Annual Report 2022

Division of Screening Technology

Nozomu Kobayashi, Masau Sekiguchi,
Special research assistants: Noriko Abeshima, Orie Kitamura, Mio Shimamura, Ayami Haneda, Mika Mori

Introduction

 The Division of Screening Technology works as a part of the Group for Prevention and Screening Research in the Institute for Cancer Control. The Division of Screening Technology consists of two staff medical doctors and five special research assistants.

The Team and What We Do

 The Division of Screening Technology aims to develop new diagnostic techniques that can be applied to cancer screening, as well as researching existing diagnostic methods that can be applied to medical examinations. We are also assessing a new close examination method in cancer screening. In addition, we also work on research aimed at risk stratification of people to be screened.

Research Activities

 1) Examinations are ongoing for the cancer detection rate of each screening modality (e.g. chest CT, upper/lower GI endoscopy, MMG/tomosynthesis and breast ultrasonography, FDG-PETCT/MRI, and CT colonography), the characteristics of the detected cancer, and the false positive rate for all individuals who underwent cancer screening from the establishment of our center in 2004. In addition, we aim to clarify the relationship between cancer screening and cancer death from long-term (prognosis survey) results. Moreover, the following research is ongoing: 2) Field construction for verification of diagnostic tools for colorectal cancer and precancerous lesions using biomarkers (Oshima Study), 3) Japan Polyp Study: multicenter prospective cohort study to elucidate the preventive effect of colorectal cancer caused by polypectomy, 4) Study on the establishment and effectiveness assessment of screening model using colonoscopy (Aomori Project), 5) Prospective multicenter study to evaluate the prevalence of sessile serrated lesions in Japan, and 6) Prospective multicenter study to evaluate the relationship between the background of detection and clinicopathological features of colorectal cancer. Furthermore, the amino index (AICS) study has received plasma samples from 8,111 screening individuals, and comprehensive amino acid analysis has been completed. Now, the analysis data will be collated with clinical data.

 Other research: We are collaborating with external researchers using 1,325 stool samples collected from the Oshima Study. (Research on colibactin-producing bacteria as fecal biomarkers, bacteria and bacterial flora as fecal biomarkers and their functions).

Future Prospects

 We will promote screening development research to create gather evidences.

List of papers published in 2022

Journal

1. Seki K, Sakamoto T, Makiguchi ME, Toyoshima N, Takamaru H, Sekiguchi M, Yamada M, Sekine S, Kanemitsu Y, Saito Y. Unexpected adhesive bowel obstruction after endoscopic submucosal dissection of early sigmoid colon cancer. DEN open, 3:e194, 2023

2. Suzuki H, Ono H, Hirasawa T, Takeuchi Y, Ishido K, Hoteya S, Yano T, Tanaka S, Toya Y, Nakagawa M, Toyonaga T, Takemura K, Hirasawa K, Matsuda M, Yamamoto H, Tsuji Y, Hashimoto S, Yuki M, Oyama T, Takenaka R, Yamamoto Y, Naito Y, Yamamoto K, Kobayashi N, Kawahara Y, Hirano M, Koizumi S, Hori S, Tajika M, Hikichi T, Yao K, Yokoi C, Ohnita K, Hisanaga Y, Sumiyoshi T, Kitamura S, Tanaka H, Shimoda R, Shimazu T, Takizawa K, Tanabe S, Kondo H, Iishi H, Ninomiya M, Oda I. Long-term Survival After Endoscopic Resection For Gastric Cancer: Real-world Evidence From a Multicenter Prospective Cohort. Clinical gastroenterology and hepatology, 21:307-318.e2, 2023

3. Hirata S, Toyoshima N, Takamaru H, Yamada M, Kobayashi N, Kozu T, Saito Y. Underwater endoscopic mucosal resection with submucosal injection. Endoscopy, 55:E70-E71, 2023

4. Hirai Y, Abe S, Makiguchi ME, Sekiguchi M, Nonaka S, Suzuki H, Yoshinaga S, Saito Y. Endoscopic Resection of Undifferentiated Early Gastric Cancer. Journal of gastric cancer, 23:146-158, 2023

5. Sekiguchi M, Westerberg M, Ekbom A, Hultcrantz R, Forsberg A. Endoscopist Characteristics and Polyp Detection in Colonoscopy: Cross-Sectional Analyses of Screening of Swedish Colons. Gastroenterology, 164:293-295.e4, 2023

