Annual Report 2023

Section of Cancer Genomics Repository

Teruhiko Yoshida, Yusuke Okuma, Azusa Takeuchi, Jun Oikawa, Tsuyuka Otsuki

Introduction

 Our section was established in June 2018 as one of the sections of the Center for Cancer Genomics and Advanced Therapeutics (C-CAT).

The Team and What We Do

 The Section of Cancer Genomics Repository (CGR) collects clinical information and genomic data from the cancer genomic medicine (CGM) hospitals (designated core, core and affiliated hospitals), and clinical laboratories for Comprehensive Genomic Profiling (CGP) test. The information and data are registered in the C-CAT Repository database and used by the CGM hospitals for the clinical purposes of the present and future patients, including the production of the C-CAT findings to list of the current clinical trials, which might be available domestically. The C-CAT Repository data are also offered widely to the academia and industries under a fair and transparent protocol to be used for the secondary or research and development purposes. By March 2024, more than 74,000 patients have given informed consents for the registration of their information and data to the C-CAT Repository.

 The CGR serves as the secretariat for the Registration of the Patient information Working Group (RPWG) of the Liaison Council of the Cancer Genomic Medicine Hospitals, which specifies the clinical information to be collected in C-CAT. In 2023, the Clinical Information List for the hematological malignancies was approved.

Education

 The CGR has offered the helpdesk support for their questions and request for the CGM hospitals. On-the-job training is the mainstay of the training for new staff in the CGR.

Future Prospects

 The CGR will keep supporting the CGP testing under the National Health Insurance system in Japan. In particular, the CGR will continue to maintain and improve the C-CAT repository system, so that the precious CGM real-world data can be used efficiently and effectively for both the clinical (primary) and research & development (secondary) purposes.