Annual Report 2024
Division of Screening Technology
Nozomu Kobayashi, Masau Sekiguchi, (Special research assistants): Orie Kitamura, Mio Shimamura, Ayami Haneda, Rie Negishi, Mika Mori
Introduction
The Division of Screening Technology works with the NCC Cancer Screening Center on the study. It consists of two staff medical doctors and five special research assistants.
The Team and What We Do
We aim to develop new diagnostic techniques that can be applied to cancer screening and research existing diagnostic methods that can be used for medical examinations. We are also assessing a new close examination method in cancer screening. In addition, we work on research aimed at risk stratification of people to be screened.
Research Activities
1) Examinations are ongoing for the cancer detection rate of each screening modality (e.g., chest CT, upper/lower GI endoscopy, MMG/tomosynthesis, and breast ultrasonography, FDG-PETCT/MRI, and CT colonography), the characteristics of the detected cancer, and the false positive rate for all individuals who underwent cancer screening from the establishment of our center in 2004. In addition, we aim to clarify the relationship between cancer screening and cancer death from long-term (prognosis survey) results. Moreover, the following research is ongoing: 2) Field construction for verification of diagnostic tools for colorectal cancer and precancerous lesions using biomarkers (Oshima Study), 3) Japan Polyp Study: multicenter prospective cohort study to elucidate the preventive effect of colorectal cancer caused by polypectomy, 4) Prospective multicenter study to evaluate the effectiveness of AI-assisted colonoscopy, which is designed as an Asian multicenter randomized controlled trial.
Other research: We are collaborating with external researchers using 1,325 stool samples collected from the Oshima Study. (Research on colibactin-producing bacteria as fecal biomarkers, bacteria, and bacterial flora as fecal biomarkers and their functions). Additionally, as a cross-sectional project of the National Cancer Center Institute for Cancer Control, we edited and published the "Colorectal Cancer Fact Sheet."
Future Prospects
We will promote screening development research to create and gather evidence.
List of papers published in 2024
Journal
1. Sekiguchi M, Kawamura T, Horiguchi G, Mizuguchi Y, Takamaru H, Toyoizumi H, Kato M, Kobayashi K, Sada M, Oda Y, Yokoyama A, Utsumi T, Tsuji Y, Ohki D, Takeuchi Y, Shichijo S, Ikematsu H, Matsuda K, Teramukai S, Kobayashi N, Matsuda T, Saito Y, Tanaka K. Colorectal Neuroendocrine Neoplasm Detection Rate During Colonoscopy: Results From Large-Scale Data of Colonoscopies in Japan. The American journal of gastroenterology, 120:473-477, 2025
2. Hirai Y, Toyoshima N, Takamaru H, Sekiguchi M, Yamada M, Kobayashi N, Sekine S, Saito Y. Procedural outcomes of a novel underwater injection endoscopic mucosal resection technique for colorectal polyps ≧10 mm. Endoscopy, 57:494-499, 2025
3. Ohmiya N, Araki A, Tsuboi A, Nakamura K, Ito K, Hotta N, Kakugawa Y, Oka S, Saito Y, Kato T, Tanaka S. Multicenter prospective feasibility study on compliance, safety, and acceptance of small bowel and colon capsule endoscopy in the out-of-clinic setting in Japan. Digestive endoscopy, 37:680-694, 2025
4. Sekiguchi M, Westerberg M, Löwbeer C, Forsberg A. Endoscopist adenoma detection rate associated with neoplasia detection during subsequent-round colonoscopy in fecal immunochemical test-based colorectal cancer screening: cross-sectional analysis of the SCREESCO randomized controlled trial. Gastrointestinal endoscopy, S0016-5107(25)00067-7, 2025
5. Sekiguchi M, Shinmura K, Sumiyama K, Matsuda T, Han KS, Kim HS, Chiu HM, Chang CY, Lee WJJ, Khor CJL, Lau LH, Pattarajierapan S, Khomvilai S, Miyata A, Shibata T, Saito Y. Protocol for a multicenter randomized controlled trial to assess the usefulness of computer-aided detection systems for colonoscopy in colorectal cancer screening in the Asia-Pacific region (project CAD/NCCH2217). Japanese journal of clinical oncology, 2025
6. Toyoshima N, Mizuguchi Y, Takamaru H, Nakamura K, Kakugawa Y, Sakamoto T, Shiroyama M, Kawagoe R, Tsuchiya K, Shinmura K, Ikematsu H, Inaba A, Minakata N, Hotta K, Imai K, Takada K, Ito S, Misawa M, Wakamura K, Kudo SE, Tamai N, Sumiyama K, Ito M, Uraoka T, Tomaru S, Matsuda T, Fujimoto A, Shibata T, Saito Y. The Efficacy of Texture and Color Enhancement Imaging Observation in the Detection of Colorectal Lesions: A Multicenter, Randomized Controlled Trial (deTXIon Study). Gastroenterology, 2025
