Jump to Main Contents
研究所ロゴ

Home > Organization > Divisions and Independent Research Units > Division of Cellular Signaling > Research Papers

Research Papers

    2024

    Division of Cellular Signaling

    1. Watanabe K, Kohsaka S, Tatsuno K, Shinozaki-Ushiku A, Isago H, Kage H, Ushiku T, Aburatani H, Mano H, Oda K. “ Analysis of quality metrics in comprehensive cancer genomic profiling using a dual DNA-RNA panel.” Pract Lab Med. [PubMed ]
    2. Shirai Y, Ueno T, Kojima S, Ikeuchi H, Kitada R, Koyama T, Takahashi F, Takahashi K, Ichimura K, Yoshida A, Sugino H, Mano H, Narita Y, Takahashi M, Kohsaka S. “ The development of a custom RNA-sequencing panel for the identification of predictive and diagnostic biomarkers in glioma.” J Neurooncol. [PubMed ]
    3. Takei S, Tanaka Y, Lin YT, Koyama S, Fukuoka S, Hara H, Nakamura Y, Kuboki Y, Kotani D, Kojima T, Bando H, Mishima S, Ueno T, Kojima S, Wakabayashi M, Sakamoto N, Kojima M, Kuwata T, Yoshino T, Nishikawa H, Mano H, Endo I, Shitara K, Kawazoe A. “ Multiomic molecular characterization of the response to combination immunotherapy in MSS/pMMR metastatic colorectal cancer. J Immunother Cancer.” [PubMed ]
    4. Sunami K, Naito Y, Saigusa Y, Amano T, Ennishi D, Imai M, Kage H, Kanai M, Kenmotsu H, Komine K, Koyama T, Maeda T, Morita S, Sakai D, Hirata M, Ito M, Kozuki T, Sakashita H, Horinouchi H, Okuma Y, Takashima A, Kubo T, Hironaka S, Segawa Y, Yakushijin Y, Bando H, Makiyama A, Suzuki T, Kinoshita I, Kohsaka S, Ohe Y, Ishioka C, Yamamoto K, Tsuchihara K, Yoshino T. “ A Learning Program for Treatment Recommendations by Molecular Tumor Boards and Artificial Intelligence.” JAMA Oncol. 2023 Nov 30:e235120.[PubMed ]

    2023

    Division of Cellular Signaling

    1. Okuma HS, Watanabe K, Tsuchihashi K, Machida R, Sadachi R, Hirakawa A, Ariyama H, Kanai M, Kamikura M, Anjo K, Hiramitsu A, Sekine S, Okita N, Mano H, Nishikawa H, Nakamura K, Yonemori K. “ Phase II Trial of Nivolumab in Metastatic Rare Cancer with dMMR or MSI-H and Relation with Immune Phenotypic Analysis (the ROCK Trial).” Clin Cancer Res. [PubMed ]
    2. Miyazaki B, Ueno T, Sugiyama M, Kojima S, Arakawa A, Tao K, Tanimura K, Shiraishi K, Yagishita S, Kohsaka S, Kato M, Kiyokawa N, Goto Y, Yatabe Y, Hamada A, Mano H, Ogawa C, Tanaka Y. “ Promoter swapping of truncated PDGFRB drives Ph-like acute lymphoblastic leukemia.” NPJ Precis Oncol. [PubMed ]
    3. Hasegawa N, Hayashi T, Niizuma H, Kikuta K, Imanishi J, Endo M, Ikeuchi H, Sasa K, Sano K, Hirabayashi K, Takagi T, Ishijima M, Kato S, Kohsaka S, Saito T, Suehara Y. “ Detection of Novel Tyrosine Kinase Fusion Genes as Potential Therapeutic Targets in Bone and Soft Tissue Sarcomas Using DNA/RNA-based Clinical Sequencing.” Clin Orthop Relat Res. [PubMed ]
    4. Ohara K, Miyawaki S, Nakatomi H, Okano A, Teranishi Y, Shinya Y, Ishigami D, Hongo H, Takayanagi S, Tanaka S, Shinozaki-Ushiku A, Kohsaka S, Kage H, Oda K, Miyagawa K, Aburatani H, Mano H, Tatsuno K, Saito N. “ Case report and literature review: exploration of molecular therapeutic targets in recurrent malignant meningioma through comprehensive genetic analysis with Todai OncoPanel.” Front Neurol. [PubMed ]
    5. Odate T, Satomi K, Kubo T, Matsushita Y, Ueno T, Kurose A, Shomori K, Nakai T, Watanabe R, Segawa K, Ohshika S, Miyake N, Kudo S, Shimoi T, Kobayashi E, Komiyama M, Yoshimoto S, Nakatani F, Kawai A, Yatabe Y, Kohsaka S, Ichimura K, Ichikawa H, Yoshida A. “ Inflammatory Rhabdomyoblastic Tumor: Clinicopathological and Molecular Analysis of 13 Cases.” Mod Pathol.2023 Oct 21: 100359. [PubMed ]
    6. Nishimura Y, Ryo E, Inoue S, Kawazu M, Ueno T, Namikawa K, Takahashi A, Ogata D, Yoshida A, Yamazaki N, Mano H, Yatabe Y, Mori T. “ Strategic Approach to Heterogeneity Analysis of Cutaneous Adnexal Carcinomas Using Computational Pathology and Genomics.” JID Innov. [PubMed ]
    7. Koyama T, Shimizu T, Kojima Y, Sudo K, Okuma HS, Shimoi T, Ichikawa H, Kohsaka S, Sadachi R, Hirakawa A, Yoshida A, Ando RM, Ueno T, Yanagaki M, Matsui N, Nakamura K, Yamamoto N, Yonemori K. “ Clinical activity and exploratory resistance mechanism of milademetan, an MDM2 inhibitor, in intimal sarcoma with MDM2 amplification: an open-label phase 1b/2 study.” Cancer Discov. 2023 Jun 27;CD-23-0419. [PubMed ]
    8. Kobayashi Y, Niida A, Nagayama S, Saeki K, Haeno H, Takahashi KK, Hayashi S, Ozato Y, Saito H, Hasegawa T, Nakamura H, Tobo T, Kitagawa A, Sato K, Shimizu D, Hirata H, Hisamatsu Y, Toshima T, Yonemura Y, Masuda T, Mizuno S, Kawazu M, Kohsaka S, Ueno T, Mano H, Ishihara S, Uemura M, Mori M, Doki Y, Eguchi H, Oshima M, Suzuki Y, Shibata T, Mimori K. “ Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers.” Br J Cancer. [PubMed ]
    9. Hirose T, Ikegami M, Kojima S, Yoshida A, Endo M, Shimada E, Kanahori M, Oyama R, Matsumoto Y, Nakashima Y, Kawai A, Mano H, Kohsaka S. “ Extensive analysis of 59 sarcoma-related fusion genes identified pazopanib as a potential inhibitor to COL1A1-PDGFB fusion gene.” Cancer Sci. [PubMed ]
    10. Kobayashi K, Kawazu M, Yoshimoto S, Ueno T, Omura G, Saito Y, Ando M, Ryo E, Sakyo A, Yoshida A, Yatabe Y, Mano H, Mori T. “ Genome Doubling Shapes High-Grade Transformation and Novel EWSR1::LARP4 Fusion Shows SOX10 Immunostaining in Hyalinizing Clear Cell Carcinoma of Salivary Gland.” Lab Invest. [PubMed ]
    11. Yamazawa K, Sugano K, Tanakaya K, Inoue S, Murakami H, Nakashima M, Adachi M, Oki S, Makabe T, Yamashita H, Ueki A, Sasaoka A, Nakashoji A, Kinoshita T, Matsunaga T, Arai M, Nakamura S, Miyata H, Ikegami M, Mano H, Kohsaka S, Matsui A. “ The pathogenic role of the BRCA2 c.7847C>T (p.Ser2616Phe) variant in breast and ovarian cancer predisposition.” Cancer Sci. [PubMed ]
    12. Terada M, Nakamura K, Matsuda T, Okuma HS, Sudo K, Yusof A, Imasa M, Sirachainan E, Anh PT, Fujiwara Y, Yamamoto N, Voon PJ, Chokephaibulkit K, Shibata T, Inoue M, Mano H, Shimoi T, Sriuranpong V, Yonemori K, Shimada K. “ A new era of the Asian clinical research network: a report from the ATLAS international symposium.” Jpn J Clin Oncol. [PubMed ]
    13. Yoshida T, Yatabe Y, Kato K, Ishii G, Hamada A, Mano H, Sunami K, Yamamoto N, Kohno T. “ The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan.” Cancer Biol Med. [PubMed ]
    14. Okuma HS, Yoshida H, Kobayashi Y, Arakaki M, Mizoguchi C, Inagaki L, Voon PJ, Malik Bin Ismail A, Fen Soo Hoo H, Yusak S, Severino BIM, Nguyen Huy T, Thai Anh T, Kohsaka S, Mano H, Yonemori K, Nakamura K, Yatabe Y. “ Molecular pathology quality control in Southeast Asia: Results of a multiregional quality assurance study from MASTER KEY Asia.” Cancer Sci. [PubMed ]
    15. Kusakabe M, Taguchi A, Tanikawa M, Wagatsuma R, Yamazaki M, Tsuchimochi S, Toyohara Y, Kawata A, Baba S, Ueno T, Sone K, Mori-Uchino M, Ikemura M, Matsunaga H, Nagamatsu T, Wada-Hiraike O, Kawazu M, Ushiku T, Takeyama H, Oda K, Kawana K, Mano H, Osuga Y. “ Cells with stem-like properties are associated with the development of HPV18-positive cervical cancer.” Cancer Sci. [PubMed ]
    16. Ishino T, Kawashima S, Tanji E, Ueno T, Ueda Y, Ogasawara S, Sato K, Mano H, Ishihara S, Kato N, Kawazu M, Togashi Y. “ Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens.” Br J Cancer. [PubMed ]
    17. Kage H, Shinozaki-Ushiku A, Ishigaki K, Sato Y, Tanabe M, Tanaka S, Tanikawa M, Watanabe K, Kato S, Akagi K, Uchino K, Mitani K, Takahashi S, Miura Y, Ikeda S, Kojima Y, Watanabe K, Mochizuki H, Yamaguchi H, Kawazoe Y, Kashiwabara K, Kohsaka S, Tatsuno K, Ushiku T, Ohe K, Yatomi Y, Seto Y, Aburatani H, Mano H, Miyagawa K, Oda “ K. Clinical utility of Todai OncoPanel in the setting of approved comprehensive cancer genomic profiling tests in Japan.” Cancer Sci. [PubMed ]
    18. Kobayashi H, Makise N, Shinozaki-Ushiku A, Zhang L, Ishibashi Y, Ikegami M, Tsuda Y, Kohsaka S, Ushiku T, Oda K, Miyagawa K, Aburatani H, Mano H, Tanaka S. “ Dramatic response to entrectinib in a patient with malignant peripheral nerve sheath tumor harboring novel SNRNP70-NTRK3 fusion gene.” Genes Chromosomes Cancer. [PubMed ]
    19. Mizuno S, Ikegami M, Koyama T, Sunami K, Ogata D, Kage H, Yanagaki M, Ikeuchi H, Ueno T, Tanikawa M, Oda K, Osuga Y, Mano H, Kohsaka S. “High-throughput functional evaluation of MAP2K1 variants in cancer.” Mol Cancer Ther. 22 (2): 227–239, 2023. [PubMed ]

