Annual Report 2023
Division of Prevention
Manami Inoue, Sarah K. Abe, Mayo Hirabayashi, Yoko Yamagiwa, Tetsuji Minami, Marina Tanitame, Aki Otsuki,
Md. Shafiur Rahman, KC Bhandari Aliza, Rokshana Parvin, Marisa Nishio, Rena Asaoka, Yoko Hirose, Yasuko Iba, Yuka Kawamura, Asami Satake, Ayako Toyama
Introduction
The Division of Prevention aims to evaluate factors contributing to cancer among the Japanese population using the latest evidence to present the best cancer prevention policies for Japan.
The Team and What We Do
The Division of Prevention focuses on lifestyle, chemoprevention, and molecular markers research to create cancer prevention methods such as risk prediction, risk stratification models, and evidence-based cancer prevention guidelines for Japanese people.
Research Activities
1. Evaluation of cancer prevention strategies in Japan and cancer prevention guidelines
To develop evidence-based cancer prevention strategies for the Japanese and Asian populations, we conducted systematic reviews, meta-analyses, and pooled analyses of epidemiological studies on the association between modifiable and non-modifiable exposure factors and cancer. We also re-evaluated and updated several associations between cancer risk and preventative factors and cancer incidence and mortality.
2. Establishment of a large-scale cohort infrastructure in Asia (Asia Cohort Consortium (ACC))
ACC is a collaborative effort, which aims to understand the relationship between factors such as genetics, environmental exposure and disease etiology through utilizing a consortium of Asian cohort studies. We have been serving as the coordinating center and data center for this large-scale consortium of healthy Asian individuals to promote research collaborations and intercultural networking.
3. Establishment of an Asian version of cancer prevention guidelines (Asian Codes Against Cancer (ACAC))
International Agency for Research on Cancer (IARC) launched the World Code Against Cancer Framework to promote regional-specific cancer guidelines. Following this framework, the Division of Prevention and Division of International Health Policy Research have been coordinating the development of cancer prevention guidelines specific for Asian nations, in collaboration with IARC and Asian National Cancer Center Alliance (ANCCA).
4. The effectiveness of Helicobacter pylori (H. pylori) eradication in gastric cancer prevention
Started in 2017, this project aims to assess whether H. pylori eradication prevents development of gastric cancer through conducting pooled analyses of large-scale epidemiological studies.
5. Attributable causes of cancer (JAPAN PAF PROJECT)
We conducted a systematic assessment to estimate the current burden of cancer attributable to known preventable and non-modifiable risk factors in Japan. We estimated the economic burden of cancer, as well as the economic burden of cancer attributable to preventable risk factors in Japan.
6. National Center (NC) collaborative projects
We conducted coronavirus antibody surveys among six NC staff.
Education
We supervised domestic and international master’s and doctoral students. We serve as the Coordinate Department of Cancer Epidemiology, Graduate School of Medicine, The University of Tokyo, and accept graduate students. In addition, we accepted researchers and trainees from overseas.
Future Prospects
We will continue to develop and evaluate effective cancer prevention guidelines and promote research further to enhance the implementation of cancer prevention strategies in Japan.
List of papers published in 2023
Journal
1. Miyawaki R, Oka K, Otsuki A, Saito J, Yaguchi-Saito A, Kuchiba A, Fujimori M, Kreps GL, Shimazu T. Trust in Mass Media as Sources of Cancer Information: Findings from a Nationally Representative Cross-Sectional Survey in Japan. Journal of health communication, 29:143-154, 2024
