Annual Report 2023
Endoscopy Center / Endoscopy Division
Yutaka Saito, Nozomu Kobayashi, Yasuo Kakugawa, Shigetaka Yoshinaga, Haruhisa Suzuki, Satoru Nonaka, Seiichiro Abe, Masayoshi Yamada, Masau Sekiguchi , Hiroyuki Takamaru. Keiko (Sogame) Nakamura, Naoya Toyoshima, and Makiguchi Mai, Kusuhara Mitsunori (Staff)
Takao Itoi, Ichiro Oda, Taku Sakamoto, and Eriko (Tsuruki) So (Attending staff)
Yasuhiko Mizuguchi, Izumi Hisada, Takayuki Yamazaki, Reona Kawamura, Takeshi Uozumi, Yuichiro Hirai, Ryuji Shudo, and Takashi Kondo, Mitsunobu Saito, Mika Miyabe, Mikio Tabuchi (Resident)
Masanori Kurashige, Masako Yamada, Wakana Yashima, Ayano Okamura, Emiko Tahara, and Yumiko Sakamoto. (Endoscopic Engineer)
Introduction
The Department of Endoscopy moved to the New Endoscopy Center on January 20th, 2014, and we believe this is one of the largest endoscopy centers in Japan (15 endoscopy rooms [251.112 m2] and recovery rooms [136.788 m2] on two floors with an area of 1949.554 m2).
The total number of nursing staff increased to 18, and three endoscopy engineers are working with us. The Gastrointestinal Endoscopy Division has 13 staff physicians in the National Cancer Center Hospital (NCCH), and in the Division of Screening Technology of the Center for Public Health Sciences, two chief residents, 11 residents, and several rotating residents.
The Respiratory Endoscopy Division has three staff members, and the total number of bronchoscopies and therapeutic procedures has dramatically increased.
The Team and What We Do
Dramatic developments have recently changed the operational mechanism and design of endoscopes along with the availability of various accessory devices and instruments, thus, the clinical applications using the latest equipment are evolving on a continuous basis.
In the Gastrointestinal Endoscopy Division, more advanced and technically difficult endoscopic treatments such as endoscopic submucosal dissection (ESD) are being used in place of conventional endoscopic mucosal resection (EMR) not only for early gastric cancer, but also for superficial esophageal and colorectal neoplasms. In addition, educational activities are an important part of the division’s activities, with many Japanese medical students, residents, and staff physicians as well as approximately 130 overseas post-graduate physicians attending our training courses annually.
Our Endoscopy Center was authorized as one of the Centers of Excellence by the World Endoscopy Organization (WEO) and got an award during Gastro 2017 in Hyderabad. This is an honorable award for us because there are only 17 famous international centers worldwide and only two centers in Japan.
We are also focusing on the development of new medical devices. A joint laboratory with Olympus has been developed in the new research building, and new medical devices are being jointly developed with the three main topics of diagnosis, treatment, and education. We are planning to apply for a joint patent for two new medical devices.
In addition, we are leading the MIRAI project, which plays a key role in the development of minimally invasive treatment techniques and devices of the near future, and are also focusing on training young human resources who will lead the future.
Research Activities
Our efforts have been focused on new diagnostic and therapeutic strategies. For a more accurate endoscopic diagnosis of gastrointestinal disease, we are utilizing the NBI and BLI systems that enable us to narrow the spectral transmittance bandwidth of the optical filters used in the light source of electronic endoscope systems. In addition, we have introduced an endocytoscopy system, which can magnify lesions up to 500x magnification and visualize nuclear atypia.
Clinical Trials
We have organized several multicenter study groups to prospectively evaluate the efficacy and clinical impact of newly developed endoscopies and medical devices.
Esophagus
We are currently enrolling our patients in several multicenter randomized controlled trials (RCTs).
A phase III study is ongoing to compare oral steroid administration with local steroid injection therapy for the prevention of esophageal stricture after endoscopic submucosal dissection (JCOG1217: Steroid EESD P3). Moreover, a randomized controlled phase II/III study has been conducted to compare endoscopic balloon dilation combined with steroid injection versus radial incision and cutting combined with steroid injection for refractory anastomotic stricture after esophagectomy (JCOG1207: RICS study).
