Annual Report 2024
Department of Musculoskeletal Oncology and Rehabilitation Medicine
Akira Kawai, Eisuke Kobayashi, Shintaro Iwata, Koichi Ogura, Shuhei Osaki, Hiroya Kondo, Toshiyuki Takemori, Satoshi Kamio, Masanori Shimomura, Daiicihro Takahara
Introduction
Since 1962, our department has accumulated a vast array of clinical knowledge regarding musculoskeletal tumors in collaboration with radiologists and pathologists specializing in sarcomas, enabling us to offer well-organized treatment strategies to patients with various types of bone and soft tissue tumors. We have also conducted basic and clinical studies using accumulated clinical samples and data to establish novel diagnostic methods and therapeutic approaches for treating musculoskeletal tumors. In addition, we have emphasized clinical trials in three distinct but inseparable areas for bone and soft tissue tumors: surgery, chemotherapy, and radiation therapy.
The Team and What We Do
Our department consists of six staff doctors and four residents. Outpatient consultations are held every weekday. A constant number of over 25 patients are hospitalized for surgery, chemotherapy, or radiation therapy. Six to 10 major surgeries for musculoskeletal tumors are routinely performed every week. The number of surgeries in our department in FY2024 was 348, of which 205 were for primary malignant bone and soft tissue tumors (Table 1).
Table 1. Number of surgeries in FY2024
In collaboration with the Department of Plastic and Reconstructive Surgery, we conduct definitive tumor resection and reconstructive surgery for cases with extensive soft tissue defects or concomitant resection of critical neurovascular structures. In addition, we actively collaborate with other departments to perform complex surgeries that may be challenging to perform in other hospitals, such as combined sacral resection for radical resection of locally advanced rectal cancer (Department of Colorectal Surgery), retroperitoneal sarcoma surgery (Departments of Urology, Colorectal Surgery, Hepatobiliary and Pancreatic Surgery, and Gastric Surgery), and chest wall sarcomas (Departments of Thoracic Surgery and Breast Surgery).
Regarding chemotherapy, we provide perioperative adjuvant chemotherapy for osteosarcoma and soft-tissue sarcoma, and chemotherapy for advanced stage bone and soft-tissue malignancies in collaboration with the Departments of Medical Oncology and Pediatric Oncology.
We hold various cross-disciplinary conferences, including a sarcoma conference, a pediatric oncology joint conference, a medical oncology joint conference, a retroperitoneal sarcoma conference, a rehabilitation conference, and a bone metastasis conference.
Research Activities
In basic research, in collaboration with the Division of Rare Cancer Research, National Cancer Center Research Institute, we have generated many sarcoma tissue mouse xenografts and new sarcoma cell lines, and have also performed comprehensive analysis of sarcoma-specific gene mutations and gene expression. In addition, we conducted several single-institution studies and domestic multi-institutional collaborative studies as part of our clinical research activities.
The number of original papers published in English in FY2024 was 23.
The research funds received in FY2023 were one MHLW Grants-in-Aid for Scientific Research, one Cancer Research and Development Fund, and one private research funds.
Clinical Trials
Our institution has the largest number of malignant bone and soft tissue tumor cases in Japan and serves as a central facility for numerous clinical studies. In FY2024, we participated in 10 national multi-institutional collaborative studies, including two ongoing JCOG trials (one of which is an international JCOG–EORTC collaborative study for which we serve as the study office). In addition, we participated in six international collaborative studies, such as retrospective research on rare sarcomas and a registry study of metastatic bone tumors in Asia.
Education
We actively accept young physicians from universities nationwide regardless of academic affiliation, and train human resources who will lead the treatment of bone and soft tissue tumors in Japan. In FY2024, four residents, including oncology residents and short-term residents, were accepted and trained.
Young doctors who have completed the training program are guided to become bone and soft tissue oncology specialists (surgeon scientists) with excellent research minds. They are also guided in clinical research from planning to implementation, conference presentations, and paper writing.