7. Sekiguchi M, Matsuda T, Saito Y. Treatment strategy and post-treatment management of colorectal neuroendocrine tumor. DEN open, 4:e254, 2024
8. Ito S, Hotta K, Sekiguchi M, Takeuchi Y, Oka S, Yamamoto H, Shinmura K, Harada K, Uraoka T, Hisabe T, Sano Y, Kondo H, Horimatsu T, Kikuchi H, Kawamura T, Nagata S, Yamamoto K, Tajika M, Tsuji S, Kusaka T, Okuyama Y, Yoshida N, Moriyama T, Hasebe A, So S, Saito Y, Nakahira H, Ishikawa H, Matsuda T. Short-term outcomes of endoscopic resection for colorectal neuroendocrine tumors: Japanese multicenter prospective C-NET STUDY. Digestive endoscopy, 36:942-951, 2024
9. Tanaka H, Uraoka T, Kobayashi N, Ohata K, Takeuchi Y, Chino A, Yamada M, Tsuji Y, Hotta K, Harada K, Ikematsu H, Murakami T, Tsuji S, Katagiri A, Hori S, Michida T, Suzuki T, Fukuzawa M, Kiriyama S, Fukase K, Murakami Y, Ishikawa H, Nagahara A, Saito Y. Short-term and long-term outcomes of submucosal dissection for residual or recurrent colorectal tumors after endoscopic resection: Analysis of a multicenter prospective study. Digestive endoscopy, 36:1003-1011, 2024
10. Sekiguchi M, Suzuki H, Takizawa K, Hirasawa T, Takeuchi Y, Ishido K, Hoteya S, Yano T, Tanaka S, Toya Y, Nakagawa M, Toyonaga T, Takemura K, Hirasawa K, Matsuda M, Yamamoto H, Tsuji Y, Hashimoto S, Maeda Y, Oyama T, Takenaka R, Yamamoto Y, Shimazu T, Ono H, Tanabe S, Kondo H, Iishi H, Ninomiya M, Oda I. Potential for expanding indications and curability criteria of endoscopic resection for early gastric cancer in elderly patients: results from a Japanese multicenter prospective cohort study. Gastrointestinal endoscopy, 100:438-448.e1, 2024
11. Oka S, Tanaka S, Kajiwara Y, Saito S, Fukunaga Y, Takamatsu M, Kawachi H, Hotta K, Ikematsu H, Kojima M, Saito Y, Yamada M, Kanemitsu Y, Sekine S, Nagata S, Yamada K, Kobayashi N, Ishihara S, Saitoh Y, Matsuda K, Togashi K, Komori K, Ishiguro M, Kuwai T, Okuyama T, Ohuchi A, Ohnuma S, Sakamoto K, Sugai T, Katsumata K, Matsushita HO, Yamano HO, Eda H, Uraoka T, Akimoto N, Kobayashi H, Sugihara K, Ueno H. Treatment Decision for Locally Resected T1 Colorectal Carcinoma-Verification of the Japanese Guideline Criteria for Additional Surgery Based on Long-Term Clinical Outcomes. The American journal of gastroenterology, 119:2019-2027, 2024
12. Sekiguchi M, Kishida Y, Ikematsu H, Konno M, Mizuguchi Y, Hotta K, Imai K, Ito S, Takada K, Shiomi A, Yasui H, Tsukamoto S, Hirano H, Kobayashi N, Saito Y, Inaba A, Shinmura K, Konishi J, Ozawa H, Fujita S, Murakami Y, Matsuda T. Proportions and characteristics of interval cancer in annual fecal immunochemical test screening and postcolonoscopy colorectal cancer: Results from a Japanese multicenter prospective study using questionnaires, the C-DETECT study. Digestive endoscopy, 36:1140-1151, 2024
13. Matsuda T, Sekiguchi M, Kobayashi N. [Current status and issues of colorectal cancer screening - toward the introduction of colonoscopy into the population-based screening program]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 121:177-185, 2024
14. Igarashi M, Iwasaki M, Katagiri R, Tsugane S, Kobayashi N, Yamaji T. Sex difference in the association of dietary fiber intake with visceral fat volume in Japanese adults. European journal of nutrition, 63:1973-1981, 2024
15. Nakamura K, Kakukgawa Y, Sekiguchi M, Tsuruki ES, Matsumoto M, Hisada I, Mizuguchi Y, Takamaru H, Sakamoto T, Saito Y, Kobayashi N, Matsuda T. Chronological Trend of Opportunistic Endoscopic Screening for Gastric Cancer and Atrophic Gastritis. Asian Pacific journal of cancer prevention : APJCP, 25:1247-1255, 2024
16. Uozumi T, Abe S, Mizuguchi Y, Sekiguchi M, Toyoshima N, Takamaru H, Yamada M, Kobayashi N, Sadachi R, Ito S, Takada K, Kishida Y, Imai K, Hotta K, Ono H, Saito Y. Endoscopic hand suturing using a modified through-the-scope needle holder for mucosal closure after colorectal endoscopic submucosal dissection: Prospective multicenter study (with video). Digestive endoscopy, 36:1245-1252, 2024
17. Tsuji S, Doyama H, Kobayashi N, Ohata K, Takeuchi Y, Chino A, Takamaru H, Tsuji Y, Hotta K, Harada K, Ikematsu H, Uraoka T, Murakami T, Katagiri A, Hori S, Michida T, Suzuki T, Fukuzawa M, Kiriyama S, Fukase K, Murakami Y, Ishikawa H, Saito Y. Outcomes of noncurative endoscopic submucosal dissection for T1 colorectal cancer: Prospective, multicenter, cohort study in Japan. Digestive endoscopy, 36:1369-1379, 2024
18. Esaki M, Igarashi A, Tsukamoto S, Sugawara S, Sekiguchi M, Fujinaga A. [Health Economic Evaluation of Surgical Treatment for Cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 51:795-800, 2024