Annual Report 2022

Innovation Center for Supportive, Palliative and Psychosocial Care

Yosuke Uchitomi, Maiko Fujimori, Sadamoto Zenda, Eriko Satomi, Hiromichi Matsuoka, Tempei Miyaji, Takuhiro Yamaguchi, Hiromi Hasegawa, Miyuki Kurosaki, Tomoe Mashiko, Naho Noguchi

Introduction

 The Japan Supportive, Palliative, and Psychosocial Oncology Group (J-SUPPORT) was established in February 2016 as an organization with a hub to promote and support multicenter collaborative clinical trials on palliative, supportive, and psychosocial care, that is, an area of high unmet need (Figure 1).

The Team and What We Do

 J-SUPPORT has established a Stakeholder Coordination Center (SCC) to promote patient-public involvement (PPI) in the area of palliative and supportive care research. This collaborative effort involves the PPI Committee of the National Federation of Cancer Patient Organizations (ZENGANREN), and PPI has been incorporated into the review board for all approved research. By FY2022, PPI was included in seven out of the 19 approved proposals from the research plan formulation stage. We hold review meetings to discuss the selection of new research topics, and opinions are continuously exchanged. In FY2022, a report on J-SUPPORT-approved research and a report on the Survivorship Needs Survey by ZENGANREN were presented. A patient representative and a representative of the Japan Agency for Medical Research and Development (AMED) were invited to discuss the theme, "Development of Supportive, Palliative, and Psychological Care with Patients and the Public."

 During FY2022, 18 new research consultations were initiated, and 44 studies, including continuing studies, were supported. One new intervention study was also approved as a clinical study. The total number of approved studies was 19, with seven* completed, three in preparation for paper submission, four in tracking case completion, four in enrollment in progress, and one in preparation (Table 1). In FY2022, 909 cases were registered. Regarding completed studies, J-SUPPORT1703's result paper was published in FY2022, and J-SUPPORT1902 received Japanese Journal of Clinical Oncology Highly Commended Paper Award 2022.

 As part of the development of the Supportive and Palliative Care Research Policy, the Clinical Outcome Assessments (COA) Working Group translated the ISPOR Task Force Report "Clinical Outcome Assessments: Conceptual Foundations- ISPOR Clinical Outcome Assessments Report New Standards of Practice for Outcomes Research Task Force." This translated report was published on a special page related to Patient-Reported Outcome (PRO) assessments by the publisher of Pharmacology and Therapeutics (JPT).

 *J-SUPPORT1601, 1603, 1703, 1704, 2001, 2101, 2104

Table 1. List of Research Projects (2016 - 2023.3)

Education

 The National Cancer Center - Community Health Research Network (N-COMMUNITY) was improved to allow mutual support of research and educational resources through collaboration with other research support organizations. An 11-organization collaborative system was established, with four new organizations added to the network.

 Ten "Behavioral Science Seminars" were held jointly with the Support and Survivorship Research Group of the National Cancer Center Institution for Cancer Control and the Faculty of Human Sciences of Waseda University, and co-sponsored by J-SUPPORT, National Center Consortium in Implementation Science for Health Equity (N-EQUITY) and The Research Association for Dissemination and Implementation Science in Health (RADISH).

 Ten "Implementation Science Seminars" were held jointly with the Support and Survivorship Research Group of the National Cancer Center Institution for Cancer Control and N-EQUITY, and co-sponsored by RADISH, J-SUPPORT, and the Faculty of Human Sciences of Waseda University.

Future Prospects

 The J-SUPPORT will make effort sustainably to support the clinical trials and studies for cancer supportive, palliative, and psychosocial care, as well as PPI.

Organized Conferences and Symposiums

Organizer: J-SUPPORT

Conference Title: The 4th J-SUPPORT Research Results Report Meeting

Theme: J-SUPPORT with patients and citizens ~Toward the development of supportive, palliative, and psychological care

Date: Sunday, November 13, 2022

Venue (prefecture): Online

List of papers published in 2022

Journal

1. Hirayama T, Fujimori M, Ito Y, Ishida Y, Tsumura A, Ozawa M, Maeda N, Yamamoto K, Takita S, Mori M, Tanaka K, Horibe K, Akechi T. Feasibility and preliminary effectiveness of a psychosocial support program for adolescent and young adult cancer patients in clinical practice: a retrospective observational study. Supportive care in cancer, 31:146, 2023

2. Zenda S, Arai Y, Sugawara S, Inaba Y, Hashimoto K, Yamamoto K, Saigusa Y, Kawaguchi T, Shimada S, Yokoyama M, Miyaji T, Okano T, Nakamura N, Kobayashi E, Takagi T, Matsumoto Y, Uchitomi Y, Sone M. Protocol for a confirmatory trial of the effectiveness and safety of palliative arterial embolization for painful bone metastases. BMC cancer, 23:109, 2023

