Annual Report 2024
Division of Cohort Research
Norie Sawada, Manami Inoue, Motoki Iwasaki, Ayami Ono, Rieko Kanehara, Mariko Hanafusa, Takahiro Mita, Yukai Lu, Jun Umezawa, Shinichiro Shiozawa, Katsura Ito, Tagayasu Anzai, Yuri Ishii, Yasuko Kikuchi, Madoka Kishino, Ren Sato, Aoi Suzuki, Tetsuya Tajima, Mizuki Hino
Introduction
The Division of Cohort Research aims to (i) create evidence for the prevention of non-communicable diseases such as cancer, and (ii) conduct epidemiological research to extend the healthy life expectancy among people living in Japan using population-based cohorts, domestic and international epidemiological research network framework, and the collaborative epidemiological research network project of the six national centers in Japan (6NCs) for advanced and specialized medicine-National Center Cohort Collaborative for Advancing Population Health (NC-CCAPH).
Research Activities
1. Using NC-CCAPH as a six National Centers (6NC) research network to conduct collaborative epidemiological research on advanced and specialized medical care
NC-CCAPH is the core research project of the Division of Cohort Research. Initiated in 2017, the project aims to establish a 6NC Epidemiological Research Collaboration Platform to conduct pooled and mutual data analyses. As part of this project, we worked to strengthen the maintenance and stability of the collaborative analysis platform, including planning the replacement of remote terminals and the analysis server, as well as enhancing security measures to facilitate efficient collaboration.
In 2024, based on standardized evaluation criteria, we completed most of the evidence evaluation. This evaluation focused on the 19 diseases and 46 risk or preventive factors highlighted in the published recommendations for extending healthy life expectancy in Japan. The evaluation results will be published in 2025. The recommendations, adapted for public use, have been released. To facilitate broad dissemination, we considered establishing collaborations with municipalities and academic societies, as well as further developing related materials.
2. Promotion of collaborative research among the six National Centers using ongoing cohort studies in the NCC
There are four Japan Public Health Centre-based Prospective (JPHC) Studies and seven JPHC Study for the Next Generation (JPHC-NEXT) collaborative studies. Using the JPHC Study, we reported that individuals who continued to live alone had a higher risk of suicide compared to those who lived with others.
Using the JPHC-NEXT, we reported that higher intake of sugar-sweetened beverages, fruit and vegetable juices, and sugar-sweetened coffee was associated with an increased risk of depression, in contrast to higher intake of black coffee, which was associated with a lower risk.
Within the NC-CCAPH consortium, eight projects are in progress. In one pooled analysis, we reported that multimorbidity in midlife was associated with a higher risk of all-cause and cause-specific mortality.
3. JPHC Study / JPHC-NEXT
We have been conducting follow-up surveys and data analysis for the JPHC Study with 140,000 residents from all over Japan since 1990. This year, we reported that changes in the health status of close relatives affected individuals' mortality; specifically, having a spouse diagnosed with cancer was associated with an increased risk of death from external causes, particularly with suicide among men. We also examined the relatively rare cancer of the head and neck region and found a U-shaped association between BMI and cancer risk in the Japanese population, with higher risks at both low and high BMI levels, especially evident among non-smokers.
The baseline survey for the JPHC-NEXT was completed at the end of 2016, and we initiated the 5-year follow-up survey in 2016 and then the 10-year follow-up survey in 2021 (Table 1). Using the JPHC-NEXT data, we evaluated the validity of self-reported cancer screening and health checkup histories by comparing questionnaire responses with official records. Moderate agreement was observed overall; however, discrepancies were frequent for lung cancer screening, which was highlighted as an important consideration for analyses. Similarly, high concordance was observed between self-reported or interview-based histories of Helicobacter pylori eradication and claims data.
In addition, large-scale molecular epidemiology cohorts, based on baseline data, launched case-cohort studies for gastric, hepatobiliary-pancreatic, and breast cancers. Using whole-genome, exome, and targeted sequencing, we further advanced the risk evaluation of genetic variants related to breast and gastrointestinal cancers.