We also enrolled our patients in a non-randomized study for investigating the usefulness of endoscopic ultrasonography (JCOG1604: Odyssey trial) by comparing the results with those of magnified endoscopy with narrow band imaging for diagnosing cancer invasion depth of clinical stage IA esophageal squamous cell carcinoma.
Stomach
A nationwide cancer registry system has been developed for early gastric cancer treated with EMR/ESD. A five-year multicenter prospective cohort study has been conducted using this cancer registry system since 2010 (J-WEB/EGC) and the short-term outcomes were published in DEN. The long-term outcomes were being analyzed this year and will be published.
Our division has developed and is leading the single-arm phase III confirmatory trial on indications of endoscopic submucosal dissection for elderly patients with early gastric cancer (JCOG1902: Elderly G-ESD study). This study has been ongoing since 2020.
In a prospective multicenter clinical trial of using confocal LASER endomicroscopy (pCLE) for the diagnosis of gastric epithelial lesion, our institution conducts a prospective multicenter trial with a total of 8 tertiary centers as Advanced Medical Technology B to clarify the efficacy of pCLE using fluorescein for the diagnosis of early gastric cancer.
Duodenum
A non-randomized confirmatory trial of cold snare polypectomy for superficial non-ampullary duodenal epithelial tumor (D-COP trial) has been conducted at more than 100 institutions in Japan since 2017. Recently, cold snare polypectomy is widely performed on the colorectal region, and it is expected that the same concept can be applied for duodenal small tumors (familial adenomatous polyposis [FAP] is excluded from this trial).
Colorectum
RCTs on colorectal neoplasms are ongoing as well.
The Japan Polyp Study (JPS), a multicenter RCT conducted at 11 participating centers was initiated in 2003. The aim of this study was to assess whether follow-up colonoscopy using high definition colonoscope at three years as well as at both one and three years would detect important lesions including non-polypoid colorectal neoplasia. The JPS will provide preexisting comorbidity data, including the prevalence of both flat and depressed colorectal lesions, the quality of colonoscopy, and the risk of colorectal cancer (CRC). Furthermore, the study will clarify the long-term impact of colonoscopic removal on mortality due to CRC. The evidence will help elaborate the fundamental basis for the updated Japanese surveillance guidelines (JPS participants: 3,926, JPS cohort: 1,291). The first outcome of the JPS has just been published in Gut.
We play a leading role in a multicenter single-arm study (JCOG1612) on the possibility of CRT for high-risk rectal submucosal cancer after endoscopic resections. When the results of this study show a non-inferiority of CRT compared to surgery, we could propose a new non-invasive treatment strategy for rectal T1 cancer patients.
A nationwide cancer registry system has also been developed for early CRC treated with ESD. A five-year multicenter prospective cohort study has been ongoing using this cancer registry system since 2013. A total of 2,074 patients were enrolled in this multicenter cohort study and 5-year surveillance of all enrolled patients has been completed. This should be the largest cohort study in colorectal ESD in the world.
We have conducted a multicenter prospective cohort study on colorectal neuroendocrine tumors (NETs) since January 2017. This study is expected to provide new important findings on colorectal NETs.
A multicenter prospective cohort study on T1 CRC has also been performed since May 2017. In this study, T1 CRC cases were accumulated from over 70 institutions all over Japan, which will provide important information on the management of T1 cancer.
J-CAPP Study II: To evaluate the influence of low-dose, aspirin tablets (100 mg/day for four years) on colorectal tumor recurrence, we have conducted a multicenter prospective study since 2015 (Chief conductor: Hideki Ishikawa, M.D, Kyoto Prefectural University of Medicine).
Molecular and fluorescence Imaging and Database Study
Molecular imaging endoscopy is one of the imaging modalities in this new era for very early cancer diagnosis and detection of metastasis. We have started a collaborative study with the Departments of Endoscopy, Colorectal Surgery, Gastric Surgery, and Pathology and Clinical Laboratories, the NCC, Research Institute, the University of Tokyo, and the Jikei University School of Medicine.
We have been collaborating with the Japan Gastroenterological Endoscopy Society (JGES) to build a Japan Endoscopy Database (JED) of gastrointestinal endoscopies including not only therapeutic but also diagnostic procedures. This all-Japan project is named JED and has the potential to construct the largest and most precise database of all endoscopic procedures. Japanese endoscopists are well known as the most excellent endoscopists; therefore, we can obtain much evidence using this huge endoscopy database from now on.
