Annual Report 2023
Division of Epidemiology
Motoki Iwasaki, Taiki Yamaji, Shiori Nakano, Maki Igarashi, Yoko Shimizu, Akiko Hanyuda, Kenshiro Nishihara, Tomoko Jinno
Introduction
Research is conducted to construct evidence connected to the development of cancer prevention by clarifying the causes of cancer in humans by leveraging large-scale cohort studies and others of local residents.
Research Activities
1) Utilization of Biorepository Samples for the Epidemiological Research
To advance genomic research using next-generation sequencing technology, we have developed a methodology for constructing a cancer case-cohort study by using a base population of 54,068 individuals who responded to a questionnaire and provided blood samples during the baseline survey of the Japan Public Health Center-based prospective study for the next-generation (the JPHC-NEXT study). As an initial step, we established a case-cohort study using 935 cases of stomach, liver, pancreatic, and biliary tract cancers identified by the end of 2020, and 10,500 randomly selected individuals from the base population as a control cohort. We conducted targeted sequencing of five genes associated with homologous recombination repair: BRCA1, BRCA2, ATM, CDH1, and PALB2.
2) Epidemiological Research on Cancer Etiology and Prevention
We have conducted molecular epidemiological research to investigate cancer causes and prevention, utilizing biological samples collected in the JPHC study. In 2023, we published a study in an international journal that examined the associations between smoking and risk of colorectal cancer according to KRAS and BRAF mutation status. One significant finding was that ever-smokers had an approximately 2-fold higher risk of KRAS wild-type colorectal cancer than never-smokers. In contrast, an increased risk of KRAS-mutated colorectal cancer was not observed in ever-smokers. In another international journal publication, we reported that none of the 25 SNPs in the LPAL2-LPA region was found to be significantly associated with cancer incidence or mortality. Additionally, we co-authored several manuscripts on genetic research as members of the international consortium for lung and colorectal cancer.
3) Consortium on Large-scale Molecular Epidemiological Studies in Japan
Using the Japanese Consortium of Genetic Epidemiology, we conducted a genome-wide association study and Mendelian randomization analysis. In 2023, we published a study in an international journal, investigating genetic architecture of alcohol consumption and its impact on esophageal cancer risk. This study revealed several loci that interact with rs671 of ALDH2 variant in alcohol consumption and the effects of most identified loci were strong enough to influence not only drinking behavior but also esophageal cancer risk. In another international journal publication, we did not find evidence for a relationship between fasting glucose and HbA1c levels and colorectal cancer but found a potential positive association between higher fasting C-peptide and colorectal cancer based on Mendelian randomization analysis.
Education
We supervised the research of four graduate students.
Future Prospects
By constructing and utilizing research infrastructure for epidemiological studies, we hope to contribute to developing evidence for personalized cancer prevention and promoting a lifetime of health.
List of papers published in 2023
Journal