4. The conditions and factors of coronavirus infection among National Center staff as a part of Multicenter Observational Study
We are participating in a multicenter observational study of COVID-19 supported by the Japan Health Research Promotion Bureau. As a part of the study, we are conducting an observational study of new coronavirus infections (COVID-19) among National Cancer Center staff at the Tsukiji Campus. Web questionnaire surveys and collection of blood samples for antibody measurement were conducted between July and August 2024, including approximately 310 participants. We are preparing to conduct a follow-up survey in 2025. Currently, 18 research projects are ongoing using harmonized data from all six National Centers.
Education
We supervised the research of domestic and international Master's and PhD students. We accept postgraduate students from the Graduate School of Medicine, Yokohama City University, and the Graduate School of Humanities and Sciences, Nara Women's University.
Future Prospects
We will continue to develop cohort infrastructures, strengthen collaboration with domestic and international institutions, and generate evidence to extend healthy life expectancy through cross-disease prevention. We will also update our operational systems to further promote the use of existing resources.
List of papers published in 2024
Journal
1. Jenkins DJA, Willett WC, Yusuf S, Hu FB, Glenn AJ, Liu S, Mente A, Miller V, Bangdiwala SI, Gerstein HC, Sieri S, Ferrari P, Patel AV, McCullough ML, Le Marchand L, Freedman ND, Loftfield E, Sinha R, Shu XO, Touvier M, Sawada N, Tsugane S, van den Brandt PA, Shuval K, Khan TA, Paquette M, Sahye-Pudaruth S, Patel D, Siu TFY, Srichaikul K, Kendall CWC, Sievenpiper JL. Association of glycaemic index and glycaemic load with type 2 diabetes, cardiovascular disease, cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants. Lancet Diabetes Endocrinol, 2024;12(2):107-118.
2. Xu J, Goto A, Konishi M, Kato M, Mizoue T, Terauchi Y, Tsugane S, Sawada N, Noda M. Development and validation of prediction models for the 5-year risk of type 2 diabetes in a Japanese population: Japan Public Health Center-based Prospective (JPHC) Diabetes Study. J Epidemiol, 2024;34(4):170-179.
3. Hiwasa T, Yoshida Y, Kubota M, Li SY, Zhang BS, Matsutani T, Mine S, Machida T, Ito M, Yajima S, Shirouzu M, Yokoyama S, Sata M, Yamagishi K, Iso H, Sawada N, Tsugane S, Takemoto M, Hayashi A, Yokote K, Kobayashi Y, Matsushita K, Tatsumi K, Takizawa H, Tomiyoshi G, Shimada H, Higuchi Y. Serum antiKIAA0513 antibody as a common biomarker for mortal atherosclerotic and cancerous diseases. Med Int (Lond), 2024;4(5):45.
4. Murai U, Ishihara J, Takachi R, Kotemori A, Ishii Y, Nakamura K, Tanaka J, Iso H, Tsugane S, Sawada N. Validity of the Intake of Sugars, Amino Acids, and Fatty Acids Estimated Using a Self-administered Food Frequency Questionnaire in Middle-aged and Elderly Japanese: The Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT) Protocol Area. J Epidemiol, 2024;34(8):372-379.
5. Li C, Bishop TRP, Imamura F, Sharp SJ, Pearce M, Brage S, Ong KK, Ahsan H, Bes-Rastrollo M, Beulens JWJ, den Braver N, Byberg L, Canhada S, Chen Z, Chung HF, Cortés-Valencia A, Djousse L, Drouin-Chartier JP, Du H, Du S, Duncan BB, Gaziano JM, Gordon-Larsen P, Goto A, Haghighatdoost F, Härkänen T, Hashemian M, Hu FB, Ittermann T, Järvinen R, Kakkoura MG, Neelakantan N, Knekt P, Lajous M, Li Y, Magliano DJ, Malekzadeh R, Le Marchand L, Marques-Vidal P, Martinez-Gonzalez MA, Maskarinec G, Mishra GD, Mohammadifard N, O'Donoghue G, O'Gorman D, Popkin B, Poustchi H, Sarrafzadegan N, Sawada N, Schmidt MI, Shaw JE, Soedamah-Muthu S, Stern D, Tong L, van Dam RM, Völzke H, Willett WC, Wolk A, Yu C, Forouhi NG, Wareham NJ. Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries. Lancet Diabetes Endocrinol, 2024;12(9):619-630.
6. Nakashima Y, Hanafusa M, Ishibashi H, Hosoda H. Stapler-induced vascular injury during uniportal VATS lobectomy: lessons learned from a rare complication case. Surg Case Rep, 2024;10(1):249.
