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Research Papers

Suzuki Kenichi

2024

  1. Kenmoku H, Takahashi K, Mukai K, Mori T, Hirosawa KM, Kiku F, Uchida Y, Kuchitsu Y, Nishioka Y, Sawa M, Kishimoto T, Tanaka K, Yokota Y, Arai H, Suzuki KGN#(#corresponding author), Taguchi T#. Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol. Nat Commun, 15: 220, 2024. doi: 10.1038/s41467-023-44317-5. PMID: 38212328

2023

  1. Isogami A, Higashi SL, Okumura B, Shibata A, Hirosawa KM, Suzuki KGN, Matsuura K, Ikeda M. Hierarchical supramolecular structure comprising reduction-responsive DNA microspheres and semi-artificial glycopeptide-based micro-asters. Polymer J., 50:1103-1107, 2023. doi: 10.1038/s41428-023-00809-1.

  2. Fujiwara TK, Tsunoyama TA, Takeuchi S, Kalay Z, Nagai Y, Kalkbrenner T, Nemoto YL, Chen LH, Shibata ACE, Iwasawa K, Ritchie KP, Suzuki KGN, Kusumi A. Ultrafast single-molecule imaging reveals focal adhesion nano-architecture and molecular dynamics. J Cell Biol, 222: e202110162, 2023. doi: 10.1083/jcb.202110162. PMID: 37278764

  3. Fujiwara TK, Takeuchi S, Kalay Z, Nagai Y, Tsunoyama TA, Kalkbrenner T, Iwasawa K, Ritchie KP, Suzuki KGN, Kusumi A. Development of ultrafast camera-based single fluorescent-molecule imaging for cell biology. J Cell Biol, 222: e202110160, 2023. doi: 10.1083/jcb.202110160. PMID: 37278763

  4. Suzuki KGN#(#corresponding author), Komura N#, Ando H#. Recently developed glycosphingolipid probes and their dynamic behavior in cell plasma membranes as revealed by single-molecule imaging. Glycoconj J, 40: 305-314, 2023. doi: 10.1007/s10719-023-10116-9. PMID: 37133616

  5. Kusumi A, Tsunoyama TA, Tang B, Hirosawa KM, Morone N, Fujiwara TK, Suzuki KGN. Cholesterol- and actin-centered view of the plasma membrane: updating the Singer-Nicolson fluid mosaic model to commemorate its 50th anniversary. Mol Biol Cell, 34: 2023. doi: 10.1091/mbc.E20-12-0809. PMID: 37039596

  6. Yamaguchi E, Komura N, Tanaka, HN, Imamura A, Ishida H, Groux-Degroote S, Muhlenhoff M, Suzuki KGN#(#corresponding author), Ando H#. Fluorescent GD2 analog for single-molecule imaging. Glycoconj J, 40: 247-257, 2023. doi: 10.1007/s10719-023-10102-1. PMID: 36701103
  7. Suzuki KGN#(#corresponding author), Kusumi A#. Refinement of Singer-Nicolson fluid-mosaic model by microscopy imaging: Lipid rafts and actin-induced membrane compartmentalization. Biochim Biophys Acta, 1865: 184093, 2023. doi: 10.1016/j.bbamem.2022.  PMID: 36423676
  8. Suzuki KGN. Single-molecule imaging of ganglioside probes in living cell plasma membranes. Methods Mol Biol, 2613: 215-227, 2023. doi: 10.1007/978-1-0716-2910-9_17.PMID: 36587082
  9. Sugiura A, Shintani Y, Mori D, Higashi SL, Shibata A, Kitamura Y, Kawano SI, Hirosawa KM, Suzuki KGN, Ikeda M. Design of supramolecular hybrid nanomaterials comprising peptide-based supramolecular nanofibers and in situ generated DNA nanoflowers through rolling circle amplification. Nanoscale, 15: 1024-1031, 2023. doi: 10.1039/d2nr04556g.PMID: 36444534

