Annual Report 2023

Division of Cohort Research

Norie Sawada, Manami Inoue, Motoki Iwasaki, Ryoko Katagiri, Jun Umezawa, Yukai Lu, Ayami Ono, Takahiro Mita, Rieko Kanehara, Yuri Ishii, Yasuko Kikuchi, Kumiko Kito, Ren Sato, Utako Murai, Katsura Ito, Tagayasu Anzai, Tetsuya Tajima, Shinichiro Shiozawa, Takashi Matsunaga, Mizuki Hino

Introduction

 The Division of Cohort Research aims to (i) create evidence for the prevention of non-communicable diseases such as cancer, and (ii) conduct epidemiological research to extend the healthy life expectancy among people living in Japan using population-based cohorts, domestic and international epidemiological research network framework, and the collaborative epidemiological research network project of the six national centers in Japan (6NCs) for advanced and specialized medicine – National Center Cohort Collaborative for Advancing Population Health (NC-CCAPH).

Research Activities

1.  Using NC-CCAPH as a six national centers (6NC) research network to conduct collaborative epidemiological research on advanced and specialized medical care

 NC-CCAPH is the core research project of the Division of Cohort Research. Initiated in 2017, the project aims to establish a 6NC Epidemiological Research Collaboration Platform to conduct pooled and mutual data analyses. As a part of this project, the collaborative analysis platform expanded on a secure cloud workspace and the analysis server was upgraded for smooth collaboration.

 Based on standardized evaluation criteria, we have re-evaluated the published recommendations on the association between several risk/preventive factors and diseases to extend healthy life expectancy in Japan. We will finish the evidence evaluation in 2024. The recommendations modified for the use of the general public were created and will be published in 2024.

2.  Promotion of collaborative research among the six National Centers using ongoing cohort studies in the NCC

 There are four Japan Public Health Centre-based Prospective (JPHC) Studies and seven JPHC Study for the Next Generation (JPHC-NEXT) collaborative studies. Using JPHC-NEXT, we reported that lower birth weight was associated with a higher prevalence of cardiovascular disease, hypertension, and diabetes, respectively.

 There are also seven ongoing collaborative studies from the NC-CCAPH consortium. We examined the association of multimorbidity with all-cause and cause-specific mortality in Japan as a pooled project and presented the findings at a conference.

3. JPHC Study / JPHC-NEXT

 We have been conducting follow-up surveys and data analysis for the JPHC Study with 140,000 residents from all over Japan since 1990. Using the JPHC Study, we reported that high consumption of n-3 polyunsaturated fatty acids was associated with renal cell carcinoma (RCC) risk. We also found a higher risk of RCC diagnosed at the hospital for another condition than other reasons. In another study, we examined the association between BMI trajectories and mortality. We found that being underweight, losing weight, and normal weight to obese were associated with a high risk of cancer mortality. However, a slight gain in weight did not increase the risk. Our findings suggest that not gaining too much weight is recommended for cancer prevention.

 The baseline survey for the JPHC-NEXT was completed at the end of 2016, and we initiated the 5-year follow-up survey in 2016 and then the 10-year follow-up survey in 2021 (Table 1). Using JPHC-NEXT data, we reported that individuals who skipped breakfast were more likely to eat out and eat instant meals. The study suggested that the awareness of time and the effort that can be invested in breakfast is important. In another study, we evaluated the validity of polyphenol intakes calculated from weighed food records and food frequency questionnaires, providing a basis for examining the association with diseases.

4.  The conditions and factors of coronavirus infection among National Center staff as a part of Multicenter Observational Study

 As a part of a research project supported by the Japan Health Research Promotion Bureau, we are conducting a multicenter observational study of new coronavirus infections (COVID-19) among National Cancer Center staff at the Tsukiji Campus. Web questionnaire surveys and collection of blood samples were conducted between June and July 2023, including over 400 participants. We are preparing to conduct a follow-up survey in 2024. There are two ongoing studies using data from the NCC and four studies using harmonized data from all six national centers.

Education

 We supervised the research of domestic and international Master's and PhD students. We accept postgraduate students from the Graduate School of Medicine, Yokohama City University, and the Graduate School of Humanities and Sciences, Nara Women's University.