    2022

    Division of Cellular Signaling

    1. Ando T, Kage H, Shinozaki-Ushiku A, Tatsuno K, Tsutsumi S, Nagayama K, Nakajima J, Kohsaka S, Miyagawa K, Aburatani H, Mano H and Nagase T. “Composite Clonal Analysis Reveals Transition of NSCLC Subtypes Through Accumulation of Gene Mutations: A Case Report.” JTO Clin Res Rep 3: 100277, 2022. [PubMed ]
    2. Odintsov I, Ortiz MV, Khodos I, Mattar MS, Lui AJW, Kohsaka S, de Stanchina E, Glade Bender JL, Ladanyi M, Somwar R. “CIC-mediated modulation of MAPK signaling opposes receptor tyrosine kinase inhibitor response in kinase-addicted sarcoma.” Cancer Res. canres.1397.2021, 2022 Jan 24. Online ahead of print. [PubMed ]
    3. Jo H, Yagishita S, Hayashi Y, Ryu S, Suzuki M, Kohsaka S, Ueno T, Matsumoto Y, Horinouchi H, Ohe Y, Watanabe SI, Motoi N, Yatabe Y, Mano H, Takahashi K and Hamada A. “Comparative Study on the Efficacy and Exposure of Molecular Target Agents in Non-small Cell Lung Cancer PDX Models with Driver Genetic Alterations.” Mol Cancer Ther 21: 359-370, 2022. [PubMed ]
    4. Nagasaki J, Inozume T, Sax N, Ariyasu R, Ishikawa M, Yamashita K, Kawazu M, Ueno T, Irie T, Tanji E, Morinaga T, Honobe A, Ohnuma T, Yoshino M, Iwata T, Kawase K, Sasaki K, Hanazawa T, Kochin V, Kawamura T, Matsue H, Hino M, Mano H, Suzuki Y, Nishikawa H and Togashi Y. “PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes.” Cell Rep 38:110331, 2022. [PubMed ]
    5. Kumagai S, Koyama S, Itahashi K, Tanegashima T, Lin YT, Togashi Y, Kamada T, Irie T, Okumura G, Kono H, Ito D, Fujii R, Watanabe S, Sai A, Fukuoka S, Sugiyama E, Watanabe G, Owari T, Nishinakamura H, Sugiyama D, Maeda Y, Kawazoe A, Yukami H, Chida K, Ohara Y, Yoshida T, Shinno Y, Takeyasu Y, Shirasawa M, Nakama K, Aokage K, Suzuki J, Ishii G, Kuwata T, Sakamoto N, Kawazu M, Ueno T, Mori T, Yamazaki N, Tsuboi M, Yatabe Y, Kinoshita T, Doi T, Shitara K, Mano H and Nishikawa H. “Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments.” Cancer Cell 40:201-218 e9, 2022.01.001. [PubMed ]
    6. Taguchi A, Rokutan H, Oda K, Tanikawa M, Tanimoto S, Sone K, Mori M, Tsuruga T, Kohsaka S, Tatsuno K, Shinozaki-Ushiku A, Miyagawa K, Mano H, Aburatani H, Ushiku T and Osuga Y. “Genetic diagnosis of pseudomyxoma peritonei originating from mucinous borderline tumor inside an ovarian teratoma.” BMC Med Genomics 15: 51, 2022. [PubMed ]
    7. Kishigami F, Tanaka Y, Yamamoto Y, Ueno T, Kojima S, Sato K, Inoue S, Sugaya S, Ishihara S, Mano H and Kawazu M. “Exploration of predictive biomarkers for postoperative recurrence of stage II/III colorectal cancer using genomic sequencing.” Cancer Med, 2022 Mar 28 [PubMed ]
    8. Sasame J, Ikegaya N, Kawazu M, Natsumeda M, Hayashi T, Isoda M, Satomi K, Tomiyama A, Oshima A, Honma H, Miyake Y, Takabayashi K, Nakamura T, Ueno T, Matsushita Y, Iwashita H, Kanemaru Y, Murata H, Ryo A, Terashima K, Yamanaka S, Fujii Y, Mano H, Komori T, Ichimura K, Cahill DP, Wakimoto H, Yamamoto T and Tateishi K. “HSP90 inhibition overcomes resistance to molecular targeted therapy in BRAFV600E mutant high-grade glioma.” Clin Cancer Res, 2022 Mar 28. [PubMed ]
    9. Ikeuchi H, Hirose T, Ikegami M, Takamochi K, Suzuki K, Mano H and Kohsaka S. “Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.” Oncogene, 2022. [PubMed ]
    10. Chida K, Kawazoe A, Suzuki T, Kawazu M, Ueno T, Takenouchi K, Nakamura Y, Kuboki Y, Kotani D, Kojima T, Bando H, Mishima S, Kuwata T, Sakamoto N, Watanabe J, Mano H, Ikeda M, Shitara K, Endo I, Nakatsura T and Yoshino T. “Transcriptomic profiling of MSI-H/dMMR gastrointestinal tumors to identify determinants of responsiveness to anti-PD-1 therapy.” Clin Cancer Res, CCR-22-0041, 2022. [PubMed ]
    11. Kishigami F, Tanaka Y, Yamamoto Y, Ueno T, Kojima S, Sato K, Inoue S, Sugaya S, Ishihara S, Mano H, Kawazu M. ”Exploration of predictive biomarkers for postoperative recurrence of stage II/III colorectal cancer using genomic sequencing.” Cancer Med. 2022 Sep;11(18):3457-3470. [PubMed ]
    12. Kohsaka S, Tada Y, Ando M, Nakaguro M, Shirai Y, Ueno T, Kojima S, Hirai H, Saigusa N, Kano S, Tsukahara K, Togashi T, Ozawa H, Kondo T, Okami K, Takahashi H, Kawakita D, Fushimi C, Suzuki T, Shimizu A, Okamoto I, Okada T, Sato Y, Imanishi Y, Watanabe Y, Sakai A, Ebisumoto K, Sato Y, Urano M, Honma Y, Yamazaki K, Ueki Y, Hanazawa T, Saito Y, Shimura T, Nagao T, Mano H. ”Identification of novel prognostic and predictive biomarkers in salivary duct carcinoma via comprehensive molecular profiling.” NPJ Precis Oncol. 6(1): 82, 2022. (co-corresponding) [PubMed ]

