Annual Report 2023

Division of Screening Technology

Nozomu Kobayashi, Masau Sekiguchi, (Special research assistants): Orie Kitamura, Mio Shimamura, Ayami Haneda, Rie Negishi, Mika Mori

Introduction

 The Division of Screening Technology works with the NCC Cancer Screening Center on the study. It consists of two staff medical doctors and five special research assistants.

The Team and What We Do

 We aim to develop new diagnostic techniques that can be applied to cancer screening and research existing diagnostic methods that can be used for medical examinations. We are also assessing a new close examination method in cancer screening. In addition, we work on research aimed at risk stratification of people to be screened.

Research Activities

 1) Examinations are ongoing for the cancer detection rate of each screening modality (e.g., chest CT, upper/lower GI endoscopy, MMG/tomosynthesis, and breast ultrasonography, FDG-PETCT/MRI, and CT colonography), the characteristics of the detected cancer, and the false positive rate for all individuals who underwent cancer screening from the establishment of our center in 2004. In addition, we aim to clarify the relationship between cancer screening and cancer death from long-term (prognosis survey) results. Moreover, the following research is ongoing: 2) Field construction for verification of diagnostic tools for colorectal cancer and precancerous lesions using biomarkers (Oshima Study), 3) Japan Polyp Study: multicenter prospective cohort study to elucidate the preventive effect of colorectal cancer caused by polypectomy, 4) Prospective multicenter study to evaluate the effectiveness of AI-assisted colonoscopy, 5) Prospective multicenter study to evaluate the prevalence of sessile serrated lesions in Japan, and 6) Prospective multicenter study to evaluate the relationship between the background of detection and clinicopathological features of colorectal cancer. Furthermore, the amino index (AICS) study received plasma samples from 8,111 screening individuals, and a comprehensive amino acid analysis was completed. We assessed the usefulness of AICS for colorectal cancer screening.

 Other research: We are collaborating with external researchers using 1,325 stool samples collected from the Oshima Study. (Research on colibactin-producing bacteria as fecal biomarkers, bacteria, and bacterial flora as fecal biomarkers and their functions).

Future Prospects

 We will promote screening development research to create and gather evidence.

List of papers published in 2023

Journal

1. Sano Y, Hotta K, Matsuda T, Murakami Y, Fujii T, Kudo SE, Oda Y, Ishikawa H, Saito Y, Kobayashi N, Sekiguchi M, Ikematsu H, Katagiri A, Konishi K, Takeuchi Y, Iishi H, Igarashi M, Kobayashi K, Sada M, Osera S, Shinohara T, Yamaguchi Y, Hasuda K, Morishima T, Miyashiro I, Shimoda T, Taniguchi H, Fujimori T, Ajioka Y, Yoshida S. Endoscopic Removal of Premalignant Lesions Reduces Long-Term Colorectal Cancer Risk: Results From the Japan Polyp Study. Clinical gastroenterology and hepatology, 22:542-551.e3, 2024

2. Kawamura T, Sekiguchi M, Takamaru H, Mizuguchi Y, Horiguchi G, Toyoizumi H, Kato M, Kobayashi K, Sada M, Oda Y, Yokoyama A, Utsumi T, Tsuji Y, Ohki D, Takeuchi Y, Shichijo S, Ikematsu H, Matsuda K, Teramukai S, Kobayashi N, Matsuda T, Saito Y, Tanaka K. Endoscopist-related factors affecting adenoma detection during colonoscopy: Data from the J-SCOUT study. Digestive endoscopy, 36:51-58, 2024

3. Sekiguchi M, Matsuda T, Saito Y. Treatment strategy and post-treatment management of colorectal neuroendocrine tumor. DEN open, 4:e254, 2024

4. Saito Y, Sakamoto T, Dekker E, Pioche M, Probst A, Ponchon T, Messmann H, Dinis-Ribeiro M, Matsuda T, Ikematsu H, Saito S, Wada Y, Oka S, Sano Y, Fujishiro M, Murakami Y, Ishikawa H, Inoue H, Tanaka S, Tajiri H. First report from the International Evaluation of Endoscopic classification Japan NBI Expert Team: International multicenter web trial. Digestive endoscopy, 36:591-599, 2024

