Annual Report 2024
Endoscopy Center / Endoscopy Division
Yutaka Saito, Nozomu Kobayashi, Seiichiro Abe, Yasuo Kakugawa, Masau Sekiguchi , Satoru Nonaka, Masayoshi Yamada, Hiroyuki Takamaru. Keiko (Sogame) Nakamura, Naoya Toyoshima, and Ryoji Kusuhara Mitsunori, Ichijima, Yasuhiko Mizuguchi, Reona Kawamura (Staff)
Takao Itoi, Ichiro Oda, Taku Sakamoto, Eriko (Tsuruki) So, Makiguchi Mai, Keiko Niimi, Izumi Hisada (Attending staff)
Takeshi Uozumi, Yuichiro Hirai, Mika Miyabe, Ryosuke Kawagoe, Yuki Koyo, Satoru Mizutani, Yudai Kumamoto, Ryuji Shudo, and Takashi Kondo (Resident)
Masanori Kurashige, Masako Yamada, Wakana Yashima, Ayano Okamura, Emiko Tahara, and Yumiko Sakamoto, Shino Tsuruta (Endoscopic Engineer)
Introduction
The Department of Endoscopy moved to the New Endoscopy Center on January 20th, 2014, and we believe this is one of the largest endoscopy centers in Japan (15 endoscopy rooms [251.112 m2] and recovery rooms [136.788 m2] on two floors with an area of 1949.554 m2).
The Team and What We Do
Dramatic developments have recently changed the operational mechanism and design of endoscopes along with the availability of various accessory devices and instruments, thus, the clinical applications using the latest equipment are evolving on a continuous basis.
In the Gastrointestinal Endoscopy Division, more advanced and technically difficult endoscopic treatments such as endoscopic submucosal dissection (ESD) are being used in place of conventional endoscopic mucosal resection (EMR) not only for early gastric cancer, but also for superficial esophageal and colorectal neoplasms. In addition, educational activities are an important part of the division’s activities, with many Japanese medical students, residents, and staff physicians as well as approximately 130 overseas post-graduate physicians attending our training courses annually.
Our Endoscopy Center was authorized as one of the Centers of Excellence by the World Endoscopy Organization (WEO) and got an award during Gastro 2017 in Hyderabad. This is an honorable award for us because there are only 17 famous international centers worldwide and only two centers in Japan.
We are also focusing on the development of new medical devices. A joint laboratory with Olympus has been developed in the new research building, and new medical devices are being jointly developed with the three main topics of diagnosis, treatment, and education. We are planning to apply for a joint patent for two new medical devices.
In addition, we are leading the MIRAI project, which plays a key role in the development of minimally invasive treatment techniques and devices of the near future, and are also focusing on training young human resources who will lead the future.
Research Activities
Our efforts have been focused on new diagnostic and therapeutic strategies. For more precise endoscopic diagnosis of gastrointestinal diseases, we are utilizing the NBI and BLI systems, which narrow the spectral transmittance bandwidth of the optical filters used in the light source of electronic endoscope systems. In addition, we have introduced an endocytoscopy system, which can magnify lesions up to 500x magnification and visualize nuclear atypia.
Clinical Trials
We have organized several multicenter study groups to prospectively evaluate the efficacy and clinical impact of newly developed endoscopies and medical devices.
Esophagus
We are currently enrolling our patients in several multicenter randomized controlled trials (RCTs).
A phase III study is ongoing to compare oral steroid administration with local steroid injection therapy for the prevention of esophageal stricture after endoscopic submucosal dissection (JCOG1217: Steroid EESD P3). Moreover, a randomized controlled Phase II/III study has been conducted to compare endoscopic balloon dilation combined with steroid injection versus radial incision and cutting combined with steroid injection for refractory anastomotic stricture after esophagectomy (JCOG1207: RICS study).