We encourage trainees to obtain various certifications during their training in the department, including certified oncologists. In FY2024, two trainees were certified as oncologists, three as bone and soft tissue oncologists by the Japanese Orthopaedic Association.
Future Prospects
As Japan’s largest high-volume center for bone and soft tissue tumors, our institution fulfills its mission as the nation’s leading facility for the diagnosis and treatment of these diseases. Aiming to further improve treatment outcomes for malignant bone and soft tissue tumors, we are pursuing innovative approaches, including surgeries utilizing advanced technologies and the development of novel therapeutic agents. We also strive to take leadership in bone and soft tissue tumor research across Asia while actively promoting international collaborative studies with Europe and the United States. Furthermore, by serving as an educational and training institution where young physicians from across Japan gather to become specialists in bone and soft tissue tumors, we contribute to raising the overall standard of care for these diseases nationwide.
List of papers published in 2024
Journal
1. Morii T, Ogura K, Sato K, Kawai A. Infection of surgery for bone and soft tissue sarcoma with biological reconstruction: Data from the Japanese nationwide bone tumor registry. Journal of orthopaedic science, 30:390-396, 2025
2. Winer LK, Akumuo R, Fredette JD, Deng M, Hasler JS, Greco SH, von Mehren M, Bartholomew AJ, Blazer DG, Gabrielova L, Adamkova D, Bernard-Bedard E, Nessim C, Kollár A, Olariu R, Cencelj-Arnez R, Hompes D, Ford SJ, Cardona K, Sato K, Iwata S, Farma JM, Villano AM. Current patterns of care and outcomes for dermatofibrosarcoma protuberans: An international multi-institutional collaborative. Cancer, 131:e35468, 2025
3. Tsuchiya K, Akisue T, Ehara S, Kawai A, Kawano H, Hiraga H, Hosono A, Hutani H, Morii T, Morioka H, Nishida Y, Oda Y, Ogose A, Shimose S, Yamaguchi T, Yamamoto T, Yoshida M. Japanese orthopaedic association (JOA) clinical practice guideline on the management of primary malignant bone tumors - Secondary publication. Journal of orthopaedic science, 30:1-17, 2025
4. Katsuno T, Sugiura Y, Morishita M, Osaki S, Suzuki M, Takasaki J, Iikura M, Izumi S, Hojo M, Sugiyama H. Spinal Echinococcosis in a Japanese Woman Living in Tokyo: Diagnostic Challenges in Non-endemic Areas and Public Health Implications. Internal medicine (Tokyo, Japan), 64:971-977, 2025
5. Muramatsu S, Ogura K, Morizane C, Satake T, Toda Y, Iwata S, Kobayashi E, Higashi T, Ikeuchi M, Kawai A. Statistics of Visceral Sarcoma in Japan: Report From the Population-Based National Cancer Registry (NCR) in Japan. Journal of surgical oncology, 131:274-284, 2025
