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Annual Report 2022

Department of Palliative Medicine

Eriko Satomi, Koji Amano, Hiroto Ishiki, Sayaka Arakawa, Akiko Abe, Ayaka Ishikawa, Yuka Suzuki, Rebekah Kojima

Introduction

 The palliative care service started with a palliative care team of multidisciplinary professionals (palliative care specialists, psycho-oncologists, certified nurses, pharmacists, psychologists, hospital play staff, acupuncturists) in the National Cancer Center Hospital (NCCH) in 1999 and the Department of Palliative Care and Psycho-Oncology was established in 2010 with the reorganization of the NCCH. In 2013, the Department of Palliative Medicine started.

The Team and What We Do

 We provide palliative care to patients and their families as members of the palliative care team collaborating with primary doctors, nurses, and other professionals to create an individualized palliative care plan. Our goals are:

- Relieve pain and other physical symptoms

- Focus on patients’ emotional and spiritual concerns, and those of their caregivers

- Coordinate patients’ care

- Improve the quality of life of patients with cancer

- Advance care planning

 Patient demography in the outpatient clinic and palliative care team (Table 1)

Table 1. Number of patients
Table 1. Number of patients

Table 1. Number of patients
Table 1. Number of patients

Research Activities

 We are participating in and conducting multicenter observational studies and interventional studies for supportive and palliative care, and continuously planning palliative care research for the innovation of palliative care.

Clinical Trials

 EASED (East-Asian collaborative Study to Elucidate the Dying process), JORTC-PAL16 (A Phase III, international, multi-center, double-blind, dose increment, parallel-arm, randomized controlled trial of duloxetine versus pregabalin over 14 days for opioid unresponsive cancer- related neuropathic pain), EORTC-QOL study (EORTC PATSAT-C33, EORTC OUT-PATSAT7, EORTC COMU26, Development of a module to supplement the EORTC Core instruments for assessment of Health Related Quality of Life in patients with Metastatic Breast Cancer (Phase I-III)), Development of measurement of eating-related distress, ACT-1 (Phase II study of the efficacy and safety of acupuncture for CIPN), PAL20 (Exploratory trial of preventive Olanzapine for opioid induced nausea and vomiting) etc.

Education

 We have two training courses for doctors who will be palliative care specialists and for residents to learn primary palliative care. One resident took training course of specialized palliative medicine. All the medical oncology residents in the NCCH need to acquire knowledge and skills in primary supportive and palliative care in oncology. They participate in our team for four weeks and undergo on-the-job training for palliative medicine. A total of 22 residents finished the four-week palliative medicine course in 2022. They learned specialist palliative care in oncology including physical, psychosocial, and spiritual supportive care during anti-cancer therapy as well as end-of-life care, and support for patients’ decision making and advance care planning.

Future Prospects

 We will continue to provide qualified palliative cancer care with an integrated palliative care model in clinical practice throughout the continuum of a person’s disease, regardless of whether it is early or later in its course. In addition, we will enhance our palliative care education program for specialists and oncologists. We will also continuously conduct high-level palliative care research in order to strengthen evidence to improve palliative care practice.

List of papers published in 2022

Journal

1. Ishiki H, Kikawa Y, Terada M, Mizusawa J, Honda M, Iwatani T, Mizutani T, Mori K, Nakamura N, Miyaji T, Yamaguchi T, Ando M, Nakamura K, Fukuda H, Kiyota N. Patient-reported outcome and quality of life research policy: Japan Clinical Oncology Group (JCOG) policy. Japanese journal of clinical oncology, 53:195-202, 2023

2. Mori M, Yamaguchi T, Suzuki K, Matsuda Y, Matsunuma R, Watanabe H, Ikari T, Matsumoto Y, Imai K, Yokomichi N, Miwa S, Yamauchi T, Okamoto S, Inoue S, Inoue A, Morita T, Satomi E. The feasibility and effects of a pharmacological treatment algorithm for cancer patients with terminal dyspnea: A multicenter cohort study. Cancer medicine, 12:5397-5408, 2023

3. Amano K, Morita T, Miura T, Mori N, Tatara R, Kessoku T, Matsuda Y, Tagami K, Otani H, Mori M, Taniyama T, Nakajima N, Nakanishi E, Kako J, Ishiki H, Matsuoka H, Satomi E, Hopkinson JB, Baracos VE, Miyashita M. Development and validation of questionnaires for eating-related distress among advanced cancer patients and families. Journal of cachexia, sarcopenia and muscle, 14:310-325, 2023

4. Amano K, Bruera E, Hui D. Diagnostic and prognostic utility of phase angle in patients with cancer. Reviews in endocrine & metabolic disorders, 24:479-489, 2023

5. Watanabe A, Shimada N, Ishiki H, Fujiwara N, Nojima M, Tojo A. Differences in Fentanyl Requirements in Terminally Ill Cancer Patients. Journal of pain & palliative care pharmacotherapy, 37:26-33, 2023