    2021

    Division of Cellular Signaling

    1. Miyamoto Y, Nonaka S, Oda I, Abe S, Suzuki H, Yoshinaga S, Mano H, Saito Y. “Safety and usefulness of endoscopic submucosal dissection for early esophageal cancers in elderly patients aged 80 years or older” Esophagus 18:81-89, 2021. [PubMed ]
    2. Tsuyama S, Kohsaka S, Hayashi T, Suehara Y, Hashimoto T, Kajiyama Y, Tsurumaru M, Ueno T, Mano H, Yao T, Saito T. “Comprehensive clinicopathological and molecular analysis of primary malignant melanoma of the oesophagus” Histopathology 78:240-251, 2021. [PubMed ]
    3. Hirose T, Ikegami M, Endo M, Matsumoto Y, Nakashima Y, Mano H, Kohsaka S. “Extensive functional evaluation of exon 20 insertion mutations of EGFR” Lung Cancer 152:135-142, 2021. [PubMed ]
    4. Kohsaka S, Hirata M, Ikegami M, Ueno T, Kojima S, Sakai T, Ito K, Naka N, Ogura K, Kawai A, Iwata S, Okuma T, Yonemoto T, Kobayashi H, Suehara Y, Hiraga H, Kawamoto T, Motoi T, Oda Y, Matsubara D, Matsuda K, Nishida Y, Mano H. “Comprehensive molecular and clinicopathological profiling of desmoid tumours” Eur J Cancer 145:109-120, 2021. [PubMed ]
    5. Miyanaga A, Matsumoto M, Beck JA, Horikawa I, Oike T, Okayama H, Tanaka H, Burkett SS, Robles AI, Khan M, Lissa D, Seike M, Gemma A, Mano H, Harris CC. “EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in hTERT-transduced normal human cells” BMC Cancer 21 : 310, 2021. [PubMed ]
    6. Matsuno Y, Hyodo M, Suzuki M, Tanaka Y, Horikoshi Y, Murakami Y, Torigoe H, Mano H, Tashiro S and Yoshioka KI. “Replication-stress-associated DSBs induced by ionizing radiation risk genomic destabilization and associated clonal evolution.” iScience, 24:102313, 2022. [PubMed ]
    7. Suehara Y, Kohsaka S, Hayashi T, Akaike K, Kurisaki-Arakawa A, Sato S, Kobayashi E, Mizuno S, Ueno T, Morii T, Okuma T, Kurihara T, Hasegawa N, Sano K, Sasa K, Okubo T, Kim Y, Mano H and Saito T. “Identification of a novel MAN1A1-ROS1 fusion gene through mRNA-based screening for tyrosine kinase gene aberrations in a patient with leiomyosarcoma.” Clin Orthop Relat Res 479:838-852, 2021. [PubMed ]
    8. Yasuda T, Sanada M, Kawazu M, Kojima S, Tsuzuki S, Ueno H, Iwamoto E, Iijima-Yamashita Y, Yamada T, Kanamori T, Nishimura R, Kuwatsuka Y, Takada S, Tanaka M, Ota S, Dobashi N, Yamazaki E, Hirose A, Murayama T, Sumi M, Sato S, Tange N, Nakamura Y, Katsuoka Y, Sakaida E, Kawamata T, Iida H, Shiraishi Y, Nannya Y, Ogawa S, Taniwaki M, Asou N, Hatta Y, Kiyoi H, Matsumura I, Horibe K, Mano H, Naoe T, Miyazaki Y and Hayakawa F. “Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2 and IDH1 /2 mutations.” Blood, 2021. [PubMed ]
    9. Nakamura IT, Ikegami M, Hasegawa N, Hayashi T, Ueno T, Kawazu M, Yagishita S, Goto Y, Shinno Y, Kojima Y, Takamochi K, Takahashi F, Takahashi K, Mano H and Kohsaka S. “Development of an optimal protocol for molecular profiling of tumor cells in pleural effusions at single-cell level.” Cancer Sci 112: 2006-2019, 2021. [PubMed ]
    10. Sano K, Hayashi T, Suehara Y, Hosoya M, Takamochi K, Kohsaka S, Kishikawa S, Kishi M, Saito S, Takahashi F, Kaneko K, Suzuki K, Yao T, Ishijima M, Saito T. “Transcription start site-level expression of thyroid transcription factor 1 isoforms in lung adenocarcinoma and its clinicopathological significance.” J Pathol Clin Res, 2021 May 20. Online ahead of print. [PubMed ]
    11. Yagishita S, Kato K, Takahashi M, Imai T, Yatabe Y, Kuwata T, Suzuki M, Ochiai A, Ohtsu A, Shimada K, Nishida T, Hamada A and Mano H. “Characterization of the large-scale Japanese patient-derived xenograft (J-PDX) library.” Cancer Sci 112: 2454-2466, 2021. [PubMed ]
    12. Sunami K, Bando H, Yatabe Y, Naito Y, Takahashi H, Tsuchihara K, Toyooka S, Mimori K, Kohsaka S, Uetake H, Kinoshita I, Komine K, Takeda M, Hayashida T, Tamura K, Nishio K, Yamamoto N; Working Group of a Joint Task Force of Three Academic Societies for the Promotion of Cancer Genomic Medicine. “Appropriate use of cancer comprehensive genome profiling assay using circulating tumor DNA.” Cancer Sci, 2021 Jun 15. Online ahead of print. [PubMed ]
    13. Nagano M, Kohsaka S, Hayashi T, Ueno T, Kojima S, Shinozaki-Ushiku A, Morita S, Tsuda M, Tanaka S, Shinohara T, Omori Y, Sugaya F, Kato H, Narita Y, Nakajima J, Suzuki K, Takamochi K and Mano H. “Comprehensive molecular profiling of pulmonary pleomorphic carcinoma.” NPJ Precis Oncol 5: 57, 2021. [PubMed ]
    14. Chida K, Kawazoe A, Kawazu M, Suzuki T, Nakamura Y, Nakatsura T, Kuwata T, Ueno T, Kuboki Y, Kotani D, Kojima T, Taniguchi H, Mano H, Ikeda M, Shitara K, Endo I and Yoshino T. “A Low Tumor Mutational Burden and PTEN Mutations Are Predictors of a Negative Response to PD-1 Blockade in MSI-H/dMMR Gastrointestinal Tumors.” Clin Cancer Res 27:3714-3724, CCR-21-0401, 2021. [PubMed ]
    15. Nakamura IT, Kohsaka S, Ikegami M, Ikeuchi H, Ueno T, Li K, Beyett TS, Koyama T, Shimizu T, Yamamoto N, Takahashi F, Takahashi K, Eck MJ and Mano H. “Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer.” NPJ Precis Oncol 5:66, 2021. [PubMed ]
    16. Suzuka J, Tsuda M, Wang L, Kohsaka S, Kishida K, Semba S, Sugino H, Aburatani S, Frauenlob M, Kurokawa T, Kojima S, Ueno T, Ohmiya Y, Mano H, Yasuda K, Gong JP and Tanaka S. “Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels.” Nat Biomed Eng 5:914-925, 2021. [PubMed ]
    17. Tanaka Y, Chiwaki F, Kojima S, Kawazu M, Komatsu M, Ueno T, Inoue S, Sekine S, Matsusaki K, Matsushita H, Boku N, Kanai Y, Yatabe Y, Sasaki H and Mano H. “Multi-omic profiling of peritoneal metastases in gastric cancer identifies molecular subtypes and therapeutic vulnerabilities.” Nat Cancer 2:962-977, 2021. [PubMed ]
    18. Inano T, Araki M, Morishita S, Imai M, Kihara Y, Okuda M, Yang Y, Ito M, Osaga S, Mano H, Edahiro Y, Ochiai T, Misawa K, Fukuda Y, Ando J and Komatsu N. “Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia.” Sci Rep 11: 17702, 2021. [PubMed ]
    19. Takamochi K, Hara K, Hayashi T, Kohsaka S, Takahashi F, Suehara Y, Suzuki K. “Programmed death-ligand 1 expression and its associations with clinicopathological features, prognosis, and driver oncogene alterations in surgically resected lung adenocarcinoma.” Lung Cancer 161:163-170 2021 Nov, 2021. [PubMed ]
    20. Kobayashi H, Makise N, Shinozaki-Ushiku A, Ishibashi Y, Ikegami M, Kohsaka S, Ushiku T, Oda K, Miyagawa K, Aburatani H, Mano H and Tanaka S. “Scapular Angiomatoid Fibrous Histiocytoma with EWSR1-CREB1 Fusion in an Adult Patient.” Case Rep Orthop 2021:9434222, 2021. [PubMed ]
    21. Hasegawa N, Kohsaka S, Kurokawa K, Shinno Y, Takeda Nakamura I, Ueno T, Kojima S, Kawazu M, Suehara Y, Ishijima M, Goto Y, Kojima Y, Yonemori K, Hayashi T, Saito T, Shukuya T, Takahashi F, Takahashi K and Mano H. “Highly sensitive fusion detection using plasma cell-free RNA in non-small-cell lung cancers.” Cancer Sci 112: 4393-4403, 2021. [PubMed ]
    22. Kawazu M, Ueno T, Saeki K, Sax N, Togashi Y, Kaneseki T, Chida K, Kishigami F, Sato K, Kojima S, Otsuka M, Kawazoe A, Nishinakamura H, Maeda Y, Yamamoto Y, Yamashita K, Inoue S, Tanegashima T, Matsubara D, Tane K, Tanaka Y, Iinuma H, Hashiguchi Y, Hazama S, Khor SS, Tokunaga K, Tsuboi M, Niki T, Eto M, Shitara K, Torigoe T, Ishihara S, Aburatani H, Haeno H, Nishikawa H and Mano H. “HLA Class I analysis provides insight into the genetic and epigenetic background of immune evasion in colorectal cancer with high microsatellite instability.” Gastroenterology, 2021.10.010. [PubMed ]
    23. Kawashima S, Inozume T, Kawazu M, Ueno T, Nagasaki J, Tanji E, Honobe A, Ohnuma T, Kawamura T, Umeda Y, Nakamura Y, Kawasaki T, Kiniwa Y, Yamasaki O, Fukushima S, Ikehara Y, Mano H, Suzuki Y, Nishikawa H, Matsue H and Togashi Y. “TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment.” J Immunother Cancer, 2021. [PubMed ]
    24. Namba S, Ueno T, Kojima S, Kobayashi K, Kawase K, Tanaka Y, Inoue S, Kishigami F, Kawashima S, Maeda N, Ogawa T, Hazama S, Togashi Y, Ando M, Shiraishi Y, Mano H and Kawazu M. “Transcript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer.” Commun Biol 4: 1320, 2021. [PubMed ]
    25. Okuma HS, Yonemori K, Kojima Y, Tanioka M, Sudo K, Noguchi E, Hijioka S, Wakakuwa K, Kato K, Hirakawa A, Kuchiba A, Kubo T, Ichikawa H, Yoshida A, Yatabe Y, Nakamura K, Mano H, Yamamoto N and Fujiwara Y. “Clinical Utility of Circulating Tumor DNA in Advanced Rare Cancers.” Front Oncol 11:732525, 2021. [PubMed ]
    26. Kishikawa S, Hayashi T, Saito T, Takamochi K, Sasa K, Suehara Y, Takahashi F, Sasahara N, Kohsaka S, Suzuki K, Yao T. “Distinct properties of pure- and mixed-type high-grade fetal lung adenocarcinomas by genetic profiling and transcription factor expression.” Virchows Arch, 2021 Nov 30. [PubMed ]
    27. Ikegami M, Kohsaka S, Hirose T, Ueno T, Inoue S, Kanomata N, Yamauchi H, Mori T, Sekine S, Inamoto Y, Yatabe Y, Kobayashi H, Tanaka S and Mano H. “MicroSEC filters sequence errors for formalin-fixed and paraffin-embedded samples. ”Commun Biol 4: 1396, 2021. [PubMed ]

