Annual Report 2021

Division of Science and Technology for Endoscopy (Kashiwa Campus)

Hiroaki Ikematsu, Tomonori Yano, Tatsuro Murano, Keiichiro Nakajo, Toshihiro Takamatsu, Takako Mamada, Eri Oishibashi

Introduction

 Endoscopic diagnostic and therapeutic devices have made remarkable progress. However, there are still some devices that have not yet been developed, such as cancer screening devices, devices for diagnosing commonly missed cancers, devices for diagnosing deep lesions, and devices for treatment complications. We are therefore conducting basic research by incorporating the seeds of science and engineering academia into developing these devices and joint development with companies.

The Team and What We Do

 Basic research and pre-clinical studies on medical device development

Research activities

 The equipment development in 2021 was as follows: (1) Research targeting submucosal tumors and gastric cancer by irradiating with near-infrared light in the wavelength range of 1,000 nm or more, as well as the development of a flexible endoscope for this purpose (Figure 1), (2) Development of automatic colon insertion endoscopes, (3) Molecular biological analysis of early gastrointestinal cancer, which is the basis for non-invasive diagnostic methods, (4) Development of an application for judging fecal discharge at the time of preparation for colonoscopy, and (5) Development of highly quantitative imaging of fecal occult blood. All of these are highly novel seeds and systems that have never existed before, and can be expected to be clinically useful. Regarding (4), a venture was formed and clinical trials were initiated.

Figure 1. Development of Near-Infrared Hyperspectral Imaging Endoscope

Clinical trials

1)  Development of diagnostic endoscopy for GIST and gastric cancer using near-infrared light

2)  Development of an application to determine the nature of defecation during colonoscopy preparation

3)  Development of imaging of fecal occult blood with highly quantitative values

Education

 One researcher at Tokyo University of Science was sent to our hospital (National Cancer Center Hospital East: NCCHE) by a cross-appointment with Tokyo University of Science. Meetings are constantly conducted with faculties including technology and science students from Tokyo University of Science.

 We held a symposium with academia. We have also provided many opportunities for matching seeds and needs with academia.

Future Prospects

 We aim to develop innovative medical devices desired by the next generation that reflect the needs of clinical practice.

 In the future, we will continue to develop endoscopic equipment in cooperation with the Department of Gastroenterology and Endoscopy of the NCCHE and attempt innovative approaches to produce all-new endoscopy approaches/devices in collaboration with academia and corporations. With the aim of acquiring new seeds, we are developing the research infrastructure necessary to collaborate with academia.

List of papers published in 2021

Journal

1. Horiuchi Y, Takizawa K, Yoshio T, Mizusawa J, Ono H, Hasuike N, Yano T, Yoshida N, Miwa H, Boku N, Terashima M, Muto M. Pretreatment risk factors for endoscopic noncurative resection of gastric cancers with undifferentiated-type components. Journal of gastroenterology and hepatology, 37:758-765, 2022

2. Yoshio T, Minashi K, Mizusawa J, Morita Y, Tajika M, Fujiwara J, Yamamoto Y, Katada C, Hori S, Yano T, Takizawa K, Fukuda H, Muto M. Effect of chemoradiation on the development of second primary cancers after endoscopic resection of T1 esophageal squamous cell carcinoma. Esophagus: official journal of the Japan Esophageal Society, 19:469-476, 2022

3. Sekiguchi M, Oda I, Morita S, Katai H, Yano T, Terashima M, Kataoka T, Muto M. Management of elderly patients with early gastric cancer in Japan. Japanese journal of clinical oncology, 52:425-432, 2022

4. Iwasaki M, Kanehara R, Yamaji T, Katagiri R, Mutoh M, Tsunematsu Y, Sato M, Watanabe K, Hosomi K, Kakugawa Y, Ikematsu H, Hotta K, Kunisawa J, Wakabayashi K, Matsuda T. Association of Escherichia coli containing polyketide synthase in the gut microbiota with colorectal neoplasia in Japan. Cancer science, 113:277-286, 2022