5. Takuma K, Kimura Y, Okano N, Nakagawa H, Watanabe K, Yamada Y, Iwasaki S, Ito K, Igarashi Y, Matsuda T. Two-devices-in-one-channel method for fractured pancreatic duct stent retrieval in a case of severe chronic pancreatitis. Journal of hepato-biliary-pancreatic sciences, 31:e1-e2, 2024

6. Ito Y, Hamaguchi T, Takashima A, Mizusawa J, Shimada Y, Shiozawa M, Mizoguchi N, Kodaira T, Komori K, Ohue M, Konishi K, Teraishi F, Kinouchi M, Murata K, Fujita F, Watanabe M, Iinuma G, Ishida F, Saida Y, Matsuda T, Katayama H, Fukuda H, Kanemitsu Y. Definitive S-1/mitomycin-C chemoradiotherapy for stage II/III anal canal squamous cell carcinoma: a phase I/II dose-finding and single-arm confirmatory study (JCOG0903). International journal of clinical oncology, 28:1063-1072, 2023

7. Suzuki H, Nonaka S, Maetani I, Matsuda T, Abe S, Yoshinaga S, Oda I, Yamagata Y, Yoshikawa T, Saito Y. Clinical and endoscopic features of metachronous gastric cancer with possible lymph node metastasis after endoscopic submucosal dissection and Helicobacter pylori eradication. Gastric cancer, 26:743-754, 2023

8. Kajiwara Y, Oka S, Tanaka S, Nakamura T, Saito S, Fukunaga Y, Takamatsu M, Kawachi H, Hotta K, Ikematsu H, Kojima M, Saito Y, Yamada M, Kanemitsu Y, Sekine S, Nagata S, Yamada K, Kobayashi N, Ishihara S, Saitoh Y, Matsuda K, Togashi K, Komori K, Ishiguro M, Kuwai T, Okuyama T, Ohuchi A, Ohnuma S, Sakamoto K, Sugai T, Katsumata K, Matsushita HO, Yamano HO, Eda H, Uraoka T, Akimoto N, Kobayashi H, Ajioka Y, Sugihara K, Ueno H. Nomogram as a novel predictive tool for lymph node metastasis in T1 colorectal cancer treated with endoscopic resection: a nationwide, multicenter study. Gastrointestinal endoscopy, 97:1119-1128.e5, 2023

9. Kawamura T, Sekiguchi M, Takamaru H, Mizuguchi Y, Horiguchi G, Kato M, Kobayashi K, Sada M, Oda Y, Yokoyama A, Utsumi T, Tsuji Y, Ohki D, Takeuchi Y, Shichijo S, Ikematsu H, Matsuda K, Teramukai S, Kobayashi N, Matsuda T, Saito Y, Tanaka K. "Endoscopic" adenoma detection rate as a quality indicator of colonoscopy: First report from the J-SCOUT study. Digestive endoscopy, 35:615-624, 2023

10. Hihara D, Takamaru H, Sekiguchi M, Yamada M, Sakamoto T, Matsuda T, Saito Y. Factors associated with increased duration of endoscopic submucosal dissection for rectal tumors: a 22-year retrospective analysis. Gastrointestinal endoscopy, 98:420-427.e1, 2023

11. Sekiguchi M, Igarashi A, Toyoshima N, Takamaru H, Yamada M, Esaki M, Kobayashi N, Saito Y. Cost-effectiveness analysis of computer-aided detection systems for colonoscopy in Japan. Digestive endoscopy, 35:891-899, 2023

12. Ishikawa H, Yamada M, Sato Y, Tanaka S, Akiko C, Tajika M, Doyama H, Takayama T, Ohda Y, Horimatsu T, Sano Y, Tanakaya K, Ikematsu H, Saida Y, Ishida H, Takeuchi Y, Kashida H, Kiriyama S, Hori S, Lee K, Tashiro J, Kobayashi N, Nakajima T, Suzuki S, Mutoh M. Intensive endoscopic resection for downstaging of polyp burden in patients with familial adenomatous polyposis (J-FAPP Study III): a multicenter prospective interventional study. Endoscopy, 55:344-352, 2023