6. Giani C, Salawu A, Ljevar S, Denu RA, Napolitano A, Palmerini E, Connolly EA, Ogura K, Wong DD, Scanferla R, Rosenbaum E, Bajpai J, Li ZC, Bae S, D'Ambrosio L, Bialick S, Wagner AJ, Lee ATJ, Koseła-Paterczyk H, Baldi GG, Brunello A, Lee YC, Loong HH, Boikos S, Campos F, Cicala CM, Maki RG, Hindi N, Figura C, Almohsen SS, Patel S, Jones RL, Ibrahim T, Karim R, Kawai A, Carey-Smith R, Boyle R, Taverna SM, Lazar AJ, Demicco EG, Bovee JVMG, Dei Tos AP, Fletcher C, Baumhoer D, Sbaraglia M, Schaefer IM, Miceli R, Gronchi A, Stacchiotti S. International Multicenter Retrospective Study From the Ultra-rare Sarcoma Working Group on Low-grade Fibromyxoid Sarcoma, Sclerosing Epithelioid Fibrosarcoma, and Hybrid Forms: Outcome of Primary Localized Disease. The American journal of surgical pathology, 49:27-34, 2025
7. Masunaga T, Tsukamoto S, Honoki K, Fujii H, Tanaka Y, Ishida Y, Tanaka Y, Mavrogenis A, Errani C, Kawai A. Wide surgical margins may be necessary to reduce recurrence and mortality in patients with localized periosteal chondrosarcoma: retrospective analysis of twenty three patients and literature meta-analysis. International orthopaedics, 49:279-288, 2025
8. Sekita T, Asano N, Kubo T, Totsuka H, Mitani S, Hattori N, Yoshida A, Kobayashi E, Komiyama M, Ushijima T, Nakayama R, Nakamura M, Kawai A, Ichikawa H. Early separation and parallel clonal selection of dedifferentiated and well-differentiated components in dedifferentiated liposarcoma. Neoplasia (New York, N.Y.), 59:101074, 2025
9. Hirozane T, Sekita T, Kobayashi E, Mori T, Asano N, Udaka T, Tajima T, Nakagawa R, Kikuta K, Yoshiyama A, Morioka H, Watanabe I, Anazawa U, Susa M, Horiuchi K, Suzuki Y, Morii T, Nakayama R. Clinical characteristics and outcomes of patients with chondroblastoma undergoing surgery with various adjuvant procedures: a retrospective study of 59 cases. BMC surgery, 25:40, 2025
10. Jeys LM, Morris GV, Kurisunkal VJ, Botello E, Boyle RA, Ebeid W, Houdek MT, Puri A, Ruggieri P, Brennan B, Laitinen MK, Abad Repiso S, Abdelbary H, Abiad Mejia A, Abood AA, Abril Martin JC, Abudu A, Abu Elhamd A, Acosta M, Ae K, Agarwal M, Ajit Singh V, Akiyama T, Alshaygy I, Albergo JI, Alexander J, Alfaro PA, Alpan B, Amaya-Valero J, Anderson M, Andreou D, Annabell L, Anthony C, Aoude A, Arteagoitia-Colino I, Asavamongkolkul A, Aston W, Asua Mentxaka L, Azzopardi C, Baad-Hansen T, Badr IT, Baixauli-Garcia F, Baker G, Balach T, Baldi GG, Barry J, Basile G, Bastoni S, Basuki M, Bauer H, Bayliss L, Becker RG, Bedi A, Benevenia J, Bengoa F, Bergh P, Bergovec M, Bernthal N, Binitie O, Boddie D, Boffano M, Bonilla Huertas P, Borgognoni AB, Botchu R, Bramer J, Brar R, Branford-White H, Broekhuis D, Broida SE, Budny T, Burke ZD, Cabrolier J, Calvo-Haro JA, Calvo Tapies JR, Cardoso R, Carey Smith R, Carvallo PI, Casales Fresenga N, Casanova JM, Ceballos O, Cebrian Parra JL, Chacon Cartaya S, Chan CM, Cho YJ, Choong P, Chung YG, Ciechanowicz D, Clara-Altamirano MA, Clever D, Colina SM, Consuegra L, Couch C, Cribb G, Cuervo C, Cusick LA, Dadia S, Dagher T, Dammerer D, Davies M, Davies N, de la Rosa Martino LP, de Santos de la Fuente FJ, de Vaal M, Deckers C, Delgado Obando J, Deo S, Deventer N, Di Bella C, Domson G, Donati DM, Dorleijn DM, Du Toit J, Dunne D, Duran Ciarrochi R, Ekman E, El Ghoneimy AM, Endo M, Eralp L, Etaiwi M, Evans S, Evrard R, Eward W, Farese A, Ferguson PC, Ferreira Cardoso PF, Fiorenza F, Flint M, Flores H, Freitas J, Fuchs B, Fujiwara T, Funovics PT, Galli Serra M, Gamie Z, Garces-Zarzalejo C, Gazendam A, Gebert C, Gerbers JG, Gerrand C, Abou-Nouar G, Ghert M, Ghosh KM, Gibbons M, Gomez-Mier LC, Gomez-Vallejo J, Gomez-Mascard A, Gonzalez MR, Gonzalez-Lizan F, Gosheger G, Goudie S, Goulding K, Goumenos SD, Griffin A, Gulia A, Gupta S, Gupta A, Guzman M, Haitham M, Hardes J, Hardoy F, Hasan Y, et al. (複数名のため一部抜粋して記載。