2. Goto A, Ohashi K, Noda M, Noto H, Ueki K, Inoue M, Nishimura R, Takahashi S, Ioka T, Oshima M, Fujibayashi K, Tsuji A, Kodaira M, Tamakoshi A, Mimori K, Tanabe Y, Hara E, Matsuo K, Murakami Y, Watada H. Third Report of the Japan Diabetes Society/Japanese Cancer Association Joint Committee on Diabetes and Cancer: Summary of the results of a questionnaire survey of oncologists and diabetologists-Secondary publication. Cancer science, 115:672-681, 2024
3. Goto A, Ohashi K, Noda M, Noto H, Ueki K, Inoue M, Nishimura R, Takahashi S, Ioka T, Oshima M, Fujibayashi K, Tsuji A, Kodaira M, Tamakoshi A, Mimori K, Tanabe Y, Hara E, Matsuo K, Murakami Y, Watada H. Third Report of the Japan Diabetes Society (JDS)/Japanese Cancer Association (JCA) Joint Committee on diabetes and cancer: summary of the results of a questionnaire survey of oncologists and diabetologists-secondary publication. Diabetology international, 15:5-18, 2024
4. Manandhar Shrestha R, Mizoue T, Islam Z, Kawakatsu Y, Ito H, Wada K, Nagata C, Zha L, Kitamura T, Sakata R, Kimura T, Sugawara Y, Tsuji I, Sato R, Sawada N, Tsugane S, Lin Y, Oze I, Abe SK, Inoue M. Adult Height and Risk of Colorectal Cancer: A Pooled Analysis of 10 Population-based Cohort Studies in Japan. Journal of epidemiology, 34:94-103, 2024
5. Ge S, Zha L, Sobue T, Kitamura T, Ishihara J, Iwasaki M, Inoue M, Yamaji T, Tsugane S, Sawada N. Dietary Consumption of Antioxidant Vitamins in Relation to Prostate Cancer Risk in Japanese Men: The Japan Public Health Center-based Prospective Study. Journal of epidemiology, 34:144-153, 2024
6. Yatsuya H, Yamagishi K, Li Y, Saito I, Kokubo Y, Muraki I, Inoue M, Tsugane S, Iso H, Sawada N. Risk and Population Attributable Fraction of Stroke Subtypes in Japan. Journal of epidemiology, 34:211-217, 2024
7. Yamamoto N, Ejima K, Mestre LM, Owora AH, Inoue M, Tsugane S, Sawada N. Body mass index trajectories and mortality risk in Japan using a population-based prospective cohort study: the Japan Public Health Center-based Prospective Study. International journal of epidemiology, 53:dyad145, 2024
8. Kikuchi H, Inoue S, Amagasa S, Kuwahara K, Ihira H, Inoue M, Iso H, Tsugane S, Sawada N. Relationships of Total and Domain-Specific Moderate-to-Vigorous Physical Activity with All-Cause and Disease-Specific Mortality. Medicine and science in sports and exercise, 56:520-527, 2024
9. Mori N, Murphy N, Sawada N, Achaintre D, Yamaji T, Scalbert A, Ishihara J, Takachi R, Nakamura K, Tanaka J, Iwasaki M, Iso H, Inoue M, Gunter MJ, Tsugane S. Reproducibility and dietary correlates of plasma polyphenols in the JPHC-NEXT Protocol Area study. European journal of clinical nutrition, 78:34-42, 2024
10. Yang JJ, Wen W, Zahed H, Zheng W, Lan Q, Abe SK, Rahman MS, Islam MR, Saito E, Gupta PC, Tamakoshi A, Koh WP, Gao YT, Sakata R, Tsuji I, Malekzadeh R, Sugawara Y, Kim J, Ito H, Nagata C, You SL, Park SK, Yuan JM, Shin MH, Kweon SS, Yi SW, Pednekar MS, Kimura T, Cai H, Lu Y, Etemadi A, Kanemura S, Wada K, Chen CJ, Shin A, Wang R, Ahn YO, Shin MH, Ohrr H, Sheikh M, Blechter B, Ahsan H, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Inoue M, Kang D, Robbins HA, Shu XO. Lung Cancer Risk Prediction Models for Asian Ever-Smokers. Journal of thoracic oncology, 19:451-464, 2024
11. Nuamah HG, Li Y, Yatsuya H, Yamagishi K, Saito I, Kokubo Y, Muraki I, Iso H, Inoue M, Tsugane S, Sawada N. The effect of age on the relationship between body mass index and risks of incident stroke subtypes: The JPHC study. Journal of stroke and cerebrovascular diseases, 33:107486, 2024
12. Kihara T, Yamagishi K, Imatoh T, Ihira H, Goto A, Iso H, Sawada N, Tsugane S, Inoue M. Validity of self-reported Helicobacter pylori eradication treatment from questionnaire and interview surveys of the JPHC-NEXT study: comparison with prescription history from insurance claims data. Journal of epidemiology, 2024