6. Ishikawa H, Yamada M, Sato Y, Tanaka S, Akiko C, Tajika M, Doyama H, Takayama T, Ohda Y, Horimatsu T, Sano Y, Tanakaya K, Ikematsu H, Saida Y, Ishida H, Takeuchi Y, Kashida H, Kiriyama S, Hori S, Lee K, Tashiro J, Kobayashi N, Nakajima T, Suzuki S, Mutoh M. Intensive endoscopic resection for downstaging of polyp burden in patients with familial adenomatous polyposis (J-FAPP Study III): a multicenter prospective interventional study. Endoscopy, 55:344-352, 2023

7. Kajiwara Y, Oka S, Tanaka S, Nakamura T, Saito S, Fukunaga Y, Takamatsu M, Kawachi H, Hotta K, Ikematsu H, Kojima M, Saito Y, Yamada M, Kanemitsu Y, Sekine S, Nagata S, Yamada K, Kobayashi N, Ishihara S, Saitoh Y, Matsuda K, Togashi K, Komori K, Ishiguro M, Kuwai T, Okuyama T, Ohuchi A, Ohnuma S, Sakamoto K, Sugai T, Katsumata K, Matsushita HO, Yamano HO, Eda H, Uraoka T, Akimoto N, Kobayashi H, Ajioka Y, Sugihara K, Ueno H. Nomogram as a novel predictive tool for lymph node metastasis in T1 colorectal cancer treated with endoscopic resection: a nationwide, multicenter study. Gastrointestinal endoscopy, 97:1119-1128.e5, 2023

8. Ohata K, Kobayashi N, Saito Y. Reply. Gastroenterology, 164:1342-1343, 2023

9. Sekiguchi M, Igarashi A, Toyoshima N, Takamaru H, Yamada M, Esaki M, Kobayashi N, Saito Y. Cost-effectiveness analysis of computer-aided detection systems for colonoscopy in Japan. Digestive endoscopy, 2023

10. Lui RN, Wong SH, Ding NS, Sekiguchi M, Yu J, Ang TL, Yeoh KG, Chiu HM, Sung JJY. Is this the end of colonoscopy screening for colorectal cancer? An Asia-Pacific perspective. Journal of gastroenterology and hepatology, 38:671-677, 2023

11. Koyama Y, Fukuzawa M, Kono S, Madarame A, Morise T, Uchida K, Yamaguchi H, Sugimoto A, Nagata N, Kawai T, Takamaru H, Sekiguchi M, Yamada M, Sakamoto T, Matsuda T, Saito Y, Itoi T. Diagnostic efficacy of the Japan NBI Expert Team classification with dual-focus magnification for colorectal tumors. Surgical endoscopy, 36:5032-5040, 2022

12. Kobayashi N, Takeuchi Y, Ohata K, Igarashi M, Yamada M, Kodashima S, Hotta K, Harada K, Ikematsu H, Uraoka T, Sakamoto N, Doyama H, Abe T, Katagiri A, Hori S, Michida T, Yamaguchi T, Fukuzawa M, Kiriyama S, Fukase K, Murakami Y, Ishikawa H, Saito Y. Outcomes of endoscopic submucosal dissection for colorectal neoplasms: Prospective, multicenter, cohort trial. Digestive endoscopy, 34:1042-1051, 2022

13. Takamaru H, Saito Y, Hammoud GM, Mizuguchi Y, Cho H, Sekiguchi M, Yamada M, Sakamoto T, Matsuda T. Comparison of postpolypectomy bleeding events between cold snare polypectomy and hot snare polypectomy for small colorectal lesions: a large-scale propensity score-matched analysis. Gastrointestinal endoscopy, 95:982-989.e6, 2022

14. Abe S, Sekiguchi M. It is time to tailor endoscopic resection for early gastric cancer: Evaluate not only lesion but also patient. Digestive endoscopy, 34:826-827, 2022