1. Shiraishi K, Takahashi A, Momozawa Y, Daigo Y, Kaneko S, Kawaguchi T, Kunitoh H, Matsumoto S, Horinouchi H, Goto A, Honda T, Shimizu K, Torasawa M, Takayanagi D, Saito M, Saito A, Ohe Y, Watanabe SI, Goto K, Tsuboi M, Tsuchihara K, Takata S, Aoi T, Takano A, Kobayashi M, Miyagi Y, Tanaka K, Suzuki H, Maeda D, Yamaura T, Matsuda M, Shimada Y, Mizuno T, Sakamoto H, Yoshida T, Goto Y, Yoshida T, Yamaji T, Sonobe M, Toyooka S, Yoneda K, Masago K, Tanaka F, Hara M, Fuse N, Nishizuka SS, Motoi N, Sawada N, Nishida Y, Kumada K, Takeuchi K, Tanno K, Yatabe Y, Sunami K, Hishida T, Miyazaki Y, Ito H, Amemiya M, Totsuka H, Nakayama H, Yokose T, Ishigaki K, Nagashima T, Ohtaki Y, Imai K, Takasawa K, Minamiya Y, Kobayashi K, Okubo K, Wakai K, Shimizu A, Yamamoto M, Iwasaki M, Matsuda K, Inazawa J, Shiraishi Y, Nishikawa H, Murakami Y, Kubo M, Matsuda F, Kamatani Y, Hamamoto R, Matsuo K, Kohno T. Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses. Cancer communications (London, England), 44:287-293, 2024
2. Ge S, Zha L, Sobue T, Kitamura T, Ishihara J, Iwasaki M, Inoue M, Yamaji T, Tsugane S, Sawada N. Dietary Consumption of Antioxidant Vitamins in Relation to Prostate Cancer Risk in Japanese Men: The Japan Public Health Center-based Prospective Study. Journal of epidemiology, 34:144-153, 2024
3. Mori N, Murphy N, Sawada N, Achaintre D, Yamaji T, Scalbert A, Ishihara J, Takachi R, Nakamura K, Tanaka J, Iwasaki M, Iso H, Inoue M, Gunter MJ, Tsugane S. Reproducibility and dietary correlates of plasma polyphenols in the JPHC-NEXT Protocol Area study. European journal of clinical nutrition, 78:34-42, 2024
4. Okita Y, Sobue T, Zha L, Kitamura T, Iwasaki M, Inoue M, Yamaji T, Tsugane S, Sawada N. Long-term use of anti-cholesterol drugs and cancer risks in a Japanese population. Scientific reports, 14:2896, 2024
5. Yamanishi R, Yotsukura E, Hanyuda A, Uchino M, Yuki K, Negishi K, Yasuda N, Saito I, Kato T, Arima K, Aoyagi K, Tanno K, Yamagishi K, Muraki I, Yamaji T, Iwasaki M, Inoue M, Tsugane S, Sawada N. Relation between a history of glaucoma and subjective happiness: the JPHC-Next study. BMJ open ophthalmology, 9:e001553, 2024
6. Kawai M, Ohtani S, Iwasaki M, Yamamoto S, Takamatsu K, Okamura H, Arai M, Nomura T, Ozaki S, Shibata KI, Akabane A, Motoi F, Yamauchi C, Yamamoto Y, Iwata H, Saji S. The Japanese Breast Cancer Society clinical practice guidelines for epidemiology and prevention of breast cancer, 2022 edition. Breast cancer (Tokyo, Japan), 31:166-178, 2024
7. Koyanagi YN, Nakatochi M, Namba S, Oze I, Charvat H, Narita A, Kawaguchi T, Ikezaki H, Hishida A, Hara M, Takezaki T, Koyama T, Nakamura Y, Suzuki S, Katsuura-Kamano S, Kuriki K, Nakamura Y, Takeuchi K, Hozawa A, Kinoshita K, Sutoh Y, Tanno K, Shimizu A, Ito H, Kasugai Y, Kawakatsu Y, Taniyama Y, Tajika M, Shimizu Y, Suzuki E, Hosono Y, Imoto I, Tabara Y, Takahashi M, Setoh K, Matsuda K, Nakano S, Goto A, Katagiri R, Yamaji T, Sawada N, Tsugane S, Wakai K, Yamamoto M, Sasaki M, Matsuda F, Okada Y, Iwasaki M, Brennan P, Matsuo K. Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people. Science advances, 10:eade2780, 2024
8. Suzuki A, Takachi R, Ishihara J, Maruya S, Ishii Y, Kito K, Nakamura K, Tanaka J, Yamaji T, Iso H, Iwasaki M, Tsugane S, Sawada N. Urinary Biomarkers in Screening for the Usual Intake of Fruit and Vegetables, and Sodium, Potassium, and the Sodium-to-Potassium Ratio: Required Number and Accuracy of Measurements. Nutrients, 16:442, 2024