    2020

    Division of Cellular Signaling

    1. Mano H. “Cancer genomic medicine in Japan” Proc Jpn Acad Ser B Phys Biol Sci 96:316-321, 2020. [PubMed ]
    2. Hayakawa D, Takahashi F, Mitsuishi Y, Tajima K, Hidayat M, Winardi W, Ihara H, Kanamori K, Matsumoto N, Asao T, Ko R, Shukuya T, Takamochi K, Hayashi T, Suehara Y, Takeda Nakamura I, Ueno T, Kohsaka S, Mano H, Takahashi K. “Activation of insulin-like growth factor-1 receptor confers acquired resistance to osimertinib in non-small cell lung cancer with EGFR T790M mutation” Thorac Cancer 11: 140-149, 2020. [PubMed ]
    3. Kohsaka S, Hayashi T, Nagano M, Ueno T, Kojima S, Kawazu M, Shiraishi Y, Kishikawa S, Suehara Y, Takahashi F, Takahashi K, Suzuki K, Takamochi K, Mano H. “Identification of Novel CD74-NRG2alpha Fusion From Comprehensive Profiling of Lung Adenocarcinoma in Japanese Never or Light Smokers” J Thorac Oncol 15:948-961, 2020. [PubMed ]
    4. Makise N, Mori T, Kobayashi H, Nakagawa K, Ryo E, Nakajima J, Kohsaka S, Mano H, Aburatani H, Yoshida A, Ushiku T. “Mesenchymal tumours with RREB1-MRTFB fusion involving the mediastinum: extra-glossal ectomesenchymal chondromyxoid tumours?” Histopathology 76:1023-1031, 2020. [PubMed ]
    5. Matsubara D, Yoshimoto T, Soda M, Amano Y, Kihara A, Funaki T, Ito T, Sakuma Y, Shibano T, Endo S, Hagiwara K, Ishikawa S, Fukayama M, Murakami Y, Mano H, Niki T. “Reciprocal expression of trefoil factor-1 and thyroid transcription factor-1 in lung adenocarcinomas” Cancer Sci 111: 2183-2195, 2020. [PubMed ]
    6. Tateishi K, Miyake Y, Kawazu M, Sasaki N, Nakamura T, Sasame J, Yoshii Y, Ueno T, Miyake A, Watanabe J, Matsushita Y, Shiba N, Udaka N, Ohki K, Fink AL, Tummala SS, Natsumeda M, Ikegaya N, Nishi M, Ohtake M, Miyazaki R, Suenaga J, Murata H, Aoki I, Miller JJ, Fujii Y, Ryo A, Yamanaka S, Mano H, Cahill DP, Wakimoto H, Chi AS, Batchelor TT, Nagane M, Ichimura K, Yamamoto T. “A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma” Cancer Res 80:5330-5343, 2020. [PubMed ]
    7. Kumagai S, Togashi Y, Sakai C, Kawazoe A, Kawazu M, Ueno T, Sato E, Kuwata T, Kinoshita T, Yamamoto M, Nomura S, Tsukamoto T, Mano H, Shitara K, Nishikawa H. “An oncogenic alteration creates a microenvironment that promotes tumor progression by conferring a metabolic advantage to regulatory T Cells” Immunity 53:187-203 e188, 2020. [PubMed ]
    8. Akahane K, Yasuda T, Tsuzuki S, Hayakawa F, Kiyokawa N, Somazu S, Watanabe A, Kagami K, Abe M, Harama D, Goi K, Kawazu M, Kojima S, Imamura T, Goto H, Iwamoto S, Minegishi M, Abe M, Hojo H, Inaba T, Mano H, Sugita K, Inukai T. “High prevalence of MEF2D fusion in human B-cell precursor acute lymphoblastic leukemia cell lines” Hematol Oncol 38:614-617, 2020. [PubMed ]
    9. Hirose T, Ikegami M, Endo M, Matsumoto Y, Nakashima Y, Mano H, Kohsaka S. “Extensive functional evaluation of exon 20 insertion mutations of EGFR” Lung Cancer 152:135-142, 2020. [PubMed ]
    10. Aizawa H, Karasaki T, Nagayama K, Shinozaki-Ushiku A, Aburatani H, Mano H, Nakajima J. “Clinical Application of Next-generation Sequencing for the Diagnosis of Lung Squamous Cell Carcinoma: Is It Primary or Secondary?” Intern Med 59:1299-1302, 2020. [PubMed ]
    11. Hayashi T, Takamochi K, Kohsaka S, Kishikawa S, Suehara Y, Takahashi F, Suzuki K, Saito T, Yao T. “Transformation from EGFR/PTEN co-mutated lung adenocarcinoma to small cell carcinoma in lymph node metastasis” Pathology International. 2020 Mar 12. doi: 10.1111/pin.12919. [PubMed ]
    12. Ikegami M, Kohsaka S, Ueno T, Momozawa Y, Inoue S, Tamura K, Shimomura A, Hosoya N, Kobayashi H, Tanaka S, Mano H. “High-throughput functional evaluation of BRCA2 variants of unknown significance” Nat Commun 11: 2573, 2020. [PubMed ]
    13. Inoue S, Yoshida E, Fukui Y, Ueno T, Kawazu M, Takeyama R, Ikemura M, Osuga Y, Terao Y, Hirota Y, Mano H. “KRAS mutations in uterine endometrium are associated with gravidity and parity” Cell Death Dis 11: 347, 2020. [PubMed ]
    14. Hirata E, Ishibashi K, Kohsaka S, Shinjo K, Kojima S, Kondo Y, Mano H, Yano S, Kiyokawa E, Sahai E. “The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells” iScience 23: 101480, 2020. [PubMed ]
    15. Hayashi T, Kohsaka S, Takamochi K, Hara K, Kishikawa S, Sano K, Takahashi F, Suehara Y, Saito T, Takahashi K, Suzuki K, Yao T. “Clinicopathological characteristics of lung adenocarcinoma with compound EGFR mutations” Hum Pathol. 2020 Sep;103: 42-51. [PubMed ]