Future Prospects

 We hope to continue to expand and strengthen research collaboration networks to extend healthy life expectancy among Japanese, promote comprehensive inter-disciplinary disease prevention strategies, and provide scientific evidence to do so.

List of papers published in 2023

Journal

1. Shiraishi K, Takahashi A, Momozawa Y, Daigo Y, Kaneko S, Kawaguchi T, Kunitoh H, Matsumoto S, Horinouchi H, Goto A, Honda T, Shimizu K, Torasawa M, Takayanagi D, Saito M, Saito A, Ohe Y, Watanabe SI, Goto K, Tsuboi M, Tsuchihara K, Takata S, Aoi T, Takano A, Kobayashi M, Miyagi Y, Tanaka K, Suzuki H, Maeda D, Yamaura T, Matsuda M, Shimada Y, Mizuno T, Sakamoto H, Yoshida T, Goto Y, Yoshida T, Yamaji T, Sonobe M, Toyooka S, Yoneda K, Masago K, Tanaka F, Hara M, Fuse N, Nishizuka SS, Motoi N, Sawada N, Nishida Y, Kumada K, Takeuchi K, Tanno K, Yatabe Y, Sunami K, Hishida T, Miyazaki Y, Ito H, Amemiya M, Totsuka H, Nakayama H, Yokose T, Ishigaki K, Nagashima T, Ohtaki Y, Imai K, Takasawa K, Minamiya Y, Kobayashi K, Okubo K, Wakai K, Shimizu A, Yamamoto M, Iwasaki M, Matsuda K, Inazawa J, Shiraishi Y, Nishikawa H, Murakami Y, Kubo M, Matsuda F, Kamatani Y, Hamamoto R, Matsuo K, Kohno T. Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses. Cancer communications (London, England), 44:287-293, 2024

2. Manandhar Shrestha R, Mizoue T, Islam Z, Kawakatsu Y, Ito H, Wada K, Nagata C, Zha L, Kitamura T, Sakata R, Kimura T, Sugawara Y, Tsuji I, Sato R, Sawada N, Tsugane S, Lin Y, Oze I, Abe SK, Inoue M. Adult Height and Risk of Colorectal Cancer: A Pooled Analysis of 10 Population-based Cohort Studies in Japan. Journal of epidemiology, 34:94-103, 2024

3. Ge S, Zha L, Sobue T, Kitamura T, Ishihara J, Iwasaki M, Inoue M, Yamaji T, Tsugane S, Sawada N. Dietary Consumption of Antioxidant Vitamins in Relation to Prostate Cancer Risk in Japanese Men: The Japan Public Health Center-based Prospective Study. Journal of epidemiology, 34:144-153, 2024

4. Yatsuya H, Yamagishi K, Li Y, Saito I, Kokubo Y, Muraki I, Inoue M, Tsugane S, Iso H, Sawada N. Risk and Population Attributable Fraction of Stroke Subtypes in Japan. Journal of epidemiology, 34:211-217, 2024

5. Yamamoto N, Ejima K, Mestre LM, Owora AH, Inoue M, Tsugane S, Sawada N. Body mass index trajectories and mortality risk in Japan using a population-based prospective cohort study: the Japan Public Health Center-based Prospective Study. International journal of epidemiology, 53:dyad145, 2024

6. Kikuchi H, Inoue S, Amagasa S, Kuwahara K, Ihira H, Inoue M, Iso H, Tsugane S, Sawada N. Relationships of Total and Domain-Specific Moderate-to-Vigorous Physical Activity with All-Cause and Disease-Specific Mortality. Medicine and science in sports and exercise, 56:520-527, 2024

7. Mori N, Murphy N, Sawada N, Achaintre D, Yamaji T, Scalbert A, Ishihara J, Takachi R, Nakamura K, Tanaka J, Iwasaki M, Iso H, Inoue M, Gunter MJ, Tsugane S. Reproducibility and dietary correlates of plasma polyphenols in the JPHC-NEXT Protocol Area study. European journal of clinical nutrition, 78:34-42, 2024