7. Klapp R, Laxamana JA, Shvetsov YB, Park SY, Kanehara R, Setiawan VW, Danquah I, Le Marchand L, Maskarinec G. The EAT-Lancet Diet Index Is Associated with Lower Obesity and Incidence of Type 2 Diabetes in the Multiethnic Cohort. J Nutr, 2024;154(11):3407-3415.
8. Uchimido R, Kami K, Yamamoto H, Yokoe R, Tsuchiya I, Nukui Y, Goto Y, Hanafusa M, Fujiwara T, Wakabayashi K. Longitudinal Metabolomics Reveals Metabolic Dysregulation Dynamics in Patients with Severe COVID-19. Metabolites, 2024;14(12):656.
9. Tajima T, Kanehara R, Fujii M, Tanaka S, Umezawa J, Ohno Y, Inoue M. Trajectory Patterns of Three Lifestyle Behaviors and Subsequent Health Conditions in Japanese Adults: A Retrospective Longitudinal Study Using a Health Checkup Database. Jma j, 2024;7(4):506-517.
10. Koyanagi YN, Nakatochi M, Namba S, Oze I, Charvat H, Narita A, Kawaguchi T, Ikezaki H, Hishida A, Hara M, Takezaki T, Koyama T, Nakamura Y, Suzuki S, Katsuura-Kamano S, Kuriki K, Nakamura Y, Takeuchi K, Hozawa A, Kinoshita K, Sutoh Y, Tanno K, Shimizu A, Ito H, Kasugai Y, Kawakatsu Y, Taniyama Y, Tajika M, Shimizu Y, Suzuki E, Hosono Y, Imoto I, Tabara Y, Takahashi M, Setoh K, Matsuda K, Nakano S, Goto A, Katagiri R, Yamaji T, Sawada N, Tsugane S, Wakai K, Yamamoto M, Sasaki M, Matsuda F, Okada Y, Iwasaki M, Brennan P, Matsuo K. Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people. Sci Adv, 2024;10(4):eade2780.
11. Shiraishi K, Takahashi A, Momozawa Y, Daigo Y, Kaneko S, Kawaguchi T, Kunitoh H, Matsumoto S, Horinouchi H, Goto A, Honda T, Shimizu K, Torasawa M, Takayanagi D, Saito M, Saito A, Ohe Y, Watanabe SI, Goto K, Tsuboi M, Tsuchihara K, Takata S, Aoi T, Takano A, Kobayashi M, Miyagi Y, Tanaka K, Suzuki H, Maeda D, Yamaura T, Matsuda M, Shimada Y, Mizuno T, Sakamoto H, Yoshida T, Goto Y, Yoshida T, Yamaji T, Sonobe M, Toyooka S, Yoneda K, Masago K, Tanaka F, Hara M, Fuse N, Nishizuka SS, Motoi N, Sawada N, Nishida Y, Kumada K, Takeuchi K, Tanno K, Yatabe Y, Sunami K, Hishida T, Miyazaki Y, Ito H, Amemiya M, Totsuka H, Nakayama H, Yokose T, Ishigaki K, Nagashima T, Ohtaki Y, Imai K, Takasawa K, Minamiya Y, Kobayashi K, Okubo K, Wakai K, Shimizu A, Yamamoto M, Iwasaki M, Matsuda K, Inazawa J, Shiraishi Y, Nishikawa H, Murakami Y, Kubo M, Matsuda F, Kamatani Y, Hamamoto R, Matsuo K, Kohno T. Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses. Cancer Commun (Lond), 2024;44(2):287-293.
12. Suzuki A, Takachi R, Ishihara J, Maruya S, Ishii Y, Kito K, Nakamura K, Tanaka J, Yamaji T, Iso H, Iwasaki M, Tsugane S, Sawada N, for the JPHC-NEXT. Urinary Biomarkers in Screening for the Usual Intake of Fruit and Vegetables, and Sodium, Potassium, and the Sodium-to-Potassium Ratio: Required Number and Accuracy of Measurements. Nutrients, 2024;16(3):442.
