Annual Report 2022
Department of Psycho-Oncology Service
Asao Ogawa, Masanori Enokido, Yusei Iwata, Daisuke Fujisawa
Introduction
The aim of the Department of Psycho-Oncology Service is to develop mind-centered interventions to restore, maintain, and improve the quality of life of patients and their families throughout cancer treatment, including the end-of-life period. Our service has focused on developing effective interventions for delirium, dementia, and depression in cancer patients as well as on determining the mechanism underlying the relationship between cancer and the mind through a combination of neuropsychiatric, psychosocial, and behavioral sciences.
In particular, increases in the number of individuals diagnosed with cancer each year, due in large part to the growth of the aging population, as well as improving survival rates have resulted in an ever-increasing number of elderly cancer patients with deteriorating cognitive functions. Therefore, we conduct research on the development and validation of geriatric assessments such as Mini-Cog and comprehensive geriatric assessment (CGA), etc., and the evaluation of the effectiveness of multidisciplinary interventions among hospitalized cancer patients with delirium or cognitive function disorders, including mild cognitive impairment.
The Team and What We Do
The Department of Psycho-Oncology Service is composed of three attending psychiatrists and three clinical psychologists. The clinical activity includes psychiatric consultation involving comprehensive assessment and addressing the psychiatric problems of cancer patients. Patients are either self-referred or referred by their oncologist in charge. The consultation data are shown in Tables 1 and 2. Psychiatric diagnosis is established based on the DSM-5 (Diagnostic and Statistical Manual of Mental Disorder, 5th edition) criteria. Consultation data also include individuals who are family members of cancer patients.
Table 1. Supportive care team consultation data (n=1,794; April 2022 to March 2023)
Table 2. Psycho-oncology outpatient consultation data (n=715; April 2022 to March 2023)
A conference with the Supportive Care Team is held every Wednesday, and a multicenter joint clinical teleconference involving six cancer center hospitals and three university hospitals is held every Thursday.
Research Activities
1. A multicenter, cluster randomized controlled study comparing usual care and multidisciplinary interventions such as DELirium Team Approach-program (DELTA program) to prevent the development and severity of delirium among hospitalized cancer patients (Research and Development grants for cancer at the Japan Agency for Medical Research and Development)
Delirium, defined as an acute disorder of attention and global cognitive function, is a common, serious, and potentially preventable source of morbidity and mortality in hospitalized elderly individuals. Primary prevention, i.e., preventing delirium before it develops, is the most effective strategy for reducing delirium. We have reported the effectiveness of multidisciplinary intervention to prevent the development and reduce the severity of delirium among hospitalized patients, designed through a multicenter, cluster randomized controlled study.
2. Development of a dementia care support system utilizing artificial intelligence that proposes prevention and early detection of BPSD and appropriate care (Health Labour Sciences Research Grant)
With the growing number of elderly people, the prevalence of dementia with physical and mental conditions in acute care hospitals has increased. The purpose of this study is to disseminate appropriate dementia care in acute care hospitals in Japan through the development of a support system that utilizes artificial intelligence for physical care and dementia care for people with dementia. We have reported the educational effects of dementia care for acute care hospital nurses and plan to evaluate the clinical effects.
3. Multicenter, double-blind, placebo-controlled, randomized controlled study on the efficacy and safety of ramelteon in preventing postoperative delirium in delirium high-risk cancer patients (Research and Development grants for cancer at the Japan Agency for Medical Research and Development) Delirium is common in the elderly and is associated with worsening surgical outcomes, decreased quality of life, and mortality; however, no standard pharmacological preventive measures have been established. We are planning to start a multicenter, double-blind, placebo controlled trial to verify the delirium preventive effect and safety of the melatonin agonist ramelteon in elderly people before cancer surgery.