3. Okamura M, Fujimori M, Goto S, Obama K, Kadowaki M, Sato A, Hirayama T, Uchitomi Y. Prevalence and associated factors of psychological distress among young adult cancer patients in Japan. Palliative & supportive care, 21:93-99, 2023

4. Kurisu K, Fujimori M, Harashima S, Akechi T, Matsuda T, Saika K, Yoshiuchi K, Miyashiro I, Uchitomi Y. Suicide, other externally caused injuries, and cardiovascular disease within 2 years after cancer diagnosis: A nationwide population-based study in Japan (J-SUPPORT 1902). Cancer medicine, 12:3442-3451, 2023

5. Akechi T, Yamaguchi T, Uchida M, Imai F, Momino K, Katsuki F, Sakurai N, Miyaji T, Mashiko T, Horikoshi M, Furukawa TA, Yoshimura A, Ohno S, Uehiro N, Higaki K, Hasegawa Y, Akahane K, Uchitomi Y, Iwata H. Smartphone Psychotherapy Reduces Fear of Cancer Recurrence Among Breast Cancer Survivors: A Fully Decentralized Randomized Controlled Clinical Trial (J-SUPPORT 1703 Study). Journal of clinical oncology, 41:1069-1078, 2023

6. Matsuoka A, Shimazu T, Takahashi M, Nagashima F, Nishiyama H, Fujimori M, Ando Y. A nationwide, cross-sectional, web-based survey on healthcare providers’ knowledge about, attitudes toward, and perceived barriers to adherence to clinical practice guidelines for anticancer drug therapy for older patients with cancer in Japan. Journal of geriatric oncology, 14:101399, 2023

7. Okamura M, Fujimori M, Goto S, Ohisa K, Boku N, Nakahara R, Uchitomi Y, Suzuki T, Matsuda T. Psychological distress among healthcare providers in oncology during the COVID-19 pandemic in Japan: The mediating role of moral distress and resilience. Frontiers in psychology, 14:1105800, 2023

8. Mitsutake S, Takahashi Y, Otsuki A, Umezawa J, Yaguchi-Saito A, Saito J, Fujimori M, Shimazu T. Chronic Diseases and Sociodemographic Characteristics Associated With Online Health Information Seeking and Using Social Networking Sites: Nationally Representative Cross-sectional Survey in Japan. Journal of medical Internet research, 25:e44741, 2023

9. Okusaka T, Nakamura M, Yoshida M, Kitano M, Ito Y, Mizuno N, Hanada K, Ozaka M, Morizane C, Takeyama Y. Clinical Practice Guidelines for Pancreatic Cancer 2022 from the Japan Pancreas Society: a synopsis. International journal of clinical oncology, 28:493-511, 2023

10. Okamura M, Fujimori M, Saito E, Osugi Y, Akizuki N, Uchitomi Y. Development of an Online Communication Skills Training Program for Oncologists Working with Adolescents and Young Adults. Journal of adolescent and young adult oncology, 12:433-439, 2023

11. Obama K, Fujimori M, Okamura M, Kadowaki M, Ueno T, Boku N, Mori M, Akechi T, Yamaguchi T, Oyamada S, Okizaki A, Miyaji T, Sakurai N, Uchitomi Y. Effectiveness of a facilitation programme using a mobile application for initiating advance care planning discussions between patients with advanced cancer and healthcare providers: protocol for a randomised controlled trial (J-SUPPORT 2104). BMJ open, 13:e069557, 2023

12. Sadahiro R, Wada S, Matsuoka YJ, Uchitomi Y, Yamaguchi T, Sato T, Esaki M, Yoshimoto S, Daiko H, Kanemitsu Y, Kawai A, Kato T, Fujimoto H, Uezono Y, Shimizu K, Matsuoka H. Prevention of delirium with agitation by yokukansan in older adults after cancer surgery. Japanese journal of clinical oncology, 52:1276-1281, 2022

13. Matsuoka A, Fujimori M, Narikazu B, Takashima A, Okusaka T, Mori K, Akechi T, Shimazu T, Okizaki A, Miyaji T, Majima Y, Nagashima F, Uchitomi Y. Geriatric assessment and management with question prompt list using a web-based application for elderly patients with cancer (MAPLE) to communicate ageing-related concerns: J-SUPPORT 2101 study protocol for a multicentre, parallel group, randomised controlled trial. BMJ open, 12:e063445, 2022

14. Sato A, Fujimori M, Shirai Y, Umezawa S, Mori M, Jinno S, Umehashi M, Okamura M, Okusaka T, Majima Y, Miyake S, Uchitomi Y. Assessing the need for a question prompt list that encourages end-of-life discussions between patients with advanced cancer and their physicians: A focus group interview study. Palliative & supportive care, 20:564-569, 2022

