estimate the probability of developing upper aero-digestive tract cancer for Japanese men. Another example of a genetic study is the genome-wide association meta-analysis of pancreatic cancer, in which we reported a new susceptibility locus in the glycoprotein 2 gene.
2) Consortium of large-scale molecular epidemiologic studies in Japan
We established the Japanese Consortium of Genetic Epidemiology studies (J-CGE), a consortium of large-scale molecular epidemiologic studies in Japan, and have conducted “genome-wide association studies (GWAS) stratified by single nucleotide polymorphisms of the ALDH2 gene” and “meta-GWAS on chronic kidney disease”. Using the results of GWAS on body mass index (BMI) from this consortium, we have performed Mendelian randomization analyses for BMI and colorectal cancer. We reported that BMI is significantly associated with increased colorectal cancer risk.
3) Innovative molecular epidemiologic studies to investigate the causes of cancer
We are conducting innovative molecular epidemiologic studies to investigate the causes of cancer. One example is the use of somatic genomic information in a cohort study, which may provide novel evidence according to cancer subtype. Another example is the use of gut microflora genomes to discover previously unknown pathogenic bacteria in colorectal neoplasms. We are also preparing a new study to evaluate the emerging risk factor of heated tobacco products.
Education
We have supervised the research of four graduate students.
Future Prospects
By analyzing data from the epidemiological studies both within and outside Japan, we hope to contribute to developing evidence for personalized cancer prevention and promoting life-long health.
List of papers published in 2020
Journal
1. Kihara T, Yamagishi K, Honda K, Ikeda A, Yatsuya H, Saito I, Kokubo Y, Yamaji T, Shimazu T, Sawada N, Iwasaki M, Iso H, Tsugane S. Apolipoprotein A2 Isoforms in Relation to the Risk of Myocardial Infarction: A Nested Case-Control Analysis in the JPHC Study. J Atheroscler Thromb, 28:483-490, 2021
2. Shirabe R, Saito E, Sawada N, Ishihara J, Takachi R, Abe SK, Shimazu T, Yamaji T, Goto A, Iwasaki M, Inoue M, Tsugane S. Fermented and nonfermented soy foods and the risk of breast cancer in a Japanese population-based cohort study. Cancer Med, 10:757-771, 2021
3. Adachi S, Sawada N, Yuki K, Uchino M, Iwasaki M, Tsubota K, Tsugane S. Intake of Vegetables and Fruits and the Risk of Cataract Incidence in a Japanese Population: The Japan Public Health Center-Based Prospective Study. J Epidemiol, 31:21-29, 2021
4. Zha L, Liu R, Sobue T, Kitamura T, Ishihara J, Kotemori A, Ikeda S, Sawada N, Iwasaki M, Tsugane S, For The Jphc Study Group. Dietary Acrylamide Intake and the Risk of Hematological Malignancies: The Japan Public Health Center-Based Prospective Study. Nutrients, 13:2021
5. Wilunda C, Sawada N, Goto A, Yamaji T, Takachi R, Ishihara J, Mori N, Kotemori A, Iwasaki M, Tsugane S. Associations between changes in fruit and vegetable consumption and weight change in Japanese adults. Eur J Nutr, 60:217-227, 2021
6. Svensson T, Inoue M, Saito E, Sawada N, Iso H, Mizoue T, Goto A, Yamaji T, Shimazu T, Iwasaki M, Tsugane S. The Association Between Habitual Sleep Duration and Mortality According to Sex and Age: The Japan Public Health Center-based Prospective Study. J Epidemiol, 31:109-118, 2021