13. Chen Z, Guo X, Tao R, Huyghe JR, Law PJ, Fernandez-Rozadilla C, Ping J, Jia G, Long J, Li C, Shen Q, Xie Y, Timofeeva MN, Thomas M, Schmit SL, Díez-Obrero V, Devall M, Moratalla-Navarro F, Fernandez-Tajes J, Palles C, Sherwood K, Briggs SEW, Svinti V, Donnelly K, Farrington SM, Blackmur J, Vaughan-Shaw PG, Shu XO, Lu Y, Broderick P, Studd J, Harrison TA, Conti DV, Schumacher FR, Melas M, Rennert G, Obón-Santacana M, Martín-Sánchez V, Oh JH, Kim J, Jee SH, Jung KJ, Kweon SS, Shin MH, Shin A, Ahn YO, Kim DH, Oze I, Wen W, Matsuo K, Matsuda K, Tanikawa C, Ren Z, Gao YT, Jia WH, Hopper JL, Jenkins MA, Win AK, Pai RK, Figueiredo JC, Haile RW, Gallinger S, Woods MO, Newcomb PA, Duggan D, Cheadle JP, Kaplan R, Kerr R, Kerr D, Kirac I, Böhm J, Mecklin JP, Jousilahti P, Knekt P, Aaltonen LA, Rissanen H, Pukkala E, Eriksson JG, Cajuso T, Hänninen U, Kondelin J, Palin K, Tanskanen T, Renkonen-Sinisalo L, Männistö S, Albanes D, Weinstein SJ, Ruiz-Narvaez E, Palmer JR, Buchanan DD, Platz EA, Visvanathan K, Ulrich CM, Siegel E, Brezina S, Gsur A, Campbell PT, Chang-Claude J, Hoffmeister M, Brenner H, Slattery ML, Potter JD, Tsilidis KK, Schulze MB, Gunter MJ, Murphy N, Castells A, Castellví-Bel S, Moreira L, Arndt V, Shcherbina A, Bishop DT, Giles GG, Southey MC, Idos GE, McDonnell KJ, Abu-Ful Z, Greenson JK, Shulman K, Lejbkowicz F, Offit K, Su YR, Steinfelder R, Keku TO, van Guelpen B, Hudson TJ, Hampel H, Pearlman R, Berndt SI, Hayes RB, Martinez ME, Thomas SS, Pharoah PDP, Larsson SC, Yen Y, Lenz HJ, White E, Li L, Doheny KF, Pugh E, Shelford T, Chan AT, Cruz-Correa M, Lindblom A, Hunter DJ, Joshi AD, Schafmayer C, Scacheri PC, Kundaje A, Schoen RE, Hampe J, Stadler ZK, Vodicka P, Vodickova L, Vymetalkova V, Edlund CK, Gauderman WJ, Shibata D, Toland A, Markowitz S, Kim A, Chanock SJ, van Duijnhoven F, Feskens EJM, Sakoda LC, Gago-Dominguez M, Wolk A, Pardini B, FitzGerald LM, Lee SC, Ogino S, Bien SA, Kooperberg C, Li CI, Lin Y, Prentice R, Qu C, Bézieau S, Yamaji T, Sawada N, Iwasaki M, Le Marchand L, Wu AH, Qu C, McNeil CE, Coetzee G, Hayward C, Deary IJ, Harris SE, Theodoratou E, Reid S, Walker M, Ooi LY, Lau KS, Zhao H, Hsu L, Cai Q, Dunlop MG, Gruber SB, Houlston RS, Moreno V, Casey G, Peters U, Tomlinson I, Zheng W. Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes. Nat Commun, 2024;15(1):3557.
14. Igarashi M, Iwasaki M, Katagiri R, Tsugane S, Kobayashi N, Yamaji T. Sex difference in the association of dietary fiber intake with visceral fat volume in Japanese adults. Eur J Nutr, 2024;63(5):1973-1981.
15. Hishida A, Nakatochi M, Sutoh Y, Nakano S, Momozawa Y, Narita A, Tanno K, Shimizu A, Hozawa A, Kinoshita K, Yamaji T, Goto A, Noda M, Sawada N, Ikezaki H, Nagayoshi M, Hara M, Suzuki S, Koyama T, Koriyama C, Katsuura-Kamano S, Kadota A, Kuriki K, Yamamoto M, Sasaki M, Iwasaki M, Matsuo K, Wakai K. GWAS meta-analysis of kidney function traits in Japanese populations. J Epidemiol, 2024;34(11):526-534.
