Annual Report 2020
Division of Prevention
Manami Inoue, Sarah K. Abe, Shiori Tanaka, Michihiro Mutoh, Ayami Ono, Tetsuji Minami, Yoko Yamagiwa, Md. Rashedul Islam, Md. Shafiur Rahman, Chi-Yan Leung, Hsi-Lan Huang, Yoko Hirose, Yasuko Iba, Michiko Okajima, Hanako Saito
Introduction
The Division of Prevention has planned and conducted studies on cancer prevention.
The Team and What We Do
The Division of Prevention focuses on prevention research to investigate and develop prevention methods (lifestyle, chemoprevention, molecular markers, etc.), risk prediction, risk stratification models, and evidence-based cancer prevention guidelines.
Research activities
1. Evaluation of cancer prevention strategies in Japan and cancer prevention guidelines
To develop an evidence-based cancer prevention strategy in Japan, we have conducted systematic reviews, meta-analyses, and pooled analyses of Japanese epidemiological research. We have also created a booklet for junior and senior high school students in collaboration with experts to disseminate the Cancer Prevention Law.
2. Asia Cohort Consortium (ACC)
The ACC is a collaborative effort that seeks to understand the relationship between genetics, environmental exposures and disease etiology by establishing a consortium of cohort studies with healthy individuals throughout Asian countries. Our division serves as the coordinating center and data center of the ACC, and directs many of its ongoing projects.
3. The effectiveness of Helicobacter pylori (H. pylori) eradication in gastric cancer prevention
This study aims to assess whether H. pylori eradication prevents the subsequent development of gastric cancer using a pooled analysis of large-scale epidemiological studies with information on H. pylori infection status (JPHC-NEXT in the Yokote, Saku and Chikusei areas; the Yamagata Cohort; and the Tokyo Gastric Cancer Screening Study). This project started in 2017.
4. Attributable causes of cancer (JAPAN PAF PROJECT)
We conducted a systematic assessment to estimate the current burden of cancer attributable to known preventable risk factors in Japan. The first estimation was conducted for cancer incidence and mortality in 2005. The estimation is currently being updated for 2015.
5. Development of prevention measures based on interventional research.
We have completed and reported a double-blind, randomized clinical trial of aspirin and mesalazine to see if these drugs suppress the onset of new adenomas in patients with a history of multiple colorectal adenomas. Another clinical research project aimed at developing colorectal cancer chemopreventive drugs is in progress.
6. National Center for Advanced Medical Research (NC-CCAPH or 6NC) Cross-sectional Research, Medical Research Collaboration Promotion Headquarters
In collaboration with 6NC, we are using the existing cohort and life log data for predictive preemptive medical care, and are conducting antibody surveys for new coronavirus infections among 6NC staff.
Education
We supervised the research of domestic and international Masters and PhD students. We serve as Coordinating Department of Cancer Epidemiology, Graduate School of Medicine, The University of Tokyo. We accepted guest researchers and trainees from overseas.
Future Prospects
We focus on research for the development and assessment of effective cancer prevention strategies.