13. Nabila S, Choi JY, Abe SK, Islam MR, Rahman MS, Saito E, Shin A, Merritt MA, Katagiri R, Shu XO, Sawada N, Tamakoshi A, Sakata R, Hozawa A, Kim J, Nagata C, Park SK, Kweon SS, Cai H, Tsugane S, Kimura T, Kanemura S, Sugawara Y, Wada K, Shin MH, Ahsan H, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D. Differential patterns of reproductive and lifestyle risk factors for breast cancer according to birth cohorts among women in China, Japan and Korea. Breast cancer research, 26:15, 2024
14. Miyata J, Muraki I, Iso H, Yamagishi K, Yasuda N, Sawada N, Inoue M, Tsugane S. Sleep duration, its change, and risk of dementia among Japanese: The Japan Public Health Center-based Prospective Study. Preventive medicine, 180:107884, 2024
15. Kawai S, Lin Y, Tsuge H, Ito H, Matsuo K, Wada K, Nagata C, Narii N, Kitamura T, Utada M, Sakata R, Kimura T, Tamakoshi A, Sugawara Y, Tsuji I, Suzuki S, Sawada N, Tsugane S, Mizoue T, Oze I, Abe SK, Inoue M. Body mass index and lung cancer risk: Pooled analysis of 10 prospective cohort studies in Japan. Cancer science, 115:1346-1359, 2024
16. Okita Y, Sobue T, Zha L, Kitamura T, Iwasaki M, Inoue M, Yamaji T, Tsugane S, Sawada N. Long-term use of anti-cholesterol drugs and cancer risks in a Japanese population. Scientific reports, 14:2896, 2024
17. Yamanishi R, Yotsukura E, Hanyuda A, Uchino M, Yuki K, Negishi K, Yasuda N, Saito I, Kato T, Arima K, Aoyagi K, Tanno K, Yamagishi K, Muraki I, Yamaji T, Iwasaki M, Inoue M, Tsugane S, Sawada N. Relation between a history of glaucoma and subjective happiness: the JPHC-Next study. BMJ open ophthalmology, 9:e001553, 2024
18. Yin X, Kishida R, Abe SK, Islam MR, Rahman MS, Saito E, Lan Q, Blechter B, Merritt M, Choi JY, Shin A, Katagiri R, Shu XO, Sawada N, Tamakoshi A, Koh WP, Tsuji I, Nagata C, Park SK, Kweon SS, Gao YT, Tsugane S, Kimura T, Yuan JM, Lu Y, Kanemura S, Sugawara Y, Wada K, Shin MH, Ahsan H, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D, Seow WJ. Association between reproductive factors with lung cancer incidence and mortality: A pooled analysis of over 308,000 females in the Asia cohort consortium. International journal of cancer, 154:2090-2105, 2024
19. Ong SK, Abe SK, Gek Phua GL, Jayasekara H, Togawa K, Gatellier L, Kim J, Zhang Y, Kahan SZ, Yusof SN, Han JS, Pramesh CS, Sengar M, Shankar A, Cairo C, Sangrajran S, Nansalmaa E, Badamsuren T, Dendup T, Tshering K, He J, Werdi Nindito D RS, Ritana A, Im JS, Park EY, Huong GN, Thanh Huong TT, Biglari M, Yusuf A, Pradhananga KK, Vongdala C, Bin Jaafar MT, Ibrahim Tamin NS, Myint YY, Kaung KK, Rahman MS, Fernando E, Rath B, Sukumaran B, Hwang WY, Espina C, Schüz J, Inoue M, Matsuda T. Mapping recommendations towards an Asian Code Against Cancer (ACAC) as part of the World Code Against Cancer Framework: an Asian National Cancer Centers Alliance (ANCCA) initiative. The Lancet regional health. Southeast Asia, 24:100316, 2024
20. Mieno MN, Yamasaki M, Kuchiba A, Yamaji T, Ide K, Tanaka N, Sawada N, Inoue M, Tsugane S, Sawabe M, Iwasaki M. Lack of significant associations between single nucleotide polymorphisms in LPAL2-LPA genetic region and all cancer incidence and mortality in Japanese population: The Japan public health center-based prospective study. Cancer epidemiology, 85:102395, 2023
21. Nakano S, Yamaji T, Shiraishi K, Hidaka A, Shimazu T, Kuchiba A, Saito M, Kunishima F, Nakaza R, Kohno T, Sawada N, Inoue M, Tsugane S, Iwasaki M. Smoking and risk of colorectal cancer according to KRAS and BRAF mutation status in a Japanese prospective Study. Carcinogenesis, 44:476-484, 2023