6. Toda Y, Ishiki H, Machida T, Kawasaki N, Kobayashi E. Pain, Analgesic Use, and Patient Satisfaction With Spinal Versus General Anesthesia for Hip Fracture Surgery. Annals of internal medicine, 176:eL220366, 2023

7. Koshimoto S, Amano K, Mori N, Oyamada S, Arakawa S, Ishiki H, Satomi E, Morita T, Takeuchi T. Perspectives of registered dietitians and factors associated with their personal accomplishment in the management of cancer cachexia. Supportive care in cancer, 31:124, 2023

8. Imai K, Morita T, Mori M, Kiuchi D, Yokomichi N, Miwa S, Okamoto S, Yamauchi T, Naito AS, Matsuda Y, Maeda I, Sugano K, Ikenaga M, Inoue S, Satomi E. Visualizing How to Use Antipsychotics for Agitated Delirium in the Last Days of Life. Journal of pain and symptom management, 65:479-489, 2023

9. Hiroyuki Otani, Amano K, Morita T, Miura T, Mori N, Tatara R, Kessoku T, Matsuda Y, Tagami K, Mori M, Taniyama T, Nakajima N, Nakanishi E, Kako J, Shirado AN, Yokomichi N, Miyashita M. Impact of taste/smell disturbances on dietary intakes and cachexia-related quality of life in patients with advanced cancer. Supportive care in cancer, 31:141, 2023

10. De Feo G, Case AA, Crawford GB, Hui D, To J, Sbrana A, Alderman B, Mukhopadhyay S, Bouleuc C, Amano K, Tanco K, Garsed J, Davis M. Multinational Association of Supportive Care in Cancer (MASCC) guidelines: cannabis for psychological symptoms including insomnia, anxiety, and depression. Supportive care in cancer, 31:176, 2023

11. To J, Davis M, Sbrana A, Alderman B, Hui D, Mukhopadhyay S, Bouleuc C, Case AA, Amano K, Crawford GB, de Feo G, Tanco K, Garsed J. MASCC guideline: cannabis for cancer-related pain and risk of harms and adverse events. Supportive care in cancer, 31:202, 2023

12. Masuda K, Ishiki H, Yokomichi N, Yamaguchi T, Ito T, Takatsu H, Amano K, Hiramoto S, Yamauchi T, Kawaguchi T, Mori M, Matsuda Y, Yamaguchi T. Effect of paracentesis on the survival of patients with terminal cancer and ascites: a propensity score-weighted analysis of the East Asian Collaborative Cross-cultural Study to Elucidate the Dying Process. Supportive care in cancer, 30:6233-6241, 2022

13. Hirayama T, Kojima R, Udagawa R, Yanai Y, Ogawa Y, Shindo A, Tanaka M, Kobayashi M, Ishiki H, Satomi E. A Questionnaire Survey on Adolescent and Young Adult Hiroba, a Peer Support System for Adolescent and Young Adult Cancer Patients at a Designated Cancer Center in Japan. Journal of adolescent and young adult oncology, 11:309-315, 2022

14. Kaku S, Miyata K, Tsuchiya M, Kusaka S, Koitabashi M, Moroi N, Shimizu R, Shimizu M, Arai M, Yabumoto M, Matsunaga N, Maeda R, Iwasa S, Horinouchi H, Satomi E. [Investigation the contents of employment consultation and support in a cancer center hospital]. Sangyo eiseigaku zasshi = Journal of occupational health, 64:337-344, 2022

15. Ishiki H, Hasuo H, Matsuda Y, Matsuoka H, Hiramoto S, Higuchi M, Yoshida K, Tokoro A, Hatano Y, Hori T, Kinkawa J, Nojima M. Prevalence of Myofascial Pain Syndrome and Efficacy of Trigger Point Injection in Patients with Incurable Cancer: A Multicenter, Prospective Observational Study (MyCar Study). Pain medicine (Malden, Mass.), 23:1259-1265, 2022

16. Amano K, Hopkinson J, Baracos V. Psychological symptoms of illness and emotional distress in advanced cancer cachexia. Current opinion in clinical nutrition and metabolic care, 25:167-172, 2022

17. Hirayama T, Kojima R, Udagawa R, Yanai Y, Ogawa Y, Tanaka M, Kayano A, Mashiko Y, Ogata K, Ishiki H, Satomi E. A Hospital-Based Online Patients Support Program, Online Adolescent and Young Adult Hiroba, for Adolescent and Young Adult Cancer Patients at a Designated Cancer Center in Japan. Journal of adolescent and young adult oncology, 11:588-595, 2022

18. Hatano Y, Morita T, Mori M, Aoyama M, Yoshida S, Amano K, Terabayashi T, Oya K, Tsukuura H, Hiratsuka Y, Maeda I, Kizawa Y, Tsuneto S, Shima Y, Masukawa K, Miyashita M. Association between experiences of advanced cancer patients at the end of life and depression in their bereaved caregivers. Psycho-oncology, 31:1243-1252, 2022