List of papers published in 2020
Journal
1. Hamoya T, Fujii G, Iizumi Y, Narita T, Komiya M, Matsuzawa Y, Miki K, Kondo T, Kishimoto S, Watanabe K, Wakabayashi K, Sakai T, Toshima J, Mutoh M. Artesunate inhibits intestinal tumorigenesis through inhibiting wnt signaling. Carcinogenesis, 42:148-158, 2021
2. Shirabe R, Saito E, Sawada N, Ishihara J, Takachi R, Abe SK, Shimazu T, Yamaji T, Goto A, Iwasaki M, Inoue M, Tsugane S. Fermented and nonfermented soy foods and the risk of breast cancer in a Japanese population-based cohort study. Cancer Med, 10:757-771, 2021
3. Takeuchi T, Kitamura Y, Sobue T, Utada M, Ozasa K, Sugawara Y, Tsuji I, Hori M, Sawada N, Tsugane S, Koyanagi YN, Ito H, Wang C, Tamakoshi A, Wada K, Nagata C, Shimazu T, Mizoue T, Matsuo K, Naito M, Tanaka K, Inoue M. Impact of reproductive factors on breast cancer incidence: Pooled analysis of nine cohort studies in Japan. Cancer Med, 10:2153-2163, 2021
4. Saito E, Inoue M, Sawada N, Kokubo Y, Yamagishi K, Iso H, Shimazu T, Yamaji T, Iwasaki M, Tsugane S. Risk of stroke in cancer survivors using a propensity score-matched cohort analysis. Sci Rep, 11:5599, 2021
5. Abe SK, Sawada N, Ishihara J, Takachi R, Mori N, Yamaji T, Shimazu T, Goto A, Iwasaki M, Inoue M, Tsugane S. Comparison between the impact of fermented and unfermented soy intake on the risk of liver cancer: the JPHC Study. Eur J Nutr, 60:1389-1401, 2021
6. Ota A, Li Y, Yatsuya H, Tanno K, Sakata K, Yamagishi K, Iso H, Yasuda N, Saito I, Kato T, Arima K, Sou Y, Shimazu T, Yamaji T, Goto A, Inoue M, Iwasaki M, Sawada N, Tsugane S. Working cancer survivors' physical and mental characteristics compared to cancer-free workers in Japan: a nationwide general population-based study. J Cancer Surviv, 2021
7. Nozue M, Shimazu T, Charvat H, Mori N, Mutoh M, Sawada N, Iwasaki M, Yamaji T, Inoue M, Kokubo Y, Yamagishi K, Iso H, Tsugane S. Fermented soy products intake and risk of cardiovascular disease and total cancer incidence: The Japan Public Health Center-based Prospective study. Eur J Clin Nutr, 75:954-968, 2021
8. Akter S, Mizoue T, Nanri A, Goto A, Noda M, Sawada N, Yamaji T, Iwasaki M, Inoue M, Tsugane S. Low carbohydrate diet and all cause and cause-specific mortality. Clin Nutr, 40:2016-2024, 2021
9. Katagiri R, Goto A, Shimazu T, Yamaji T, Sawada N, Iwasaki M, Inoue M, Tsugane S. Dietary fiber intake and risk of gastric cancer: The Japan Public Health Center-based prospective study. Int J Cancer, 148:2664-2673, 2021
10. Matsuyama S, Sawada N, Tomata Y, Zhang S, Goto A, Yamaji T, Iwasaki M, Inoue M, Tsuji I, Tsugane S. Association between adherence to the Japanese diet and all-cause and cause-specific mortality: the Japan Public Health Center-based Prospective Study. Eur J Nutr, 60:1327-1336, 2021
11. Leung CY, Abe SK, Sawada N, Ishihara J, Takachi R, Yamaji T, Iwasaki M, Hashizume M, Inoue M, Tsugane S. Sugary Drink Consumption and Subsequent Colorectal Cancer Risk: The Japan Public Health Center-Based Prospective Cohort Study. Cancer Epidemiol Biomarkers Prev, 30:782-788, 2021
12. Iwase M, Matsuo K, Koyanagi YNY, Ito H, Tamakoshi A, Wang C, Utada M, Ozasa K, Sugawara Y, Tsuji I, Sawada N, Tanaka S, Nagata C, Kitamura Y, Shimazu T, Mizoue T, Naito M, Tanaka K, Inoue M. Alcohol consumption and breast cancer risk in Japan: A pooled analysis of eight population-based cohort studies. Int J Cancer, 148:2736-2747, 2021