Research and development of new endoscopy using artificial intelligence (AI): Recent development of artificial intelligence (AI) using deep learning is expected to be applicable in precision medicine. We have been researching and developing new endoscopic systems using AI. First, in order to support endoscopist’s detection of CRC and precancerous lesions during colonoscopy by AI, we have been researching and developing a software program using convolutional neural networks based on mathematical morphology and hardware, which works in real-time. We will extend this system to genomic data and other gastrointestinal organs, such as the stomach and esophagus, in the future. Second, we have joined a multicenter image analyzing study led by Prof. Kudo’s group to compare a new automatic diagnosis system using AI with endoscopist’s diagnosis of colorectal lesions using endocytoscopy. We have also started the research and development of an endoscopic diagnosis support system on tumor invasion of gastrointestinal cancer using AI.
We are collaborating with the NCCH Research Institute and Osaka University and performed fecal metagenomic and metabolomic studies on samples from a large cohort of 616 participants who underwent colonoscopy to assess the taxonomic and functional characteristics of gut microbiota and metabolites. The multi-omics data from our large cohort study indicate that the shifts in the microbiome and metabolome occur from the very early stages of the development of colorectal cancer, which is of possible etiological and diagnostic importance and has been published in Nature Medicine.
Future Prospects
Research and development of new endoscopy
Olympus Medical Systems Corp. has opened a laboratory at our new research center, and we are collaborating with them to develop innovative endoscopy systems and devices.
List of papers published in 2023
Journal
1. Suzuki H, Kawata Y, Aokage K, Matsumoto Y, Sugiura T, Tanabe N, Nakano Y, Tsuchida T, Kusumoto M, Marumo K, Kaneko M, Niki N. Aorta and main pulmonary artery segmentation using stacked U-Net and localization on non-contrast-enhanced computed tomography images. Medical physics, 51:1232-1243, 2024
2. Sano Y, Hotta K, Matsuda T, Murakami Y, Fujii T, Kudo SE, Oda Y, Ishikawa H, Saito Y, Kobayashi N, Sekiguchi M, Ikematsu H, Katagiri A, Konishi K, Takeuchi Y, Iishi H, Igarashi M, Kobayashi K, Sada M, Osera S, Shinohara T, Yamaguchi Y, Hasuda K, Morishima T, Miyashiro I, Shimoda T, Taniguchi H, Fujimori T, Ajioka Y, Yoshida S. Endoscopic Removal of Premalignant Lesions Reduces Long-Term Colorectal Cancer Risk: Results From the Japan Polyp Study. Clinical gastroenterology and hepatology, 22:542-551.e3, 2024
3. Repici A, Khalaf K, Troncone E, Subramaniam S, Hassan C, Bhandari P. International Delphi Consensus Study on disposable single-use endoscopy: A path to clinical adoption. Digestive and liver disease, 56:322-329, 2024
4. Yoshida N, Hayashi Y, Togo D, Oka S, Takada K, Fukunaga S, Morita Y, Hayashi T, Kozuka K, Tsuji Y, Murakami T, Yamamura T, Komeda Y, Takeuchi Y, Shinmura K, Fukuda H, Yoshii S, Ono S, Katsuki S, Kawashima K, Nemoto D, Yamamoto H, Saito Y, Tamai N, Iwao A, Itoi Y, Tsuji S, Inagaki Y, Inada Y, Soga K, Hasegawa D, Murakami T, Yoriki H, Fukumoto K, Motoyoshi T, Nakatani Y, Sano Y, Iguchi M, Fujii S, Ban H, Harada K, Okamoto K, Nishiyama H, Sasaki F, Mizukami K, Shono T, Shimoda R, Miike T, Yamaguchi N. An Analysis of Delayed Bleeding in Cases of Colorectal Endoscopic Submucosal Dissection Due to Types of Direct Oral Anticoagulants in Japan. Clinical gastroenterology and hepatology, 22:271-282.e3, 2024