8. Nuamah HG, Li Y, Yatsuya H, Yamagishi K, Saito I, Kokubo Y, Muraki I, Iso H, Inoue M, Tsugane S, Sawada N. The effect of age on the relationship between body mass index and risks of incident stroke subtypes: The JPHC study. Journal of stroke and cerebrovascular diseases, 33:107486, 2024

9. Kihara T, Yamagishi K, Imatoh T, Ihira H, Goto A, Iso H, Sawada N, Tsugane S, Inoue M. Validity of self-reported Helicobacter pylori eradication treatment from questionnaire and interview surveys of the JPHC-NEXT study: comparison with prescription history from insurance claims data. Journal of epidemiology, 2024

10. Nabila S, Choi JY, Abe SK, Islam MR, Rahman MS, Saito E, Shin A, Merritt MA, Katagiri R, Shu XO, Sawada N, Tamakoshi A, Sakata R, Hozawa A, Kim J, Nagata C, Park SK, Kweon SS, Cai H, Tsugane S, Kimura T, Kanemura S, Sugawara Y, Wada K, Shin MH, Ahsan H, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D. Differential patterns of reproductive and lifestyle risk factors for breast cancer according to birth cohorts among women in China, Japan and Korea. Breast cancer research, 26:15, 2024

11. Miyata J, Muraki I, Iso H, Yamagishi K, Yasuda N, Sawada N, Inoue M, Tsugane S. Sleep duration, its change, and risk of dementia among Japanese: The Japan Public Health Center-based Prospective Study. Preventive medicine, 180:107884, 2024

12. Kawai S, Lin Y, Tsuge H, Ito H, Matsuo K, Wada K, Nagata C, Narii N, Kitamura T, Utada M, Sakata R, Kimura T, Tamakoshi A, Sugawara Y, Tsuji I, Suzuki S, Sawada N, Tsugane S, Mizoue T, Oze I, Abe SK, Inoue M. Body mass index and lung cancer risk: Pooled analysis of 10 prospective cohort studies in Japan. Cancer science, 115:1346-1359, 2024

13. Okita Y, Sobue T, Zha L, Kitamura T, Iwasaki M, Inoue M, Yamaji T, Tsugane S, Sawada N. Long-term use of anti-cholesterol drugs and cancer risks in a Japanese population. Scientific reports, 14:2896, 2024

14. Yamanishi R, Yotsukura E, Hanyuda A, Uchino M, Yuki K, Negishi K, Yasuda N, Saito I, Kato T, Arima K, Aoyagi K, Tanno K, Yamagishi K, Muraki I, Yamaji T, Iwasaki M, Inoue M, Tsugane S, Sawada N. Relation between a history of glaucoma and subjective happiness: the JPHC-Next study. BMJ open ophthalmology, 9:e001553, 2024

15. Yin X, Kishida R, Abe SK, Islam MR, Rahman MS, Saito E, Lan Q, Blechter B, Merritt M, Choi JY, Shin A, Katagiri R, Shu XO, Sawada N, Tamakoshi A, Koh WP, Tsuji I, Nagata C, Park SK, Kweon SS, Gao YT, Tsugane S, Kimura T, Yuan JM, Lu Y, Kanemura S, Sugawara Y, Wada K, Shin MH, Ahsan H, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D, Seow WJ. Association between reproductive factors with lung cancer incidence and mortality: A pooled analysis of over 308,000 females in the Asia cohort consortium. International journal of cancer, 154:2090-2105, 2024

16. Koyanagi YN, Nakatochi M, Namba S, Oze I, Charvat H, Narita A, Kawaguchi T, Ikezaki H, Hishida A, Hara M, Takezaki T, Koyama T, Nakamura Y, Suzuki S, Katsuura-Kamano S, Kuriki K, Nakamura Y, Takeuchi K, Hozawa A, Kinoshita K, Sutoh Y, Tanno K, Shimizu A, Ito H, Kasugai Y, Kawakatsu Y, Taniyama Y, Tajika M, Shimizu Y, Suzuki E, Hosono Y, Imoto I, Tabara Y, Takahashi M, Setoh K, Matsuda K, Nakano S, Goto A, Katagiri R, Yamaji T, Sawada N, Tsugane S, Wakai K, Yamamoto M, Sasaki M, Matsuda F, Okada Y, Iwasaki M, Brennan P, Matsuo K. Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people. Science advances, 10:eade2780, 2024