13. Watanabe M, Yamada Y, Kurumida Y, Kameda T, Sukeno M, Iizuka-Ohashi M, Sowa Y, Iizumi Y, Takakura H, Miyamoto S, Sakai T, Mutoh M. Rabdosianone I, a Bitter Diterpene from an Oriental Herb, Suppresses Thymidylate Synthase Expression by Directly Binding to ANT2 and PHB2. Cancers (Basel), 13:2021
14. Murano Y, Ueno R, Shi S, Kawashima T, Tanoue Y, Tanaka S, Nomura S, Shoji H, Shimizu T, Nguyen H, Miyata H, Gilmour S, Yoneoka D. Impact of domestic travel restrictions on transmission of COVID-19 infection using public transportation network approach. Sci Rep, 11:3109, 2021
15. Akter S, Islam Z, Mizoue T, Sawada N, Ihira H, Tsugane S, Koyanagi YN, Ito H, Wang C, Tamakoshi A, Wada K, Nagata C, Tanaka K, Kitamura Y, Utada M, Ozasa K, Sugawara Y, Tsuji I, Shimazu T, Matsuo K, Naito M, Tanaka K, Inoue M. Smoking and colorectal cancer: A pooled analysis of 10 population-based cohort studies in Japan. Int J Cancer, 148:654-664, 2021
16. Terasaki M, Hamoya T, Kubota A, Kojima H, Tanaka T, Maeda H, Miyashita K, Mutoh M. Fucoxanthin Prevents Colorectal Cancer Development in Dextran Sodium Sulfate-treated Apc Min/+ Mice. Anticancer Res, 41:1299-1305, 2021
17. Yoneoka D, Nomura S, Tanaka S, Ishizuka A, Peter U, Rauniyar SK, Nakamura K, Uneyama H, Hayashi N, Shibuya K. Prediction of disability-adjusted life years for diseases due to low fruit intake in 2017-2040 in Japan. Public Health Nutr, 24:3156-3166, 2021
18. Yokoyama R, Kojima H, Takai R, Ohta T, Maeda H, Miyashita K, Mutoh M, Terasaki M. Effects of CLIC4 on Fucoxanthinol-Induced Apoptosis in Human Colorectal Cancer Cells. Nutr Cancer, 73:889-898, 2021
19. Yang JJ, Yu D, Shu XO, Freedman ND, Wen W, Rahman S, Abe SK, Saito E, Gupta PC, He J, Tsugane S, Gao YT, Xiang YB, Yuan JM, Tomata Y, Tsuji I, Sugawara Y, Matsuo K, Ahn YO, Park SK, Chen Y, Pan WH, Pednekar M, Gu D, Sawada N, Cai H, Li HL, Koh WP, Wang R, Zhang S, Kanemura S, Ito H, Shin MH, Wu PE, Yoo KY, Ahsan H, Chia KS, Boffetta P, Inoue M, Kang D, Potter JD, Zheng W. Quantifying the association of low-intensity and late initiation of tobacco smoking with total and cause-specific mortality in Asia. Tob Control, 30:328-335, 2021
20. Katanoda K, Hori M, Saito E, Shibata A, Ito Y, Minami T, Ikeda S, Suzuki T, Matsuda T. Updated trends in cancer in Japan: incidence in 1985-2015 and mortality in 1958-2018 - a sign of decrease in cancer incidence. J Epidemiol, 2021
21. Abe SK, Inoue M. Green tea and cancer and cardiometabolic diseases: a review of the current epidemiological evidence. Eur J Clin Nutr, 75:865-876, 2021
22. Iwasaki M, Budhathoki S, Yamaji T, Tanaka-Mizuno S, Kuchiba A, Sawada N, Goto A, Shimazu T, Inoue M, Tsugane S. Inclusion of a gene-environment interaction between alcohol consumption and the aldehyde dehydrogenase 2 genotype in a risk prediction model for upper aerodigestive tract cancer in Japanese men. Cancer Sci, 111:3835-3844, 2020
23. Adachi S, Hamoya T, Fujii G, Narita T, Komiya M, Miyamoto S, Kurokawa Y, Takahashi M, Takayama T, Ishikawa H, Tashiro K, Mutoh M. Theracurmin inhibits intestinal polyp development in Apc-mutant mice by inhibiting inflammation-related factors. Cancer Sci, 111:1367-1374, 2020