15. Yokota T, Ueno T, Soga Y, Ishiki H, Uezono Y, Mori T, Zenda S, Uchitomi Y. J-SUPPORT research policy for oral mucositis associated with cancer treatment. Cancer medicine, 11:4816-4829, 2022

16. Hirayama T, Fujimori M, Yanai Y, Ishiki H, Shindo A, Tanaka M, Kobayashi T, Kojima R, Satomi E. Development and evaluation of the feasibility, validity, and reliability of a screening tool for determining distress and supportive care needs of adolescents and young adults with cancer in Japan. Palliative & supportive care, 1-11, 2022

17. Okamura M, Fujimori M, Hata K, Mori M, Mack JW, Prigerson HG, Uchitomi Y. Validity and reliability of the Japanese version of the Peace, Equanimity, and Acceptance in the Cancer Experience (PEACE) questionnaire. Palliative & supportive care, 20:549-555, 2022

18. Matsuoka A, Fujimori M. Interpretation of the Efficacy of Multidisciplinary Geriatric Assessment Intervention on Chemotherapy-Related Toxic Effects in Older Adults With Cancer. JAMA oncology, 8:1, 2022

19. Kurisu K, Hashimoto M, Ishizawa T, Shibayama O, Inada S, Fujisawa D, Inoguchi H, Shimoda H, Inoue S, Ogawa A, Akechi T, Shimizu K, Uchitomi Y, Matsuyama Y, Yoshiuchi K. Development of computer adaptive testing for measuring depression in patients with cancer. Scientific reports, 12:8247, 2022

20. Yaguchi-Saito A, Kaji Y, Matsuoka A, Okuyama A, Fujimori M, Saito J, Odawara M, Otsuki A, Uchitomi Y, Zenda S, Shimazu T. Factors affecting the implementation of guideline-based prophylactic antiemetic therapy for chemotherapy-induced nausea and vomiting in Japan: a protocol for a hospital-based qualitative study. BMJ open, 12:e055473, 2022

21. Yamada Y, Fujiwara M, Shimazu T, Etoh T, Kodama M, So R, Matsushita T, Yoshimura Y, Horii S, Fujimori M, Takahashi H, Nakaya N, Miyaji T, Hinotsu S, Harada K, Okada H, Uchitomi Y, Yamada N, Inagaki M. Patients’ acceptability and implementation outcomes of a case management approach to encourage participation in colorectal cancer screening for people with schizophrenia: a qualitative secondary analysis of a mixed-method randomised clinical trial. BMJ open, 12:e060621, 2022

22. Yamada Y, Fujiwara M, Etoh T, Wada R, Inoue S, Kodama M, Yoshimura Y, Horii S, Matsushita T, Fujimori M, Shimazu T, Nakaya N, Hinotsu S, Tabata M, Tamura K, Uchitomi Y, Yamada N, Inagaki M. Issues of cancer care in people with mental disorders as perceived by cancer care providers: A quantitative questionnaire survey. Psycho-oncology, 31:1572-1580, 2022

23. Asai M, Matsumoto Y, Miura T, Hasuo H, Maeda I, Ogawa A, Morita T, Uchitomi Y, Kinoshita H. Psychological Distress among Caregivers for Patients Who Die of Cancer: A Preliminary Study in Japan. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 89:428-435, 2022

24. Maeda O, Matsuoka A, Yanagawa M, Muroyama Y, Watanabe K, Liang Y, Ishikawa T, Ohno E, Kawashima H, Umegaki H, Kuzuya M, Ando Y. Selection of chemotherapy for older patients with pancreatic cancer based on geriatric assessment. Journal of geriatric oncology, 13:1260-1263, 2022

25. Fang JT, Chen SY, Yang LY, Liao KC, Lin CH, Fujimori M, Tang WR. Improving transitional care through online communication skills training. Aging clinical and experimental research, 34:3063-3071, 2022

26. Odawara M, Saito J, Yaguchi-Saito A, Fujimori M, Uchitomi Y, Shimazu T. Using implementation mapping to develop strategies for preventing non-communicable diseases in Japanese small- and medium-sized enterprises. Frontiers in public health, 10:873769, 2022

27. Yoshida S, Shimizu K, Matsui M, Fujimori M, Uchitomi Y, Horibe K. Preferred Communication with Adolescent and Young Adult Patients Receiving Bad News About Cancer. Journal of adolescent and young adult oncology, 2022

Book

1. Fujisawa D, Akechi T, Uchitomi Y. Depressive Disorders. In: Kissane D, Watson M, Breitbart W (ed), Psycho-Oncology in palliative and wend of Life Care, UK, Oxford Academic, pp 70-93, 2022