17. Xu J, Goto A, Konishi M, Kato M, Mizoue T, Terauchi Y, Tsugane S, Sawada N, Noda M. Development and Validation of Prediction Models for the 5-year Risk of Type 2 Diabetes in a Japanese Population: Japan Public Health Center-based Prospective (JPHC) Diabetes Study. Journal of epidemiology, 34:170-179, 2024

18. Murai U, Ishihara J, Takachi R, Kotemori A, Ishii Y, Nakamura K, Tanaka J, Iso H, Tsugane S, Sawada N. Validity of the intake of sugars, amino acids, and fatty acids estimated using a self-administered food frequency questionnaire in middle-aged and elderly Japanese: the Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT) Protocol Area. Journal of epidemiology, 2024

19. Jenkins DJA, Willett WC, Yusuf S, Hu FB, Glenn AJ, Liu S, Mente A, Miller V, Bangdiwala SI, Gerstein HC, Sieri S, Ferrari P, Patel AV, McCullough ML, Le Marchand L, Freedman ND, Loftfield E, Sinha R, Shu XO, Touvier M, Sawada N, Tsugane S, van den Brandt PA, Shuval K, Khan TA, Paquette M, Sahye-Pudaruth S, Patel D, Siu TFY, Srichaikul K, Kendall CWC, Sievenpiper JL. Association of glycaemic index and glycaemic load with type 2 diabetes, cardiovascular disease, cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants. The lancet. Diabetes & endocrinology, 12:107-118, 2024

20. Mieno MN, Yamasaki M, Kuchiba A, Yamaji T, Ide K, Tanaka N, Sawada N, Inoue M, Tsugane S, Sawabe M, Iwasaki M. Lack of significant associations between single nucleotide polymorphisms in LPAL2-LPA genetic region and all cancer incidence and mortality in Japanese population: The Japan public health center-based prospective study. Cancer epidemiology, 85:102395, 2023

21. Nakano S, Yamaji T, Shiraishi K, Hidaka A, Shimazu T, Kuchiba A, Saito M, Kunishima F, Nakaza R, Kohno T, Sawada N, Inoue M, Tsugane S, Iwasaki M. Smoking and risk of colorectal cancer according to KRAS and BRAF mutation status in a Japanese prospective Study. Carcinogenesis, 44:476-484, 2023