詳細は掲載先をご参照ください). Identifying consensus and areas for future research in chondrosarcoma : a report from the Birmingham Orthopaedic Oncology Meeting. The bone & joint journal, 107-B:246-252, 2025
11. Kondo H, Ogura K, Morizane C, Satake T, Iwata S, Toda Y, Muramatsu S, Takemori T, Kobayashi E, Higashi T, Kawai A. Chondrosarcoma in Japan: an analytic study using population-based National Cancer Registry. Japanese journal of clinical oncology, 55:490-497, 2025
12. Nakamura T, Kobayashi E, Takenaka S, Endo M, Hayashi K, Nakata E, Ohshika S, Kawashima H, Hamada T, Horiuchi K, Nishida Y, Hasegawa M, Morii T. Predictive variables for intraoperative blood loss and surgical time in resection of malignant soft tissue tumors without reconstruction. Japanese journal of clinical oncology, 55:610-614, 2025
13. Toda Y, Ogura K, Morizane C, Satake T, Iwata S, Kobayashi E, Takemori T, Kondo H, Muramatsu S, Higashi T, Kawai A. Prognostic factors and management of elderly sarcoma in Japan: the population-based National Cancer Registry (NCR) in Japan. International journal of clinical oncology, 30:1018-1032, 2025
14. Winer LK, Fredette JD, Hasler J, Akumuo R, Greco SH, von Mehren M, Bartholomew AJ, Blazer DG, Gabrielova L, Adamkova D, Bernard-Bedard E, Nessim C, Kollár A, Olariu R, Cencelj-Arnez R, Hompes D, Ford SJ, Cardona K, Sato K, Iwata S, Farma JM, Villano AM. Examining the Impact of Biopsy Technique on Clinical and Pathologic Outcomes in Dermatofibrosarcoma Protuberans: An International, Multi-Institutional Study. Annals of surgical oncology, 32:3752-3762, 2025
15. Hayashi K, Takenaka S, Ohshika S, Kawashima H, Endo M, Kobayashi E, Nakata E, Nakamura T, Horiuchi K, Hamada T, Nishida Y, Morii T. Comparative surgical invasiveness of internal fixation for pathological fractures in metastatic bone disease versus traumatic fractures: a quantitative analysis of operative time and blood loss. Japanese journal of clinical oncology, 55:615-620, 2025
16. Takemori T, Ogura K, Morizane C, Satake T, Iwata S, Toda Y, Muramatsu S, Kondo H, Kobayashi E, Higashi T, Kawai A. Incidence and site specific characteristics of angiosarcoma in Japan using a population-based national cancer registry from 2016 to 2019. Scientific reports, 15:9960, 2025
17. Furukawa N, Hasegawa N, Kubota D, Nakamura Y, Tanaka H, Iwata S, Kawai A, Saito T, Takagi T, Kohsaka S, Ishijima M. Prognostic potential of fusion gene analysis using plasma cell-free RNA in malignant bone and soft tissue tumours. BMC cancer, 25:587, 2025
18. Morii T, Ogura K, Sato K, Kawai A. Incidence and risk of surgical site infection/periprosthetic joint infection in tumor endoprosthesis-data from the nationwide bone tumor registry in Japan. Journal of orthopaedic science, 29:1112-1118, 2024