5. Minamide T, Ikematsu H, Kajiwara Y, Oka S, Ajioka Y, Ueno H. Impact of Lesion Location on Recurrence After Resection of T1 Colorectal Cancer: Post Hoc Analysis of a Nationwide Multicenter Cohort Study. Gastroenterology, 166:198-201.e3, 2024
6. Kawamura T, Sekiguchi M, Takamaru H, Mizuguchi Y, Horiguchi G, Toyoizumi H, Kato M, Kobayashi K, Sada M, Oda Y, Yokoyama A, Utsumi T, Tsuji Y, Ohki D, Takeuchi Y, Shichijo S, Ikematsu H, Matsuda K, Teramukai S, Kobayashi N, Matsuda T, Saito Y, Tanaka K. Endoscopist-related factors affecting adenoma detection during colonoscopy: Data from the J-SCOUT study. Digestive endoscopy, 36:51-58, 2024
7. Nakai T, Matsumoto Y, Ueda T, Kuwae Y, Tanaka S, Miyamoto A, Matsumoto Y, Sawa K, Sato K, Yamada K, Watanabe T, Asai K, Furuse H, Uchimura K, Imabayashi T, Uenishi R, Fukui M, Tanaka H, Ohsawa M, Kawaguchi T, Tsuchida T. Comparison of the specimen quality of endobronchial ultrasound-guided intranodal forceps biopsy using standard-sized forceps versus mini forceps for lung cancer: A prospective study. Respirology (Carlton, Vic.), 29:396-404, 2024
8. Fujita K, Saito Y. A novel hood with a small-caliber tip and two traction strings for endoscopic submucosal dissection. Endoscopy, 56:E111-E113, 2024
9. Hotta K, Otake Y, Yamaguchi D, Shimodate Y, Hanabata N, Ikematsu H, Yabuuchi Y, Sano Y, Shimoda R, Sugimoto S, Oba M, Takamaru H, Kimura K, Kishida Y, Takada K, Ito S, Imai K, Hosotani K, Murano T, Yamada M, Shinmura K, Takezawa R, Tomonaga M, Saito Y. Comparison of the efficacy and tolerability of elobixibat plus sodium picosulfate with magnesium citrate and split-dose 2-L polyethylene glycol with ascorbic acid for bowel preparation before outpatient colonoscopy: a study protocol for the multicentre, randomised, controlled E-PLUS trial. BMC gastroenterology, 24:61, 2024
10. Takada K, Imai K, Yamada T, Ohata K, Kanesaka T, Nagami Y, Yamasaki Y, Kobara H, Inokuchi Y, Chino A, Yamaguchi S, Ikehara H, Kawamura T, Yabuuchi Y, Mizuguchi Y, Ikematsu H, Yokoi C, Hattori S, Ohno K, Yoshizawa Y, Fukuzawa M, Tsuji Y, Konishi J, Yamamura T, Osawa S, Oka S, Hikichi T, Togashi K, Hirasawa K, Uraoka T, Takeuchi Y, Chiba H, Komeda Y, Doyama H, Oba MS, Saito Y. Efficacy of endoscopic submucosal resection with a ligation device for small rectal neuroendocrine tumor: study protocol of a multicenter open-label randomized control trial (BANDIT trial). BMC gastroenterology, 24:69, 2024
11. Kang SJ, Tae CH, Bang CS, Shin CM, Jeong YH, Choi M, Hwang JH, Saito Y, Chiu PWY, Rerknimitr R, Khor C, Khien VV, Choi KD, Shim KN, Song GA, Lee OY. International Digestive Endoscopy Network consensus on the management of antithrombotic agents in patients undergoing gastrointestinal endoscopy. Clinical endoscopy, 57:141-157, 2024
12. Adachi M, Matsumoto Y, Furuse H, Uchimura K, Imabayashi T, Yotsukura M, Yoshida Y, Nakagawa K, Igaki H, Watanabe SI, Tsuchida T. Utility of the endobronchial Watanabe spigot for intractable cancer-related pneumothorax: a retrospective observational study. Japanese journal of clinical oncology, 53:829-836, 2023