9. Mieno MN, Yamasaki M, Kuchiba A, Yamaji T, Ide K, Tanaka N, Sawada N, Inoue M, Tsugane S, Sawabe M, Iwasaki M. Lack of significant associations between single nucleotide polymorphisms in LPAL2-LPA genetic region and all cancer incidence and mortality in Japanese population: The Japan public health center-based prospective study. Cancer epidemiology, 85:102395, 2023
10. Nakano S, Yamaji T, Shiraishi K, Hidaka A, Shimazu T, Kuchiba A, Saito M, Kunishima F, Nakaza R, Kohno T, Sawada N, Inoue M, Tsugane S, Iwasaki M. Smoking and risk of colorectal cancer according to KRAS and BRAF mutation status in a Japanese prospective Study. Carcinogenesis, 44:476-484, 2023
11. Shi J, Shiraishi K, Choi J, Matsuo K, Chen TY, Dai J, Hung RJ, Chen K, Shu XO, Kim YT, Landi MT, Lin D, Zheng W, Yin Z, Zhou B, Song B, Wang J, Seow WJ, Song L, Chang IS, Hu W, Chien LH, Cai Q, Hong YC, Kim HN, Wu YL, Wong MP, Richardson BD, Funderburk KM, Li S, Zhang T, Breeze C, Wang Z, Blechter B, Bassig BA, Kim JH, Albanes D, Wong JYY, Shin MH, Chung LP, Yang Y, An SJ, Zheng H, Yatabe Y, Zhang XC, Kim YC, Caporaso NE, Chang J, Ho JCM, Kubo M, Daigo Y, Song M, Momozawa Y, Kamatani Y, Kobayashi M, Okubo K, Honda T, Hosgood DH, Kunitoh H, Patel H, Watanabe SI, Miyagi Y, Nakayama H, Matsumoto S, Horinouchi H, Tsuboi M, Hamamoto R, Goto K, Ohe Y, Takahashi A, Goto A, Minamiya Y, Hara M, Nishida Y, Takeuchi K, Wakai K, Matsuda K, Murakami Y, Shimizu K, Suzuki H, Saito M, Ohtaki Y, Tanaka K, Wu T, Wei F, Dai H, Machiela MJ, Su J, Kim YH, Oh IJ, Lee VHF, Chang GC, Tsai YH, Chen KY, Huang MS, Su WC, Chen YM, Seow A, Park JY, Kweon SS, Chen KC, Gao YT, Qian B, Wu C, Lu D, Liu J, Schwartz AG, Houlston R, Spitz MR, Gorlov IP, Wu X, Yang P, Lam S, Tardon A, Chen C, Bojesen SE, Johansson M, Risch A, Bickeböller H, Ji BT, Wichmann HE, Christiani DC, Rennert G, Arnold S, Brennan P, McKay J, Field JK, Shete SS, Le Marchand L, Liu G, Andrew A, Kiemeney LA, Zienolddiny-Narui S, Grankvist K, Johansson M, Cox A, Taylor F, Yuan JM, Lazarus P, Schabath MB, Aldrich MC, Jeon HS, Jiang SS, Sung JS, Chen CH, Hsiao CF, Jung YJ, Guo H, Hu Z, Burdett L, Yeager M, Hutchinson A, Hicks B, Liu J, Zhu B, Berndt SI, Wu W, Wang J, Li Y, Choi JE, Park KH, Sung SW, Liu L, Kang CH, Wang WC, Xu J, Guan P, Tan W, Yu CJ, Yang G, Sihoe ADL, Chen Y, Choi YY, Kim JS, Yoon HI, Park IK, Xu P, He Q, Wang CL, Hung HH, Vermeulen RCH, Cheng I, Wu J, Lim WY, Tsai FY, Chan JKC, Li J, Chen H, Lin HC, Jin L, Liu J, Sawada N, Yamaji T, Wyatt K, Li SA, Ma H, Zhu M, Wang Z, Cheng S, Li X, Ren Y, Chao A, Iwasaki M, Zhu J, Jiang G, Fei K, Wu G, Chen CY, Chen CJ, Yang PC, Yu J, Stevens VL, Fraumeni JF Jr, Chatterjee N, Gorlova OY, Hsiung CA, Amos CI, Shen H, Chanock SJ,. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population. Nature communications, 14:3043, 2023
12. Kitagawa Y, Ishihara R, Ishikawa H, Ito Y, Oyama T, Oyama T, Kato K, Kato H, Kawakubo H, Kawachi H, Kuribayashi S, Kono K, Kojima T, Takeuchi H, Tsushima T, Toh Y, Nemoto K, Booka E, Makino T, Matsuda S, Matsubara H, Mano M, Minashi K, Miyazaki T, Muto M, Yamaji T, Yamatsuji T, Yoshida M. Esophageal cancer practice guidelines 2022 edited by the Japan Esophageal Society: part 2. Esophagus, 20:373-389, 2023