We also enrolled our patients in a non-randomized study for investigating the usefulness of endoscopic ultrasonography (JCOG1604: Odyssey trial) by comparing the results with those of magnified endoscopy with narrow band imaging for diagnosing cancer invasion depth of clinical stage IA esophageal squamous cell carcinoma.
Stomach
A nationwide cancer registry system has been developed for early gastric cancer treated with EMR/ESD. A five-year multicenter prospective cohort study has been conducted using this cancer registry system since 2010 (J-WEB/EGC) and the short-term outcomes were published in DEN. The long-term outcomes were being analyzed this year and will be published.
Our division has developed and is leading the single-arm phase III confirmatory trial on indications of endoscopic submucosal dissection for elderly patients with early gastric cancer (JCOG1902: Elderly G-ESD study). This study has been ongoing since 2020.
In a prospective multicenter clinical trial of using confocal LASER endomicroscopy (pCLE) for the diagnosis of gastric epithelial lesion, our institution conducts a prospective multicenter trial with a total of 8 tertiary centers as Advanced Medical Technology B to clarify the efficacy of pCLE using fluorescein for the diagnosis of early gastric cancer.
Duodenum
A non-randomized confirmatory trial of cold snare polypectomy for superficial non-ampullary duodenal epithelial tumor (D-COP trial) has been conducted at more than 100 institutions in Japan since 2017. Recently, cold snare polypectomy is widely performed on the colorectal region, and it is expected that the same concept can be applied for duodenal small tumors (familial adenomatous polyposis [FAP] is excluded from this trial).
Colorectum
RCTs on colorectal neoplasms are ongoing as well.
The Japan Polyp Study (JPS), a multicenter RCT conducted at 11 participating centers was initiated in 2003. The aim of this study was to assess whether follow-up colonoscopy using high definition colonoscope at three years as well as at both one and three years would detect important lesions including non-polypoid colorectal neoplasia. The JPS will provide preexisting comorbidity data, including the prevalence of both flat and depressed colorectal lesions, the quality of colonoscopy, and the risk of colorectal cancer (CRC). Furthermore, the study will clarify the long-term impact of colonoscopic removal on mortality due to CRC. The evidence will help elaborate the fundamental basis for the updated Japanese surveillance guidelines (JPS participants: 3,926, JPS cohort: 1,291). The first outcome of the JPS has been published in Gut and the second in CGH2024 Mar;22(3):542-551.e3.
We play a leading role in a multicenter single-arm study (JCOG1612) on the possibility of CRT for high-risk rectal submucosal cancer after endoscopic resections. When the results of this study show a non-inferiority of CRT compared to surgery, we could propose a new non-invasive treatment strategy for rectal T1 cancer patients.
A nationwide cancer registry system has also been developed for early CRC treated with ESD. A five-year multicenter prospective cohort study has been ongoing using this cancer registry system since 2013. A total of 2,074 patients were enrolled in this multicenter cohort study and 5-year surveillance of all enrolled patients has been completed. This should be the largest cohort study in colorectal ESD in the world. The study demonstrated favorable long-term prognosis and was published in Gastroenterology. [IF: 22.68], 2022 Nov;163(5):1423-1434.e2.
We have conducted a multicenter prospective cohort study on colorectal neuroendocrine tumors (NETs) since January 2017. This study is expected to provide new important findings on colorectal NETs.
A multicenter prospective cohort study on T1 CRC has also been performed since May 2017. In this study, T1 CRC cases were accumulated from over 70 institutions all over Japan, which will provide important information on the management of T1 cancer.
J-CAPP Study II: To evaluate the influence of low-dose, aspirin tablets (100 mg/day for four years) on colorectal tumor recurrence, we have conducted a multicenter prospective study since 2015 (Chief conductor: Hideki Ishikawa, M.D, Kyoto Prefectural University of Medicine).
Molecular and fluorescence Imaging and Database Study
Molecular imaging endoscopy is one of the imaging modalities in this new era for very early cancer diagnosis and detection of metastasis. We have started a collaborative study with the Departments of Endoscopy, Colorectal Surgery, Gastric Surgery, and Pathology and Clinical Laboratories, the NCC, Research Institute, the University of Tokyo, and the Jikei University School of Medicine.