13. Takamaru H, Saito Y, Toyoshima N, Yamada M, Sakamoto T, Matsuda T. Polyglycolic acid sheet with clipping for closing delayed perforation after colonic endoscopic submucosal dissection. Endoscopy, 55:E211-E213, 2023

14. Ito K, Okano N, Takuma K, Iwasaki S, Watanabe K, Kimura Y, Yamada Y, Yoshimoto K, Hara S, Kishimoto Y, Matsuda T, Igarashi Y. Are Newer Extracorporeal Shock Wave Lithotripsy Models Truly Improving Pancreatolithiasis Lithotripsy Performance? A Japanese Single-Center Study Using Endoscopic Adjunctive Treatment. Gut and liver, 17:647-658, 2023

15. Hayashi Y, Kaneko R, Ogino H, Uekusa T, Kitajima M, Ikehara T, Nagai H, Matsuda T. A case of multiple hepatocellular carcinoma experiencing complete responses to sorafenib and atezolizumab-bevacizumab and developing severe, refractory venous congestive cutaneous ulcers on either regimen. Clinical journal of gastroenterology, 16:229-236, 2023

16. Ogino Y, Wakui N, Nagai H, Matsuda T. Comparison of strain elastography and shear wave elastography in diagnosis of fibrosis in nonalcoholic fatty liver disease. Journal of medical ultrasonics (2001), 50:187-195, 2023

17. Abe SK, Ihira H, Minami T, Imatoh T, Inoue Y, Tsutsumimoto K, Kobayashi N, Kashima R, Konishi M, Doi T, Teramoto M, Kabe I, Lee S, Watanabe M, Dohi S, Sakai Y, Nishita Y, Morisaki N, Tachimori H, Kokubo Y, Yamaji T, Shimada H, Mizoue T, Sawada N, Tsugane S, Iwasaki M, Inoue M. Prevalence of family history of cancer in the NC-CCAPH consortium of Japan. Scientific reports, 13:3128, 2023

18. Toba T, Ikegami R, Nogami A, Watanabe N, Fujii K, Ogawa Y, Hojo A, Fujimoto A, Matsuda T. Multiple ulcerative colitis-associated aseptic abscesses successfully treated with infliximab: a case report. Clinical journal of gastroenterology, 16:537-542, 2023

19. Yoshida Y, Maetani I, Shigoka H, Matsuda T. Preprocedural control of nutritional status score and prediction of early death after percutaneous endoscopic gastrostomy. JGH open, 7:504-508, 2023

20. Kikuchi Y, Yamaguchi K, Shimizu R, Matsumoto Y, Kurose Y, Okano N, Otsuka Y, Shibuya K, Matsuda T, Shimada H. Intrahepatic cholangiocarcinoma with FGFR2 fusion gene positive that responded to pemigatinib and caused hypophosphatemia. International cancer conference journal, 12:285-290, 2023

21. Saito E, Mutoh M, Ishikawa H, Kamo K, Fukui K, Hori M, Ito Y, Chen Y, Sigel B, Sekiguchi M, Hemmi O, Katanoda K. Cost-effectiveness of preventive aspirin use and intensive downstaging polypectomy in patients with familial adenomatous polyposis: A microsimulation modeling study. Cancer medicine, 12:19137-19148, 2023

22. Kobayashi K, Nagai H, Matsui T, Matsuda T, Higai K. Importance of Atezolizumab Plus Bevacizumab Combination Treatment as First-line Therapy for Immunological Changes in Patients With Unresectable Hepatocellular Carcinoma. Anticancer research, 43:4601-4609, 2023

23. Ono M, Fujimoto A, Yamaguchi K, Toba T, Matsuda T. A new treatment method for patients with cancer that cannot be resected en bloc by endoscopic submucosal dissection: the monorail method with clip-line traction. Endoscopy, 55:E1118-E1119, 2023