7. Hamazaki K, Matsuoka YJ, Yamaji T, Sawada N, Mimura M, Nozaki S, Shikimoto R, Tsugane S. Plasma phospholipid n-3 polyunsaturated fatty acids and major depressive disorder in Japanese elderly: the Japan Public Health Center-based Prospective Study. Sci Rep, 11:4003, 2021
8. Takeuchi T, Kitamura Y, Sobue T, Utada M, Ozasa K, Sugawara Y, Tsuji I, Hori M, Sawada N, Tsugane S, Koyanagi YN, Ito H, Wang C, Tamakoshi A, Wada K, Nagata C, Shimazu T, Mizoue T, Matsuo K, Naito M, Tanaka K, Inoue M. Impact of reproductive factors on breast cancer incidence: Pooled analysis of nine cohort studies in Japan. Cancer Med, 10:2153-2163, 2021
9. Saito E, Inoue M, Sawada N, Kokubo Y, Yamagishi K, Iso H, Shimazu T, Yamaji T, Iwasaki M, Tsugane S. Risk of stroke in cancer survivors using a propensity score-matched cohort analysis. Sci Rep, 11:5599, 2021
10. Ikeda S, Sobue T, Kitamura T, Ishihara J, Kotemori A, Zha L, Liu R, Sawada N, Iwasaki M, Tsugane S, On Behalf Of The Jphc Study Group. Dietary Acrylamide Intake and the Risks of Renal Cell, Prostate, and Bladder Cancers: A Japan Public Health Center-Based Prospective Study. Nutrients, 13:2021
11. Abe SK, Sawada N, Ishihara J, Takachi R, Mori N, Yamaji T, Shimazu T, Goto A, Iwasaki M, Inoue M, Tsugane S. Comparison between the impact of fermented and unfermented soy intake on the risk of liver cancer: the JPHC Study. Eur J Nutr, 60:1389-1401, 2021
12. Sasaki M, Ito Y, Yamasaki T, Yanagi Y, Gemmy Cheung CM, Motomura K, Kawakami S, Kinoshita T, Yuki K, Hanyuda A, Mimura M, Sawada N, Tsugane S, Tsubota K. Association of Choroidal Thickness with Intermediate Age-Related Macular Degeneration in a Japanese Population. Ophthalmol Retina, 5:528-535, 2021
13. Ota A, Li Y, Yatsuya H, Tanno K, Sakata K, Yamagishi K, Iso H, Yasuda N, Saito I, Kato T, Arima K, Sou Y, Shimazu T, Yamaji T, Goto A, Inoue M, Iwasaki M, Sawada N, Tsugane S. Working cancer survivors' physical and mental characteristics compared to cancer-free workers in Japan: a nationwide general population-based study. J Cancer Surviv, 2021
14. Nozue M, Shimazu T, Charvat H, Mori N, Mutoh M, Sawada N, Iwasaki M, Yamaji T, Inoue M, Kokubo Y, Yamagishi K, Iso H, Tsugane S. Fermented soy products intake and risk of cardiovascular disease and total cancer incidence: The Japan Public Health Center-based Prospective study. Eur J Clin Nutr, 75:954-968, 2021
15. Matsui S, Sobue T, Zha L, Kitamura T, Sawada N, Iwasaki M, Shimazu T, Tsugane S. Long-term antihypertensive drug use and risk of cancer: The Japan Public Health Center-based prospective study. Cancer Sci, 112:1997-2005, 2021
16. Akter S, Mizoue T, Nanri A, Goto A, Noda M, Sawada N, Yamaji T, Iwasaki M, Inoue M, Tsugane S. Low carbohydrate diet and all cause and cause-specific mortality. Clin Nutr, 40:2016-2024, 2021
17. Katagiri R, Goto A, Shimazu T, Yamaji T, Sawada N, Iwasaki M, Inoue M, Tsugane S. Dietary fiber intake and risk of gastric cancer: The Japan Public Health Center-based prospective study. Int J Cancer, 148:2664-2673, 2021
18. Suzuki S, Goto A, Nakatochi M, Narita A, Yamaji T, Sawada N, Katagiri R, Iwagami M, Hanyuda A, Hachiya T, Sutoh Y, Oze I, Koyanagi YN, Kasugai Y, Taniyama Y, Ito H, Ikezaki H, Nishida Y, Tamura T, Mikami H, Takezaki T, Suzuki S, Ozaki E, Kuriki K, Takashima N, Arisawa K, Takeuchi K, Tanno K, Shimizu A, Tamiya G, Hozawa A, Kinoshita K, Wakai K, Sasaki M, Yamamoto M, Matsuo K, Tsugane S, Iwasaki M. Body mass index and colorectal cancer risk: A Mendelian randomization study. Cancer Sci, 112:1579-1588, 2021
