Research Projects

Understanding Disease Dynamics

We investigate how disease onset and progression are shaped by diverse factors, including intrinsic factors represented by genetic predisposition, extrinsic factors such as environmental exposures, and somatic alterations. In addition, by viewing disease as a dynamic process that incorporates temporal changes such as aging and clonal dynamics, we aim to better understand the diversity of disease risk and pathophysiology. We also seek to apply these insights to more refined approaches for risk assessment.

Understanding Relationships Between Diseases

We systematically analyze relationships across diseases by focusing on shared molecular foundations as well as their differences. Through these approaches, we aim to advance a cross-disease understanding of disease mechanisms.

Development and Application of Novel Analytical Platforms

In collaboration with diverse research groups, we are developing novel genomic analytical technologies. For example, the use of peripheral blood–derived DNA enables the acquisition of information from different perspectives, including germline genetic predisposition and acquired genomic alterations (Figure).
We have established a high-throughput platform for evaluating clonal hematopoiesis that can be applied to epidemiological studies. Using this framework, we are currently investigating clonal hematopoiesis in large population cohorts. Through these approaches, we aim to visualize biological features and changes that have been difficult to detect using conventional methods, thereby contributing to a deeper understanding of disease.