16. Taguri M, Kuchiba A, Yamaji T, Sawada N, Goto A, Iwasaki M, Tsugane S. Importance of Circulating Leptin and Adiponectin in the Causal Pathways Between Obesity and the Development of Colorectal Cancer in Japanese Men. J Epidemiol, 2024;34(12):563-569.
17. Mori N, Murphy N, Sawada N, Achaintre D, Yamaji T, Scalbert A, Ishihara J, Takachi R, Nakamura K, Tanaka J, Iwasaki M, Iso H, Inoue M, Gunter MJ, Tsugane S. Reproducibility and dietary correlates of plasma polyphenols in the JPHC-NEXT Protocol Area study. Eur J Clin Nutr, 2024;78(1):34-42.
18. Shimizu Y, Yamaji T, Inoue M, Yasuda N, Yamagishi K, Sawada N, Tsugane S, Iwasaki M. Plasma uric acid levels and risk of dementia in a population-based cohort study. J Neurol Sci, 2024;467:123323.
19 Nabila S, Choi JY, Abe SK, Islam MR, Rahman MS, Saito E, Shin A, Merritt MA, Katagiri R, Shu XO, Sawada N, Tamakoshi A, Sakata R, Hozawa A, Kim J, Nagata C, Park SK, Kweon SS, Cai H, Tsugane S, Kimura T, Kanemura S, Sugawara Y, Wada K, Shin MH, Ahsan H, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D. Differential patterns of reproductive and lifestyle risk factors for breast cancer according to birth cohorts among women in China, Japan and Korea. Breast Cancer Res, 2024;26(1):15.
20. Manandhar Shrestha R, Mizoue T, Islam Z, Kawakatsu Y, Ito H, Wada K, Nagata C, Zha L, Kitamura T, Sakata R, Kimura T, Sugawara Y, Tsuji I, Sato R, Sawada N, Tsugane S, Lin Y, Oze I, Abe SK, Inoue M. Adult height and risk of colorectal cancer: a pooled analysis of ten population-based cohort studies in Japan. J Epidemiol, 2024;34(2):94-103.
21. Nuamah HG, Li Y, Yatsuya H, Yamagishi K, Saito I, Kokubo Y, Muraki I, Iso H, Inoue M, Tsugane S, Sawada N. The effect of age on the relationship between body mass index and risks of incident stroke subtypes: The JPHC study. J Stroke Cerebrovasc Dis, 2024;33(2):107486.
22. Yamamoto N, Ejima K, Mestre LM, Owora AH, Inoue M, Tsugane S, Sawada N. Body mass index trajectories and mortality risk in Japan using a population-based prospective cohort study: the Japan Public Health Center-based Prospective Study. Int J Epidemiol, 2024;53(1):dyad145.
23. Kikuchi H, Inoue S, Amagasa S, Kuwahara K, Ihira H, Inoue M, Iso H, Tsugane S, Sawada N. Relationships of Total and Domain-Specific Moderate-to-Vigorous Physical Activity with All-Cause and Disease-Specific Mortality. Med Sci Sports Exerc, 2024;56(3):520-527.
24. Miyata J, Muraki I, Iso H, Yamagishi K, Yasuda N, Sawada N, Inoue M, Tsugane S, Jphc Disabling Dementia Study Group. Sleep duration, its change, and risk of dementia among Japanese: The Japan Public Health Center-based Prospective Study. Prev Med, 2024;180:107884.
25. Kawai S, Lin Y, Tsuge H, Ito H, Matsuo K, Wada K, Nagata C, Narii N, Kitamura T, Utada M, Sakata R, Kimura T, Tamakoshi A, Sugawara Y, Tsuji I, Suzuki S, Sawada N, Tsugane S, Mizoue T, Oze I, Abe SK, Inoue M. Body mass index and lung cancer risk: Pooled analysis of 10 prospective cohort studies in Japan. Cancer Sci, 2024;115(4):1346-1359.