2022

  1. Hirata T, Harada Y, Hirosawa KM, Toroko Y, Suzuki KGN, Kizuka Y. N-acetylglucosaminyltransferase-V (GnT-V)-enriched small extracellular vesicles mediate N-glycan remodeling in recipient cells. iScience, 26: 105747, 2022. doi: 10.1016/j.isci.2022.105747. PMID: 36590176
  2. Yasuda T, Watanabe H, Hirosawa KM, Suzuki KGN, Suga K, Hanashima S. Fluorescence spectroscopic analysis of lateral and transbilayer fluidity of exosome membranes. Langmuir, 38: 14695-14703, 2022. doi: 10.1021/acs.langmuir.2c02258. PMID: 36421004
  3. Takahashi M, Komura N, Yoshida Y, Yamaguchi E, Hasegawa A, Tanaka HN, Imamura A, Ishida H, Suzuki KGN#(#corresponding author), Ando H#. Development of lacto-series ganglioside fluorescent probe using late-stage sialylation and behavior analysis with single-molecule imaging. RSC Chem Biol, 3: 868-885, 2022. doi: 10.1039/d2cb00083k. eCollection 2022 Jul 6.PMID: 35866169
  4. Higashi SL, Isogami A, Takahashi J, Shibata A, Hirosawa KM, Suzuki KGN, Sawada S, Tsukiji S, Matsuura K, Ikeda M. Construction of a reduction-responsive DNA microsphere using a reduction-cleavable spacer based on a nitrobenxene scaffold. Chem Asian J, 25: e202200142, 2022. doi: 10.1002/asia.202200142. PMID: 35338588
  5. Shintani Y, Ohtomi T, Shibata A, Kitamura Y, Hirosawa KM, Suzuki KGN, Ikeda M. Formation of supermolecular nanostructures through in situ self-assembly and post-assembly modification of a biocatalytically constructured dipeptide hydrazide. Chemistry, 28: e202104421, 2022. doi: 10.1002/chem.202104421. PMID: 34984747

2021

  1. Nagai R, Sugimachi A, Tanimoto Y, Suzuki KGN, Hayashi F, Weikert D, Gmeiner P, Kasai RS, Morigaki K. Functional reconstitution of Dopamin D2 receptor into a supported model membrane in a nanometric confinement. Adv Biol, 5: e2100636, 2021. doi: 10.1002/adbi.202100636. PMID: 34761565

2020

  1. Konishi M, Komura N, Hirose Y, Suganuma Y, Tanaka H, Imamura A, Ishida H, Suzuki KGN#(#corresponding author), Ando H#. Development of fluorescent ganglioside GD3 and QG1b analogs for elucidation of raft-associated interactions. J Org Chem, 85: 15998-16013, 2020. doi: 10.1021/acs.joc.0c01493. PMID: 32951428
  2. Koyama-Honda I, Fujiwara TK, Kasai RS, Suzuki KGN, Kajikawa E, Tsunoyama TA, Kusumi A. High-speed single-molecule imaging reveals signal transduction by induced transbilayer raft phases. J Cell Biol, 12: e202006125, 2020. doi: 10.1083/jcb.202006125. PMID: 33053147
  3. Higashi SL, Hirosawa KM, Suzuki KGN, Matsuura K, Ikeda M. One-pot construction of microcomponent supramolecular materials comprising self-sorted supramolecular architectures of DNA and semi-artificial glycopeptides. ACS Appl Bio Mater, 30: 9082-9092, 2020. doi: 10.1021/acsabm.0c01316. PMID: 35019585
  4. Sil P, Mateos N, Nath S, Buschow S, Manzo C, Suzuki KGN, Fujiwara T, Kusumi A, Garcia-Parajo MF, Mayor S. Dynamic actin-mediated nano-scale clustering of CD44 regulates its meso-scale organization at the plasma membrane. Mol Biol Cell, 31: 561-579, 2020. doi: 10.1091/mbc.E18-11-0715. PMID: 31577524
  5. Kusumi A, Fujiwara TK, Tsunoyama TA, Kasai RS, Liu AA, Hirosawa KM, Kinoshita M, Matsumori N, Komura N, Ando H, Suzuki KGN. Defining raft domains in the plasma membrane. Traffic, 21: 106-137, 2020. doi: 10.1111/tra.12718. PMID: 31760668