    16. Shinozaki-Ushiku A, Kohsaka S, Kage H, Oda K, Miyagawa K, Nakajima J, Aburatani H, Mano H, Ushiku T. “Genomic profiling of multiple primary cancers including synchronous lung adenocarcinoma and bilateral malignant mesotheliomas: Identification of a novel BAP1 germline variant” Pathol Int 70:775-780, 2020. [PubMed ]
    17. Kishikawa S, Hayashi T, Saito T, Takamochi K, Kohsaka S, Sano K, Sasahara N, Sasa K, Kurihara T, Hara K, Suehara Y, Takahashi F, Suzuki K, Yao T. “Diffuse expression of MUC6 defines a distinct clinicopathological subset of pulmonary invasive mucinous adenocarcinoma” Mod Pathol. 2020 Oct 6. doi: 10.1038/s41379-020-00690-w. [PubMed ]
    18. Kurihara T, Suehara Y, Akaike K, Hayashi T, Kohsaka S, Ueno T, Hasegawa N, Takagi T, Sasa K, Okubo T, Kim Y, Mano H, Yao T, Kaneko K, Saito T. “Nanostring-based screening for tyrosine kinase fusions in inflammatory myofibroblastic tumors” Sci Rep 10: 18724, 2020. [PubMed ]
    19. Kumagai S, Togashi Y, Kamada T, Sugiyama E, Nishinakamura H, Takeuchi Y, Vitaly K, Itahashi K, Maeda Y, Matsui S, Shibahara T, Yamashita Y, Irie T, Tsuge A, Fukuoka S, Kawazoe A, Udagawa H, Kirita K, Aokage K, Ishii G, Kuwata T, Nakama K, Kawazu M, Ueno T, Yamazaki N, Goto K, Tsuboi M, Mano H, Doi T, Shitara K, Nishikawa H. “The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies” Nat Immunol 21: 1346-1358, 2020. [PubMed ]
    20. Sasaki K, Fukui R, Hata K, Nozawa H, Ushiku T, Aburatani H, Mano H, Ishihara S. “Clinical diagnosis of a double primary sigmoid colon cancer and metastatic tumour using a gene-targeted panel test: a case report” ANZ J Surg 90:E139-E140, 2020. [PubMed ]
    21. Suehara Y, Kohsaka S, Yamaguchi S, Hayashi T, Kurihara T, Sano K, Sasa K, Akaike K, Ueno T, Kojima S, Ikegami M, Mizuno S, Okubo T, Kim Y, Kaneko K, Saito T, Kato S, Mano H. “Assessment of Predictive Biomarkers of the Response to Pazopanib Based on an Integrative Analysis of High-grade Soft-tissue Sarcomas: Analysis of a Tumor Sample from a Responder and Patients with Other Soft-tissue Sarcomas” Clin Orthop Relat Res 478:2461-2476, 2020. [PubMed ]
    22. Kawazoe A, Kuboki Y, Shinozaki E, Hara H, Nishina T, Komatsu Y, Yuki S, Wakabayashi M, Nomura S, Sato A, Kuwata T, Kawazu M, Mano H, Togashi Y, Nishikawa H, Yoshino T. “Multicenter Phase I/II Trial of Napabucasin and Pembrolizumab in Patients with Metastatic Colorectal Cancer (EPOC1503/SCOOP Trial)” Clin Cancer Res 26:5887-5894, 2020. [PubMed ]
    23. Kobayashi H, Shin M, Makise N, Shinozaki-Ushiku A, Ikegami M, Taniguchi Y, Shinoda Y, Kohsaka S, Ushiku T, Oda K, Miyagawa K, Aburatani H, Mano H, Tanaka S. “Genetic Testing Distinguishes Multiple Chondroid Chordomas with Neuraxial Bone Metastases from Multicentric Tumors” Case Rep Genet 2020:8877722, 2020. [PubMed ]
    24. Hayashi T, Kohsaka S, Takamochi K, Kishikawa S, Ikarashi D, Sano K, Hara K, Onagi H, Suehara Y, Takahashi F, Saito T, Nakatsura T, Kitano S, Suzuki K, Yao T. “Histological Characteristics of Lung Adenocarcinoma with Uncommon Actionable Alterations: Special Emphasis on MET exon 14 Skipping Alterations. Histopathology. 2020 Nov 29. doi: 10.1111/his.14311. [PubMed ]
    25. Naito Y, Aburatani H, Amano T, Baba E, Furukawa T, Hayashida T, Hiyama E, Ikeda S, Kanai M, Kato M, Kinoshita I, Kiyota N, Kohno T, Kohsaka S, Komine K, Matsumura I, Miura Y, Nakamura Y, Natsume A, Nishio K, Oda K, Oda N, Okita N, Oseto K, Sunami K, Takahashi H, Takeda M, Tashiro S, Toyooka S, Ueno H, Yachida S, Yoshino T, Tsuchihara K; Japanese Society of Medical Oncology; Japan Society of Clinical Oncology; Japanese Cancer Association. “Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1)” Int J Clin Oncol. 2020 Nov 29. doi: 10.1007/s10147-020-01831-6. [PubMed ]
    26. Ando M, Kobayashi H, Shinozaki-Ushiku A, Chikuda H, Matsubayashi Y, Yoshida M, Saito Y, Kohsaka S, Oda K, Miyagawa K, Aburatani H, Mano H, Yamasoba T. “Spinal solitary fibrous tumor of the neck: Next-generation sequencing-based analysis of genomic aberrations” Auris Nasus Larynx 47:1058-1063, 2020. [PubMed ]
    27. Hayashi T, Odintsov I, Smith RS, Ishizawa K, Liu AJW, Delasos L, Kurzatkowski C, Tai H, Gladstone E, Vojnic M, Kohsaka S, Suzawa K, Liu Z, Kunte S, Mattar MS, Khodos I, Davare MA, Drilon A, Cheng E, Stanchina E, Ladanyi M, Somwar R. “RET inhibition in novel patient-derived models of RET-fusion positive lung adenocarcinoma reveals a role for MYC upregulation” Dis Model Mech. 2020 Dec 14, doi: 10.1242/dmm.047779. [PubMed ]