19. Morii T, Sato K, Ogura K, Kawai A. Incidence and risk of infection in malignant soft tissue tumor resection: Data from the nationwide soft tissue tumor registry. Journal of orthopaedic science, 29:1300-1305, 2024
20. Fukushima T, Okita Y, Watanabe N, Yokota S, Nakano J, Kawai A. Evaluation of clinical factors associated with early postoperative physical function and lower extremity functional impairment in patients with soft tissue sarcoma. Disability and rehabilitation, 46:3426-3431, 2024
21. Kojima N, Kubo T, Mori T, Satomi K, Matsushita Y, Iwata S, Yatabe Y, Ichimura K, Kawai A, Ichikawa H, Yoshida A. Myxoid liposarcoma with nuclear pleomorphism: a clinicopathological and molecular study. Virchows Archiv, 484:71-81, 2024
22. Fukushima T, Watanabe N, Okita Y, Yokota S, Kurita D, Ishiyama K, Oguma J, Kawai A, Daiko H. Preoperative physical activity is associated with prognosis in patients with esophageal cancer undergoing thoracoscopic-laparoscopic esophagectomy after neoadjuvant chemotherapy. General thoracic and cardiovascular surgery, 72:134-143, 2024
23. Mori T, Kobayashi E, Sato Y, Takenaka S, Endo M, Nakamura T, Morii T, Yoshida Y, Ueda T, Kawano H, Kawai A. What Are the Complication Rates and Factors Associated With Total Femur Replacement After Tumor Resection? Findings From the Japanese Musculoskeletal Oncology Group. Clinical orthopaedics and related research, 482:702-712, 2024
24. Odate T, Satomi K, Kubo T, Matsushita Y, Ueno T, Kurose A, Shomori K, Nakai T, Watanabe R, Segawa K, Ohshika S, Miyake N, Kudo S, Shimoi T, Kobayashi E, Komiyama M, Yoshimoto S, Nakatani F, Kawai A, Yatabe Y, Kohsaka S, Ichimura K, Ichikawa H, Yoshida A. Inflammatory Rhabdomyoblastic Tumor: Clinicopathologic and Molecular Analysis of 13 Cases. Modern pathology, 37:100359, 2024
25. Yoshimatsu Y, Noguchi R, Osaki J, Sin Y, Tsuchiya R, Ono T, Akiyama T, Adachi Y, Tanzawa Y, Yoshida A, Kawai A, Kondo T. Establishment and characterization of NCC-LMS3-C1: a novel patient-derived cell line of leiomyosarcoma. Human cell, 37:337-344, 2024
26. Masunaga T, Tsukamoto S, Nitta Y, Honoki K, Fujii H, Akahane M, Takeda M, Tanaka Y, Mavrogenis AF, Errani C, Kawai A. Is perioperative chemotherapy effective in patients with localized myxoid liposarcoma? Japanese journal of clinical oncology, 54:297-304, 2024
27. Kobayashi H, Okajima K, Zhang L, Hirai T, Ishibashi Y, Tsuda Y, Ikegami M, Kawai A, Tanaka S. Prognostic factors and treatment outcomes in patients with pleomorphic rhabdomyosarcoma: a population-based cohort study. Japanese journal of clinical oncology, 54:471-478, 2024
28. Shimizu J, Emori M, Murahashi Y, Kawai A, Teramoto A. Clinical outcomes in patients with adamantinoma: Report from the bone and soft tissue tumor registry in Japan. Journal of surgical oncology, 129:1000-1005, 2024
29. Ono T, Noguchi R, Osaki J, Akiyama T, Adachi Y, Kojima N, Toda Y, Fukushima S, Yoshimatsu Y, Yoshida A, Kawai A, Kondo T. Establishment and characterization of NCC-DFSP5-C1: a novel patient-derived dermatofibrosarcoma protuberans cell line. Human cell, 37:854-864, 2024