2019

  1. Asano S, Pal R, Tanaka HN, Imamura A, Ishida H, Suzuki KGN#(#corresponding author), Ando H#. Development of fluorescently labeled SSEA-3, SSEA-4 and Globo-H glycosphingolipids for elucidating molecular interactions in the cell membrane. Int J Mol Sci, 20: 6187, 2019. doi: 10.3390/ijms20246187. PMID: 31817926
  2. Morise J, Suzuki KGN#(#corresponding authors), Kitagawa A, Wakazono Y, Takamiya K, Tsunoyama TA, Nemoto YL, Takematsu H, Kusumi A#, Oka S#. AMPA receptors in the synapse turnover by monomer diffusion. Nat Commun, 10: 5245, 2019. doi: 10.1038/s41467-019-13229-8. PMID: 31748519
  3. Higashi SL, Shibata A, Kitamura Y, Hirosawa KM, Suzuki KGN, Matsuura K, Ikeda M. Hybrid soft nanomaterials composed of DNA microspheres and supermolecular nanostructures of semi-artificial glycopeptides. Chemistry, 25: 11955-11962, 2019. doi: 10.1002/chem.201902421. PMID: 31268200
  4. Matsu-ura T, Shirakawa H, Suzuki KGN, Miyamoto A, Sugiura K, Michikawa T, Kusumi A, Mikoshiba K. Dual-FRET imaging of IP3 and Ca2+ revealed Ca2+-induced IP3 production maintains long lasting Ca2+ oscillations in fertilized mouse eggs. Sci Rep, 9: 4829, 2019. doi: 10.1038/s41598-019-40931-w. PMID: 30886280

2018

  1. Suzuki KGN#(#corresponding authors), Ando H, Komura N, Fujiwara T, Kiso M, Kusumi A. Unraveling of lipid raft organization in cell plasma membranes by single-molecule imaging of ganglioside probes. Adv Exp Med Biol, 1104: 41-58, 2018. doi: 10.1007/978-981-13-2158-0_3. PMID: 30484243
  2. Kinoshita M, Suzuki KGN, Murata M, Matsumori N. Evidence of lipid rafts based on the partition and dynamic behavior of sphingomyelins. Chem Phys Lipids, 215: 84-95, 2018. doi: 10.1016/j.chemphyslip.2018.07.002. PMID: 30005889
  3. Tsunoyama TA, Watanabe Y, Goto J, Naito K, Suzuki KGN, Fujiwara TK, Kusumi A. Super-long tracking reveals dynamic-anchorage-induced integrin function. Nat Chem Biol, 14: 497-506, 2018. doi: 10.1038/s41589-018-0032-5. PMID: 29610485
  4. Suzuki KGN#(#corresponding authors), Ando H, Komura N, Konishi M, Imamura A, Ishida H, Kiso M, Fujiwara TK, Kusumi A#. Revealing the raft domain organization in the plasma membrane by single-molecule imaging of fluorescent ganglioside analogs. Methods Enzymol, 598: 267-282, 2018. doi: 10.1016/bs.mie.2017.06.038. PMID: 29306438
  5. Tiwari SS, Shirai YM, Nemoto YL, Kojima K, Suzuki KGN(#corresponding author). Native prion protein homodimers are destabilized by oligomeric amyloid beta 1-42 species as shown by single-molecule imaging. Neuroreport, 29: 106-111, 2018. doi: 10.1097/WNR.0000000000000916. PMID: 29120943

2017

  1. Komura N, Suzuki KGN, Ando H, Konishi M, Imamura A, Ishida H, Kusumi A, Kiso M. Syhtheses of fluorescent gangliosides for the studies of raft domains. Methods Enzymol, 597: 239-263, 2017. doi: 10.1016/bs.mie.2017.06.004. PMID: 28935104
  2. Suzuki KGN#(#corresponding authors), Ando H#, Komura N, Fujiwara TK, Kiso M, Kusumi A. Development of new ganglioside probes and unraveling of raft domain structure by single-molecule imaging. Biochim Biophys Acta, 1861: 2494-2506, 2017. doi: 10.1016/j.bbagen.2017.07.012. PMID: 28734966
  3. Kinoshita M*, Suzuki KGN*(*equal contribution), Matsumori N, Takeda M, Ano H, Morigaki K, Abe M, Makino A, Kobayashi T, Hirosawa KM, Fujiwara T, Kusumi A, Murata M. Raft-based sphingomyelin interactions revealed by new fluorescent sphingomyelin analogs. J Cell Biol, 216: 1183-1204, 2017. doi: 10.1083/jcb.201607086. PMID: 28330937