13. Nishimatsu K, Matsumoto Y, Kashima J, Imabayashi T, Uchimura K, Furuse H, Masuda K, Shinno Y, Okuma Y, Yoshida T, Goto Y, Horinouchi H, Yamamoto N, Tsuchida T, Ohe Y, Yatabe Y. Concordance between cryobiopsy and forceps biopsy specimens in assessment of immunohistochemistry staining for non-small cell lung carcinoma. Translational lung cancer research, 12:1245-1255, 2023
14. Suzuki H, Nonaka S, Maetani I, Matsuda T, Abe S, Yoshinaga S, Oda I, Yamagata Y, Yoshikawa T, Saito Y. Clinical and endoscopic features of metachronous gastric cancer with possible lymph node metastasis after endoscopic submucosal dissection and Helicobacter pylori eradication. Gastric cancer, 26:743-754, 2023
15. Hayashi T, Takasawa K, Yoshikawa T, Hashimoto T, Sekine S, Wada T, Yamagata Y, Suzuki H, Abe S, Yoshinaga S, Saito Y, Kouno N, Hamamoto R. A discrimination model by machine learning to avoid gastrectomy for early gastric cancer. Annals of gastroenterological surgery, 7:913-921, 2023
16. Kajiwara Y, Oka S, Tanaka S, Nakamura T, Saito S, Fukunaga Y, Takamatsu M, Kawachi H, Hotta K, Ikematsu H, Kojima M, Saito Y, Yamada M, Kanemitsu Y, Sekine S, Nagata S, Yamada K, Kobayashi N, Ishihara S, Saitoh Y, Matsuda K, Togashi K, Komori K, Ishiguro M, Kuwai T, Okuyama T, Ohuchi A, Ohnuma S, Sakamoto K, Sugai T, Katsumata K, Matsushita HO, Yamano HO, Eda H, Uraoka T, Akimoto N, Kobayashi H, Ajioka Y, Sugihara K, Ueno H. Nomogram as a novel predictive tool for lymph node metastasis in T1 colorectal cancer treated with endoscopic resection: a nationwide, multicenter study. Gastrointestinal endoscopy, 97:1119-1128.e5, 2023
17. Mori Y, Wang P, Løberg M, Misawa M, Repici A, Spadaccini M, Correale L, Antonelli G, Yu H, Gong D, Ishiyama M, Kudo SE, Kamba S, Sumiyama K, Saito Y, Nishino H, Liu P, Glissen Brown JR, Mansour NM, Gross SA, Kalager M, Bretthauer M, Rex DK, Sharma P, Berzin TM, Hassan C. Impact of Artificial Intelligence on Colonoscopy Surveillance After Polyp Removal: A Pooled Analysis of Randomized Trials. Clinical gastroenterology and hepatology, 21:949-959.e2, 2023
18. Hijioka S, Sakamoto Y, Nagashio Y, Maruki Y, Okusaka T, Saito Y. Novel and safe plastic stent exchange method after endoscopic ultrasound-guided hepaticogastrostomy with incomplete fistula (side hole method). Endoscopy, 55:E24-E25, 2023
19. Hijioka S, Sakamoto Y, Nagashio Y, Maruki Y, Okusaka T, Saito Y. Troubleshooting for endoscopic ultrasound-guided hepaticogastrostomy stent migration: Additional stenting by the partial stent-in-stent method. Endoscopy, 55:E122-E124, 2023
20. Maehara K, Hijioka S, Kawasaki Y, Tamada K, Okusaka T, Saito Y. A novel triple stenting in the treatment of post-choledochojejunostomy reflux cholangitis. Endoscopy, 55:E191-E193, 2023
21. Takeshita K, Hijioka S, Maehara K, Maruki Y, Nagashio Y, Okusaka T, Saito Y. Bile duct radiofrequency ablation for a residual adenoma after endoscopic papillectomy. Endoscopy, 55:E185-E188, 2023
22. Sakamoto T, Ikematsu H, Tamai N, Mizuguchi Y, Takamaru H, Murano T, Shinmura K, Sasabe M, Furuhashi H, Sumiyama K, Saito Y. Detection of colorectal adenomas with texture and color enhancement imaging: Multicenter observational study. Digestive endoscopy, 35:529-537, 2023