We have been collaborating with the Japan Gastroenterological Endoscopy Society (JGES) to build a Japan Endoscopy Database (JED) of gastrointestinal endoscopies including not only therapeutic but also diagnostic procedures. This all-Japan project is named JED and has the potential to construct the largest and most precise database of all endoscopic procedures. Japanese endoscopists are well known as the most excellent endoscopists; therefore, we can obtain much evidence using this huge endoscopy database from now on.
Research and development of new endoscopy using artificial intelligence (AI): Recent development of artificial intelligence (AI) using deep learning is expected to be applicable in precision medicine. We have been researching and developing new endoscopic systems using AI. First, in order to support endoscopist’s detection of CRC and precancerous lesions during colonoscopy by AI, we have been researching and developing a software program using convolutional neural networks based on mathematical morphology and hardware, which works in real-time. We will extend this system to genomic data and other gastrointestinal organs, such as the stomach and esophagus, in the future. Second, we have joined a multicenter image analyzing study led by Prof. Kudo’s group to compare a new automatic diagnosis system using AI with endoscopist’s diagnosis of colorectal lesions using endocytoscopy. We have also started the research and development of an endoscopic diagnosis support system on tumor invasion of gastrointestinal cancer using AI.
We are collaborating with the NCC Research Institute and Osaka University and performed fecal metagenomic and metabolomic studies on samples from a large cohort of 616 Participants who underwent colonoscopy to assess the taxonomic and functional characteristics of gut microbiota and metabolites. The multi-omics data from our large cohort study indicate that the shifts in the microbiome and metabolome occur from the very early stages of the development of colorectal cancer, which is of possible etiological and diagnostic importance. These findings were published in Nature Medicine. Multiple subsequent papers have since been accepted by the metagenomic/metabolomic and Biopsy Bank projects.
Future Prospects
Research and development of new endoscopy
Olympus Medical Systems Corp. has opened a laboratory at our new research center, and we are collaborating with them to develop innovative endoscopy systems and devices.
List of papers published in 2024
Journal
1. Parasa S, Berzin T, Leggett C, Gross S, Repici A, Ahmad OF, Chiang A, Coelho-Prabhu N, Cohen J, Dekker E, Keswani RN, Kahn CE, Hassan C, Petrick N, Mountney P, Ng J, Riegler M, Mori Y, Saito Y, Thakkar S, Waxman I, Wallace MB, Sharma P. Consensus statements on the current landscape of artificial intelligence applications in endoscopy, addressing roadblocks, and advancing artificial intelligence in gastroenterology. Gastrointestinal endoscopy, 101:2-9.e1, 2025
2. Sakamoto T, Oda I, Okamura T, Cho H, Toyoshima N, Nonaka S, Suzuki H, Nakamura T, Watanabe D, Matsuo K, Hanano K, Takeyama T, Yoshinaga S, Saito Y. Exploratory investigation of virtual lesions in gastrointestinal endoscopy using a novel phase-shift method for three-dimensional shape measurement. DEN open, 5:e381, 2025