15. Ohata K, Kobayashi N, Sakai E, Takeuchi Y, Chino A, Takamaru H, Kodashima S, Hotta K, Harada K, Ikematsu H, Uraoka T, Murakami T, Tsuji S, Abe T, Katagiri A, Hori S, Michida T, Suzuki T, Fukuzawa M, Kiriyama S, Fukase K, Murakami Y, Ishikawa H, Saito Y. Long-term Outcomes After Endoscopic Submucosal Dissection for Large Colorectal Epithelial Neoplasms: A Prospective, Multicenter, Cohort Trial From Japan. Gastroenterology, 163:1423-1434.e2, 2022

16. Uozumi T, Saito Y, Toyoshima N, Takamaru H, Sekiguchi M, Yamada M, Abe S. Effective use of image-enhanced endoscopy and endoscopic submucosal dissection for multiple flat non-polypoid colorectal neoplasms. Endoscopy, 54:E684-E685, 2022

17. Koyama Y, Yamada M, Makiguchi ME, Sekiguchi M, Takamaru H, Sakamoto T, Kono S, Fukuzawa M, Sylvia Wu SY, Sugumaran A, Kawai T, Matsuda T, Itoi T, Saito Y. New scoring system to distinguish deep invasive submucosal and muscularis propria colorectal cancer during colonoscopy: a development and global multicenter external validation study (e-T2 Score). Gastrointestinal endoscopy, 96:321-329.e2, 2022

18. Sekiguchi M, Hotta K, Takeuchi Y, Tanaka S, Yamamoto H, Shinmura K, Harada K, Uraoka T, Hisabe T, Sano Y, Kondo H, Horimatsu T, Kikuchi H, Kawamura T, Nagata S, Yamamoto K, Tajika M, Tsuji S, Kusaka T, Okuyama Y, Yoshida N, Moriyama T, Hasebe A, So S, Kobara H, Kashida H, Miyanaga R, Kato S, Hayashi Y, Sada M, Fukuzawa M, Kato H, Takayama T, Konishi J, Matsushita HO, Narasaka T, Ohata K, Togashi K, Nakamura H, Moriichi K, Oda Y, Kanda N, Kuwai T, Terai S, Sanomura M, Kitamura S, Miyamoto H, Kiriyama S, Mizuno C, Saito Y, Sekine S, Ito S, Nakahira H, Oka S, Hayashi Y, Yoshimura K, Ishikawa H, Matsuda T. Characteristics of colorectal neuroendocrine tumors in patients prospectively enrolled in a Japanese multicenter study: a first report from the C-NET STUDY. Journal of gastroenterology, 57:547-558, 2022

19. Sekiguchi M, Matsuda T, Hotta K, Saito Y. Post-polypectomy surveillance: the present and the future. Clinical endoscopy, 55:489-495, 2022

20. Takamaru H, Stammers M, Yanagisawa F, Mizuguchi Y, Sekiguchi M, Yamada M, Sakamoto T, Matsuda T, Saito Y. Conditional inference tree models to perceive depth of invasion in T1 colorectal cancer. Surgical endoscopy, 36:9234-9243, 2022

21. Sung JJY, Chiu HM, Lieberman D, Kuipers EJ, Rutter MD, Macrae F, Yeoh KG, Ang TL, Chong VH, John S, Li J, Wu K, Ng SSM, Makharia GK, Abdullah M, Kobayashi N, Sekiguchi M, Byeon JS, Kim HS, Parry S, Cabral-Prodigalidad PAI, Wu DC, Khomvilai S, Lui RN, Wong S, Lin YM, Dekker E. Third Asia-Pacific consensus recommendations on colorectal cancer screening and postpolypectomy surveillance. Gut, 71:2152-2166, 2022

22. Sekiguchi M, Westerberg M, Ekbom A, Hultcrantz R, Forsberg A. Detection rates of colorectal neoplasia during colonoscopies and their associated factors in the SCREESCO study. Journal of gastroenterology and hepatology, 37:2120-2130, 2022

23. Kawamura T, Sekiguchi M, Takamaru H, Mizuguchi Y, Horiguchi G, Kato M, Kobayashi K, Sada M, Oda Y, Yokoyama A, Utsumi T, Tsuji Y, Ohki D, Takeuchi Y, Shichijo S, Ikematsu H, Matsuda K, Teramukai S, Kobayashi N, Matsuda T, Saito Y, Tanaka K. "Endoscopic" adenoma detection rate as a quality indicator of colonoscopy: First report from the J-SCOUT study. Digestive endoscopy, 2022