19. Kako J, Kobayashi M, Kajiwara K, Kimura Y, Oosono Y, Takegata M, Nakano K, Matsuda Y, Nakamura N, Kawashima N, Hirano Y, Kitae M, Yamaguchi K, Iwamoto H, Hattori N, Sawatari H, Shiono S, Ogino H, Nishioka Y, Amano K, Yorke J. Validity and Reliability of the Japanese Version of the Dyspnea-12 Questionnaire in Patients With Lung Cancer. Journal of pain and symptom management, 64:e83-e89, 2022

20. Ozaki A, Kessoku T, Tanaka K, Yamamoto A, Takahashi K, Takeda Y, Kasai Y, Iwaki M, Kobayashi T, Yoshihara T, Kato T, Suzuki A, Honda Y, Ogawa Y, Fuyuki A, Imajo K, Higurashi T, Yoneda M, Taguri M, Ishiki H, Kobayashi N, Saito S, Ichikawa Y, Nakajima A. Effectiveness of Naldemedine Compared with Magnesium Oxide in Preventing Opioid-Induced Constipation: A Randomized Controlled Trial. Cancers, 14:2112, 2022

21. Kubo E, Ishiki H, Abe K, Kaku S, Yokota S, Arakawa S, Kiuchi D, Amano K, Satomi E. Clinical role and safety of tapentadol in patients with cancer: A single-center experience. Journal of opioid management, 18:273-280, 2022

22. Hatano Y, Mori M, Izumi H, Amano K, Ito T, Nozato J, Kaneishi K, Kawamura T, Morita T. End-of-life experiences in advanced cancer: gender differences. BMJ supportive & palliative care, bmjspcare-2022-003761, 2022

23. Yokota T, Ueno T, Soga Y, Ishiki H, Uezono Y, Mori T, Zenda S, Uchitomi Y. J-SUPPORT research policy for oral mucositis associated with cancer treatment. Cancer medicine, 11:4816-4829, 2022

24. Hiratsuka Y, Suh SY, Hui D, Morita T, Mori M, Oyamada S, Amano K, Imai K, Baba M, Kohara H, Hisanaga T, Maeda I, Hamano J, Inoue A. Are Prognostic Scores Better Than Clinician Judgment? A Prospective Study Using Three Models. Journal of pain and symptom management, 64:391-399, 2022

25. Abe A, Takeda Y, Ishiki H. Sublingual Dexmedetomidine vs Placebo and Acute Agitation Associated With Bipolar Disorder. JAMA, 328:213, 2022

26. Hirayama T, Fujimori M, Yanai Y, Ishiki H, Shindo A, Tanaka M, Kobayashi T, Kojima R, Satomi E. Development and evaluation of the feasibility, validity, and reliability of a screening tool for determining distress and supportive care needs of adolescents and young adults with cancer in Japan. Palliative & supportive care, 1-11, 2022

27. Abe A, Amano K, Morita T, Miura T, Mori N, Tatara R, Kessoku T, Matsuda Y, Tagami K, Otani H, Mori M, Taniyama T, Nakajima N, Nakanishi E, Kako J, Kiuchi D, Ishiki H, Matsuoka H, Satomi E, Miyashita M. Beliefs and Perceptions About Parenteral Nutrition and Hydration by Advanced Cancer Patients. Palliative medicine reports, 3:132-139, 2022

28. Ikari T, Hiratsuka Y, Cheng SY, Miyashita M, Morita T, Mori M, Uneno Y, Amano K, Uehara Y, Yamaguchi T, Maeda I, Inoue A. Factors associated with good death of patients with advanced cancer: a prospective study in Japan. Supportive care in cancer, 30:9577-9586, 2022

29. Uehara Y, Matsumoto Y, Kosugi T, Sone M, Nakamura N, Mizushima A, Miyashita M, Morita T, Yamaguchi T, Satomi E. Availability of and factors related to interventional procedures for refractory pain in patients with cancer: a nationwide survey. BMC palliative care, 21:166, 2022

30. Suzuki K, Morita T, Mori M, Azuma Y, Funaki H, Amano K, Imai K, Tanaka K, Kizawa Y, Tsuneto S, Shima Y, Masukawa K, Miyashita M. Comparative study of clinicians’ and family members’ perceptions of patients’ end-of-life experiences. BMJ supportive & palliative care, spcare-2022-003883, 2022

31. Nishimura R, Ishiki H, Sato J, Satomi E. Dexamethasone for cancer-related dyspnoea. The Lancet. Oncology, 23:e525, 2022

32. Alderman B, Hui D, Mukhopadhyay S, Bouleuc C, Case AA, Amano K, Crawford GB, de Feo G, Sbrana A, Tanco K, To J, Garsed J, Davis M. Multinational Association of Supportive Care in Cancer (MASCC) expert opinion/consensus guidance on the use of cannabinoids for gastrointestinal symptoms in patients with cancer. Supportive care in cancer, 31:39, 2022

33. Amano K, Koshimoto S, Hopkinson JB, Baracos VE, Mori N, Morita T, Oyamada S, Ishiki H, Satomi E, Takeuchi T. Perspectives of Health Care Professionals on Multimodal Interventions for Cancer Cachexia. Palliative medicine reports, 3:244-254, 2022