3. Mizutani S, Tamaki A, Shiba S, Salim F, Yamada M, Takamaru H, Nakajima T, Yoshida N, Ikuta S, Yachida T, Shibata T, Soga T, Saito Y, Fukuda S, Ishikawa H, Yamada T, Yachida S. Dynamics of the gut microbiome in FAP patients undergoing intensive endoscopic reduction of polyp burden. Gut, 74:335-338, 2025
4. Goto O, Morita Y, Takayama H, Hirasawa K, Sato C, Oyama T, Takahashi A, Abe S, Saito Y, Ono H, Kawata N, Otsuka T, Iwakiri K. Endoscopic hand suturing has the potential to reduce bleeding after gastric endoscopic submucosal dissection in patients on antithrombotic agents: Multicenter phase II study. Digestive endoscopy, 37:266-274, 2025
5. Sekiguchi M, Kawamura T, Horiguchi G, Mizuguchi Y, Takamaru H, Toyoizumi H, Kato M, Kobayashi K, Sada M, Oda Y, Yokoyama A, Utsumi T, Tsuji Y, Ohki D, Takeuchi Y, Shichijo S, Ikematsu H, Matsuda K, Teramukai S, Kobayashi N, Matsuda T, Saito Y, Tanaka K. Colorectal Neuroendocrine Neoplasm Detection Rate During Colonoscopy: Results From Large-Scale Data of Colonoscopies in Japan. The American journal of gastroenterology, 120:473-477, 2025
6. Hirai Y, Toyoshima N, Saito Y. Endoscopic Resection for Colorectal Tumors. Digestion, 106:115-121, 2025
7. Pattarajierapan S, Saito Y, Takamaru H, Toyoshima N, Wisedopas N, Wanpiyarat N, Lerttanatum N, Khomvilai S. Learning curve of colorectal endoscopic submucosal dissection of an endoscopist experienced hands-on training in Japan. Journal of gastroenterology and hepatology, 40:226-234, 2025
8. Hotta K, Matsuda T, Sano Y, Fujii T, Saito Y. Surveillance after Endoscopic Resection for Colorectal Tumors: A Comprehensive Review. Digestion, 106:131-137, 2025
9. Romańczyk M, Desai M, Kamiński MF, Abe S, Alkandari AA, Beyna T, Bisschops R, Budzyń K, Bugdol M, Grover SC, Gyawali CP, Inoue H, Iyer PG, Messmann H, Ragunath K, Saito Y, Srinivasan S, Teshima C, Yadlapati R, Hassan C, Sharma P. International Validation of a Novel PEACE Scale to Improve the Quality of Upper Gastrointestinal Mucosal Inspection During Endoscopy. Clinical and translational gastroenterology, 16:e00786, 2025
10. Takamaru H, Tsay C, Shiba S, Yachida S, Saito Y. Microbiome and Colorectal Cancer in Humans: A Review of Recent Studies. Journal of the anus, rectum and colon, 9:20-24, 2025
11. Nanami H, Matsumoto Y, Furuse H, Tanaka M, Tsuchida T, Ohe Y. Efficacy of cryobiopsy during medical thoracoscopy for diagnosing malignant pleural mesothelioma. Lung cancer (Amsterdam, Netherlands), 199:108074, 2025
12. Yamashige D, Hijioka S, Nagashio Y, Maruki Y, Fukuda S, Yagi S, Okamoto K, Hara H, Hagiwara Y, Agarie D, Takasaki T, Ohba A, Kondo S, Morizane C, Ueno H, Sone M, Saito Y, Okusaka T. Potential of 6-mm-diameter fully covered self-expandable metal stents for unresectable malignant distal biliary obstruction: a propensity score-matched study. Clinical endoscopy, 58:121-133, 2025
13. Saito Y, Sakamoto T, Dekker E, Pioche M, Probst A, Ponchon T, Messmann H, Dinis-Ribeiro M, Matsuda T, Ikematsu H, Saito S, Wada Y, Oka S, Sano Y, Fujishiro M, Murakami Y, Ishikawa H, Inoue H, Tanaka S, Tajiri H. First report from the International Evaluation of Endoscopic classification Japan NBI Expert Team: International multicenter web trial. Digestive endoscopy, 36:591-599, 2024