22. Shi J, Shiraishi K, Choi J, Matsuo K, Chen TY, Dai J, Hung RJ, Chen K, Shu XO, Kim YT, Landi MT, Lin D, Zheng W, Yin Z, Zhou B, Song B, Wang J, Seow WJ, Song L, Chang IS, Hu W, Chien LH, Cai Q, Hong YC, Kim HN, Wu YL, Wong MP, Richardson BD, Funderburk KM, Li S, Zhang T, Breeze C, Wang Z, Blechter B, Bassig BA, Kim JH, Albanes D, Wong JYY, Shin MH, Chung LP, Yang Y, An SJ, Zheng H, Yatabe Y, Zhang XC, Kim YC, Caporaso NE, Chang J, Ho JCM, Kubo M, Daigo Y, Song M, Momozawa Y, Kamatani Y, Kobayashi M, Okubo K, Honda T, Hosgood DH, Kunitoh H, Patel H, Watanabe SI, Miyagi Y, Nakayama H, Matsumoto S, Horinouchi H, Tsuboi M, Hamamoto R, Goto K, Ohe Y, Takahashi A, Goto A, Minamiya Y, Hara M, Nishida Y, Takeuchi K, Wakai K, Matsuda K, Murakami Y, Shimizu K, Suzuki H, Saito M, Ohtaki Y, Tanaka K, Wu T, Wei F, Dai H, Machiela MJ, Su J, Kim YH, Oh IJ, Lee VHF, Chang GC, Tsai YH, Chen KY, Huang MS, Su WC, Chen YM, Seow A, Park JY, Kweon SS, Chen KC, Gao YT, Qian B, Wu C, Lu D, Liu J, Schwartz AG, Houlston R, Spitz MR, Gorlov IP, Wu X, Yang P, Lam S, Tardon A, Chen C, Bojesen SE, Johansson M, Risch A, Bickeböller H, Ji BT, Wichmann HE, Christiani DC, Rennert G, Arnold S, Brennan P, McKay J, Field JK, Shete SS, Le Marchand L, Liu G, Andrew A, Kiemeney LA, Zienolddiny-Narui S, Grankvist K, Johansson M, Cox A, Taylor F, Yuan JM, Lazarus P, Schabath MB, Aldrich MC, Jeon HS, Jiang SS, Sung JS, Chen CH, Hsiao CF, Jung YJ, Guo H, Hu Z, Burdett L, Yeager M, Hutchinson A, Hicks B, Liu J, Zhu B, Berndt SI, Wu W, Wang J, Li Y, Choi JE, Park KH, Sung SW, Liu L, Kang CH, Wang WC, Xu J, Guan P, Tan W, Yu CJ, Yang G, Sihoe ADL, Chen Y, Choi YY, Kim JS, Yoon HI, Park IK, Xu P, He Q, Wang CL, Hung HH, Vermeulen RCH, Cheng I, Wu J, Lim WY, Tsai FY, Chan JKC, Li J, Chen H, Lin HC, Jin L, Liu J, Sawada N, Yamaji T, Wyatt K, Li SA, Ma H, Zhu M, Wang Z, Cheng S, Li X, Ren Y, Chao A, Iwasaki M, Zhu J, Jiang G, Fei K, Wu G, Chen CY, Chen CJ, Yang PC, Yu J, Stevens VL, Fraumeni JF Jr, Chatterjee N, Gorlova OY, Hsiung CA, Amos CI, Shen H, Chanock SJ,. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population. Nature communications, 14:3043, 2023

23. Hose Y, Ishihara J, Kotemori A, Nakadate M, Maruya S, Tanaka J, Yatsuya H, Aoyama A, Chiang C, Konta T, Kayama T, Ueno Y, Inoue M, Sawada N, Tsugane S, Takachi R. Applicability of a Web-based 24-hour Dietary Recall Tool for Japanese Populations in Large-scale Epidemiological Studies. Journal of epidemiology, 33:419-427, 2023

24. Matsumura T, Muraki I, Ikeda A, Yamagishi K, Shirai K, Yasuda N, Sawada N, Inoue M, Iso H, Brunner EJ, Tsugane S. Hobby Engagement and Risk of Disabling Dementia. Journal of epidemiology, 33:456-463, 2023

25. Miyamoto Y, Katagiri R, Yamaji T, Inoue M, Goto A, Iwasaki M, Noda M, Tsugane S, Sawada N. Association of chronic kidney disease with total and site-specific cancer incidence in participants of the Japan Public Health Center-based Prospective Study. Nephrology, dialysis, transplantation, 38:1487-1496, 2023

26. Okada C, Iso H, Yamagishi K, Ikeda A, Umesawa M, Muraki I, Yasuda N, Kato T, Saito I, Arima K, Nishimura T, Tanno K, Sakata K, Goto A, Yamaji T, Iwasaki M, Shimazu T, Inoue M, Sawada N, Tsugane S. Dietary behaviours and related lifestyles according to the presence or absence of skipping breakfast in Japanese adults: the JPHC-NEXT study. Public health nutrition, 26:1230-1237, 2023

27. Kanehara R, Katagiri R, Goto A, Yamaji T, Sawada N, Iwasaki M, Inoue M, Tsugane S. Sugar intake and colorectal cancer risk: A prospective Japanese cohort study. Cancer science, 114:2584-2595, 2023

28. Otsuka R, Zhang S, Ihira H, Sawada N, Inoue M, Yamagishi K, Yasuda N, Tsugane S. Dietary diversity and risk of late-life disabling dementia in middle-aged and older adults. Clinical nutrition (Edinburgh, Scotland), 42:541-549, 2023