5. Kadota T, Sato D, Inaba A, Nishihara K, Takashima K, Nakajo K, Yukami H, Mishima S, Sawada K, Kotani D, Fujiwara H, Nakamura M, Hojo H, Yoda Y, Kojima T, Fujita T, Yano T. Long-term clinical outcomes of patients diagnosed with pT1a-muscularis mucosae with lymphovascular invasion or pT1b after endoscopic resection for cT1N0M0 esophageal squamous cell carcinoma. Esophagus: official journal of the Japan Esophageal Society, 19:153-162, 2022

6. Ikematsu H, Ishihara M, Okawa S, Minamide T, Mitsui T, Kuwata T, Ito M, Kinoshita T, Fujita T, Yano T, Omori T, Ozawa S, Murakoshi D, Irisawa K, Ochiai A. Photoacoustic imaging of fresh human surgically and endoscopically resected gastrointestinal specimens. DEN open, 2:e28, 2022

7. Sato D, Kadota T, Inaba A, Nishihara K, Takashima K, Nakajo K, Sawada K, Kotani D, Fujiwara H, Yoda Y, Kojima T, Fujita T, Fujii S, Yano T. Long-term clinical outcome after endoscopic resection of esophageal squamous cell carcinoma invading the muscularis mucosae without lymphovascular invasion. Gastrointestinal endoscopy, 95:634-641.e3, 2022

8. Shinmura K, Yamamoto Y, Inaba A, Okumura K, Nishihara K, Kumahara K, Sunakawa H, Furue Y, Ito R, Sato D, Minamide T, Suyama M, Takashima K, Nakajo K, Murano T, Kadota T, Yoda Y, Hori K, Oono Y, Ikematsu H, Yano T. The safety and feasibility of endoscopic submucosal dissection using a flexible three-dimensional endoscope for early gastric cancer and superficial esophageal cancer: A prospective observational study. Journal of gastroenterology and hepatology, 37:749-757, 2022

9. Yamashita H, Kadota T, Minamide T, Sunakawa H, Sato D, Takashima K, Nakajo K, Murano T, Shinmura K, Yoda Y, Ikematsu H, Yano T. Efficacy and safety of second photodynamic therapy for local failure after salvage photodynamic therapy for esophageal cancer. Digestive endoscopy: official journal of the Japan Gastroenterological Endoscopy Society, 34:488-496, 2022

10. Yano T, Yoda Y, Nonaka S, Abe S, Kawata N, Yoshio T, Sasaki T, Tanaka S, Sasaki F, Maekita T, Kitano M, Matsumoto K, Isayama H, Ono H. Pivotal trial of a biodegradable stent for patients with refractory benign esophageal stricture. Esophagus: official journal of the Japan Esophageal Society, 19:516-524, 2022

11. Yano T. What is the next critical finding to change our mind in esophagogastroduodenoscopy? Digestive endoscopy: official journal of the Japan Gastroenterological Endoscopy Society, 34:766-768, 2022

12. Ikematsu H, Murano T, Shinmura K. Depth diagnosis of early colorectal cancer: Magnifying chromoendoscopy or image enhanced endoscopy with magnification? Digestive endoscopy: official journal of the Japan Gastroenterological Endoscopy Society, 34:265-273, 2022

13. Guarner-Argente C, Ikematsu H, Osera S, Fraile M, Ibañez B, Marra-López C, Jerusalén-Gargallo C, Alonso Aguirre PA, Martinez-Ares D, Soto S, Ramos Zabala F, Alvarez-Gonzalez MA, Rodriguez Sánchez J, Múgica F, Nogales Rincon O, Herreros de Tejada A, Redondo-Cerezo E, Martínez-Cara J, López-Rosés L, Rodriguez-Tellez M, Garcia-Bosch O, de la Peña J, Pellisé M, Rivero-Sanchez L, Saperas E, Pérez-Roldán F, Lopez Viedma B, González-Santiago JM, Álvarez Delgado A, Cobian C, Pardeiro R, Valdivielso Cortázar E, Colan-Hernandez J, Gordillo J, Kaneko K, Albéniz E . Location, morphology and invasiveness of lateral spreading tumors in the colorectum differ between two large cohorts from an eastern and western country. Gastroenterologia y hepatologia, 45:440-449, 2022