14. Ito S, Hotta K, Sekiguchi M, Takeuchi Y, Oka S, Yamamoto H, Shinmura K, Harada K, Uraoka T, Hisabe T, Sano Y, Kondo H, Horimatsu T, Kikuchi H, Kawamura T, Nagata S, Yamamoto K, Tajika M, Tsuji S, Kusaka T, Okuyama Y, Yoshida N, Moriyama T, Hasebe A, So S, Saito Y, Nakahira H, Ishikawa H, Matsuda T. Short-term outcomes of endoscopic resection for colorectal neuroendocrine tumors: Japanese multicenter prospective C-NET STUDY. Digestive endoscopy, 36:942-951, 2024
15. Mandarino FV, Danese S, Uraoka T, Parra-Blanco A, Maeda Y, Saito Y, Kudo SE, Bourke MJ, Iacucci M. Precision endoscopy in colorectal polyps' characterization and planning of endoscopic therapy. Digestive endoscopy, 36:761-777, 2024
16. Tanaka H, Uraoka T, Kobayashi N, Ohata K, Takeuchi Y, Chino A, Yamada M, Tsuji Y, Hotta K, Harada K, Ikematsu H, Murakami T, Tsuji S, Katagiri A, Hori S, Michida T, Suzuki T, Fukuzawa M, Kiriyama S, Fukase K, Murakami Y, Ishikawa H, Nagahara A, Saito Y. Short-term and long-term outcomes of submucosal dissection for residual or recurrent colorectal tumors after endoscopic resection: Analysis of a multicenter prospective study. Digestive endoscopy, 36:1003-1011, 2024
17. Cho H, Abe S, Nonaka S, Suzuki H, Yoshinaga S, Okuma K, Yamamoto S, Daiko H, Kato K, Sekine S, Boku N, Saito Y. Long-term outcomes after non-curative endoscopic resection for esophageal squamous cell carcinoma followed by additional chemoradiotherapy. Diseases of the esophagus, 37:doae004, 2024
18. Sekiguchi M, Suzuki H, Takizawa K, Hirasawa T, Takeuchi Y, Ishido K, Hoteya S, Yano T, Tanaka S, Toya Y, Nakagawa M, Toyonaga T, Takemura K, Hirasawa K, Matsuda M, Yamamoto H, Tsuji Y, Hashimoto S, Maeda Y, Oyama T, Takenaka R, Yamamoto Y, Shimazu T, Ono H, Tanabe S, Kondo H, Iishi H, Ninomiya M, Oda I. Potential for expanding indications and curability criteria of endoscopic resection for early gastric cancer in elderly patients: results from a Japanese multicenter prospective cohort study. Gastrointestinal endoscopy, 100:438-448.e1, 2024
19. Fujita K, Saito Y. A novel hood with a small-caliber tip and two traction strings for endoscopic submucosal dissection. Endoscopy, 56:E111-E113, 2024
20. Oka S, Tanaka S, Kajiwara Y, Saito S, Fukunaga Y, Takamatsu M, Kawachi H, Hotta K, Ikematsu H, Kojima M, Saito Y, Yamada M, Kanemitsu Y, Sekine S, Nagata S, Yamada K, Kobayashi N, Ishihara S, Saitoh Y, Matsuda K, Togashi K, Komori K, Ishiguro M, Kuwai T, Okuyama T, Ohuchi A, Ohnuma S, Sakamoto K, Sugai T, Katsumata K, Matsushita HO, Yamano HO, Eda H, Uraoka T, Akimoto N, Kobayashi H, Sugihara K, Ueno H. Treatment Decision for Locally Resected T1 Colorectal Carcinoma-Verification of the Japanese Guideline Criteria for Additional Surgery Based on Long-Term Clinical Outcomes. The American journal of gastroenterology, 119:2019-2027, 2024