13. Kitagawa Y, Ishihara R, Ishikawa H, Ito Y, Oyama T, Oyama T, Kato K, Kato H, Kawakubo H, Kawachi H, Kuribayashi S, Kono K, Kojima T, Takeuchi H, Tsushima T, Toh Y, Nemoto K, Booka E, Makino T, Matsuda S, Matsubara H, Mano M, Minashi K, Miyazaki T, Muto M, Yamaji T, Yamatsuji T, Yoshida M. Esophageal cancer practice guidelines 2022 edited by the Japan esophageal society: part 1. Esophagus, 20:343-372, 2023
14. Nonaka T, Kawashiro S, Ishikawa H, Ito Y, Nemoto K, Ishihara R, Oyama T, Oyama T, Kato K, Kato H, Kawakubo H, Kawachi H, Kuribayashi S, Kono K, Kojima T, Takeuchi H, Tsushima T, Toh Y, Booka E, Makino T, Matsuda S, Matsubara H, Mano M, Minashi K, Miyazaki T, Muto M, Yamaji T, Yamatsuji T, Yoshida M, Kitagawa Y. Concurrent chemoradiotherapy using proton beams can reduce cardiopulmonary morbidity in esophageal cancer patients: a systematic review. Esophagus, 20:605-616, 2023
15. Miyamoto Y, Katagiri R, Yamaji T, Inoue M, Goto A, Iwasaki M, Noda M, Tsugane S, Sawada N. Association of chronic kidney disease with total and site-specific cancer incidence in participants of the Japan Public Health Center-based Prospective Study. Nephrology, dialysis, transplantation, 38:1487-1496, 2023
16. Okada C, Iso H, Yamagishi K, Ikeda A, Umesawa M, Muraki I, Yasuda N, Kato T, Saito I, Arima K, Nishimura T, Tanno K, Sakata K, Goto A, Yamaji T, Iwasaki M, Shimazu T, Inoue M, Sawada N, Tsugane S. Dietary behaviours and related lifestyles according to the presence or absence of skipping breakfast in Japanese adults: the JPHC-NEXT study. Public health nutrition, 26:1230-1237, 2023
17. Kanehara R, Katagiri R, Goto A, Yamaji T, Sawada N, Iwasaki M, Inoue M, Tsugane S. Sugar intake and colorectal cancer risk: A prospective Japanese cohort study. Cancer science, 114:2584-2595, 2023
18. Ge S, Zha L, Sobue T, Kitamura T, Iso H, Ishihara J, Kito K, Iwasaki M, Inoue M, Yamaji T, Tsugane S, Sawada N. Associations between dairy intake and mortality due to all-cause and cardiovascular disease: the Japan Public Health Center-based prospective study. European journal of nutrition, 62:2087-2104, 2023
19. Shimizu Y, Inoue M, Yasuda N, Yamagishi K, Iwasaki M, Tsugane S, Sawada N. Bowel movement frequency, stool consistency, and risk of disabling dementia: a population-based cohort study in Japan. Public health, 221:31-38, 2023
20. Takahashi M, Sobue T, Zha L, Kitamura T, Iwasaki M, Inoue M, Yamaji T, Tsugane S, Sawada N. Dietary Fish and n-3 Polyunsaturated Fatty Acid Consumption, and Renal Cell Carcinoma Risk in Japan: The Japan Public Health Center-Based Prospective Study. Cancer epidemiology, biomarkers & prevention, 32:1365-1372, 2023
21. Minami T, Inoue M, Yamaji T, Iwasaki M, Tsugane S, Sawada N. Reproductive Factors in the Risk of Bladder Cancer and Upper Urinary Tract Cancer: The Japan Public Health Center-Based Prospective Study. Cancer epidemiology, biomarkers & prevention, 32:1572-1582, 2023
22. Katagiri R, Iwasaki M, Abe SK, Islam MR, Rahman MS, Saito E, Merritt MA, Choi JY, Shin A, Sawada N, Tamakoshi A, Koh WP, Sakata R, Tsuji I, Kim J, Nagata C, Park SK, Kweon SS, Shu XO, Gao YT, Tsugane S, Kimura T, Yuan JM, Kanemura S, Lu Y, Sugawara Y, Wada K, Shin MH, Ahsan H, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D. Reproductive Factors and Endometrial Cancer Risk Among Women. JAMA network open, 6:e2332296, 2023
23. Yoshii K, Morisaki N, Piedvache A, Nakada S, Arima K, Aoyagi K, Nakashima H, Yasuda N, Muraki I, Yamagishi K, Saito I, Kato T, Tanno K, Yamaji T, Iwasaki M, Inoue M, Tsugane S, Sawada N. Association between birth weight and prevalence of cardiovascular disease and other lifestyle-related diseases among Japanese population: JPHC-NEXT Study. Journal of epidemiology, 2023