14. Nomura H, Tsuji D, Ueno S, Kojima T, Fujii S, Yano T, Daiko H, Demachi K, Itoh K, Kawasaki T. Relevance of pharmacogenetic polymorphisms with response to docetaxel, cisplatin, and 5-fluorouracil chemotherapy in esophageal cancer. Investigational new drugs, 40:420-429, 2022

15. Saito E, Yano T, Hori M, Yoneoka D, Matsuda T, Chen Y, Katanoda K. Is young-onset esophageal adenocarcinoma increasing in Japan? An analysis of population-based cancer registries. Cancer medicine, 11:1347-1356, 2022

16. Du J, Kageyama SI, Yamashita R, Hirata H, Hakozaki Y, Okumura M, Motegi A, Hojo H, Nakamura M, Hirano Y, Sunakawa H, Minamide T, Kotani D, Tanaka K, Yano T, Kojima T, Ohashi A, Tsuchihara K, Akimoto T. Impacts of the STING-IFNAR1-STAT1-IRF1 pathway on the cellular immune reaction induced by fractionated irradiation. Cancer science, 113:1352-1361, 2022

17. Takashima K, Koga Y, Anzai T, Migita K, Yamaguchi T, Ishikawa A, Sakashita S, Yasunaga M, Yano T. Evaluation of Fluorescence Intensity and Antitumor Effect Using Real-Time Imaging in Photoimmunotherapy. Pharmaceuticals (Basel, Switzerland), 15:2022

18. Mitsui T, Kadota T, Wakabayashi M, Nakajo K, Shinmura K, Sunakawa H, Sato D, Minamide T, Takashima K, Murano T, Yoda Y, Ikematsu H, Yano T. Factors of technical difficulty in conventional and traction-assisted esophageal endoscopic submucosal dissection. Esophagus: official journal of the Japan Esophageal Society, 19:452-459, 2022

19. Ikematsu H, Murano T, Shinmura K. Detection of colorectal lesions during colonoscopy. DEN open, 2:e68, 2022

20. Nakajima T, Sakamoto T, Hori S, Yamada S, Ikematsu H, Harada K, Chiu HM, Kiriyama S, Michida T, Hotta K, Sakamoto N, Abe T, Chino A, Fukuzawa M, Kobayashi N, Fukase K, Matsuda T, Murakami Y, Ishikawa H, Saito Y. Optimal surveillance interval after piecemeal endoscopic mucosal resection for large colorectal neoplasia: a multicenter randomized controlled trial. Surgical endoscopy, 36:515-525, 2022

21. Ishihara R, Mizusawa J, Kushima R, Matsuura N, Yano T, Kataoka T, Fukuda H, Hanaoka N, Yoshio T, Abe S, Yamamoto Y, Nagata S, Ono H, Tamaoki M, Yoshida N, Takizawa K, Muto M. Assessment of the Diagnostic Performance of Endoscopic Ultrasonography After Conventional Endoscopy for the Evaluation of Esophageal Squamous Cell Carcinoma Invasion Depth. JAMA network open, 4:e2125317, 2021

22. Kobayashi S, Ueno M, Ogawa G, Fukutomi A, Ikeda M, Okusaka T, Sato T, Ito Y, Kadota T, Ioka T, Sugimori K, Sata N, Nakamori S, Shimizu K, Mizuno N, Ishii H, Furuse J. Impact of Renal Function on S-1 + Radiotherapy for Locally Advanced Pancreatic Cancer: An Integrated Analysis of Data From 2 Clinical Trials. Pancreas, 50:965-971, 2021