21. Sekiguchi M, Kishida Y, Ikematsu H, Konno M, Mizuguchi Y, Hotta K, Imai K, Ito S, Takada K, Shiomi A, Yasui H, Tsukamoto S, Hirano H, Kobayashi N, Saito Y, Inaba A, Shinmura K, Konishi J, Ozawa H, Fujita S, Murakami Y, Matsuda T. Proportions and characteristics of interval cancer in annual fecal immunochemical test screening and postcolonoscopy colorectal cancer: Results from a Japanese multicenter prospective study using questionnaires, the C-DETECT study. Digestive endoscopy, 36:1140-1151, 2024
22. Saito Y. Top tips for performing high-quality optical zoom chromocolonoscopy (with video). Gastrointestinal endoscopy, 100:122-127, 2024
23. Matsuda T, Sekiguchi M, Kobayashi N. [Current status and issues of colorectal cancer screening - toward the introduction of colonoscopy into the population-based screening program]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 121:177-185, 2024
24. Agarie D, Hijioka S, Nagashio Y, Maruki Y, Chatto M, Saito Y, Okusaka T. The case of infected intra-abdominal hematoma complicating endoscopic ultrasound-guided tissue acquisition. Endoscopy, 56:E309-E310, 2024
25. Tsuchida H, Matsumoto Y, Furuse H, Tsuchida T. Adenocarcinoma originating in the anterior mediastinum diagnosed by endobronchial ultrasound-guided transbronchial cryobiopsy: a case report. BMC pulmonary medicine, 24:181, 2024
26. Makiguchi ME, Saito Y. The running suture with clip and string technique after colonic endoscopic submucosal dissection. Endoscopy, 56:E350-E351, 2024
27. Nakamura K, Kakukgawa Y, Sekiguchi M, Tsuruki ES, Matsumoto M, Hisada I, Mizuguchi Y, Takamaru H, Sakamoto T, Saito Y, Kobayashi N, Matsuda T. Chronological Trend of Opportunistic Endoscopic Screening for Gastric Cancer and Atrophic Gastritis. Asian Pacific journal of cancer prevention : APJCP, 25:1247-1255, 2024
28. Fukuda S, Hijioka S, Nagashio Y, Maruki Y, Chatto M, Saito Y, Okusaka T. Forward-viewing echoendoscope aids tissue acquisition via the afferent limb after pancreaticoduodenectomy. Endoscopy, 56:E366-E368, 2024
29. Nishizawa T, Watanabe H, Yoshida S, Matsuno T, Fujimoto A, Matsuda R, Ebinuma H, Fujishiro M, Saito Y, Toyoshima O. Association between colonic adenoma size and proliferative zone in the crypt. Scandinavian journal of gastroenterology, 59:875-879, 2024
30. Saito Y, Toyoshima N, Mizuguchi Y, Sakamoto T, Uraoka T, Ikematsu H, Tamai N, Matsuda T, Misawa M, Hotta K, Shibata T. Protocol for a prospective multicenter randomized controlled trial to evaluate the efficacy of texture and color enhancement imaging (TXI) observation in the detection of colorectal lesions (deTXIon study). Japanese journal of clinical oncology, 54:1052-1056, 2024
31. Uozumi T, Abe S, Mizuguchi Y, Sekiguchi M, Toyoshima N, Takamaru H, Yamada M, Kobayashi N, Sadachi R, Ito S, Takada K, Kishida Y, Imai K, Hotta K, Ono H, Saito Y. Endoscopic hand suturing using a modified through-the-scope needle holder for mucosal closure after colorectal endoscopic submucosal dissection: Prospective multicenter study (with video). Digestive endoscopy, 36:1245-1252, 2024
32. Fukuda S, Hijioka S, Nagashio Y, Maruki Y, Ohba A, Agarie D, Hagiwara Y, Hara H, Okamoto K, Yamashige D, Yagi S, Kuwada M, Chatto M, Kondo S, Morizane C, Ueno H, Saito Y, Okusaka T. Feasibility and safety of a novel plastic stent designed specifically for endoscopic ultrasound-guided pancreatic duct drainage. Endoscopy international open, 12:E715-E722, 2024