22. Terada M, Nakamura K, Matsuda T, Okuma HS, Sudo K, Yusof A, Imasa M, Sirachainan E, Anh PT, Fujiwara Y, Yamamoto N, Voon PJ, Chokephaibulkit K, Shibata T, Inoue M, Mano H, Shimoi T, Sriuranpong V, Yonemori K, Shimada K. A new era of the Asian clinical research network: a report from the ATLAS international symposium. Japanese journal of clinical oncology, 53:619-628, 2023
23. Hose Y, Ishihara J, Kotemori A, Nakadate M, Maruya S, Tanaka J, Yatsuya H, Aoyama A, Chiang C, Konta T, Kayama T, Ueno Y, Inoue M, Sawada N, Tsugane S, Takachi R. Applicability of a Web-based 24-hour Dietary Recall Tool for Japanese Populations in Large-scale Epidemiological Studies. Journal of epidemiology, 33:419-427, 2023
24. Matsumura T, Muraki I, Ikeda A, Yamagishi K, Shirai K, Yasuda N, Sawada N, Inoue M, Iso H, Brunner EJ, Tsugane S. Hobby Engagement and Risk of Disabling Dementia. Journal of epidemiology, 33:456-463, 2023
25. Miyamoto Y, Katagiri R, Yamaji T, Inoue M, Goto A, Iwasaki M, Noda M, Tsugane S, Sawada N. Association of chronic kidney disease with total and site-specific cancer incidence in participants of the Japan Public Health Center-based Prospective Study. Nephrology, dialysis, transplantation, 38:1487-1496, 2023
26. Masaoka H, Matsuo K, Oze I, Kimura T, Tamakoshi A, Sugawara Y, Tsuji I, Sawada N, Tsugane S, Ito H, Wada K, Nagata C, Kitamura T, Zha L, Sakata R, Ozasa K, Lin Y, Mizoue T, Tanaka K, Abe SK, Inoue M. Cigarette Smoking, Smoking Cessation, and Bladder Cancer Risk: A Pooled Analysis of 10 Cohort Studies in Japan. Journal of epidemiology, 33:582-588, 2023
27. Okada C, Iso H, Yamagishi K, Ikeda A, Umesawa M, Muraki I, Yasuda N, Kato T, Saito I, Arima K, Nishimura T, Tanno K, Sakata K, Goto A, Yamaji T, Iwasaki M, Shimazu T, Inoue M, Sawada N, Tsugane S. Dietary behaviours and related lifestyles according to the presence or absence of skipping breakfast in Japanese adults: the JPHC-NEXT study. Public health nutrition, 26:1230-1237, 2023
28. Kanehara R, Katagiri R, Goto A, Yamaji T, Sawada N, Iwasaki M, Inoue M, Tsugane S. Sugar intake and colorectal cancer risk: A prospective Japanese cohort study. Cancer science, 114:2584-2595, 2023
29. Otsuka R, Zhang S, Ihira H, Sawada N, Inoue M, Yamagishi K, Yasuda N, Tsugane S. Dietary diversity and risk of late-life disabling dementia in middle-aged and older adults. Clinical nutrition (Edinburgh, Scotland), 42:541-549, 2023
30. Shrestha RM, Inoue Y, Yamamoto S, Fukunaga A, Sampei M, Okubo R, Morisaki N, Ohmagari N, Funaki T, Ishizuka K, Yamaguchi K, Sasaki Y, Takeda K, Miyama T, Kojima M, Nakagawa T, Nishimura K, Ogata S, Umezawa J, Tanaka S, Inoue M, Konishi M, Miyo K, Mizoue T. The association between experience of COVID-19-related discrimination and psychological distress among healthcare workers for six national medical research centers in Japan. Social psychiatry and psychiatric epidemiology, 58:1421-1429, 2023
31. Ge S, Zha L, Sobue T, Kitamura T, Iso H, Ishihara J, Kito K, Iwasaki M, Inoue M, Yamaji T, Tsugane S, Sawada N. Associations between dairy intake and mortality due to all-cause and cardiovascular disease: the Japan Public Health Center-based prospective study. European journal of nutrition, 62:2087-2104, 2023
32. Saito I, Yamagishi K, Kokubo Y, Yatsuya H, Iso H, Sawada N, Inoue M, Tsugane S. Impact of Cardiovascular Disease on the Death Certificate Diagnosis of Heart Failure, Ischemic Heart Disease, and Cerebrovascular Disease - The Japan Public Health Center-Based Prospective Study. Circulation journal, 87:1196-1202, 2023
33. Koyanagi YN, Matsuo K, Ito H, Wang C, Tamakoshi A, Sugawara Y, Tsuji I, Ono A, Tsugane S, Sawada N, Wada K, Nagata C, Takeuchi T, Kitamura T, Utada M, Sakata R, Mizoue T, Abe SK, Inoue M. Body mass index and esophageal and gastric cancer: A pooled analysis of 10 population-based cohort studies in Japan. Cancer science, 114:2961-2972, 2023