23. Wada Y, Shimada M, Murano T, Takamaru H, Morine Y, Ikemoto T, Saito Y, Balaguer F, Bujanda L, Pellise M, Kato K, Saito Y, Ikematsu H, Goel A. A Liquid Biopsy Assay for Noninvasive Identification of Lymph Node Metastases in T1 Colorectal Cancer. Gastroenterology, 161:151-162.e1, 2021

24. Mori Y, Kudo SE, Misawa M, Hotta K, Kazuo O, Saito S, Ikematsu H, Saito Y, Matsuda T, Kenichi T, Kudo T, Nemoto T, Itoh H, Mori K. Artificial intelligence-assisted colonic endocytoscopy for cancer recognition: a multicenter study. Endoscopy international open, 9:E1004-E1011, 2021

25. Kobayashi N, Takeuchi Y, Ohata K, Igarashi M, Yamada M, Kodashima S, Hotta K, Harada K, Ikematsu H, Uraoka T, Sakamoto N, Doyama H, Abe T, Katagiri A, Hori S, Michida T, Yamaguchi T, Fukuzawa M, Kiriyama S, Fukase K, Murakami Y, Ishikawa H, Saito Y. Outcomes of endoscopic submucosal dissection for colorectal neoplasms: Prospective, multicenter, cohort trial. Digestive endoscopy: official journal of the Japan Gastroenterological Endoscopy Society, 2021

26. Katada C, Muto M, Fujii S, Yokoyama T, Yano T, Watanabe A, Iizuka T, Yoshinaga S, Tateya I, Mitani H, Shimizu Y, Takahashi A, Kamijo T, Hanaoka N, Abe M, Shiotani A, Kano K, Asada Y, Matsuhashi T, Umeno H, Okami K, Goda K, Hori S, Ono Y, Terai S, Nagami Y, Takemura K, Kawada K, Ando M, Shimeno N, Arai A, Sakamoto Y, Ichinoe M, Nemoto T, Fujita M, Watanabe H, Shimoda T, Ochiai A, Kato T, Hayashi R. Transoral surgery for superficial head and neck cancer: National Multi-Center Survey in Japan. Cancer medicine, 10:3848-3861, 2021

27. Sunakawa H, Yoda Y, Takeshita N, Hasegawa H, Takashima K, Kadota T, Fujita T, Akimoto T, Fujii S, Yano T. Endoscopic resection combined with the Cryoballoon focal ablation system in the porcine normal esophagus: a preclinical study. BMC gastroenterology, 21:234, 2021

28. Yano T, Minamide T, Takashima K, Nakajo K, Kadota T, Yoda Y. Clinical Practice of Photodynamic Therapy Using Talaporfin Sodium for Esophageal Cancer. Journal of clinical medicine, 10:2021

29. Minamide T, Sashiyama H, Muramatsu Y, Yada T, Matsumura T, Takeda S, Suzuki T, Kakimoto T, Yano T, Yoshii K, Arai M, Uemura N, Yamaguchi T, Ikematsu H. Second-generation narrow-band imaging to detect colorectal adenomas: A prospective study including community hospitals. Journal of gastroenterology and hepatology, 36:3084-3091, 2021

30. Sato D, Takamatsu T, Umezawa M, Kitagawa Y, Maeda K, Hosokawa N, Okubo K, Kamimura M, Kadota T, Akimoto T, Kinoshita T, Yano T, Kuwata T, Ikematsu H, Takemura H, Yokota H, Soga K. Author Correction: Distinction of surgically resected gastrointestinal stromal tumor by near-infrared hyperspectral imaging. Scientific reports, 11:19030, 2021

31. Hori K, Ikematsu H, Yamamoto Y, Matsuzaki H, Takeshita N, Shinmura K, Yoda Y, Kiuchi T, Takemoto S, Yokota H, Yano T. Detecting colon polyps in endoscopic images using artificial intelligence constructed with automated collection of annotated images from an endoscopy reporting system. Digestive endoscopy: official journal of the Japan Gastroenterological Endoscopy Society, 2021