23. Kawasaki Y, Hijioka S, Takeshita K, Tamada K, Okusaka T, Saito Y. Endoscopic ultrasound-guided choledochojejunostomy using a forward-viewing echoendoscopic saddle-cross technique. Endoscopy, 55:E233-E235, 2023
24. Kawamura T, Sekiguchi M, Takamaru H, Mizuguchi Y, Horiguchi G, Kato M, Kobayashi K, Sada M, Oda Y, Yokoyama A, Utsumi T, Tsuji Y, Ohki D, Takeuchi Y, Shichijo S, Ikematsu H, Matsuda K, Teramukai S, Kobayashi N, Matsuda T, Saito Y, Tanaka K. "Endoscopic" adenoma detection rate as a quality indicator of colonoscopy: First report from the J-SCOUT study. Digestive endoscopy, 35:615-624, 2023
25. Bak MTJ, Albéniz E, East JE, Coelho-Prabhu N, Suzuki N, Saito Y, Matsumoto T, Banerjee R, Kaminski MF, Kiesslich R, Coron E, de Vries AC, van der Woude CJ, Bisschops R, Hart AL, Itzkowitz SH, Pioche M, Moons LMG, Oldenburg B. Endoscopic management of patients with high-risk colorectal colitis-associated neoplasia: a Delphi study. Gastrointestinal endoscopy, 97:767-779.e6, 2023
26. Takeshita K, Hijioka S, Kawasaki Y, Maruki Y, Nagashio Y, Okusaka T, Saito Y. Endoscopic ultrasound-guided hepaticojejunostomy for drainage of the right posterior hepatic duct enabled total liver drainage. Endoscopy, 55:E346-E348, 2023
27. Ken O, Kobayashi N, Saito Y. Reply. Gastroenterology, 164:1342-1343, 2023
28. Oguma J, Ishiyama K, Kurita D, Kanematsu K, Kubo K, Utsunomiya D, Abe S, Makiguchi M, Nonaka S, Suzuki H, Yoshinaga S, Oda I, Saito Y, Daiko H. Oncologic significance of lymphovascular invasion in patients with superficial esophageal squamous cell carcinoma reaching the muscularis mucosae or with slight invasion of the submucosa. Surgery, 173:1162-1168, 2023
29. Djinbachian R, Saito Y, von Renteln D. Thermal ablation of the margin defect after EMR: the need for randomized controlled trials with standardized outcome assessment. Gastrointestinal endoscopy, 97:808-809, 2023
30. Ngamruengphong S, Saito Y. Commentary. Endoscopy, 55:393, 2023
31. Chan FKL, Wong MCS, Chan AT, East JE, Chiu HM, Makharia GK, Weller D, Ooi CJ, Limsrivilai J, Saito Y, Hang DV, Emery JD, Makmun D, Wu K, Ali RAR, Ng SC. Joint Asian Pacific Association of Gastroenterology (APAGE)-Asian Pacific Society of Digestive Endoscopy (APSDE) clinical practice guidelines on the use of non-invasive biomarkers for diagnosis of colorectal neoplasia. Gut, 72:1240-1254, 2023
32. Yamamoto H, Sakamoto H, Kumagai H, Abe T, Ishiguro S, Uchida K, Kawasaki Y, Saida Y, Sano Y, Takeuchi Y, Tajika M, Nakajima T, Banno K, Funasaka Y, Hori S, Yamaguchi T, Yoshida T, Ishikawa H, Iwama T, Okazaki Y, Saito Y, Matsuura N, Mutoh M, Tomita N, Akiyama T, Yamamoto T, Ishida H, Nakayama Y. Clinical Guidelines for Diagnosis and Management of Peutz-Jeghers Syndrome in Children and Adults. Digestion, 104:335-347, 2023
33. Hihara D, Takamaru H, Sekiguchi M, Yamada M, Sakamoto T, Matsuda T, Saito Y. Factors associated with increased duration of endoscopic submucosal dissection for rectal tumors: a 22-year retrospective analysis. Gastrointestinal endoscopy, 98:420-427.e1, 2023
34. Matsumoto T, Umeno J, Jimbo K, Arai M, Iwama I, Kashida H, Kudo T, Koizumi K, Sato Y, Sekine S, Tanaka S, Tanakaya K, Tamura K, Hirata K, Fukahori S, Esaki M, Ishikawa H, Iwama T, Okazaki Y, Saito Y, Matsuura N, Mutoh M, Tomita N, Akiyama T, Yamamoto T, Ishida H, Nakayama Y. Clinical Guidelines for Diagnosis and Management of Juvenile Polyposis Syndrome in Children and Adults-Secondary Publication. Journal of the anus, rectum and colon, 7:115-125, 2023