    2019

    Division of Cellular Signaling

    1. Namba S, Sato K, Kojima S, Ueno T, Yamamoto Y, Tanaka Y, Inoue S, Nagae G, Iinuma H, Hazama S, Ishihara S, Aburatani H, Mano H, Kawazu M. “Differential regulation of CpG island methylation within divergent and unidirectional promoters in colorectal cancer.” Cancer Sci. 2019. [PubMed ]
    2. Kohsaka S, Tatsuno K, Ueno T, Nagano M, Shinozaki-Ushiku A, Ushiku T, Takai D, Ikegami M, Kobayashi H, Kage H, Ando M, Hata K, Ueda H, Yamamoto S, Kojima S, Oseto K, Akaike K, Suehara Y, Hayashi T, Saito T, Takahashi F, Takahashi K, Takamochi K, Suzuki K, Nagayama S, Oda Y, Mimori K, Ishihara S, Yatomi Y, Nagase T, Nakajima J, Tanaka S, Fukayama M, Oda K, Nangaku M, Miyazono K, Miyagawa K, Aburatani H, Mano H. “Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens.” Cancer Science. 110, 1464-1479, 2019. [PubMed ]
    3. Yoshimoto T, Matsubara D, Soda M, Ueno T, Amano Y, Kihara A, Sakatani T, Nakano T, Shibano T, Endo S, Hagiwara K, Fukayama M, Denda-Nagai K, Irimura T, Mano H, Niki T. “Mucin 21 is a key molecule involved in the incohesive growth pattern in lung adenocarcinoma” Cancer Sci 110: 3006-3011, 2019. [PubMed ]
    4. Watanabe K, Kage H, Shinozaki-Ushiku A, Kohsaka S, Takai D, Nakajima J, Miyagawa K, Aburatani H, Mano H, Nagase T. “Spontaneous Transdifferentiation from Small Cell Lung Carcinoma to Squamous Cell Carcinoma.” J Thorac Oncol. 14, e31-e34, 2019. [PubMed ]
    5. Takaoka K, Kawazu M, Koya J, Yoshimi A, Masamoto Y, Maki H, Toya T, Kobayashi T, Nannya Y, Arai S, Ueno T, Ueno H, Suzuki K, Harada H, Manabe A, Hayashi Y, Mano H, Kurokawa M. “A germline HLTF mutation in familial MDS induces DNA damage accumulation through impaired PCNA polyubiquitination.” Leukemia. 2019. [PubMed ]
    6. Sato K, Kawazu M, Yamamoto Y, Ueno T, Kojima S, Nagae G, Abe H, Soda M, Oga T, Kohsaka S, Sai E, Yamashita Y, Iinuma H, Fukayama M, Aburatani H, Watanabe T, Mano H. “Fusion kinases identified by genomic analyses of sporadic microsatellite instability-high colorectal cancers.” Clinical Cancer Research. 25, 378-389, 2019. [PubMed ]
    7. Sai E, Miwa Y, Takeyama R, Kojima S, Ueno T, Yashiro M, Seto Y, Mano H. “Identification of candidates for driver oncogenes in scirrhous-type gastric cancer cell lines” Cancer Sci 110: 2643-2651, 2019. [PubMed ]
    8. Oga T, Yamashita Y, Soda M, Kojima S, Ueno T, Kawazu M, Suzuki N, Nagano H, Hazama S, Izumiya M, Koike K, Mano H. “Genomic profiles of colorectal carcinoma with liver metastases and newly identified fusion genes” Cancer Sci 110: 2973-2981, 2019. [PubMed ]
    9. Kinoshita Y, Takashi Y, Ito N, Ikegawa S, Mano H, Ushiku T, Fukayama M, Nangaku M, Fukumoto S. “Ectopic expression of Klotho in fibroblast growth factor 23 (FGF23)-producing tumors that cause tumor-induced rickets/osteomalacia (TIO)” Bone Rep 10: 100192, 2019. [PubMed ]
    10. Inoue S, Hirota Y, Ueno T, Fukui Y, Yoshida E, Hayashi T, Kojima S, Takeyama R, Hashimoto T, Kiyono T, Ikemura M, Taguchi A, Tanaka T, Tanaka Y, Sakata S, Takeuchi K, Muraoka A, Osuka S, Saito T, Oda K, Osuga Y, Terao Y, Kawazu M, Mano H. “Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations” Nat Commun 10: 5785, 2019. [PubMed ]
    11. Hayakawa D, Takahashi F, Mitsuishi Y, Tajima K, Hidayat M, Winardi W, Ihara H, Kanamori K, Matsumoto N, Asao T, Ko R, Shukuya T, Takamochi K, Hayashi T, Suehara Y, Takeda Nakamura I, Ueno T, Kohsaka S, Mano H, Takahashi K. “Activation of insulin-like growth factor-1 receptor confers acquired resistance to osimertinib in non-small cell lung cancer with EGFR T790M mutation.” Thorac Cancer. 2019 Nov 22. doi: 10.1111/ 1759-7714.13255. [PubMed ]
    12. Suehara Y, Okubo T, Kurihara T, Hayashi T, Kohsaka S, Kazuno S, Sano K, Hasegawa N, Miura Y, Akaike K, Kim Y, Takamochi K, Takahashi F, Ueno T, Kaneko K, Saito T. “Protein Expression Profiles Corresponding to Histological Changes with Denosumab Treatment in Giant Cell Tumors of Bone.” Proteomics Clinical Applications. e1800147, 2019. [PubMed ]
    13. Kage H, Kohsaka S, Shinozaki-Ushiku A, Hiraishi Y, Sato J, Nagayama K, Ushiku T, Takai D, Nakajima J, Miyagawa K, Aburatani H, Mano H, Nagase T. “Small lung tumor biopsy samples are feasible for high quality targeted next generation sequencing.” Cancer Science. 110, 2652-2657, 2019. [PubMed ]
    14. Hirano D, Hayakawa F, Yasuda T, Tange N, Yamamoto H, Kojima Y, Morishita T, Imoto N, Tsuzuki S, Mano H, Naoe T, Kiyoi H. “Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity.” Oncogene 38:2263-2274, 2019. [PubMed ]
    15. Hasegawa N, Takeda Nakamura I, Ueno T, Kojima S, Kawazu M, Akaike K, Okubo T, Takagi T, Suehara Y, Hayashi T, Saito T, Kaneko K, Mano H, Kohsaka S. “Detection of circulating sarcoma tumor cells using a microfluidic chip-type cell sorter.” Sci Rep. 2019 Dec 27;9(1):20047. doi: 10.1038/s41598-019-56377-z.[PubMed ]
    16. Ando M, Kobayashi H, Shinozaki-Ushiku A, Chikuda H, Matsubayashi Y, Yoshida M, Saito Y, Kohsaka S, Oda K, Miyagawa K, Aburatani H, Mano H, Yamasoba T. “Spinal solitary fibrous tumor of the neck: Next-generation sequencing-based analysis of genomic aberrations.” Auris Nasus Larynx. 2019.[PubMed ]