33. Hagiwara Y, Hijioka S, Nagashio Y, Maruki Y, Ohba A, Kawasaki Y, Takeshita K, Takasaki T, Agarie D, Hara H, Yagi S, Fukuda S, Kuwada M, Yamashige D, Okamoto K, Chatto M, Kondo S, Morizane C, Ueno H, Endo M, Sugawara S, Sone M, Saito Y, Tsuchiya K, Okusaka T. Efficacy of endoscopic ultrasound-guided gastroenterostomy using self-expandable metallic stent for afferent loop syndrome: A single-center retrospective study. Journal of gastroenterology and hepatology, 39:2136-2142, 2024
34. Tamaru Y, Kuwai T, Kajiwara Y, Oka S, Saito S, Fukunaga Y, Kawachi H, Takamatsu M, Hotta K, Ikematsu H, Kojima M, Saito Y, Kanemitsu Y, Yamada M, Sekine S, Tanaka S, Nagata S, Nakamura T, Yamada K, Konno M, Ishihara S, Saitoh Y, Matsuda K, Togashi K, Komori K, Ishiguro M, Okuyama T, Ohuchi A, Ohnuma S, Sakamoto K, Sugai T, Katsumata K, Matsushita HO, Yamano HO, Nakai K, Uraoka T, Akimoto N, Kobayashi H, Ajioka Y, Sugihara K, Ueno H. Long-Term Outcomes of Additional Surgery After Endoscopic Resection Versus Primary Surgery for T1 Colorectal Cancer. The American journal of gastroenterology, 119:2418-2425, 2024
35. Toyoshima O, Nishizawa T, Hiramatsu T, Matsuno T, Yoshida S, Mizutani H, Ebinuma H, Matsuda T, Saito Y, Fujishiro M. Colorectal adenoma detection rate using texture and color enhancement imaging versus white light imaging with chromoendoscopy: a propensity score matching study. Journal of gastroenterology and hepatology, 39:2105-2111, 2024
36. Sakamoto Y, Sakamoto T, Ohba A, Sasaki M, Kondo S, Morizane C, Ueno H, Saito Y, Arai Y, Okusaka T. Efficacy of hemostasis by gastroduodenal covered metal stent placement for hemorrhagic duodenal stenosis due to pancreatobiliary cancer invasion: a retrospective study. Clinical endoscopy, 57:628-636, 2024
37. Djinbachian R, Rex DK, Chiu HM, Fukami N, Aihara H, Bastiaansen BAJ, Bechara R, Bhandari P, Bhatt A, Bourke MJ, Byeon JS, Cardoso D, Chino A, Chiu PWY, Dekker E, Draganov PV, Elkholy S, Emura F, Goldblum J, Haji A, Ho SH, Jung Y, Kawachi H, Khashab M, Khomvilai S, Kim ER, Maselli R, Messmann H, Moons L, Mori Y, Nakanishi Y, Ngamruengphong S, Parra-Blanco A, Pellisé M, Pinto RC, Pioche M, Pohl H, Rastogi A, Repici A, Sethi A, Singh R, Suzuki N, Tanaka S, Vieth M, Yamamoto H, Yang DH, Yokoi C, Saito Y, von Renteln D. International consensus on the management of large (≧20 mm) colorectal laterally spreading tumors: World Endoscopy Organization Delphi study. Digestive endoscopy, 36:1253-1268, 2024
38. Takeshita K, Hijioka S, Nagashio Y, Maruki Y, Ohba A, Kawasaki Y, Takasaki T, Yagi S, Agarie D, Hara H, Hagiwara Y, Yamashige D, Okamoto K, Fukuda S, Kuwada M, Chatto M, Kondo S, Morizane C, Ueno H, Saito Y, Okusaka T. Comparison of stent patency between EUS-guided hepaticogastrostomy with bridging and endoscopic transpapillary biliary drainage for hilar obstruction. Endoscopy international open, 12:E875-E886, 2024
39. Salim F, Mizutani S, Shiba S, Takamaru H, Yamada M, Nakajima T, Yachida T, Soga T, Saito Y, Fukuda S, Yachida S, Yamada T. Fusobacterium species are distinctly associated with patients with Lynch syndrome colorectal cancer. iScience, 27:110181, 2024
