Complex Disease Cancer Pathology Study as the Basis for Comprehensive Cancer Supportive Care

Progression of cancer or susceptibility to anticancer drugs is significantly affected not only by differences based on the patient's cancer genome, but also by changes in the biologic response due to a history of non-cancer disease. However, there is little basic scientific evidence on the association between prior non-cancer diseases and cancer progression.

In the field of cancer patient pathophysiology research, we will analyze cancer cell proliferation and malignancy based on information regarding each comprehensive underlying disease in cancer patients by transplanting cancer cells into a variety of non-cancer model animals (psychiatric diseases, diabetes, hypertensive motor dysfunction, dementia, etc.) or by creating a disease complex cancer pathology model and carrying out multidimensional research. In addition, multiorgan-linked cancer research will be comprehensively conducted by performing an integrated analysis of the alteration and metastatic potential of the cancer microenvironment in the disease complex cancer model.

In addition, by analyzing the correlation between the underlying disease and the development of cancer based on the analysis of genomic pathology, driving factors will be identified and applied to animals using genetic modification technology. A model animal with the underlying disease with a high time resolution will be created, and the pathological conditions will be analyzed.