29. Shrestha RM, Inoue Y, Yamamoto S, Fukunaga A, Sampei M, Okubo R, Morisaki N, Ohmagari N, Funaki T, Ishizuka K, Yamaguchi K, Sasaki Y, Takeda K, Miyama T, Kojima M, Nakagawa T, Nishimura K, Ogata S, Umezawa J, Tanaka S, Inoue M, Konishi M, Miyo K, Mizoue T. The association between experience of COVID-19-related discrimination and psychological distress among healthcare workers for six national medical research centers in Japan. Social psychiatry and psychiatric epidemiology, 58:1421-1429, 2023

30. Ge S, Zha L, Sobue T, Kitamura T, Iso H, Ishihara J, Kito K, Iwasaki M, Inoue M, Yamaji T, Tsugane S, Sawada N. Associations between dairy intake and mortality due to all-cause and cardiovascular disease: the Japan Public Health Center-based prospective study. European journal of nutrition, 62:2087-2104, 2023

31. Saito I, Yamagishi K, Kokubo Y, Yatsuya H, Iso H, Sawada N, Inoue M, Tsugane S. Impact of Cardiovascular Disease on the Death Certificate Diagnosis of Heart Failure, Ischemic Heart Disease, and Cerebrovascular Disease - The Japan Public Health Center-Based Prospective Study. Circulation journal, 87:1196-1202, 2023

32. Koyanagi YN, Matsuo K, Ito H, Wang C, Tamakoshi A, Sugawara Y, Tsuji I, Ono A, Tsugane S, Sawada N, Wada K, Nagata C, Takeuchi T, Kitamura T, Utada M, Sakata R, Mizoue T, Abe SK, Inoue M. Body mass index and esophageal and gastric cancer: A pooled analysis of 10 population-based cohort studies in Japan. Cancer science, 114:2961-2972, 2023

33. Li J, Nakagawa T, Kojima M, Nishikimi A, Tokuda H, Nishimura K, Umezawa J, Tanaka S, Inoue M, Ohmagari N, Yamaguchi K, Takeda K, Yamamoto S, Konishi M, Miyo K, Mizoue T. Underlying medical conditions and anti-SARS-CoV-2 spike IgG antibody titers after two doses of BNT162b2 vaccination: A cross-sectional study. PloS one, 18:e0283658, 2023

34. Shimizu Y, Inoue M, Yasuda N, Yamagishi K, Iwasaki M, Tsugane S, Sawada N. Bowel movement frequency, stool consistency, and risk of disabling dementia: a population-based cohort study in Japan. Public health, 221:31-38, 2023

35. Takahashi M, Sobue T, Zha L, Kitamura T, Iwasaki M, Inoue M, Yamaji T, Tsugane S, Sawada N. Dietary Fish and n-3 Polyunsaturated Fatty Acid Consumption, and Renal Cell Carcinoma Risk in Japan: The Japan Public Health Center-Based Prospective Study. Cancer epidemiology, biomarkers & prevention, 32:1365-1372, 2023

36. Minami T, Inoue M, Yamaji T, Iwasaki M, Tsugane S, Sawada N. Reproductive Factors in the Risk of Bladder Cancer and Upper Urinary Tract Cancer: The Japan Public Health Center-Based Prospective Study. Cancer epidemiology, biomarkers & prevention, 32:1572-1582, 2023

37. Saito E, Tanaka S, Abe SK, Hirayabashi M, Ishihara J, Katanoda K, Lin Y, Nagata C, Sawada N, Takachi R, Goto A, Tanaka J, Ueda K, Hori M, Matsuda T, Inoue M. Economic burden of cancer attributable to modifiable risk factors in Japan. Global health & medicine, 5:238-245, 2023

38. Katagiri R, Iwasaki M, Abe SK, Islam MR, Rahman MS, Saito E, Merritt MA, Choi JY, Shin A, Sawada N, Tamakoshi A, Koh WP, Sakata R, Tsuji I, Kim J, Nagata C, Park SK, Kweon SS, Shu XO, Gao YT, Tsugane S, Kimura T, Yuan JM, Kanemura S, Lu Y, Sugawara Y, Wada K, Shin MH, Ahsan H, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D. Reproductive Factors and Endometrial Cancer Risk Among Women. JAMA network open, 6:e2332296, 2023