30. Rikitake R, Mizushima Y, Yoshimoto S, Higashi T, Satake T, Morizane C, Kawai A. Current status of head and neck sarcomas in Japan in 2016-2019: an analysis using the national cancer registry. International journal of clinical oncology, 29:564-570, 2024
31. Aiba H, Kojima Y, Shimoi T, Sudo K, Yazaki S, Imai T, Yoshida A, Iwata S, Kobayashi E, Kawai A, Arakawa A, Ogawa C, Kimura H, Yonemori K. Incidence of skeletal-related events in patients with Ewing sarcoma: An observational retrospective study in Japan. Cancer medicine, 13:e7060, 2024
32. Adachi Y, Noguchi R, Yoshimatsu Y, Sin Y, Osaki J, Ono T, Iwata S, Akiyama T, Tsuchiya R, Toda Y, Ishihara S, Ogura K, Kobayashi E, Kojima N, Yoshida A, Yokoo H, Kawai A, Kondo T. Establishment and characterization of two novel patient-derived cell lines from giant cell tumor of bone: NCC-GCTB8-C1 and NCC-GCTB9-C1. Human cell, 37:874-885, 2024
33. Osaki J, Noguchi R, Yanagihara K, Ono T, Adachi Y, Iwata S, Toda Y, Sekita T, Kobayashi E, Kojima N, Yoshida A, Kawai A, Kondo T. Establishment and characterization of NCC-ASPS2-C1: a novel patient-derived cell line of alveolar soft part sarcoma. Human cell, 37:865-873, 2024
34. Imai T, Kojima Y, Shimoi T, Aiba H, Okuma HS, Saito A, Kita S, Yamamoto K, Maejima A, Nishikawa T, Sudo K, Noguchi E, Yoshida A, Matsui Y, Iwata S, Kobayashi E, Kawai A, Udagawa R, Fujiwara Y, Yonemori K. Predicting Trabectedin Efficacy in Soft Tissue Sarcoma: Inflammatory Biomarker Analysis. Anticancer research, 44:2125-2132, 2024
35. Kobayashi H, Okajima K, Zhang L, Hirai T, Ishibashi Y, Tsuda Y, Ikegami M, Kawai A, Tanaka S. Embryonal and alveolar rhabdomyosarcoma in adolescents/young adults, adults and older adults: a population-based cohort study. Japanese journal of clinical oncology, 54:903-910, 2024
36. Sugiyama M, Arakawa A, Iwata S, Tao K, Shirakawa N, Watanabe Y, Nakajima M, Yoshida A, Ishigaki K, Kawai A, Ogawa C. Feasibility of multimodal therapy for rhabdomyosarcoma in a patient with Fukuyama congenital muscular dystrophy. Pediatric blood & cancer, 71:e31036, 2024
37. Sungwan P, Panaampon J, Kariya R, Kamio S, Nakagawa R, Hirozane T, Ogura Y, Abe M, Hirabayashi K, Fujiwara Y, Kikuta K, Okada S. Establishment and characterization of TK-ALCL1: a novel NPM-ALK-positive anaplastic large-cell lymphoma cell line. Human cell, 37:1215-1225, 2024
38. Kawai A, Yoshida A, Shimoi T, Kobayashi E, Yonemori K, Ogura K, Iwata S, Toshirou N. Histological diagnostic discrepancy and its clinical impact in bone and soft tissue tumors referred to a sarcoma center. Cancer science, 115:2831-2838, 2024
39. Fiore M, Sarre-Lazcano C, Smith M, Khan M, Raut CP, Honoré C, Sargos P, Cananzi F, Grignani G, Iwata S, Gronchi A. Primary pelvic soft tissue sarcomas (PELVISARC): outcomes from the TransAtlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG). The British journal of surgery, 111:znae128, 2024
40. Ogura K, Morizane C, Satake T, Iwata S, Toda Y, Muramatsu S, Kobayashi E, Arakawa A, Ogawa C, Kato Y, Higashi T, Kawai A. Statistics of bone sarcoma in Japan: report from the population-based cancer registry in Japan. International journal of clinical oncology, 29:1209-1219, 2024