2016

  1. Komura N*, Suzuki KGN*(*equal contribution), Ando H*, Konishi M, Koikeda M, Imamura A, Chadda R, Fujiwara TK, Tsuboi H, Sheng R, Cho W, Furukawa K, Furukawa K, Yamauchi Y, Ishida H, Kusumi A, Kiso M. Raft-based interactions of gangliosides with a GPI-anchored receptor. Nat Chem Biol, 12: 402-410, 2016. doi: 10.1038/nchembio.2059. PMID: 27043189
  2. Fujiwara TK, Iwasawa K, Kalay Z, Tsunoyama TA, Watanabe Y, Umemura YM, Murakoshi H, Suzuki KGN, Nemoto YL, Morone N, Kusumi A. Confined diffusion of transmembrane proteins and lipids induced by the same actin meshwork lining the plasma membrane. Mol Cell Biol, 27: 1101-1119, 2016. doi: 10.1091/mbc.E15-04-0186. PMID: 26864625
  3. Suzuki KGN#(#corresponding author). Single-molecule imaging of signal transduction via GPI-anchored receptors. Methods Mol Biol, 1376: 229-238, 2016. doi: 10.1007/978-1-4939-3170-5_19. PMID: 26552688

2015

  1. Suzuki KGN. New insights into the organization of plasma membrane and its role in signal transduction. Int Rev Cell Mol Biol, 317: 67-96, 2015. doi: 10.1016/bs.ircmb.2015.02.004. PMID: 26008784

2014

  1. Hiramoto-Yamaki N, Tanaka KAK, Suzuki KGN, Hirosawa KM, Miyahara MS, Kalay Z, Tanaka K, Kasai RS, Kusumi A, Fujiwara TK. Ultrafast diffusion of a fluorescent cholesterol analog in compartmentalized plasma membranes. Traffic, 15: 583-612, 2014. doi: 10.1111/tra.12163. PMID: 24506328

2013

  1. Suzuki KGN#(#corresponding author), Kasai RS, Fujiwara TK, Kusumi A. Single-molecule imaging of receptor-receptor interactions. Methods Cell Biol, 117: 373-390, 2013. doi: 10.1016/B978-0-12-408143-7.00020-7. PMID: 24143988

2012

  1. Kusumi A, Fujiwara TK, Chadda R, Xie M, Tsunoyama TA, Kasai RS, Suzuki KGN. Organization principles of the plasma membrane for signal transduction: molecular dynamics in the three-tiered hierarchical meso-scale domain architecture. Ann Rev Cell Dev Biol, 28: 215-250, 2012. doi: 10.1146/annurev-cellbio-100809-151736. PMID: 22905956
  2. Suzuki KGN, Kasai RS, Hirosawa KM, Nemoto YL, Ishibashi M, Miwa Y, Fujiwara TK, Kusumi A. Transient GPI-anchored protein homodimers are units for raft organization and function. Nat Chem Biol, 8: 774-783, 2012. doi: 10.1038/nchembio.1028. PMID: 22820419
  3. Shibata AC, Fujiwara TK, Chen L, Suzuki KGN, Ishikawa Y, Nemoto YL, Miwa Y, Kalay Z, Chadda R, Naruse K, Kusumi A. Archipelago architecture of the focal adhesion: Membrane molecules freely enter and exit from the focal adhesion zone. Cytoskeleton, 69: 380-392, 2012. doi: 10.1002/cm.21032. PMID: 22488960
  4. Suzuki KGN. Lipid rafts generate digital-like signal transduction in cell plasma membrane. Biotechnol J, 7: 753-761, 2012. doi: 10.1002/biot.201100360. PMID: 22488962
  5. Kusumi A, Fujiwara TK, Morone N, Yoshida KJ, Chadda R, Xie M, Kasai RS, Suzuki KGN. Membrane mechanisms for signal transduction: The coupling of the meso-scale raft domains to membrane-skeleton-induced compartments and dynamic protein complex. Sem Cell Dev Biol, 23: 126-144, 2012. doi: 10.1016/j.semcdb.2012.01.018. PMID: 22309841

2011

  1. Kusumi A, Suzuki KGN, Kasai RS, Ritchie K, Fujiwara TK.  Hierarchical mesoscale domain organization of the plasma membrane. Trends Biochem Sci, 36: 604-615, 2011. doi: 10.1016/j.tibs.2011.08.001. PMID: 21917465
  2. Kasai RS, Suzuki KGN, Prossnitz ER, Koyama-Honda I, Nakada C, Fujiwara TK, Kusumi A. Full characterization of GPCR monomer-dimer dynamic equilibrium by single molecule imaging. J Cell Biol, 192: 463-480, 2011. doi: 10.1083/jcb.201009128. PMID: 21300851