19. Matsuyama S, Sawada N, Tomata Y, Zhang S, Goto A, Yamaji T, Iwasaki M, Inoue M, Tsuji I, Tsugane S. Association between adherence to the Japanese diet and all-cause and cause-specific mortality: the Japan Public Health Center-based Prospective Study. Eur J Nutr, 60:1327-1336, 2021
20. Leung CY, Abe SK, Sawada N, Ishihara J, Takachi R, Yamaji T, Iwasaki M, Hashizume M, Inoue M, Tsugane S. Sugary Drink Consumption and Subsequent Colorectal Cancer Risk: The Japan Public Health Center-Based Prospective Cohort Study. Cancer Epidemiol Biomarkers Prev, 30:782-788, 2021
21. Iwasaki M, Budhathoki S, Yamaji T, Tanaka-Mizuno S, Kuchiba A, Sawada N, Goto A, Shimazu T, Inoue M, Tsugane S. Inclusion of a gene-environment interaction between alcohol consumption and the aldehyde dehydrogenase 2 genotype in a risk prediction model for upper aerodigestive tract cancer in Japanese men. Cancer Sci, 111:3835-3844, 2020
22. Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T, Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y. Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases. Nat Genet, 52:669-679, 2020
23. Lin Y, Nakatochi M, Hosono Y, Ito H, Kamatani Y, Inoko A, Sakamoto H, Kinoshita F, Kobayashi Y, Ishii H, Ozaka M, Sasaki T, Matsuyama M, Sasahira N, Morimoto M, Kobayashi S, Fukushima T, Ueno M, Ohkawa S, Egawa N, Kuruma S, Mori M, Nakao H, Adachi Y, Okuda M, Osaki T, Kamiya S, Wang C, Hara K, Shimizu Y, Miyamoto T, Hayashi Y, Ebi H, Kohmoto T, Imoto I, Kasugai Y, Murakami Y, Akiyama M, Ishigaki K, Matsuda K, Hirata M, Shimada K, Okusaka T, Kawaguchi T, Takahashi M, Watanabe Y, Kuriki K, Kadota A, Okada R, Mikami H, Takezaki T, Suzuki S, Yamaji T, Iwasaki M, Sawada N, Goto A, Kinoshita K, Fuse N, Katsuoka F, Shimizu A, Nishizuka SS, Tanno K, Suzuki K, Okada Y, Horikoshi M, Yamauchi T, Kadowaki T, Yu H, Zhong J, Amundadottir LT, Doki Y, Ishii H, Eguchi H, Bogumil D, Haiman CA, Le Marchand L, Mori M, Risch H, Setiawan VW, Tsugane S, Wakai K, Yoshida T, Matsuda F, Kubo M, Kikuchi S, Matsuo K. Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer. Nat Commun, 11:3175, 2020
24. Cho H, Budhathoki S, Kanehara R, Goto A, Yamaji T, Kakugawa Y, Saito Y, Matsuda T, Iwasaki M, Tsugane S. Association between dietary sugar intake and colorectal adenoma among cancer screening examinees in Japan. Cancer Sci, 111:3862-3872, 2020
25. Hanyuda A, Negishi K, Tsubota K, Ayaki M. Persistently Worsened Tear Break-up Time and Keratitis in Unilateral Pseudophakic Eyes after a Long Postoperative Period. Biomedicines, 8:2020
26. Katagiri R, Goto A, Sawada N, Yamaji T, Iwasaki M, Noda M, Iso H, Tsugane S. Dietary fiber intake and total and cause-specific mortality: the Japan Public Health Center-based prospective study. Am J Clin Nutr, 111:1027-1035, 2020
27. Hanyuda A, Sawada N, Yuki K, Uchino M, Ozawa Y, Sasaki M, Yamagishi K, Iso H, Tsubota K, Tsugane S. Relationships of diabetes and hyperglycaemia with intraocular pressure in a Japanese population: the JPHC-NEXT Eye Study. Sci Rep, 10:5355, 2020
28. Yamazaki C, Goto A, Iwasaki M, Sawada N, Oba S, Noda M, Iso H, Koyama H, Tsugane S. Body mass index and mortality among middle-aged Japanese individuals with diagnosed diabetes: The Japan Public Health Center-based prospective study (JPHC study). Diabetes Res Clin Pract, 164:108198, 2020
29. Yamagiwa Y, Sawada N, Shimazu T, Yamaji T, Goto A, Takachi R, Ishihara J, Iwasaki M, Inoue M, Tsugane S. Soy Food Intake and Pancreatic Cancer Risk: The Japan Public Health Center-based Prospective Study. Cancer Epidemiol Biomarkers Prev, 29:1214-1221, 2020