24. Yamagiwa Y, Sawada N, Shimazu T, Yamaji T, Goto A, Takachi R, Ishihara J, Iwasaki M, Inoue M, Tsugane S. Soy Food Intake and Pancreatic Cancer Risk: The Japan Public Health Center-based Prospective Study. Cancer Epidemiol Biomarkers Prev, 29:1214-1221, 2020
25. Hidaka A, Sawada N, Svensson T, Goto A, Yamaji T, Shimazu T, Iwasaki M, Inoue M, Tsugane S. Family history of cancer and subsequent risk of cancer: A large-scale population-based prospective study in Japan. Int J Cancer, 147:331-337, 2020
26. Charvat H, Shimazu T, Inoue M, Iwasaki M, Sawada N, Yamaji T, Tsugane S. Estimation of the performance of a risk prediction model for gastric cancer occurrence in Japan: Evidence from a small external population. Cancer Epidemiol, 67:101766, 2020
27. Aversa J, Song M, Shimazu T, Inoue M, Charvat H, Yamaji T, Sawada N, Pfeiffer RM, Karimi P, Dawsey SM, Rabkin CS, Tsugane S, Camargo MC. Prediagnostic circulating inflammation biomarkers and esophageal squamous cell carcinoma: A case-cohort study in Japan. Int J Cancer, 147:686-691, 2020
28. Van Alsten SC, Rabkin CS, Sawada N, Shimazu T, Charvat H, Yamaji T, Inoue M, Kemp TJ, Pinto LA, Camargo MC, Tsugane S, Song M. Metabolic Syndrome, Physical Activity, and Inflammation: A Cross-Sectional Analysis of 110 Circulating Biomarkers in Japanese Adults. Cancer Epidemiol Biomarkers Prev, 29:1639-1646, 2020
29. Khankari NK, Yang JJ, Sawada N, Wen W, Yamaji T, Gao J, Goto A, Li HL, Iwasaki M, Yang G, Shimazu T, Xiang YB, Inoue M, Shu XO, Tsugane S, Zheng W. Soy Intake and Colorectal Cancer Risk: Results from a Pooled Analysis of Prospective Cohort Studies Conducted in China and Japan. J Nutr, 150:2442-2450, 2020
30. Honjo K, Iso H, Ikeda A, Yamagishi K, Saito I, Kato T, Yasuda N, Aoyagi K, Arima K, Sakata K, Tanno K, Inoue M, Iwasaki M, Shimazu T, Goto A, Yamaji T, Sawada N, Tsugane S. Cross-Sectional Association Between Employment Status and Self-Rated Health Among Middle-Aged Japanese Women: The Influence of Socioeconomic Conditions and Work-Life Conflict. J Epidemiol, 30:396-403, 2020
31. Sawada N, Iwasaki M, Yamaji T, Shimazu T, Inoue M, Tsugane S. Soy and isoflavone consumption and subsequent risk of prostate cancer mortality: the Japan Public Health Center-based Prospective Study. Int J Epidemiol, 49:1553-1561, 2020
32. Saito E, Tang X, Abe SK, Sawada N, Ishihara J, Takachi R, Iso H, Shimazu T, Yamaji T, Iwasaki M, Inoue M, Tsugane S. Association between meat intake and mortality due to all-cause and major causes of death in a Japanese population. PLoS One, 15:e0244007, 2020
33. Ono A, Inoue M, Sawada N, Saito E, Yamaji T, Shimazu T, Goto A, Iwasaki M, Tsugane S. Impact of alcohol drinking on cancer risk with consideration of flushing response: The Japan Public Health Center-based Prospective Study Cohort (JPHC study). Prev Med, 133:106026, 2020
34. Saito I, Yamagishi K, Kokubo Y, Yatsuya H, Iso H, Sawada N, Inoue M, Tsugane S. Non-High-Density Lipoprotein Cholesterol and Risk of Stroke Subtypes and Coronary Heart Disease: The Japan Public Health Center-Based Prospective (JPHC) Study. J Atheroscler Thromb, 27:363-374, 2020
35. Nolen LD, Vindigni SM, Parsonnet J. Combating Gastric Cancer in Alaska Native People: An Expert and Community Symposium. Gastroenterology, 158:1197-1201, 2020