2010

  1. Tanaka KAK*, Suzuki KGN*(*equal contribution), Shirai YM, Shibutani ST, Miyahara MS, Tsuboi H, Yahara M, Yoshimura A, Mayor S, Fujiwara TK, Kusumi A. Membrane molecules mobile even after chemical fixation. Nat Methods, 7: 865-866, 2010. doi: 10.1038/nmeth.f.314. PMID: 20881966
  2. Kusumi A, Shirai Y, Koyama-Honda I, Suzuki KGN, Fujiwara TK. Hierarchical organization of the plasma membrane investigations by single-molecule tracking vs. fluorescence correlation spectroscopy. FEBS Lett, 584:1814-1823, 2010. doi: 10.1016/j.febslet.2010.02.047. PMID: 20178787

2008

  1. Suzuki KGN#(#corresponding author), Kusumi A. Mechanism for signal transduction in the induced-raft domains as revealed by single molecule tracking. Trends Glycosci Glycotechnol, 20時34分1-351, 2008. 10.4052/tigg.20.341.
  2. Umemura YM, Vrljic M, Nishimura SY, Fujiwara TK, Suzuki KGN, Kusumi A. Both MHC class II and its GPI-anchored form undergo hop diffusion as observed by single-molecule tracking. Biophys J, 95: 435-450, 2008. doi: 10.1529/biophysj.107.123018. PMID: 18339737

2007

  1. Suzuki KGN, Fujiwara TK, Sanematsu F, Iino R, Edidin M, Kusumi A. GPI-anchored receptor clusters transiently recruit Lyn and G alpha for temporary cluster immobilization and Lyn activation: single molecule tracking study 1. J Cell Biol, 177: 717-730, 2007. doi: 10.1083/jcb.200609174. PMID: 17517964
  2. Suzuki KGN, Fujiwara TK, Edidin M, Kusumi A. Dynamic recruitment of phospholipase C gamma at transiently immobilized GPI-anchored receptor clusters induces IP3-Ca2+ signaling: single molecule study 2. J Cell Biol, 177: 731-742, 2007. doi: 10.1083/jcb.200609175. PMID: 1751796




Kasai Rinshi

2023

  1. Nishiguchi S#, Kasai RS#, Uchihashi T#. (# corresponding author) Antiparallel dimer structure of CELSR cadherin in solution revealed by high-speed atomic force microscopy. Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.2302047120

2022

  1. Yamamoto T&, Yasuda S&, Kasai RS, Nakano R, Hikiri S, Sugaya K, Hayashi T, Ogasawara S, Shiroishi M, Fujiwara TK, Kinoshita M#, Murata T#. A methodology for creating mutants of G-protein coupled receptors stabilized in active state by combining statistical thermodynamics and evolutionary molecular engineering. Protein Sci. doi: 10.1002/pro.4425 (& equally contributed)

2021

  1. Nagai R, Sugimachi A, Tanimoto Y, Suzuki KGN, Hayashi F, Weikert D, Gmeiner P, Kasai RS#, Morigaki K#. Functional reconstitution of dopamine D2 receptor into a supported model membrane in a nanometric confinement. Adv. Biol. (Weinh) doi: 10.1002/adbi.202100636
  2. Nagai R, Sugimachi A, Tanimoto Y, Suzuki KGN, Hayashi F, Kasai RS, Morigaki K#. パターン化人工膜への膜タンパク質の再構成 電気学会論文誌C 141: 1340-1343

