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Research Papers

2024

  1. Machitani M, Nomura A, Yamashita T, Yasukawa M, Ueki S, Fujita K, Ueno T, Yamashita A, Tanzawa Y, Watanabe M, Taniguchi T, Saitoh N, Kaneko S, Kato Y, Mano H, Masutomi K.
    Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity.

    Nat Cell Biol. In press.

2023

  1. Matsuda Y, Ye J, Yamakawa K, Mukai Y, Azuma K, Wu L, Masutomi K, Yamashita T, Daigo Y, Miyagi Y, Yokose T, Oshima T, Ito H, Morinaga S, Kishida T, Minamoto T, Kojima M, Kaneko S, Haba R, Kontani K, Kanaji N, Okano K, Muto-Ishizuka M, Yokohira M, Saoo K, Imaida K, Suizu F.
    Association of longer telomere length in cancer cells and cancer-associated fibroblasts with worth prognosis.

    J Natl Cancer Inst. 2023 Feb 8;115(2):208-218. doi: 10.1093/jnci/djac226.
    (PubMed ID:36567450)

  2. Niwa T, Tahara T, Chase CE, Fang FG, Nakaoka T, Irie S, Hayashinaka E, Wada Y, Mukai H, Masutomi K, Watanabe Y, Cui Y, Hosoya T.
    Synthesis of 11C-Radiolabeled Eribulin as a Companion Diagnostics PET Tracer for Brain Glioblastoma.
    Bull Chem Soc Jpn. 2023, 96, 283–290. doi:10.1246/bcsj.20220335.

2022

  1. Machitani M, Takei J, Kaneko MK, Ueki S, Ohashi H, Watashi K, Kato Y, Masutomi K.
    Development of novel monoclonal antibodies against nsp12 of SARS-CoV-2.

    Virol J. 2022 Dec 10;19(1):213. doi: 10.1186/s12985-022-01948-2.
    (PubMed ID:36496472)

  2. Matsuda Y, Yamashita T, Ye J, Yasukawa M, Yamakawa K, Mukai Y, Machitani M, Daigo Y, Miyagi Y, Yokose T, Oshima T, Ito H, Morinaga S, Kishida T, Minamoto T, Yamada S, Takei J, Kaneko MK, Kojima M, Kaneko S, Masaki T, Hirata M, Haba R, Kontani K, Kanaji N, Miyatake N, Okano K, Kato Y, Masutomi K.
    Phosphorylation of hTERT at threonine 249 is a novel tumor biomarker of aggressive cancer with poor prognosis in multiple organs.

    J Pathol. 2022 Jun;257(2):172-185. doi: 10.1002/path.5876.
    (PubMed ID:35094384)

  3. Nakano T, Fujimoto K, Tomiyama A, Takahashi M, Achiha T, Arita H, Kawauchi D, Yasukawa M, Masutomi K, Kondo A, Narita Y, Maehara T, Ichimura K.
    Eribulin prolongs survival in an orthotopic xenograft mouse model of malignant meningioma.

    Cancer Sci. 2022 Feb;113(2):697-708. doi: 10.1111/cas.15221.
    (PubMed ID:34839570)

2020

  1. Machitani M, Yasukawa M, Nakashima J, Furuichi Y, Masutomi K.
    RNA-dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID-19.
    Cancer Sci. 2020 Nov;111(11):3976-3984. doi: 10.1111/cas.14618.
    (PubMed ID: 32805774)

  2. Yasukawa M, Ando Y, Yamashita T, Matsuda Y, Shoji S, Morioka MS, Kawaji H, Shiozawa K, Machitani M, Abe T, Yamada S, Kaneko MK, Kato Y, Furuta Y, Kondo T, Shirouzu M, Hayashizaki Y, Kaneko S, Masutomi K.
    CDK1 dependent phosphorylation of hTERT contributes to cancer progression.
    Nat Commun. 2020 Mar 25;11(1):1557. doi: 10.1038/s41467-020-15289-7.
    (PubMed ID: 32214089)

2019

  1. Takahashi M, Miki S, Fujimoto K, Fukuoka K, Matsushita Y, Maida Y, Yasukawa M, Hayashi M, Shinkyo R, Kikuchi K, Mukasa A, Nishikawa R, Tamura K, Narita Y, Hamada A, Masutomi K, Ichimura K.
    Eribulin penetrates brain tumor tissue and prolongs survival of mice harboring intracerebral glioblastoma xenografts.
    Cancer Sci. 2019 May 17. doi: 10.1111/cas.14067.
    (PubMed ID: 31099446) 
  2. Maishi N, Kikuchi H, Sato M, Nagao-Kitamoto H, Annan DA, Baba S, Hojo T, Yanagiya M, Ohba Y, Ishii G, Masutomi K, Shinohara N, Hida Y, Hida K.
    Development of Immortalized Human Tumor Endothelial Cells from Renal Cancer.
    Int J Mol Sci. 2019 Sep 17;20(18). pii: E4595. doi: 10.3390/ijms20184595.
    (PubMed ID:31533313) 