30. Matsunaga H, Ito K, Akiyama M, Takahashi A, Koyama S, Nomura S, Ieki H, Ozaki K, Onouchi Y, Sakaue S, Suna S, Ogishima S, Yamamoto M, Hozawa A, Satoh M, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Tanaka K, Arisawa K, Ikezaki H, Takashima N, Naito M, Wakai K, Tanaka H, Sakata Y, Morita H, Sakata Y, Matsuda K, Murakami Y, Akazawa H, Kubo M, Kamatani Y, Komuro I. Transethnic Meta-Analysis of Genome-Wide Association Studies Identifies Three New Loci and Characterizes Population-Specific Differences for Coronary Artery Disease. Circ Genom Precis Med, 13:e002670, 2020
31. Ogata T, Muramatsu K, Miyana K, Ozawa H, Iwasaki M, Arakawa H. Neurodevelopmental outcome and respiratory management of congenital central hypoventilation syndrome: a retrospective study. BMC Pediatr, 20:342, 2020
32. Ho WK, Tan MM, Mavaddat N, Tai MC, Mariapun S, Li J, Ho PJ, Dennis J, Tyrer JP, Bolla MK, Michailidou K, Wang Q, Kang D, Choi JY, Jamaris S, Shu XO, Yoon SY, Park SK, Kim SW, Shen CY, Yu JC, Tan EY, Chan PMY, Muir K, Lophatananon A, Wu AH, Stram DO, Matsuo K, Ito H, Chan CW, Ngeow J, Yong WS, Lim SH, Lim GH, Kwong A, Chan TL, Tan SM, Seah J, John EM, Kurian AW, Koh WP, Khor CC, Iwasaki M, Yamaji T, Tan KMV, Tan KTB, Spinelli JJ, Aronson KJ, Hasan SN, Rahmat K, Vijayananthan A, Sim X, Pharoah PDP, Zheng W, Dunning AM, Simard J, van Dam RM, Yip CH, Taib NAM, Hartman M, Easton DF, Teo SH, Antoniou AC. European polygenic risk score for prediction of breast cancer shows similar performance in Asian women. Nat Commun, 11:3833, 2020
33. Hidaka A, Sawada N, Svensson T, Goto A, Yamaji T, Shimazu T, Iwasaki M, Inoue M, Tsugane S. Family history of cancer and subsequent risk of cancer: A large-scale population-based prospective study in Japan. Int J Cancer, 147:331-337, 2020
34. Zha L, Sobue T, Kitamura T, Kitamura Y, Ishihara J, Kotemori A, Liu R, Ikeda S, Sawada N, Iwasaki M, Tsugane S, Jphc Study Group FT. Dietary Acrylamide Intake and the Risk of Liver Cancer: The Japan Public Health Center-Based Prospective Study. Nutrients, 12:2020
35. Liu R, Zha L, Sobue T, Kitamura T, Ishihara J, Kotemori A, Ikeda S, Sawada N, Iwasaki M, Tsugane S. Dietary Acrylamide Intake and Risk of Lung Cancer: The Japan Public Health Center Based Prospective Study. Nutrients, 12:2020
36. Hanyuda A, Rosner BA, Wiggs JL, Willett WC, Tsubota K, Pasquale LR, Kang JH. Low-carbohydrate-diet scores and the risk of primary open-angle glaucoma: data from three US cohorts. Eye (Lond), 34:1465-1475, 2020
37. Charvat H, Shimazu T, Inoue M, Iwasaki M, Sawada N, Yamaji T, Tsugane S. Estimation of the performance of a risk prediction model for gastric cancer occurrence in Japan: Evidence from a small external population. Cancer Epidemiol, 67:101766, 2020
38. Aversa J, Song M, Shimazu T, Inoue M, Charvat H, Yamaji T, Sawada N, Pfeiffer RM, Karimi P, Dawsey SM, Rabkin CS, Tsugane S, Camargo MC. Prediagnostic circulating inflammation biomarkers and esophageal squamous cell carcinoma: A case-cohort study in Japan. Int J Cancer, 147:686-691, 2020
39. Van Alsten SC, Rabkin CS, Sawada N, Shimazu T, Charvat H, Yamaji T, Inoue M, Kemp TJ, Pinto LA, Camargo MC, Tsugane S, Song M. Metabolic Syndrome, Physical Activity, and Inflammation: A Cross-Sectional Analysis of 110 Circulating Biomarkers in Japanese Adults. Cancer Epidemiol Biomarkers Prev, 29:1639-1646, 2020