32. Morita S, Goda K, Yano T, Kaise M, Kato M, Inoue H, Niwa Y, Kodashima S, Miyahara R, Ochiai A, Ikegami M, Hamatani S, Shimoda T, Ohkura Y, Aida J, Nakanishi Y, Yoshimura K, Ishikawa H, Takubo K, Muto M. Multicenter prospective in vivo study of an endocytoscope system (ECS) for superficial esophageal cancer. Journal of gastroenterology, 56:808-813, 2021

33. Ishikawa H, Mutoh M, Sato Y, Doyama H, Tajika M, Tanaka S, Horimatsu T, Takeuchi Y, Kashida H, Tashiro J, Ezoe Y, Nakajima T, Ikematsu H, Hori S, Suzuki S, Otani T, Takayama T, Ohda Y, Mure K, Wakabayashi K, Sakai T. Chemoprevention with low-dose aspirin, mesalazine, or both in patients with familial adenomatous polyposis without previous colectomy (J-FAPP Study IV): a multicentre, double-blind, randomised, two-by-two factorial design trial. The lancet. Gastroenterology & hepatology, 6:474-481, 2021

34. Noguchi M, Shitara K, Kawazoe A, Yamamoto D, Takii Y, Saito Y, Sato T, Horimatsu T, Ishikawa H, Ito Y, Ito M, Ikematsu H. Short-term safety of adjuvant chemoradiotherapy after local resection for patients with high-risk submucosal invasive rectal cancer: a single-arm, multicenter phase II trial. Japanese journal of clinical oncology, 51:707-712, 2021

35. Abe S, Takizawa K, Oda I, Mizusawa J, Kadota T, Ono H, Hasuike N, Yano T, Yamamoto Y, Horiuchi Y, Nagata S, Yoshikawa T, Terashima M, Muto M. Incidence and treatment outcomes of metachronous gastric cancer occurring after curative endoscopic submucosal dissection of undifferentiated-type early gastric cancer: Japan Clinical Oncology Group study-post hoc analysis of JCOG1009/1010. Gastric cancer: official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 24:1123-1130, 2021

36. Kadota T, Minashi K, Wakabayashi M, Yano T, Ezoe Y, Tsuchida T, Ono H, Iizuka T, Matsuura N, Oda I, Takizawa K, Katayama H, Fukuda H, Muto M. Diagnostic yield of conventional endoscopy with endoscopic ultrasonography for submucosal invasion of superficial esophageal squamous cell carcinoma: a post hoc analysis of multicenter prospective confirmatory study (JCOG0508). Esophagus: official journal of the Japan Esophageal Society, 18:604-611, 2021

37. Nakajo K, Yoda Y, Kadota T, Murano T, Shinmura K, Ikematsu H, Akimoto T, Yano T. Radial incision and cutting for dilation before endoscopic submucosal dissection in patients with esophageal cancer on the distal side of severe benign esophageal strictures. Diseases of the esophagus: official journal of the International Society for Diseases of the Esophagus, 34:2021

38. Ito R, Kadota T, Murano T, Yoda Y, Hori K, Minamide T, Sato D, Yamamoto Y, Takashima K, Shinmura K, Ikematsu H, Yano T. Clinical features and risk factors of gastric cancer detected by esophagogastroduodenoscopy in esophageal cancer patients. Esophagus: official journal of the Japan Esophageal Society, 18:621-628, 2021

39. Takamatsu T, Kitagawa Y, Akimoto K, Iwanami R, Endo Y, Takashima K, Okubo K, Umezawa M, Kuwata T, Sato D, Kadota T, Mitsui T, Ikematsu H, Yokota H, Soga K, Takemura H. Over 1000 nm Near-Infrared Multispectral Imaging System for Laparoscopic In Vivo Imaging. Sensors (Basel, Switzerland), 21:2021