24. Kanehara R, Goto A, Goto M, Takahashi T, Iwasaki M, Noda M, Ihira H, Tsugane S, Sawada N. Validation Study of Diabetes Definitions Using Japanese Diagnosis Procedure Combination Data Among Hospitalized Patients. Journal of epidemiology, 33:165-169, 2023
25. Ogawa F, Takachi R, Ishihara J, Yamagishi M, Maruya S, Ishii Y, Kito K, Nakamura K, Tanaka J, Yamaji T, Iso H, Iwasaki M, Tsugane S, Sawada N. Dietary sodium sources according to four 3-d weighed food records and their association with multiple 24-h urinary excretions among middle-aged and elderly Japanese participants in rural areas. The British journal of nutrition, 129:1955-1963, 2023
26. Nomura T, Kawai M, Fukuma Y, Koike Y, Ozaki S, Iwasaki M, Yamamoto S, Takamatsu K, Okamura H, Arai M, Ootani S, Iwata H, Saji S. Alcohol consumption and breast cancer prognosis after breast cancer diagnosis: a systematic review and meta‑analysis of the Japanese Breast Cancer Society Clinical Practice Guideline, 2022 edition. Breast cancer (Tokyo, Japan), 30:519-530, 2023
27. Hanyuda A, Goto A, Katagiri R, Koyanagi YN, Nakatochi M, Sutoh Y, Nakano S, Oze I, Ito H, Yamaji T, Sawada N, Iwagami M, Kadota A, Koyama T, Katsuura-Kamano S, Ikezaki H, Tanaka K, Takezaki T, Imoto I, Suzuki M, Momozawa Y, Takeuchi K, Narita A, Hozawa A, Kinoshita K, Shimizu A, Tanno K, Matsuo K, Tsugane S, Wakai K, Sasaki M, Yamamoto M, Iwasaki M. Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation. Scientific reports, 13:7052, 2023
28. Sasaki M, Yuki K, Hanyuda A, Yamagishi K, Motomura K, Kurihara T, Tomita Y, Mori K, Ozawa N, Ozawa Y, Sawada N, Negishi K, Tsubota K, Tsugane S, Iso H. Associations between fatty acid intake and diabetic retinopathy in a Japanese population. Scientific reports, 13:12903, 2023
29. Thomas M, Su YR, Rosenthal EA, Sakoda LC, Schmit SL, Timofeeva MN, Chen Z, Fernandez-Rozadilla C, Law PJ, Murphy N, Carreras-Torres R, Diez-Obrero V, van Duijnhoven FJB, Jiang S, Shin A, Wolk A, Phipps AI, Burnett-Hartman A, Gsur A, Chan AT, Zauber AG, Wu AH, Lindblom A, Um CY, Tangen CM, Gignoux C, Newton C, Haiman CA, Qu C, Bishop DT, Buchanan DD, Crosslin DR, Conti DV, Kim DH, Hauser E, White E, Siegel E, Schumacher FR, Rennert G, Giles GG, Hampel H, Brenner H, Oze I, Oh JH, Lee JK, Schneider JL, Chang-Claude J, Kim J, Huyghe JR, Zheng J, Hampe J, Greenson J, Hopper JL, Palmer JR, Visvanathan K, Matsuo K, Matsuda K, Jung KJ, Li L, Le Marchand L, Vodickova L, Bujanda L, Gunter MJ, Matejcic M, Jenkins MA, Slattery ML, D'Amato M, Wang M, Hoffmeister M, Woods MO, Kim M, Song M, Iwasaki M, Du M, Udaltsova N, Sawada N, Vodicka P, Campbell PT, Newcomb PA, Cai Q, Pearlman R, Pai RK, Schoen RE, Steinfelder RS, Haile RW, Vandenputtelaar R, Prentice RL, Küry S, Castellví-Bel S, Tsugane S, Berndt SI, Lee SC, Brezina S, Weinstein SJ, Chanock SJ, Jee SH, Kweon SS, Vadaparampil S, Harrison TA, Yamaji T, Keku TO, Vymetalkova V, Arndt V, Jia WH, Shu XO, Lin Y, Ahn YO, Stadler ZK, Van Guelpen B, Ulrich CM, Platz EA, Potter JD, Li CI, Meester R, Moreno V, Figueiredo JC, Casey G, Lansdorp Vogelaar I, Dunlop MG, Gruber SB, Hayes RB, Pharoah PDP, Houlston RS, Jarvik GP, Tomlinson IP, Zheng W, Corley DA, Peters U, Hsu L. Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations. Nature communications, 14:6147, 2023