26. Oze I, Ito H, Koyanagi YN, Abe SK, Rahman MS, Islam MR, Saito E, Gupta PC, Sawada N, Tamakoshi A, Shu XO, Sakata R, Malekzadeh R, Tsuji I, Kim J, Nagata C, You SL, Park SK, Yuan JM, Shin MH, Kweon SS, Pednekar MS, Tsugane S, Kimura T, Gao YT, Cai H, Pourshams A, Lu Y, Kanemura S, Wada K, Sugawara Y, Chen CJ, Chen Y, Shin A, Wang R, Ahn YO, Shin MH, Ahsan H, Boffetta P, Chia KS, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D, Matsuo K. Obesity is associated with biliary tract cancer mortality and incidence: A pooled analysis of 21 cohort studies in the Asia Cohort Consortium. Int J Cancer, 2024;154(7):1174-1190.
27. Wada K, Nagata C, Utada M, Sakata R, Kimura T, Tamakoshi A, Sugawara Y, Tsuji I, Sato R, Sawada N, Tsugane S, Oze I, Ito H, Kitamura T, Koyanagi YN, Lin Y, Matsuo K, Abe SK, Inoue M. Active and passive smoking and breast cancer in Japan: a pooled analysis of nine population-based cohort studies. Int J Epidemiol, 2024;53(3):dyae047.
28. Yatsuya H, Yamagishi K, Li Y, Saito I, Kokubo Y, Muraki I, Inoue M, Tsugane S, Iso H, Sawada N. Risk and population attributable fraction of stroke subtypes in Japan. J Epidemiol, 2024;34(5):211-217.
29. Ho DSM, Zaitsu T, Ihira H, Iwasaki M, Yoshihara A, Suzuki S, Inoue M, Yamagishi K, Yasuda N, Aida J, Shinozaki T, Goto A, Tsugane S, Sawada N. Association Between Oral Malodor and Dementia: An 11-Year Follow-Up Study in Japan. J Alzheimers Dis Rep, 2024;8(1):805-816.
30. Kishida R, Yamagishi K, Iso H, Ishihara J, Yasuda N, Inoue M, Tsugane S, Sawada N, for the JPHC. Fruit and Vegetable Intake and Risk of Disabling Dementia: Japan Public Health Center Disabling Dementia Study. J Nutr, 2024;154(6):1842-1852.
31. Yin X, Kishida R, Abe SK, Islam MR, Rahman MS, Saito E, Lan Q, Blechter B, Merritt M, Choi JY, Shin A, Katagiri R, Shu XO, Sawada N, Tamakoshi A, Koh WP, Tsuji I, Nagata C, Park SK, Kweon SS, Gao YT, Tsugane S, Kimura T, Yuan JM, Lu Y, Kanemura S, Sugawara Y, Wada K, Shin MH, Ahsan H, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D, Seow WJ. Association between reproductive factors with lung cancer incidence and mortality: A pooled analysis of over 308,000 females in the Asia cohort consortium. Int J Cancer, 2024;154(12):2090-2105.
32. De la Torre K, Song M, Abe SK, Rahman MS, Islam MR, Saito E, Min S, Huang D, Chen Y, Gupta PC, Sawada N, Tamakoshi A, Shu XO, Wen W, Sakata R, Kim J, Nagata C, Ito H, Park SK, Shin MH, Pednekar MS, Tsugane S, Kimura T, Gao YT, Cai H, Wada K, Oze I, Shin A, Ahn YO, Ahsan H, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D. Diabetes and gastric cancer incidence and mortality in the Asia Cohort Consortium: A pooled analysis of more than a half million participants. J Diabetes, 2024;16(6):e13561.
33. Downward GS, Hystad P, Tasmin S, Abe SK, Saito E, Rahman MS, Islam MR, Gupta PC, Sawada N, Malekzadeh R, You SL, Ahsan H, Park SK, Pednekar MS, Tsugane S, Etemadi A, Chen CJ, Shin A, Chen Y, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D, Lan Q, Vermeulen RCH. Long-term exposure to particulate matter and all-cause and cause-specific mortality in an analysis of multiple Asian cohorts. Environ Int, 2024;189:108803.
34. Huang D, Song M, Abe SK, Rahman MS, Islam MR, Saito E, De la Torre K, Sawada N, Tamakoshi A, Shu XO, Cai H, Hozawa A, Kanemura S, Kim J, Chen Y, Ito H, Sugawara Y, Park SK, Shin MH, Hirabayashi M, Kimura T, Gao YT, Wen W, Oze I, Shin A, Ahn YO, Ahsan H, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D. Family history and gastric cancer incidence and mortality in Asia: a pooled analysis of more than half a million participants. Gastric Cancer, 2024;27(4):701-713.