39. Tajima T, Ikeda A, Tanigawa T, Iso H, Yamagishi K, Matsumura T, Yasuda N, Inoue M, Tsugane S, Sawada N. Perceived Level of Life Enjoyment and Risk of Developing Disabling Dementia: The Japan Public Health Center-Based Study. The journals of gerontology. Series B, Psychological sciences and social sciences, 78:2001-2008, 2023

40. Yoshii K, Morisaki N, Piedvache A, Nakada S, Arima K, Aoyagi K, Nakashima H, Yasuda N, Muraki I, Yamagishi K, Saito I, Kato T, Tanno K, Yamaji T, Iwasaki M, Inoue M, Tsugane S, Sawada N. Association between birth weight and prevalence of cardiovascular disease and other lifestyle-related diseases among Japanese population: JPHC-NEXT Study. Journal of epidemiology, 2023

41. Tashiro M, Yasuda N, Inoue M, Yamagishi K, Tsugane S, Sawada N. Body mass index, weight change in midlife, and dementia incidence: the Japan Public Health Center-based Prospective Study. Alzheimer's & dementia (Amsterdam, Netherlands), 15:e12507, 2023

42. Kanehara R, Goto A, Goto M, Takahashi T, Iwasaki M, Noda M, Ihira H, Tsugane S, Sawada N. Validation Study of Diabetes Definitions Using Japanese Diagnosis Procedure Combination Data Among Hospitalized Patients. Journal of epidemiology, 33:165-169, 2023

43. Ogawa F, Takachi R, Ishihara J, Yamagishi M, Maruya S, Ishii Y, Kito K, Nakamura K, Tanaka J, Yamaji T, Iso H, Iwasaki M, Tsugane S, Sawada N. Dietary sodium sources according to four 3-d weighed food records and their association with multiple 24-h urinary excretions among middle-aged and elderly Japanese participants in rural areas. The British journal of nutrition, 129:1955-1963, 2023

44. Hanyuda A, Goto A, Katagiri R, Koyanagi YN, Nakatochi M, Sutoh Y, Nakano S, Oze I, Ito H, Yamaji T, Sawada N, Iwagami M, Kadota A, Koyama T, Katsuura-Kamano S, Ikezaki H, Tanaka K, Takezaki T, Imoto I, Suzuki M, Momozawa Y, Takeuchi K, Narita A, Hozawa A, Kinoshita K, Shimizu A, Tanno K, Matsuo K, Tsugane S, Wakai K, Sasaki M, Yamamoto M, Iwasaki M. Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation. Scientific reports, 13:7052, 2023

45. Sasaki M, Yuki K, Hanyuda A, Yamagishi K, Motomura K, Kurihara T, Tomita Y, Mori K, Ozawa N, Ozawa Y, Sawada N, Negishi K, Tsubota K, Tsugane S, Iso H. Associations between fatty acid intake and diabetic retinopathy in a Japanese population. Scientific reports, 13:12903, 2023