40. Yagi S, Hijioka S, Okamoto K, Nagashio Y, Chatto M, Saito Y, Okusaka T. Successful gastroduodenal stenting using the endoscopic ultrasound-guided rendezvous technique by Treitz ligament puncture. Endoscopy, 56:E653-E655, 2024
41. Matsumoto Y, Kho SS, Furuse H. Improving diagnostic strategies in bronchoscopy for peripheral pulmonary lesions. Expert review of respiratory medicine, 18:581-595, 2024
42. Tsuji S, Doyama H, Kobayashi N, Ohata K, Takeuchi Y, Chino A, Takamaru H, Tsuji Y, Hotta K, Harada K, Ikematsu H, Uraoka T, Murakami T, Katagiri A, Hori S, Michida T, Suzuki T, Fukuzawa M, Kiriyama S, Fukase K, Murakami Y, Ishikawa H, Saito Y. Outcomes of noncurative endoscopic submucosal dissection for T1 colorectal cancer: Prospective, multicenter, cohort study in Japan. Digestive endoscopy, 36:1369-1379, 2024
43. Kho SS, Tan SH, Soo CI, Ramarmuty HYD, Chai CS, Huan NC, Ng KL, Matsumoto Y, Poletti V, Tie ST. An explorative analysis on the optimal cryo-passes and freezing time of the ultrathin cryoprobe in endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy. Scientific reports, 14:18653, 2024
44. Esaki M, Igarashi A, Tsukamoto S, Sugawara S, Sekiguchi M, Fujinaga A. [Health Economic Evaluation of Surgical Treatment for Cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 51:795-800, 2024
45. Kang SJ, Tae CH, Bang CS, Shin CM, Jeong YH, Choi M, Hwang JH, Saito Y, Chiu PWY, Rerknimitr R, Khor C, Khien VV, Choi KD, Shim KN, Song GA, Lee OY. International Digestive Endoscopy Network Consensus on the Management of Antithrombotic Agents in Patients Undergoing Gastrointestinal Endoscopy. Gut and liver, 18:764-780, 2024
46. Furuse H, Matsumoto Y, Nakai T, Tanaka M, Nishimatsu K, Uchimura K, Imabayashi T, Tsuchida T. Diagnostic efficacy of cryobiopsy for peripheral pulmonary lesions with ground-glass opacity: a propensity score-matched analysis. Translational lung cancer research, 13:2175-2186, 2024
47. Ikuta S, Saito Y, Takata S, Nakatani Y, Nagatomo I, Shiba S, Takeda Y, Totoki Y, Mizutani S, Sunakawa H, Ikematsu H, Takamaru H, Kumanogoh A, Yachida S. Variability in non-tumor areas of colorectal cancer patients as revealed by endoscopic intestinal step biopsies. Molecular cancer, 23:249, 2024
48. Toyoshima O, Nishizawa T, Watanabe H, Matsuno T, Yoshida S, Takahashi Y, Mizutani H, Ebinuma H, Fujishiro M, Saito Y. Endoscopic characteristics to differentiate SSLs and microvesicular hyperplastic polyps from goblet cell-rich hyperplastic polyps. Endoscopy international open, 12:E1251-E1259, 2024
49. Uozumi T, Abe S, Sugimoto M, Kusuhara M, Mizuguchi Y, Nonaka S, Saito Y. Computed tomography-based virtual reality-guided preoperative simulation for endoscopic full-thickness resection of a gastric submucosal tumor. Endoscopy, 56:E1010-E1011, 2024
50. Kawamura R, Abe S, Mizuguchi Y, Nonaka S, Saito Y. Over-the-scope pre-looping method using an endoloop in endoscopic full-thickness resection of gastric gastrointestinal stromal tumor. Endoscopy, 56:E1034-E1035, 2024
51. Khor CJL, Ichimasa K, Tsao SKK, Biber U, Saito Y. Safety and performance of the HYBRIDknife flex in a porcine model of esophageal endoscopic submucosal dissection: A pilot study. JGH open, 8:e70036, 2024