Annual Report 2023
Department of Cardiology
Kazuko Tajiri
Introduction
In the Department of Cardiology, we provide comprehensive cardiovascular management for cancer patients. This includes assessing cardiovascular risks before surgery or cancer drug therapy, optimizing cardiovascular conditions, monitoring for early detection and intervention of cardiovascular toxicity during cancer drug therapy, long-term monitoring following cancer drug therapy, and treating cardiovascular diseases that develop during cancer treatment.
The Team and What We Do
In 2023, we managed 2,333 consultations for new patients and 512 for follow-up patients, resulting in a total of 2,845 patient consultations. For cases requiring emergency interventions, such as catheter treatments or advanced intensive care, patients are promptly transferred to nearby specialized cardiovascular hospitals, ensuring close collaboration for optimal treatment.
Research Activities
Several clinical studies and translational research projects are conducted on various cardiovascular issues faced by patients with cancer, including immune checkpoint inhibitor-related myocarditis, cancer therapy-related cardiac dysfunction, and venous thrombosis. These studies focus on elucidating pathophysiology, conducting real-world investigations, and exploring early detection and treatment strategies. In 2023, eight English-language papers, six Japanese-language papers, and three authored books were published.
Education
Education related to cardio-oncology was conducted through regular meetings with oncologists, physiological testing technicians, nurses, and pharmacists.
Future Prospects
Maximizing the effectiveness of cancer treatment requires pre-treatment evaluation of the cardiovascular system, ongoing monitoring after treatment initiation, and appropriate treatment for cardiovascular toxicity when it occurs. This necessitates a deep understanding of cancer treatments and enhanced cardiovascular management tailored to them. Additionally, it is crucial to train experts in cardiovascular oncology and to equip general cardiologists with the necessary skills for cardiovascular oncology practice.
List of papers published in 2023
Journal
1. Shoji M, Yamashita Y, Ishii M, Inoue H, Kato H, Fujita S, Matsui K, Tajiri K, Nameki M, Muraoka N, Nonaka A, Sugino H, Kono M, Oka T, Sueta D, Komuro I, Tsujita K. A Predictive Model for Cancer-Associated Thrombosis in Japanese Cancer Patients: Findings from the J-Khorana Registry. TH open, 8:e9-e18, 2024
2. Osawa T, Tajiri K, Hoshi T, Ieda M, Ishizu T. Successful Treatment of Malignant Lymphoma Following Transcatheter Aortic Valve Replacement: A Case Report. Internal medicine (Tokyo, Japan), 2024
3. Inoue K, Machino-Ohtsuka T, Nakazawa Y, Iida N, Sasamura R, Bando H, Chiba S, Tasaka N, Ishizu T, Murakoshi N, Xu D, Sekine I, Tajiri K. Early Detection and Prediction of Anthracycline-Induced Cardiotoxicity - A Prospective Cohort Study. Circulation journal, 88:751-759, 2024
4. Tajiri K. Immune Checkpoint Inhibitor Myotoxicities: An Autoimmune Perspective. Internal medicine (Tokyo, Japan), 2024
5. Shibutani Y, Tajiri K, Suzuki S, Enokida T, Sagara A, Okano S, Fujisawa T, Sato F, Yumoto T, Sano M, Kawasaki T, Tahara M. Association between baseline blood pressure and the incidence of lenvatinib-induced hypertension in patients with thyroid cancer. Cancer medicine, 12:20773-20782, 2023
6. Osawa T, Tajiri K. Neoplastic Cardiac Tamponade. Internal medicine (Tokyo, Japan), 62:2447-2448, 2023
7. Nagai T, Inomata T, Kohno T, Sato T, Tada A, Kubo T, Nakamura K, Oyama-Manabe N, Ikeda Y, Fujino T, Asaumi Y, Okumura T, Yano T, Tajiri K, Matsuura H, Baba Y, Sunami H, Tsujinaga S, Ota Y, Ohta-Ogo K, Ishikawa Y, Matama H, Nagano N, Sato K, Yasuda K, Sakata Y, Kuwahara K, Minamino T, Ono M, Anzai T. JCS 2023 Guideline on the Diagnosis and Treatment of Myocarditis. Circulation journal, 87:674-754, 2023
8. Osawa T, Tajiri K, Ieda M, Ishizu T. Clinical outcomes of takotsubo syndrome in patients with cancer: a systematic review and meta-analysis. Frontiers in cardiovascular medicine, 10:1244808, 2023
9. Ishizuka Y, Tajiri K. The Need for Next-generation Anticoagulation Therapies for Cancer-associated Venous Thromboembolism. Internal medicine (Tokyo, Japan), 2023