46. Thomas M, Su YR, Rosenthal EA, Sakoda LC, Schmit SL, Timofeeva MN, Chen Z, Fernandez-Rozadilla C, Law PJ, Murphy N, Carreras-Torres R, Diez-Obrero V, van Duijnhoven FJB, Jiang S, Shin A, Wolk A, Phipps AI, Burnett-Hartman A, Gsur A, Chan AT, Zauber AG, Wu AH, Lindblom A, Um CY, Tangen CM, Gignoux C, Newton C, Haiman CA, Qu C, Bishop DT, Buchanan DD, Crosslin DR, Conti DV, Kim DH, Hauser E, White E, Siegel E, Schumacher FR, Rennert G, Giles GG, Hampel H, Brenner H, Oze I, Oh JH, Lee JK, Schneider JL, Chang-Claude J, Kim J, Huyghe JR, Zheng J, Hampe J, Greenson J, Hopper JL, Palmer JR, Visvanathan K, Matsuo K, Matsuda K, Jung KJ, Li L, Le Marchand L, Vodickova L, Bujanda L, Gunter MJ, Matejcic M, Jenkins MA, Slattery ML, D'Amato M, Wang M, Hoffmeister M, Woods MO, Kim M, Song M, Iwasaki M, Du M, Udaltsova N, Sawada N, Vodicka P, Campbell PT, Newcomb PA, Cai Q, Pearlman R, Pai RK, Schoen RE, Steinfelder RS, Haile RW, Vandenputtelaar R, Prentice RL, Küry S, Castellví-Bel S, Tsugane S, Berndt SI, Lee SC, Brezina S, Weinstein SJ, Chanock SJ, Jee SH, Kweon SS, Vadaparampil S, Harrison TA, Yamaji T, Keku TO, Vymetalkova V, Arndt V, Jia WH, Shu XO, Lin Y, Ahn YO, Stadler ZK, Van Guelpen B, Ulrich CM, Platz EA, Potter JD, Li CI, Meester R, Moreno V, Figueiredo JC, Casey G, Lansdorp Vogelaar I, Dunlop MG, Gruber SB, Hayes RB, Pharoah PDP, Houlston RS, Jarvik GP, Tomlinson IP, Zheng W, Corley DA, Peters U, Hsu L. Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations. Nature communications, 14:6147, 2023

47. Svensson T, Sawada N, Mimura M, Nozaki S, Shikimoto R, Tsugane S. Midlife Intakes of the Isoflavone Genistein and Soy and the Risk of Late-life Cognitive Impairment: The JPHC Saku Mental Health Study. Journal of epidemiology, 33:342-349, 2023

48. Kito K, Yamamoto J, Kotemori A, Nakadate M, Maruyama K, Miyazaki S, Okada C, Ishihara J, Tsugane S, Sawada N. Validity and reproducibility of the intake of trans-fatty acids estimated using a FFQ and characteristics of trans-fatty acid intake of the Japanese population: the JPHC FFQ Validation Study. The British journal of nutrition, 130:895-903, 2023

49. Shimomura Y, Zha L, Komukai S, Narii N, Sobue T, Kitamura T, Shiba S, Mizutani S, Yamada T, Sawada N, Yachida S. Mediation effect of intestinal microbiota on the relationship between fiber intake and colorectal cancer. International journal of cancer, 152:1752-1762, 2023

50. Iwasaki M, Yoshihara A, Suwama K, Zaitsu T, Suzuki S, Ihira H, Sawada N, Aida J. A cross-sectional study of the association between periodontitis and physical activity in the Japanese population. Journal of periodontal research, 58:350-359, 2023

51. Miki T, Nanri A, Mizoue T, Goto A, Noda M, Sawada N, Tsugane S. Association of body mass index and weight change with pneumonia mortality in a Japanese population: Japan Public Health Center-based Prospective Study. International journal of obesity (2005), 47:479-486, 2023

52. Takata Y, Yang JJ, Yu D, Smith-Warner SA, Blot WJ, White E, Robien K, Prizment A, Wu K, Sawada N, Lan Q, Park Y, Gao YT, Cai Q, Song M, Zhang X, Pan K, Agudo A, Panico S, Liao LM, Tsugane S, Chlebowski RT, Nøst TH, Schulze MB, Johannson M, Zheng W, Shu XO. Calcium Intake and Lung Cancer Risk: A Pooled Analysis of 12 Prospective Cohort Studies. The Journal of nutrition, 153:2051-2060, 2023

53. Kabasawa K, Ito Y, Iino N, Nakamura K, Sawada N, Tsugane S, Tanaka J, Narita I. Chronic kidney disease awareness and its determinants in middle-aged and older Japanese adults: Observations from a 5-year follow-up of the Uonuma cohort study. Nephrology (Carlton, Vic.), 28:567-575, 2023

54. Gapstur SM, Bouvard V, Nethan ST, Freudenheim JL, Abnet CC, English DR, Rehm J, Balbo S, Buykx P, Crabb D, Conway DI, Islami F, Lachenmeier DW, McGlynn KA, Salaspuro M, Sawada N, Terry MB, Toporcov T, Lauby-Secretan B. The IARC Perspective on Alcohol Reduction or Cessation and Cancer Risk. The New England journal of medicine, 389:2486-2494, 2023