2018

  1. Maida Y, Yasukawa M, Ghilotti M, Ando Y, Masutomi K  
    Semi-quantitative Detection of RNA-dependent RNA Polymerase Activity of Human Telomerase Reverse Transcriptase Protein. 
    J Vis Exp, 136: e57021, doi:10.3791/57021, 2018.
    (PubMed ID:29985366)   
  2. Miki S, Imamichi S, Fujimori H, Tomiyama A, Fujimoto K, Satomi K, Matsushita Y, Matsuzaki S, Takahashi M, Ishikawa E, Yamamoto T, Matsumura A, Mukasa A, Nishikawa R, Masutomi K, Narita Y, Masutani M, Ichimura K
    Concomitant administration of radiation with eribulin improves the survival of mice harboring intracerebral glioblastoma.
    Cancer Sci, 109: 2275-2285. doi: 10.1111/cas.13637, 2018
    (PubMed ID 29758120)
  3. Masui K, Komori T, Kato Y, Masutomi K, Ichimura K, Ogasawara S, Kaneko MK, Oki H, Suzuki H, Nitta M, Maruyama T, Muragaki Y, Kawamata T, Sawada T, Shibata N
    Elevated TERT Expression in TERT-Wildtype Adult Diffuse Gliomas: Histological Evaluation with a Novel TERT-Specific Antibody.  
    Biomed Res Int, 2018: 7945845. doi: 10.1155/2018/7945845, 2018  
    (PubMed ID 29693015)  
  4. Maekawa T, Liu B, Nakai D, Yoshida K, Nakamura KI, Yasukawa M, Koike M, Takubo K, Chatton B, Ishikawa F, Masutomi K, Ishii S
    ATF7 mediates TNF-α-induced telomere shortening.  
    Nucleic Acids Res, 46: 4487-4504. doi: 10.1093/nar/gky155, 2018  
    (PubMed ID 29490055)  

2017

  1. Ishibashi M, Neri S, Hashimoto H, Miyashita T, Yoshida T, Nakamura Y, Udagawa H, Kirita K, Matsumoto S, Umemura S, Yoh K, Niho S, Tsuboi M, Masutomi K, Goto K, Ochiai A, Ishii G  
    CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocinomas to EGFR Tyrosine kinase inhibitors.  
    Sci Rep, 7: 46662. doi: 10.1038/srep46662, 2017  
    (PubMed ID 28429795)  
  2. Hashimoto H, Suda Y, Miyashita T, Ochiai A, Tsuboi M, Masutomi K, Kiyono T, Ishii G  
    A novel method to generate single-cell-derived cancer-associated fibroblast clones.  
    J Cancer Res Clin Oncol, 143: 1409-1419. doi: 10.1007/s00432-017-2409-3, 2017  
    (PubMed ID 28364361)  

2016

  1. Suda Y, Neri S, Hashimoto H, Higuchi Y, Ishibashi M, Sugano M, Masutomi K, Tsuboi M, Ochiai A, Ishii G  
    Clonal heterogeneity in osteogenic potential of lung cancer-associated fibroblasts:   promotional effect of osteogenic progenitor cells on cancer cell migration.  
    J Cancer Res Clin Oncol, 142: 1487-1498, 2016  
    (PubMed ID 27119516)  
  2. Maida Y, Yasukawa M, Masutomi K  
    De novo RNA synthesis by RNA-dependent RNA polymerase activity of TERT.  
    Mol Cell Biol, 36: 1248-1259, 2016  
    (PubMed ID 26830230)  
  3. Neri S, Hashimoto H, Kii H, Watanabe H, Masitomi K, Kuwata T, Date H, Tsuboi M, Goto K, Ochiai A, Ishii G  
    Cancer cell invasion driven by extracellular matrix remodeling is dependent on the properties of cancer-associated fibroblasts.  
    J Cancer Res Clin Oncol, 142: 437-446, 2016  
    (PubMed ID 26374424)  

2015

  1. Maida Y, Masutomi K
    Telomerase reverse transcriptase moonlights: Therapeutic targets beyond telomerase.
    Cancer Sci, 106: 1486-1492, 2015
    (PubMed ID 26331588)
  2. Lassmann T, Maida Y, Tomaru Y, Yasukawa M, Ando Y, Kojima M, Kasim V, Simon C, Daub C, Carninci P, Hayashizaki Y,
    Masutomi K
    Telomerase reverse transcriptase regulates microRNAs.
    Int J Mol Sci, 16: 1192-1208, 2015
    (PubMed ID 25569094)