    2018

    Division of Cellular Signaling

    1. Kawamata F, Nishihara H, Homma S, Kato Y, Tsuda M, Konishi Y, Wang L, Kohsaka S, Liu C, Yoshida T, Tanino M, Tanaka S, Kawamura H, Kamiyama T, Taketomi A. “Chorionic Gonadotropin-β Modulates Epithelial-Mesenchymal Transition in Colorectal Carcinoma Metastasis.” The American Journal of Pathology. 188, 204-215, 2018. [PubMed ]
    2. Kohsaka S, Saito T, Akaike K, Suehara Y, Hayashi T, Takagi T, Kaneko K, Ueno T, Kojima S, Kohashi KI, Mano H, Oda Y, Yao T. “Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion” Hum Pathol 72:167-73, 2018. [PubMed ]
    3. Tanabe Y, Suehara Y, Kohsaka S, Hayashi T, Akaike K, Mukaihara K, Kurihara T, Kim Y, Okubo T, Ishii M, Kazuno S, Kaneko K, Saito T. “IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing’s sarcoma.” Oncotarget. 9, 14428-14443, 2018. [PubMed ]
    4. Murakami N, Okuno Y, Yoshida K, Shiraishi Y, Nagae G, Suzuki K, Narita A, Sakaguchi H, Kawashima N, Wang X, Xu Y, Chiba K, Tanaka H, Hama A, Sanada M, Ito M, Hirayama M, Watanabe A, Ueno T, Kojima S, Aburatani H, Mano H, Miyano S, Ogawa S, Takahashi Y & Muramatsu H. “Integrated molecular profiling of juvenile myelomonocytic leukemia” Blood 131:1576-1586, 2018. [PubMed ]
    5. Komuro A, Raja E, Iwata C, Soda M, Isogaya K, Yuki K, Ino Y, Morikawa M, Todo T, Aburatani H, Suzuki H, Ranjit M, Natsume A, Mukasa A, Saito N, Okada H, Mano H, Miyazono K & Koinuma D. “Identification of a novel fusion gene HMGA2-EGFR in glioblastoma” Int J Cancer 142:1627-1639, 2018. [PubMed ]
    6. Tanaka Y, Kawazu M, Yasuda T, Tamura M, Hayakawa F, Kojima S, Ueno T, Kiyoi H, Naoe T, Mano H. “Transcriptional activities of DUX4 fusions in B-cell acute lymphoblastic leukemia.” Haematologica. 2018 Nov;103(11):e522-e526. doi:10.3324/haematol.2017.183152. [PubMed ]
    7. Takahashi K, Ehata S, Koinuma D, Morishita Y, Soda M, Mano H & Miyazono K. “Pancreatic tumor microenvironment confers highly malignant properties on pancreatic cancer cells” Oncogene 37:2757-2772, 2018. [PubMed ]
    8. Takashima K, Maru Y, Mori S, Mano H, Noda T & Muto K. “Ethical concerns on sharing genomic data including patients' family members” BMC Med Ethics 19:61, 2018. [PubMed ]
    9. Kage H, Kohsaka S, Shinozaki-Ushiku A, Ushiku T, Takai D, Nakajima J, Miyagawa K, Aburatani H, Mano H & Nagase T. “Spontaneous Transformation from EGFR and ALK Wild-Type Lung Adenocarcinoma to Neuroendocrine Carcinoma” J Thorac Oncol 13:e126-e128, 2018. [PubMed ]
    10. Morita K, Hama Y, Izume T, Tamura N, Ueno T, Yamashita Y, Sakamaki Y, Mimura K, Morishita H, Shihoya W, Nureki O, Mano H, Mizushima N. “Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation.” J Cell Biol. 217, 3817-3828, 2018. [PubMed ]
    11. Matsuo H, Yoshida K, Fukumura K, Nakatani K, Noguchi Y, Takasaki S, Noura M, Shiozawa Y, Shiraishi Y, Chiba K, Tanaka H, Okada A, Nannya Y, Takeda J, Ueno H, Shiba N, Yamato G, Handa H, Ono Y, Hiramoto N, Ishikawa T, Usuki K, Ishiyama K, Miyawaki S, Itonaga H, Miyazaki Y, Kawamura M, Yamaguchi H, Kiyokawa N, Tomizawa D, Taga T, Tawa A, Hayashi Y, Mano H, Miyano S, Kamikubo Y, Ogawa S, Adachi S. “Recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia.” Blood Adv. 2, 2879-2889, 2018. [PubMed ]
    12. Li JF, Dai YT, Lilljebjorn H, Shen SH, Cui BW, Bai L, Liu YF, Qian MX, Kubota Y, Kiyoi H, Matsumura I, Miyazaki Y, Olsson L, Tan AM, Ariffin H, Chen J, Takita J, Yasuda T, Mano H, Johansson B, Yang JJ, Yeoh AE, Hayakawa F, Chen Z, Pui CH, Fioretos T, Chen SJ, Huang JY. “Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases.” Proc Natl Acad Sci U S A. 115, E11711-E11720, 2018. [PubMed ]
    13. Komuro A, Raja E, Iwata C, Soda M, Isogaya K, Yuki K, Ino Y, Morikawa M, Todo T, Aburatani H, Suzuki H, Ranjit M, Natsume A, Mukasa A, Saito N, Okada H, Mano H, Miyazono K, Koinuma D. “Identification of a novel fusion gene HMGA2-EGFR in glioblastoma.” Int J Cancer. 142, 1627-1639, 2018. [PubMed ]
    14. Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S, Kawazu M, Mano H, Kitamura T. “Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.” Nat Commun. 9, 2733, 2018. [PubMed ]
    15. Ishii M, Suehara Y, Sano K, Kohsaka S, Hayashi T, Kazuno S, Akaike K, Mukaihara K, Kim Y, Okubo T, Takamochi K, Takahashi F, Kaneko K, Saito T. “Proteomic signatures corresponding to the SS18/SSX fusion gene in synovial sarcoma.” Oncotarget. 9, 37509-37519, 2018. [PubMed ]
    16. Yachi K, Tsuda M, Kohsaka S, Wang L, Oda Y, Tanikawa S, Ohba Y, Tanaka S. “miR-23a promotes invasion of glioblastoma via HOXD10-regulated glial-mesenchymal transition.” Signal Transduct Target Ther. 3, 33. doi: 10.1038/s41392-018-0033-6. eCollection 2018. [PubMed ]
    17. Kohsaka S, Petronczki M, Solca F, Maemondo M. “Tumor clonality and resistance mechanisms in EGFR mutation-positive non-small-cell lung cancer: implications for therapeutic sequencing.” Future Oncol. 15, 637-652, 2018. [PubMed ]
    18. Nagano M, Kohsaka S, Ueno T, Kojima S, Saka K, Iwase H, Kawazu M, and Mano H. “High-throughput functional evaluation of variants of unknown significance in ERBB2.” Clinical Cancer Research. 24, 5112-5122, 2018. [PubMed ]
    19. Konishi Y, Kawamata F, Nishihara H, Homma S, Kato Y, Tsuda M, Kohsaka S, Einama T, Liu C, Yoshida T, Nagatsu A, Tanino M, Tanaka S, Kawamura H, Kamiyama T, Taketomi A. “Tumor budding and human chorionic gonadotropin-β expression correlate with unfavorable patient outcome in colorectal carcinoma.” Med Oncol. 35, 104, 2018. [PubMed ]
    20. Akaike K, Suehara Y, Kohsaka S, Hayashi T, Tanabe Y, Kazuno S, Mukaihara K, Toda-Ishii M, Kurihara T, Kim Y, Okubo T, Hayashi Y, Takamochi K, Takahashi F, Kaneko K, Ladanyi M, Saito T. “PPP2R1A regulated by PAX3/FOXO1 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma.” Oncotarget. 9, 25206-25215, 2018. [PubMed ]