35. Shin A, Cho S, Abe SK, Islam MR, Rahman MS, Saito E, Kazmi SZ, Katagiri R, Merritt M, Choi JY, Shu XO, Sawada N, Tamakoshi A, Koh WP, Sakata R, Hozawa A, Kim J, Park SK, Kweon SS, Wen W, Tsugane S, Kimura T, Yuan JM, Kanemura S, Sugawara Y, Shin MH, Ahsan H, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D. Association of female reproductive and hormonal factors with gallbladder cancer risk in Asia: A pooled analysis of the Asia Cohort Consortium. Int J Cancer, 2024;155(2):240-250.
36. Paragomi P, Zhang Z, Abe SK, Islam MR, Rahman MS, Saito E, Shu XO, Dabo B, Pham YT, Chen Y, Gao YT, Koh WP, Sawada N, Malekzadeh R, Sakata R, Hozawa A, Kim J, Kanemura S, Nagata C, You SL, Ito H, Park SK, Yuan JM, Pan WH, Wen W, Wang R, Cai H, Tsugane S, Pourshams A, Sugawara Y, Wada K, Chen CJ, Oze I, Shin A, Ahsan H, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D, Luu HN. Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia. JAMA Netw Open, 2024;7(8):e2429494.
37. Ho NT, Abe SK, Rahman MS, Islam R, Saito E, Gupta PC, Pednekar MS, Sawada N, Tsugane S, Tamakoshi A, Kimura T, Shu XO, Gao YT, Koh WP, Cai H, Wen W, Sakata R, Tsuji I, Malekzadeh R, Pourshams A, Kanemura S, Kim J, Chen Y, Ito H, Oze I, Nagata C, Wada K, Sugawara Y, Park SK, Shin A, Yuan JM, Wang R, Kweon SS, Shin MH, Poustchi H, Vardanjani HM, Ahsan H, Chia KS, Matsuo K, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D, Boffetta P. Diabetes is associated with increased liver cancer incidence and mortality in adults: A report from Asia Cohort Consortium. Int J Cancer, 2024;155(5):854-870.
38. Kihara T, Yamagishi K, Imatoh T, Ihira H, Goto A, Iso H, Sawada N, Tsugane S, Inoue M. Validity of self-reported Helicobacter pylori eradication treatment from questionnaire and interview surveys of the JPHC-NEXT study: comparison with prescription history from insurance claims data. J Epidemiol, 2024;34(9):453-457.
39. Wada K, Kuboyama K, Abe SK, Rahman MS, Islam MR, Saito E, Nagata C, Sawada N, Tamakoshi A, Shu XO, Sakata R, Hozawa A, Kanemura S, Ito H, Sugawara Y, Park SK, Kweon SS, Ono A, Kimura T, Wen W, Oze I, Shin MH, Shin A, Kim J, Lee JE, Matsuo K, Rothman N, Qiao YL, Zheng W, Boffetta P, Inoue M. Body mass index and breast cancer risk in premenopausal and postmenopausal East Asian women: a pooled analysis of 13 cohort studies. Breast Cancer Res, 2024;26(1):158.
40. Abe SK, Nishio M, Huang HL, Leung CY, Islam MR, Rahman MS, Saito E, Shin A, Merritt MA, Choi JY, Katagiri R, Mohammadi Z, Shu XO, Wakai K, Sawada N, Ideno Y, Tamakoshi A, Seow WJ, Koh WP, Sakata R, Hozawa A, Kim J, Nagata C, Sugawara Y, Park SK, Kweon SS, Azizi F, Malekzadeh R, Moy FM, Pourfarzi F, Gao YT, Kubo Y, Hirabayashi M, Nagai K, Kimura T, Yuan JM, Kanemura S, Wada K, Kang D, Shin MH, Khalili D, Poustchi H, Rezaianzadeh A, Mansour-Ghanaei F, Najafi F, Mohebbi I, Boffetta P, Lee JE, Matsuo K, Rothman N, Qiao YL, Zheng W, Inoue M. Age at menarche by birth cohort: A pooled analysis of half a million women in Asia. Public Health, 2024;237:130-134.
41. Okita Y, Sobue T, Zha L, Kitamura T, Iwasaki M, Inoue M, Yamaji T, Tsugane S, Sawada N. Long-term use of anti-cholesterol drugs and cancer risks in a Japanese population. Sci Rep, 2024;14(1):2896.