2014

  1. Yamaguchi S, Maida Y, Yasukawa M, Kato T, Yoshida M, Masutomi K  
    Eribulin mesylate targets human telomerase reverse transcriptase in ovarian cancer cells.  
    PLoS ONE, 9: e112438, 2014  
    (PubMed ID 25375122)  
  2. Kobayashi T, Masutomi K, Tamura K, Moriya T, Yamasaki T, Fujiwara Y, Takahashi S, Yamamoto J, Tsuda H  
    Nucleostemin expression in invasive breast cancer.  
    BMC Cancer, 14: 215, 2014  
    (PubMed ID 24650343)  
  3. Maida Y, Yasukawa M, Okamoto N, Ohka S, Kinoshita K, Totoki Y, Ito TK, Minamino T, Nakamura H, Yamaguchi S, Shibata T, Masutomi K  
    Involvement of TERT in heterochromatin maintenance.  
    Mol Cell Biol, 34: 1576-1593, 2014  
    (PubMed ID 24550003)  

2013

  1. Maida Y, Kyo S, Lassmann T, Hayashizaki Y, Masutomi K  
    Off-Target Effect of Endogenous si RNA Derived from RMRP in Human Cells.  
    Int J Mol Sci, 14: 9305-9318, 2013  
    (PubMed ID 23629666)  

2012

  1. Yunokawa M, Koizumi F, Kitamura Y, Katanasaka Y, Okamoto N, Kodaira M, Yonemori K, Shimizu C, Ando M, Masutomi K, Yoshida T, Fujiwara Y, Tamura K  
    Efficacy of everolimus, a novel mTOR inhibitor, against basal-like triple-negative breast cancer cells.   
    Cancer Science, 103: 1665-1671, 2012  
    (PubMed ID 22703543)  
  2. Nakajima TE, Yoshida H, Okamoto N, Nagashima K, Taniguchi H, Yamada Y, Shimoda T, Masutomi K  
    Nucleostemin and TWIST as predictive markers for recurrence after neoadjuvant chemotherapy for esophageal carcinoma.  
    Cancer Science, 103: 233-238, 2012  
    (PubMed ID 22050045)  
  3. Hirai Y, Masutomi K, Ishikawa F  
    Kinetics of DNA replication and telomerase reaction at a single-seeded telomere in human cells.  
    Genes Cells, 17: 186-204, 2012  
    (PubMed ID 22353550)  

2011

  1. Rosenbluh J, Nijhawan D, Chen Z, Wong KK, Masutomi K*, Hahn WC*  
    RMRP is a non-coding RNA essential for early murine development.  
    PLoS ONE (*: co-corresponding author), 6: e26270, 2011  
    (PubMed ID 22039455)  
  2. Jinushi M, Chiba S, Yoshiyama H, Masutomi K, Kinoshita I, Dosaka-Akita H, Yagita H, Takaoka A, Tahara H  
    Tumor-associated macrophages regulate tumorigenicity and anti-cancer drug responses of cancer stem/initiating cells.  
    Proc Natl Acad Sci U S A, 108: 12425-12430, 2011  
    (PubMed ID 21746895)
  3. Kawashima M, Kawakita T, Maida Y, Kamoi M, Ogawa Y, Shimmura S, Masutomi K, Tsubota K  
    Comparison of telomere length and association with progenitor cell markers inlacrimal gland between Sjogren and non-Sjogren syndrome dry eye patients.  
    Molecular Vision, 17: 1397-1404, 2011  
    (PubMed ID 21655359)  
  4. Okamoto N, Yasukawa M, Nguyen C, Kasim V, Maida Y, Possemato R, Shibata T,   Ligon KL, Fukami K, Hahn WC, Masutomi K  
    Maintenance of tumor initiating cells of defined genetic composition by nucleostemin.  
    Proc Natl Acad Sci U S A, 108: 20388-20393, 2011  
    (PubMed ID 21730156)  
  5. Ando Y, Maida Y, Morinaga A, Burroughs AM, Kimura R, Chiba J, Suzuki H,  Masutomi K, Hayashizaki Y  
    Two-step cleavage of hairpin RNA with 5' overhangs by human DICER.  
    BMC Molecular Biology, 9: 12-6, 2011  
    (PubMed ID 21306637)  

2009

  1. Maida Y, Yasukawa M, Furuuchi M, Lassmann T, Possemato R, Okamoto N, Kasim V, Hayashizaki Y, Hahn WC, Masutomi K  
    An RNA dependent RNA polymerase formed by TERT and the RMRP RNA.  
    Nature, 461: 230-235, 2009  
    (PubMed ID 19701182)  

2008

  1. Possemato R, Timmons JC, Bauerlein EL, Wada N, Baldwin A, Masutomi K, Hahn WC  
    Effects of Inhibition of POT1 on Telomere Length and Senescence in Diploid Human Cells.  
    Mol Cancer Res, 6時15分82-1593, 2008  
    (PubMed ID 18922974)  
  2. Imamura S, Uchiyama J, Koshimizu E, Hanai J, Raftopoulou C, Murphey RD,  Bayliss PE, Imai Y, Burns CE, Masutomi K, Gagos S, Zon LI, Roberts TM, Kishi S  
    A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase is Required for The Differentiation and Survival of Embryonic Hematopoietic Cells.  
    PLoS ONE, 3: e3364, 2008  
    (PubMed ID 18846223)  
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