41. Kawamura MM, Nakayama R, Yamaguchi SI, Kamio S, Hirozane T, Mori T, Asano N, Okita H, Matsumoto M, Nakamura M. Takayasu arteritis-associated periostitis in the distal femur mimicking periosteal osteosarcoma. The Lancet. Rheumatology, S2665-9913(24)00123-1, 2024
42. Ogura K, Morizane C, Satake T, Iwata S, Toda Y, Muramatsu S, Takemori T, Kondo H, Kobayashi E, Katoh Y, Higashi T, Kawai A. Soft-tissue sarcoma in Japan: National Cancer Registry-based analysis from 2016 to 2019. Japanese journal of clinical oncology, 54:1150-1157, 2024
43. Toda Y, Ogura K, Iwata S, Kobayashi E, Osaki S, Fukushima S, Mawatari M, Kawai A. The diagnostic and prognostic value of tartrate-resistant acid phosphatase isoform 5b for giant cell tumor of bone. International journal of clinical oncology, 29:1391-1397, 2024
44. Nishikawa T, Kakunaga S, Tamura K, Ando M, Ozaki T, Kawai A, Ueda T, Kawasaki M, Tomatsuri S, Okamura N, Kamikura M, Hamada A, Yoshida A, Hirakawa A, Shibata T, Nakamura K, Yonemori K. Efficacy and safety of nivolumab monotherapy in patients with unresectable clear cell sarcoma and alveolar soft part sarcoma (OSCAR Trial/NCCH1510). Cancer, 130:3836-3844, 2024
45. Hasei J, Ishida H, Katayama H, Maeda N, Nagano A, Ochi M, Okamura M, Iwata S, Ikuta K, Yoshida S, Fujiwara T, Nakata E, Nakahara R, Kunisada T, Ozaki T. Utilizing the Metaverse to Provide Innovative Psychosocial Support for Pediatric, Adolescent, and Young Adult Patients with Rare Cancer. Cancers, 16:2617, 2024
46. Arikawa M, Akazawa S, Kageyama D, Kawai A, Ohe Y, Sakisaka M, Miyamoto S. Nonreversed great saphenous vein grafts for vascular reconstruction after resection of lower-limb sarcoma. Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 97:65-70, 2024
47. Osaki J, Noguchi R, Ono T, Adachi Y, Iwata S, Toda Y, Funada T, Iwata S, Kojima N, Yoshida A, Kawai A, Kondo T. Establishment and characterization of NCC-SS6-C1: a novel patient-derived cell line of synovial sarcoma. Human cell, 37:1734-1741, 2024
48. Hosoi H, Miyachi M, Teramukai S, Sakabayashi S, Tsuchiya K, Kuwahara Y, Onodera R, Matsuyama K, Yokota I, Hojo H, Okita H, Hata JI, Hamasaki M, Tsuneyoshi M, Oda Y, Nakazawa A, Kato M, Takimoto T, Horibe K, Hara JI, Suita S, Hanada R, Masaki H, Nozaki M, Ikeda H, Kishimoto S, Kaneko M, Kawai A, Morikawa Y. Results of the JRS-I LRA0401 and LRB0402 Japan Rhabdomyosarcoma Study Group trials for low-risk embryonal rhabdomyosarcoma. International journal of clinical oncology, 29:1746-1755, 2024
49. Fujita S, Ohno M, Osaki S, Sugino H, Yoshida A, Takahashi M, Yanagisawa S, Osawa S, Tsuchiya T, Narita Y. Novel case of anastomosing hemangioma of the extradural space: illustrative case. Journal of neurosurgery. Case lessons, 8:CASE24265, 2024
50. Takemori T, Ogura K, Morizane C, Satake T, Iwata S, Toda Y, Muramatsu S, Kondo H, Kobayashi E, Higashi T, Kawai A. Clear cell sarcoma in Japan: an analysis of the population-based cancer registry in Japan. Japanese journal of clinical oncology, 54:1281-1287, 2024
51. Adachi Y, Noguchi R, Osaki J, Ono T, Iwata S, Akiyama T, Tsuchiya R, Toda Y, Tetsuya S, Iwata S, Kobayashi E, Kojima N, Yoshida A, Yokoo H, Kawai A, Kondo T. Establishment and characterization of two novel patient-derived cell lines from myxofibrosarcoma: NCC-MFS7-C1 and NCC-MFS8-C1. Human cell, 37:1742-1750, 2024