42. Yamanishi R, Yotsukura E, Hanyuda A, Uchino M, Yuki K, Negishi K, Yasuda N, Saito I, Kato T, Arima K, Aoyagi K, Tanno K, Yamagishi K, Muraki I, Yamaji T, Iwasaki M, Inoue M, Tsugane S, Sawada N. Relation between a history of glaucoma and subjective happiness: the JPHC-Next study. BMJ Open Ophthalmol, 2024;9(1):e001553.
43. Ge S, Zha L, Sobue T, Kitamura T, Ishihara J, Iwasaki M, Inoue M, Yamaji T, Tsugane S, Sawada N. Dietary Consumption of Antioxidant Vitamins in Relation to Prostate Cancer Risk in Japanese Men: The Japan Public Health Center-Based Prospective Study. J Epidemiol, 2024;34(3):144-153.
44. Yamagishi M, Takachi R, Ishihara J, Maruya S, Ishii Y, Kito K, Nakamura K, Tanaka J, Yamaji T, Iso H, Iwasaki M, Tsugane S, Jphc Next Protocol Validation Study Group, Sawada N. Development and preliminary validation of a prediction formula of sodium and sodium-to-potassium ratio based on multiple regression using 24-h urines. Sci Rep, 2024;14(1):9704
45. Narita Z, Hidese S, Kanehara R, Tachimori H, Hori H, Kim Y, Kunugi H, Arima K, Mizukami S, Tanno K, Takanashi N, Yamagishi K, Muraki I, Yasuda N, Saito I, Maruyama K, Yamaji T, Iwasaki M, Inoue M, Tsugane S, Sawada N. Association of sugary drinks, carbonated beverages, vegetable and fruit juices, sweetened and black coffee, and green tea with subsequent depression: A five-year cohort study. Clin Nutr, 2024;43(6):1395-1404.
46. Funakoshi Y, Maruyama K, Kato T, Saito I, Takanashi N, Tanno K, Yamagishi K, Muraki I, Yasuda N, Arima K, Nakashima H, Yamaji T, Iwasaki M, Inoue M, Tsugane S, Sawada N. Association of depressive symptoms with incident fractures: the Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT). Osteoporos Int, 2024;35(7):1261-1271.
47. Yoshii K, Morisaki N, Piedvache A, Nakada S, Arima K, Aoyagi K, Nakashima H, Yasuda N, Muraki I, Yamagishi K, Saito I, Kato T, Tanno K, Yamaji T, Iwasaki M, Inoue M, Tsugane S, Sawada N. Association between birth weight and prevalence of cardiovascular disease and other lifestyle-related diseases among Japanese population: JPHC-NEXT Study. J Epidemiol, 2024;34(7):307-315.
48. Hirabayashi M, Wilunda C, Murai U, Yamaji T, Iwasaki M, Inoue M, Tsugane S, Sawada N, for the JPHC. Association between fish and shellfish consumption, n-3 polyunsaturated fatty acids, and gastric cancer risk: the Japan Public Health Center-based Prospective Study. Eur J Nutr, 2024;63(5):1529-1544.
49. Kanehara R, Park SY, Okada Y, Iwasaki M, Tsugane S, Sawada N, Inoue M, Haiman CA, Wilkens LR, Le Marchand L. Intake of Sugar and Food Sources of Sugar and Colorectal Cancer Risk in the Multiethnic Cohort Study. J Nutr, 2024;154(8):2481-2492.
50. Nakano S, Yamaji T, Hidaka A, Shimazu T, Shiraishi K, Kuchiba A, Saito M, Kunishima F, Nakaza R, Kohno T, Sawada N, Inoue M, Tsugane S, Iwasaki M. Dietary vitamin D intake and risk of colorectal cancer according to vitamin D receptor expression in tumors and their surrounding stroma. J Gastroenterol, 2024;59(9):825-835.
51. Ihira H, Nakano S, Yamaji T, Katagiri R, Sawada N, Inoue M, Tsugane S, Iwasaki M. Plasma albumin, bilirubin, and uric acid and the subsequent risk of cancer: a case-cohort study in the Japan Public Health Center-based Prospective Study. Am J Epidemiol, 2024;193(10):1460-1469.