List of papers published in 2022
Journal
1. Hashimoto S, Kitakata H, Kohsaka S, Fujisawa D, Shiraishi Y, Nakano N, Sekine O, Kishino Y, Katsumata Y, Yuasa S, Fukuda K, Kohno T. Confidence in self-care after heart failure hospitalization. Journal of cardiology, 81:42-48, 2023
2. Kim Y, Ting A, Carver CS, Bahcivan O, Bergerot CD, Csaba D, Estape T, Fujisawa D, Goswami SS, Tak Lam WW, Parvu A, Shim EJ, Serpentini S, Takeuchi E, Wang A. International collaboration for assessing unmet needs of cancer survivors and family caregivers: Lens of healthcare professionals. Psycho-oncology, 32:77-85, 2023
3. Tamura NT, Shikimoto R, Nagashima K, Sato Y, Nakagawa A, Irie S, Iwashita S, Mimura M, Fujisawa D. Group multi-component programme based on cognitive behavioural therapy and positive psychology for family caregivers of people with dementia: a randomised controlled study (3C study). Psychogeriatrics, 23:141-156, 2023
4. Matsumoto Y, Umemura S, Okizaki A, Fujisawa D, Kobayashi N, Tanaka Y, Sasaki C, Shimizu K, Ogawa A, Kinoshita H, Uchitomi Y, Yoshiuchi K, Matsuyama Y, Morita T, Goto K, Ohe Y. Early specialized palliative care for patients with metastatic lung cancer receiving chemotherapy: a feasibility study of a nurse-led screening-triggered programme. Japanese journal of clinical oncology, 52:375-382, 2022
5. Kurisu K, Hashimoto M, Ishizawa T, Shibayama O, Inada S, Fujisawa D, Inoguchi H, Shimoda H, Inoue S, Ogawa A, Akechi T, Shimizu K, Uchitomi Y, Matsuyama Y, Yoshiuchi K. Development of computer adaptive testing for measuring depression in patients with cancer. Scientific reports, 12:8247, 2022
6. Asai M, Matsumoto Y, Miura T, Hasuo H, Maeda I, Ogawa A, Morita T, Uchitomi Y, Kinoshita H. Psychological Distress among Caregivers for Patients Who Die of Cancer: A Preliminary Study in Japan. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 89:428-435, 2022
7. Usui Y, Kosugi K, Nishiguchi Y, Miura T, Fujisawa D, Uehara Y, Kawaguchi T, Izumi K, Takehana J, Matsumoto Y. Parenting experiences of cancer patients with minor children and their conversations about the possibility of death: a cross-sectional web-based survey for an online cancer community. Supportive care in cancer, 30:7715-7720, 2022
8. Yokomichi N, Maeda I, Morita T, Yoshiuchi K, Ogawa A, Hisanaga T, Sakashita A, Nakahara R, Kaneishi K, Iwase S. Association of Antipsychotic Dose With Survival of Advanced Cancer Patients With Delirium. Journal of pain and symptom management, 64:28-36, 2022
9. Sakata N, Okumura Y, Ogawa A. Postoperative Pain Treatment in Patients with Dementia: A Retrospective Observational Study. Drugs & aging, 39:305-311, 2022
10. Hirooka K, Okumura Y, Matsumoto S, Fukahori H, Ogawa A. Quality of End-of-Life in Cancer Patients With Dementia: Using A Nationwide Inpatient Database. Journal of pain and symptom management, 64:1-7, 2022
11. Silbermann M, Calimag MM, Eisenberg E, Futerman B, Fernandez-Ortega P, Oliver A, Yaeger Monje JP, Guo P, Charalambous H, Nestoros S, Pozo X, Bhattacharyya G, Katz GJ, Tralongo P, Fujisawa D, Kunirova G, Punjwani R, Ayyash H, Ghrayeb I, Manasrah N, Bautista MJS, Kotinska-Lemieszek A, de Simone G, Cerutti J, Gafer N, Can G, Terzioglu F, Kebudi R, Tuncel-Oguz G, Aydin A, Ozalp Şenel G, Mwaka AD, Youssef A, Brant J, Alvarez GP, Weru J, Rudilla D, Fahmi R, Hablas M, Rassouli M, Mula-Hussain L, Faraj S, Al-Hadad S, Al-Jadiry M, Ghali H, Fadhil SA, Abu-Sharour L, Omran S, Al-Qadire M, Hassan A, Khader K, Alalfi N, Ahmed G, Galiana L, Sansó N, Abe A, Vidal-Blanco G, Rochina A. Evaluating Pain Management Practices for Cancer Patients among Health Professionals: A Global Survey. Journal of palliative medicine, 25:1243-1248, 2022