    2017

    Division of Cellular Signaling

    1. Takamochi K, Takahashi F, Suehara Y, Sato E, Kohsaka S, Hayashi T, Kitano S, Uneno T, Kojima S, Takeuchi K, Mano H, Suzuki K.“DNA mismatch repair deficiency in surgically resected lung adenocarcinoma: Microsatellite instability analysis using the Promega panel” Lung Cancer 110: 26-31, 2017. [PubMed ]
    2. Soh SX, Siddiqui FJ, Allen JC, Kim GW, Lee JC, Yatabe Y, Soda M, Mano H, Soo RA, Chin TM, Ebi H, Yano S, Matsuo K, Niu X, Lu S, Isobe K, Lee JH, Yang JC, Zhao M, Zhou C, Lee JK, Lee SH, Lee JY, Ahn MJ, Tan TJ, Tan DS, Tan EH, Ong ST, Lim WT.“A systematic review and meta-analysis of individual patient data on the impact of the BIM deletion polymorphism on treatment outcomes in epidermal growth factor receptor mutant lung cancer” Oncotarget 8: 41474-86 2017. [PubMed ]
    3. Seki M, Kimura S, Isobe T, Yoshida K, Ueno H, Nakajima-Takagi Y, Wang C, Lin L, Kon A, Suzuki H, Shiozawa Y, Kataoka K, Fujii Y, Shiraishi Y, Chiba K, Tanaka H, Shimamura T, Masuda K, Kawamoto H, Ohki K, Kato M, Arakawa Y, Koh K, Hanada R, Moritake H, Akiyama M, Kobayashi R, Deguchi T, Hashii Y, Imamura T, Sato A, Kiyokawa N, Oka A, Hayashi Y, Takagi M, Manabe A, Ohara A, Horibe K, Sanada M, Iwama A, Mano H, Miyano S, Ogawa S, Takita J. “Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia” Nat Genet 49: 1274-81, 2017. [PubMed ]
    4. Nakamura T, Yamashita S, Fukumura K, Nakabayashi J, Tanaka K, Tamura K, Tateishi K, Kinoshita M, Fukushima S, Takami H, Fukuoka K, Yamazaki K, Matsushita Y, Ohno M, Miyakita Y, Shibui S, Kubo A, Shuto T, Kocialkowski S, Yamanaka S, Mukasa A, Sasayama T, Mishima K, Maehara T, Kawahara N, Nagane M, Narita Y, Mano H, Ushijima T & Ichimura K.“Genome-wide DNA methylation profiling identifies primary central nervous system lymphoma as a distinct entity different from systemic diffuse large B-cell lymphoma” Acta Neuropathol 133:321-4, 2017. [PubMed ]
    5. Matsubara D, Soda M, Yoshimoto T, Amano Y, Sakuma Y, Yamato A, Ueno T, Kojima S, Shibano T, Hosono Y, Kawazu M, Yamashita Y, Endo S, Hagiwara K, Fukayama M, Takahashi T, Mano H, Niki T. “Inactivating mutations and hypermethylation of the NKX2-1/TTF-1 gene in non-terminal respiratory unit-type lung adenocarcinomas” Cancer Sci 108: 1888-96, 2017. [PubMed ]
    6. Kohsaka S, Nagano M, Ueno T, Suehara Y, Hayashi T, Shimada N, Takahashi K, Suzuki K, Takamochi K, Takahashi F, Mano H. “A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer” Sci Transl Med 9:eaan6556, 2017. [PubMed ]
    7. Kawazu M, Kojima S, Ueno T, Totoki Y, Nakamura H, Kunita A, Qu W, Yoshimura J, Soda M, Yasuda T, Hama N, Saito-Adachi M, Sato K, Kohsaka S, Sai E, Ikemura M, Yamamoto S, Ogawa T, Fukayama M, Tada K, Seto Y, Morishita S, Hazama S, Shibata T, Yamashita Y and Mano H: “Integrative analysis of genomic alterations in triple-negative breast cancer in association with homologous recombination deficiency” PLoS Genet 13:e1006853, 2017 [PubMed ].
    8. Mukaihara K, Tanabe Y, Kubota D, Akaike K, Hayashi T, Mogushi K, Hosoya M, Sato S, Kobayashi E, Okubo T, Kim Y, Kohsaka S, Saito T, Kaneko K, Suehara Y. “Cabozantinib and dastinib exert anti-tumor activity in alveolar soft part sarcoma.” PLoS One. 12, e018532, 2017. [PubMed ].
    9. Shimura T, Tada Y, Hirai H, Kawakita D, Kano S, Tsukahara K, Shimizu A, Takase S, Imanishi Y, Hiroyuki Ozawa H, Okami K, Sato Y, Sato Y, Fushimi C, Takahashi H, Okada T, Sato H, Otsuka K, Watanabe Y, Sakai A, Ebisumoto K, Togashi T, Ueki Y, Ota H, Ando M, Kohsaka S, Hanazawa T, Chazono H, Nagao T. “Prognostic and Histogenetic Roles of Gene Alteration and the Expression of Key Potentially Actionable Targets in Salivary Duct Carcinomas.” Oncotarget. 9, 1852-1867, 2017. [PubMed ].

    2016

    Division of Cellular Signaling

    1. Yasuda T, Tsuzuki S, Kawazu M, Hayakawa F, Kojima S, Ueno T, Imoto N, Kohsaka S, Kunita A, Doi K, Sakura T, Yujiri T, Kondo E, Fujimaki K, Ueda Y, Aoyama Y, Ohtake S, Takita J, Sai E, Taniwaki M, Kurokawa M, Morishita S, Fukayama M, Kiyoi H, Miyazaki Y, Naoe T & Mano H. “Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults” Nat Genet 48, 569-574, 2016. [PubMed ]
    2. Ando M, Kawazu M, Ueno T, Koinuma D, Ando K, Koya J, Kataoka K, Yasuda T, Yamaguchi H, Fukumura K, Yamato A, Soda M, Sai E, Yamashita Y, Asakage T, Miyazaki Y, Kurokawa M, Miyazono K, Nimer SD, Yamasoba T & Mano H. “Mutational landscape and antiproliferative functions of ELF transcription factors in human cancer” Cancer Res 76, 1814-1824, 2016. [PubMed ]
    3. Fukumura K, Kawazu M, Kojima S, Ueno T, Sai E, Soda M, Ueda H, Yasuda T, Yamaguchi H, Lee J, Shishido-Hara Y, Sasaki A, Shirahata M, Mishima K, Ichimura K, Mukasa A, Narita Y, Saito N, Aburatani H, Nishikawa R, Nagane M & Mano H. “Genomic characterization of primary central nervous system lymphoma” Acta Neuropathol 131, 865-875, 2016. [PubMed ]
    4. Katsura A, Suzuki HI, Ueno T, Mihira H, Yamazaki T, Yasuda T, Watabe T, Mano H, Yamada Y & Miyazono K. “MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-beta” Genes Cells 21, 99-116, 2016. [PubMed ]

    2015

    Division of Cellular Signaling

    1. Yamaguchi H, Kawazu M, Yasuda T, Soda M, Ueno T, Kojima S, Yashiro M, Yoshino I, Ishikawa Y, Sai E & Mano H. “Transforming somatic mutations of mammalian target of rapamycin kinase in human cancer” Cancer Sci 106, 1687-1692, 2015. [PubMed]
    2. Yamato A, Soda M, Ueno T, Kojima S, Sonehara K, Kawazu M, Sai E, Yamashita Y, Nagase T & Mano H. “Oncogenic activity of BIRC2 and BIRC3 mutants independent of nuclear factor-kappaB-activating potential” Cancer Sci 106, 1137-1142, 2015. [PubMed]
    3. Ikeda K, Horie-Inoue K, Ueno T, Suzuki T, Sato W, Shigekawa T, Osaki A, Saeki T, Berezikov E, Mano H & Inoue S. “miR-378a-3p modulates tamoxifen sensitivity in breast cancer MCF-7 cells through targeting GOLT1A” Sci Rep 5, 13170, 2015. [PubMed]
    4. Mano H. “Second-generation ALK inhibitors” Clin Adv Hematol Oncol 13, 416-417, 2015. [PubMed]
    5. Suzuki HI, Katsura A, Yasuda T, Ueno T, Mano H, Sugimoto K & Miyazono K. “Small-RNA asymmetry is directly driven by mammalian Argonautes” Nat Struct Mol Biol 22, 512-521, 2015. [PubMed]
    6. Hashizume O, Ohnishi S, Mito T, Shimizu A, Iashikawa K, Nakada K, Soda M, Mano H, Togayachi S, Miyoshi H, Okita K & Hayashi J. “Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects” Sci Rep 5, 10434, 2015. [PubMed]
    7. Mano H. “The EML4-ALK oncogene: targeting an essential growth driver in human cancer” Proc Jpn Acad Ser B Phys Biol Sci 91, 193-201, 2015. [PubMed]
    • Our Research Focus