35. Toyoshima O, Nishizawa T, Yoshida S, Matsuno T, Miyoshi K, Naito E, Shiomi C, Uozumi T, Fujishiro M, Saito Y. Hemorrhoids as a risk factor for colorectal adenomas on colonoscopy. Endoscopy international open, 11:E497-E503, 2023
36. Hirai M, Yanai S, Kunisaki R, Nishio M, Watanabe K, Sato T, Ishihara S, Anzai H, Hisabe T, Yasukawa S, Maeda Y, Takishima K, Ohno A, Shiga H, Uraoka T, Itoi Y, Ogata H, Takabayashi K, Yoshida N, Saito Y, Takamaru H, Kawasaki K, Esaki M, Tsuruoka N, Hisamatsu T, Matsumoto T. Effectiveness of endoscopic resection for colorectal neoplasms in ulcerative colitis: a multicenter registration study. Gastrointestinal endoscopy, 98:806-812, 2023
37. Koyama Y, Fukuzawa M, Aikawa H, Nemoto D, Muramatsu T, Matsumoto T, Uchida K, Madarame A, Morise T, Yamaguchi H, Kono S, Nagata N, Sugimoto M, Kawai T, Saito Y, Itoi T. Underwater endoscopic submucosal dissection for colorectal tumors decreases the incidence of post-electrocoagulation syndrome. Journal of gastroenterology and hepatology, 38:1566-1575, 2023
38. Mizuguchi Y, Saito Y. Colorectal cancer invasion calculation, a colorectal tumor depth diagnostic artificial intelligence, is promising, but its diagnostic accuracy remains a challenge. Digestive endoscopy, 35:636-637, 2023
39. Nakai T, Watanabe T, Kaimi Y, Shiomi K, Ando K, Miyamoto A, Ogawa K, Matsumoto Y, Sawa K, Sato K, Asai K, Matsumoto Y, Mikami Y, Ohsawa M, Kawaguchi T. Diagnostic Utility and Safety of Non-Intubated Cryobiopsy Technique Using a Novel Ultrathin Cryoprobe in Addition to Conventional Biopsy Techniques for Peripheral Pulmonary Lesions. Respiration; international review of thoracic diseases, 102:503-514, 2023
40. Uozumi T, Abe S, Makiguchi ME, Nonaka S, Suzuki H, Yoshinaga S, Saito Y. Complications of endoscopic resection in the upper gastrointestinal tract. Clinical endoscopy, 56:409-422, 2023
41. Takahashi Y, Taniguchi H, Haruhi F, Hattori D, Sasaki H, Makita S, Iwaki N, Fukuhara S, Munakata W, Saito Y, Izutsu K, Maeshima AM. Pathogenesis of Gastrointestinal Follicular Lymphomas: Consideration Based on Histopathology and Endoscopic Findings. The American journal of surgical pathology, 47:1134-1143, 2023
42. Saito Y. Reply to Santos-Antunes et al. Endoscopy, 55:883, 2023
43. Fujimoto K, Matsumoto Y, Imabayashi T, Uchimura K, Furuse H, Tsuchida T. Suitability of respiratory endoscopy for sampling malignant thoracic tumors for comprehensive genomic profiling. Cancer science, 114:4401-4412, 2023
44. Hihara D, Takamaru H, Matsuda T, Saito Y. Response. Gastrointestinal endoscopy, 98:683, 2023
45. Kunimasa K, Matsumoto S, Honma K, Tamiya M, Inoue T, Kawamura T, Tanada S, Miyazaki A, Kanzaki R, Maniwa T, Okami J, Matsumoto Y, Goto K, Nishino K. Utility of needle biopsy in centrally located lung cancer for genome analysis: a retrospective cohort study. BMC pulmonary medicine, 23:484, 2023
46. So C, Matsumoto Y, Imabayashi T, Uchimura K, Ohe Y, Furuse H, Tsuchida T. Identifying factors causing failure of nodal staging by endobronchial ultrasound-guided transbronchial needle aspiration in non-small cell lung cancer. Translational lung cancer research, 12:2169-2180, 2023