52. Hasei J, Nakahara R, Otsuka Y, Nakamura Y, Hironari T, Kahara N, Miwa S, Ohshika S, Nishimura S, Ikuta K, Osaki S, Yoshida A, Fujiwara T, Nakata E, Kunisada T, Ozaki T. High-quality expert annotations enhance artificial intelligence model accuracy for osteosarcoma X-ray diagnosis. Cancer science, 115:3695-3704, 2024
53. Giani C, Denu RA, Ljevar S, Gronchi A, Napolitano A, Rosenbaum E, Salawu A, Bajpai J, Connolly EA, Lee ATJ, Trent JC, Koseła-Paterczyk H, Chia-Chen Li Z, Ogura K, Palmerini E, Baldi GG, Brunello A, Campos F, Cicala CM, Maki RG, Wagner AJ, Andelkovic V, Loong HH, Wong DD, Jones RL, Tap WD, Taverna SM, Lazar AJ, Demicco EG, Hong A, Bovee JVMG, Dei Tos AP, Fletcher CDM, Baumhoer D, Sbaraglia M, Schaefer IM, Miceli R, Stacchiotti S. Low-grade fibromyxoid sarcoma and sclerosing epithelioid fibrosarcoma, outcome of advanced disease: retrospective study from the Ultra-Rare Sarcoma Working Group. ESMO open, 9:103689, 2024
54. Uotani K, Fujiwara T, Ueda K, Yoshida A, Iwata S, Morita T, Kiyono M, Kunisada T, Takeda K, Hasei J, Yoshioka Y, Ochiya T, Ozaki T. Identification of ENO-1 positive extracellular vesicles as a circulating biomarker for monitoring of Ewing sarcoma. Cancer science, 115:3660-3671, 2024
55. Sekita T, Asano N, Kobayashi H, Yonemoto T, Kobayashi E, Ishii T, Kawai A, Nakayama R. Long-term functional outcome of limb-sparing surgery for paediatric bone sarcoma around the knee. Bone & joint open, 5:868-878, 2024
56. Noguchi R, Osaki J, Ono T, Adachi Y, Iwata S, Yoshimatsu Y, Sasaki K, Kawai A, Kondo T. Pharmacoproteogenomic approach identifies on-target kinase inhibitors for cancer drug repositioning. In vitro cellular & developmental biology. Animal, 60:1200-1214, 2024
57. Nakamura T, Ogura K, Hayakawa K, Ikuta K, Nezu Y, Miwa S, Yoshida S, Nakai S, Kinoshita H, Kawabata Y, Hamada S, Nabeshima A, Outani H, Kobayashi H, Hara H, Tsugita M, Koyanagi H, Setsu N, Maekawa A, Daisaku A, Mori T, Oike N, Kubota Y, Tanaka T, Noguchi T, Tajima T, Tanaka K, Ozaki T. Real-world Referral Pattern of Unplanned Excision in Patients With Soft-tissue Sarcoma: A Multicenter Study Conducted by the Bone and Soft-tissue Tumor Study Group of the Japan Clinical Oncology Group. In vivo (Athens, Greece), 38:2712-2717, 2024
58. Masunaga T, Tsukamoto S, Honoki K, Fujii H, Kido A, Akahane M, Tanaka Y, Mavrogenis AF, Errani C, Kawai A. Prognostic factors for mesenchymal chondrosarcoma. SICOT-J, 10:46, 2024
59. Tsuchiya R, Iwata S, Fukushima S, Osaki S, Ogura K, Kobayashi E, Ohtori S, Kawai A. Developmental Patterns and Risk Factors of Scoliosis After Hemipelvectomy for the Pelvic Bone Tumor. Diagnostics (Basel, Switzerland), 14:2392, 2024
60. Suehara Y, Kitada R, Kamio S, Ogura K, Iwata S, Kobayashi E, Kawai A, Khosaka S. Analysis of cancer multigene panel testing for osteosarcoma in pediatric and adults using the center for cancer genomics and advanced therapeutics database in Japan. Journal of orthopaedic science, S0949-2658(24)00209-4, 2024
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