40. Saito E, Goto A, Kanehara R, Ohashi K, Noda M, Matsuda T, Katanoda K. Prevalence of diabetes in Japanese patients with cancer. J Diabetes Investig, 11:1159-1162, 2020
41. Khankari NK, Yang JJ, Sawada N, Wen W, Yamaji T, Gao J, Goto A, Li HL, Iwasaki M, Yang G, Shimazu T, Xiang YB, Inoue M, Shu XO, Tsugane S, Zheng W. Soy Intake and Colorectal Cancer Risk: Results from a Pooled Analysis of Prospective Cohort Studies Conducted in China and Japan. J Nutr, 150:2442-2450, 2020
42. Honjo K, Iso H, Ikeda A, Yamagishi K, Saito I, Kato T, Yasuda N, Aoyagi K, Arima K, Sakata K, Tanno K, Inoue M, Iwasaki M, Shimazu T, Goto A, Yamaji T, Sawada N, Tsugane S. Cross-Sectional Association Between Employment Status and Self-Rated Health Among Middle-Aged Japanese Women: The Influence of Socioeconomic Conditions and Work-Life Conflict. J Epidemiol, 30:396-403, 2020
43. Sawada N, Iwasaki M, Yamaji T, Shimazu T, Inoue M, Tsugane S. Soy and isoflavone consumption and subsequent risk of prostate cancer mortality: the Japan Public Health Center-based Prospective Study. Int J Epidemiol, 49:1553-1561, 2020
44. Ogawa T, Sawada N, Iwasaki M, Budhathoki S, Yamaji T, Shimazu T, Narita Y, Tsugane S. Body mass index and height in relation to brain tumor risk in a Japanese population. Ann Epidemiol, 51:1-6, 2020
45. Koyama S, Ito K, Terao C, Akiyama M, Horikoshi M, Momozawa Y, Matsunaga H, Ieki H, Ozaki K, Onouchi Y, Takahashi A, Nomura S, Morita H, Akazawa H, Kim C, Seo JS, Higasa K, Iwasaki M, Yamaji T, Sawada N, Tsugane S, Koyama T, Ikezaki H, Takashima N, Tanaka K, Arisawa K, Kuriki K, Naito M, Wakai K, Suna S, Sakata Y, Sato H, Hori M, Sakata Y, Matsuda K, Murakami Y, Aburatani H, Kubo M, Matsuda F, Kamatani Y, Komuro I. Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease. Nat Genet, 52:1169-1177, 2020
46. Kito K, Ishihara J, Kotemori A, Zha L, Liu R, Sawada N, Iwasaki M, Sobue T, Tsugane S. Dietary Acrylamide Intake and the Risk of Pancreatic Cancer: The Japan Public Health Center-Based Prospective Study. Nutrients, 12:2020
47. Cai H, Sobue T, Kitamura T, Sawada N, Iwasaki M, Shimazu T, Tsugane S. Epidemiology of nonmelanoma skin cancer in Japan: Occupational type, lifestyle, and family history of cancer. Cancer Sci, 111:4257-4265, 2020
48. Saito E, Tang X, Abe SK, Sawada N, Ishihara J, Takachi R, Iso H, Shimazu T, Yamaji T, Iwasaki M, Inoue M, Tsugane S. Association between meat intake and mortality due to all-cause and major causes of death in a Japanese population. PLoS One, 15:e0244007, 2020
49. Cai H, Sobue T, Kitamura T, Ishihara J, Sawada N, Iwasaki M, Shimazu T, Tsugane S. Association between meat and saturated fatty acid intake and lung cancer risk: The Japan Public Health Center-based prospective study. Int J Cancer, 147:3019-3028, 2020
50. Ono A, Inoue M, Sawada N, Saito E, Yamaji T, Shimazu T, Goto A, Iwasaki M, Tsugane S. Impact of alcohol drinking on cancer risk with consideration of flushing response: The Japan Public Health Center-based Prospective Study Cohort (JPHC study). Prev Med, 133:106026, 2020
51. Long L, Yang W, Liu L, Tobias DK, Katagiri R, Wu K, Jin L, Zhang FF, Luo X, Liu X, Ogino S, Chan AT, Meyerhardt JA, Giovannucci E, Zhang X. Dietary intake of branched-chain amino acids and survival after colorectal cancer diagnosis. Int J Cancer, 2020
Book
1. Yamaji T, Tsugane S. Epidemiology of Esophageal Squamous Cell Carcinoma. In: Ando, N (ed), Esophageal Squamous Cell Carcinoma, Tokyo, Springer Japan, pp 1-13, 2020