34. Li J, Nakagawa T, Kojima M, Nishikimi A, Tokuda H, Nishimura K, Umezawa J, Tanaka S, Inoue M, Ohmagari N, Yamaguchi K, Takeda K, Yamamoto S, Konishi M, Miyo K, Mizoue T. Underlying medical conditions and anti-SARS-CoV-2 spike IgG antibody titers after two doses of BNT162b2 vaccination: A cross-sectional study. PloS one, 18:e0283658, 2023
35. Shimizu Y, Inoue M, Yasuda N, Yamagishi K, Iwasaki M, Tsugane S, Sawada N. Bowel movement frequency, stool consistency, and risk of disabling dementia: a population-based cohort study in Japan. Public health, 221:31-38, 2023
36. Takahashi M, Sobue T, Zha L, Kitamura T, Iwasaki M, Inoue M, Yamaji T, Tsugane S, Sawada N. Dietary Fish and n-3 Polyunsaturated Fatty Acid Consumption, and Renal Cell Carcinoma Risk in Japan: The Japan Public Health Center-Based Prospective Study. Cancer epidemiology, biomarkers & prevention, 32:1365-1372, 2023
37. Ong SK, Abe SK, Thilagaratnam S, Haruyama R, Pathak R, Jayasekara H, Togawa K, Bhandari AKC, Shankar A, Nessa A, Jugder U, Agustina J, Biglari M, Yusuf A, Tshomo U, Fernando E, Cairo C, Kaung KK, Rath B, Vongdala C, Pradhananga KK, Kim J, Chung YK, Thanh Huong TT, Sangrajran S, Zhang Y, Basu P, Woo YL, Sukumaran B, Hwang WYK. Towards elimination of cervical cancer - human papillomavirus (HPV) vaccination and cervical cancer screening in Asian National Cancer Centers Alliance (ANCCA) member countries. The Lancet regional health. Western Pacific, 39:100860, 2023
38. Minami T, Inoue M, Yamaji T, Iwasaki M, Tsugane S, Sawada N. Reproductive Factors in the Risk of Bladder Cancer and Upper Urinary Tract Cancer: The Japan Public Health Center-Based Prospective Study. Cancer epidemiology, biomarkers & prevention, 32:1572-1582, 2023
39. Saito E, Tanaka S, Abe SK, Hirayabashi M, Ishihara J, Katanoda K, Lin Y, Nagata C, Sawada N, Takachi R, Goto A, Tanaka J, Ueda K, Hori M, Matsuda T, Inoue M. Economic burden of cancer attributable to modifiable risk factors in Japan. Global health & medicine, 5:238-245, 2023
40. Katagiri R, Iwasaki M, Abe SK, Islam MR, Rahman MS, Saito E, Merritt MA, Choi JY, Shin A, Sawada N, Tamakoshi A, Koh WP, Sakata R, Tsuji I, Kim J, Nagata C, Park SK, Kweon SS, Shu XO, Gao YT, Tsugane S, Kimura T, Yuan JM, Kanemura S, Lu Y, Sugawara Y, Wada K, Shin MH, Ahsan H, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D. Reproductive Factors and Endometrial Cancer Risk Among Women. JAMA network open, 6:e2332296, 2023
41. Tajima T, Ikeda A, Tanigawa T, Iso H, Yamagishi K, Matsumura T, Yasuda N, Inoue M, Tsugane S, Sawada N. Perceived Level of Life Enjoyment and Risk of Developing Disabling Dementia: The Japan Public Health Center-Based Study. The journals of gerontology. Series B, Psychological sciences and social sciences, 78:2001-2008, 2023
42. Nomura K, Bhandari AKC, Matsumoto-Takahashi ELA, Takahashi O. Risk Factors Associated with Stunting among Children Under Five in Timor-Leste. Annals of global health, 89:63, 2023
43. Nomura S, Nishio M, Abe SK, Eguchi A, Inoue M, Suzuki M, Hashizume M. Impact of the COVID-19 pandemic on cancer death locations in Japan: an analysis up to February 2023 on excess mortality. Journal of epidemiology, 2023
44. Yoshii K, Morisaki N, Piedvache A, Nakada S, Arima K, Aoyagi K, Nakashima H, Yasuda N, Muraki I, Yamagishi K, Saito I, Kato T, Tanno K, Yamaji T, Iwasaki M, Inoue M, Tsugane S, Sawada N. Association between birth weight and prevalence of cardiovascular disease and other lifestyle-related diseases among Japanese population: JPHC-NEXT Study. Journal of epidemiology, 2023
45. Tashiro M, Yasuda N, Inoue M, Yamagishi K, Tsugane S, Sawada N. Body mass index, weight change in midlife, and dementia incidence: the Japan Public Health Center-based Prospective Study. Alzheimer's & dementia (Amsterdam, Netherlands), 15:e12507, 2023