36. Shi S, Tanaka S, Ueno R, Gilmour S, Tanoue Y, Kawashima T, Nomura S, Eguchi A, Miyata H, Yoneoka D. Travel restrictions and SARS-CoV-2 transmission: an effective distance approach to estimate impact. Bull World Health Organ, 98:518-529, 2020
37. Kikuchi H, Inoue S, Odagiri Y, Ihira H, Inoue M, Sawada N, Noda M, Tsugane S. Intensity-specific validity and reliability of the Japan Public Health Center-based prospective study-physical activity questionnaire. Prev Med Rep, 20:101169, 2020
38. Rauniyar SK, Rahman MM, Rahman MS, Abe SK, Nomura S, Shibuya K. Inequalities and risk factors analysis in prevalence and management of hypertension in India and Nepal: a national and subnational study. BMC Public Health, 20:1341, 2020
39. Oba S, Goto A, Mizoue T, Inoue M, Sawada N, Noda M, Tsugane S. Passive smoking and type 2 diabetes among never-smoking women: The Japan Public Health Center-based Prospective Study. J Diabetes Investig, 11:1352-1358, 2020
40. Nomura S, Yoneoka D, Tanaka S, Ishizuka A, Ueda P, Nakamura K, Uneyama H, Hayashi N, Shibuya K. Forecasting disability-adjusted life years for chronic diseases: reference and alternative scenarios of salt intake for 2017-2040 in Japan. BMC Public Health, 20:1475, 2020
41. Hemmi O, Nomura Y, Konishi H, Kakizoe T, Inoue M. Impact of reduced smoking rates on lung cancer screening programs in Japan. Jpn J Clin Oncol, 50:1126-1132, 2020
42. Yoshikawa Y, Tsunematsu Y, Matsuzaki N, Hirayama Y, Higashiguchi F, Sato M, Iwashita Y, Miyoshi N, Mutoh M, Ishikawa H, Sugimura H, Wakabayashi K, Watanabe K. Characterization of Colibactin-Producing Escherichia coli Isolated from Japanese Patients with Colorectal Cancer. Jpn J Infect Dis, 73:437-442, 2020
43. Yin T, Bayanjargal S, Fang B, Inaba C, Mutoh M, Kawahara T, Tanaka S, Watanabe J. Lactobacillus plantarum Shinshu N-07 isolated from fermented Brassica rapa L. attenuates visceral fat accumulation induced by high-fat diet in mice. Benef Microbes, 11:655-667, 2020
44. Terasaki M, Kimura R, Kubota A, Kojima H, Tanaka T, Maeda H, Miyashita K, Mutoh M. Continuity of Tumor Microenvironmental Suppression in AOM/DSS Mice by Fucoxanthin May Be Able to Track With Salivary Glycine. In Vivo, 34:3205-3215, 2020
45. Zhu J, Smith-Warner SA, Yu D, Zhang X, Blot WJ, Xiang YB, Sinha R, Park Y, Tsugane S, White E, Koh WP, Park SK, Sawada N, Kanemura S, Sugawara Y, Tsuji I, Robien K, Tomata Y, Yoo KY, Kim J, Yuan JM, Gao YT, Rothman N, Lazovich D, Abe SK, Rahman MS, Loftfield E, Takata Y, Li X, Lee JE, Saito E, Freedman ND, Inoue M, Lan Q, Willett WC, Zheng W, Shu XO. Associations of coffee and tea consumption with lung cancer risk. Int J Cancer, 2020
46. Matsuoka YJ, Okubo R, Shimizu Y, Tsuji K, Narisawa T, Sasaki J, Sasai H, Akashi-Tanaka S, Hamaguchi T, Iwasa T, Iwata S, Kato T, Kurotani K, Maruyama D, Mori A, Ogawa A, Sakurai N, Shimazu T, Shimizu C, Tabuchi T, Takahashi M, Takano T, Tatematsu N, Uchitomi Y, Watanabe C, Fukui T. Developing the structure of Japan's cancer survivorship guidelines using an expert panel and modified Delphi method. J Cancer Surviv, 2020;14(3):273-283.
47. Svensson T, Inoue M, Saito E, Sawada N, Iso H, Mizoue T, Goto A, Yamaji T, Shimazu T, Iwasaki M, Tsugane S. The association between habitual sleep duration and mortality according to sex and age: the Japan Public Health Center-based Prospective Study. J Epidemiol, 2020;31(2):109-108.