12. Inoue S, Maeda I, Ogawa A, Yoshiuchi K, Terada S, Yamada N. Safety and Effectiveness of Perospirone in Comparison to Risperidone for Treatment of Delirium in Patients with Advanced Cancer: A Multicenter Prospective Observational Study in Real-World Psycho-Oncology Settings. Acta medica Okayama, 76:195-202, 2022
13. Kurisu K, Inada S, Maeda I, Ogawa A, Iwase S, Akechi T, Morita T, Oyamada S, Yamaguchi T, Imai K, Nakahara R, Kaneishi K, Nakajima N, Sumitani M, Yoshiuchi K. A decision tree prediction model for a short-term outcome of delirium in patients with advanced cancer receiving pharmacological interventions: A secondary analysis of a multicenter and prospective observational study (Phase-R). Palliative & supportive care, 20:153-158, 2022
14. Sugiura K, Kohno T, Hayashida K, Fujisawa D, Kitakata H, Nakano N, Saito T, Hase H, Yoshijima N, Tsuruta H, Itabashi Y, Kohsaka S, Fukuda K. Elderly aortic stenosis patients’ perspectives on treatment goals in transcatheter aortic valvular replacement. ESC heart failure, 9:2695-2702, 2022
15. Tanaka C, Wakaizumi K, Takaoka S, Matsudaira K, Mimura M, Fujisawa D, Kosugi S. A Cross-Sectional Study of the Impact of Pain Severity on Absenteeism and Presenteeism Among Japanese Full-Time Workers. Pain and therapy, 11:1179-1193, 2022
16. Shinohara Y, Wakaizumi K, Ishikawa A, Ito M, Hoshino R, Tanaka C, Takaoka S, Kawakami M, Tsuji O, Fujisawa D, Fujiwara T, Tsuji T, Morisaki H, Kosugi S. Improvement in Disability Mediates the Effect of Self-Efficacy on Pain Relief in Chronic Low Back Pain Patients with Exercise Therapy. Pain research & management, 2022:4203138, 2022
17. Kitakata H, Kohno T, Kohsaka S, Fujisawa D, Nakano N, Sekine O, Shiraishi Y, Kishino Y, Katsumata Y, Yuasa S, Fukuda K. Social Isolation and Implementation of Advanced Care Planning Among Hospitalized Patients With Heart Failure. Journal of the American Heart Association, 11:e026645, 2022
18. Kawano S, Ide K, Kodama K, Kikuchi Y, Sugihara H, Fujisawa D, Uchida H, Mimura M, Takeuchi H. Trazodone and Mianserin for Delirium: A Retrospective Chart Review. Journal of clinical psychopharmacology, 42:560-564, 2022
19. Kameyama N, Sato T, Arai D, Fujisawa D, Takeuchi M, Nakachi I, Kawada I, Yasuda H, Ikemura S, Terai H, Nukaga S, Nakano Y, Hirano T, Minematsu N, Asakura T, Kamatani T, Tanaka K, Suzuki S, Miyawaki M, Naoki K, Fukunaga K, Soejima K. Most Important Things and Associated Factors With Prioritizing Daily Life in Patients With Advanced Lung Cancer. JCO oncology practice, 18:e1977-e1986, 2022
20. Abe H, Inoue R, Tsuchida R, Ando M, Saita K, Konishi M, Edamura T, Ogawa A, Matsuoka Y, Sumitani M. Efficacy of treatments for pain and numbness in cancer survivors: a systematic review and meta-analysis. Annals of palliative medicine, 11:3674-3696, 2022
21. Koda R, Fujisawa D, Kawaguchi M, Kasai H. Experience of application of the meaning-centered psychotherapy to Japanese bereaved family of patients with cancer - A mixed-method study. Palliative & supportive care, 1-9, 2022
22. Uneno Y, Kotera Y, Fujisawa D, Kataoka Y, Kosugi K, Murata N, Kessoku T, Ozaki A, Miyatake H, Muto M. Development of a novel COMPAssion focused online psyChoTherapy for bereaved informal caregivers: the COMPACT feasibility trial protocol. BMJ open, 12:e067187, 2022