2020

  1. Koyama-Honda I, Fujiwara TK, Kasai RS, Suzuki KGN, Kajikawa E, Tsuboi H, Tsunoyama TA, Kusumi A#. High-speed single-molecule imaging reveals signal transduction by induced transbilayer raft phases. J. Cell Biol. doi: 10.1083/jcb.202006125
  2. Nishiguchi T, Yoshimura H, Kasai RS, Fujiwara TK, Ozawa T#. Synergetic roles of Formyl Peptide Receptor 1 oligomerization in ligand-induced signal transduction. ACS Chem. Biol. 15: 2577-2587
  3. Muraoka T#, Noguchi D, Kasai RS, Sato K, Sasaki R, Tabata KV, Ekimoto T, Ikeguchi M, Kamagata K, Hoshino N, Noji H, Akutagawa T, Ichimura K, Kinbara K#. A synthetic ion channel with anisotropic ligand response. Nat. Commun. 11: 2924
  4. Kusumi A#, Fujiwara TK, Tsunoyama TA, Kasai RS, Liu A, Hirosawa KM, Kinoshita M, Matsumori N, Komura N, Ando H, Suzuki KGN. Defining raft domains in the plasma membrane. Traffic. 21: 106-137

2019

2018

  1. Tsunoyama TA, Watanabe Y, Goto J, Naito K, Kasai RS, Suzuki KGN, Fujiwara TK, Kusumi A#. Super-long single-molecule tracking reveals dynamic-anchorage-induced integrin function. Nat. Chem. Biol. 14: 497-506
  2. Kasai RS, Ito SV, Awane RM, Fujiwara TK, Kusumi A#. The Class-A GPCR dopamine D2 receptor forms transient dimers stabilized by agonists: detection by single-molecule tracking. Cell Biochem. Biophys. 76: 29-37

2017

  1. Nemoto YL, Morris RJ, Hijikata H, Tsunoyama TA, Shibata ACE, Kasai RS, Kusumi A#, Fujiwara TK#. Dynamic meso-scale anchorage of GPI-anchored receptors in the plasma membrane: prion protein vs. Thy1. Cell Biochem. Biophys. 75: 399-412
  2. Makino A, Abe M, Ishitsuka R, Murate M, Kishimoto T, Sakai S, Hullin-Matsuda F, Shimada Y, Inaba T, Miyatake H, Tanaka H, Kurahashi A, Pack CG, Kasai RS, Kubo S, Schieber NL, Dohmae N, Tochio N, Hagiwara K, Sasaki Y, Aida Y, Fujimori F, Kigawa T, Nishibori K, Parton RG, Kusumi A, Sako Y, Anderluh G, Yamashita M, Kobayashi T, Greimel P, Kobayashi T#. A novel sphingomyelin/cholesterol domain-specific probe reveals the dynamics of the membrane domains during virus release and in Niemann-Pick type FASEB J. 31: 1301-1322

2016

2015

2014

  1. Hiramoto-Yamaki N, Tanaka KA, Suzuki KG, Hirosawa KM, Miyahara MS, Kalay Z, Tanaka K, Kasai RS, Kusumi A#, Fujiwara TK#. Ultrafast diffusion of a fluorescent cholesterol analog in compartmentalized plasma membranes. Traffic. 15: 583-612
  2. Kusumi A#. Kasai RS. Class A GPCRs’ transient homodimers might be important for some of their key functions. Physiol. 592 Online Session “CROSSTALK” 15
  3. Kusumi A#, Tsunoyama TA, Hirosawa KM, Kasai RS, Fujiwara TK. Tracking single molecules at work in living cells. Nat. Chem. Biol. 10: 524-532
  4. Kasai RS, Kusumi A#. Single-molecule imaging revealed dynamic GPCR dimerization. Curr. Opin. Cell Biol. 27: 78-86

2013

  1. Nishimura H, Ritchie K, Kasai RS, Goto M, Morone N, Sugimura H, Tanaka K, Sase I, Yoshimura A, Nakano Y, Fujiwara TK, Kusumi A#. Biocompatible fluorescent silicon nanocrystals for single-molecule tracking and fluorescence imaging. J. Cell Biol. 202: 967-983
  2. Nagata KO, Nakada C, Kasai RS, Kusumi A#, Ueda K#. ABCA1 dimer-monomer interconversion during HDL generation revealed by single-molecule imaging. Proc. Natl. Acad. Sci. U.S.A. 110: 5034-5039
  3. Suzuki KGN#, Kasai RS, Fujiwara TK, Kusumi A. Single-Molecule Imaging of Receptor–Receptor Interactions. Methods Cell Biol. 117: 373-390

2012

  1. Suzuki KGN, Kasai RS, Hirosawa KM, Nemoto YL, Ishibashi M, Miwa Y, Fujiwara TK, Kusumi A#. Transient GPI-anchored protein homodimers are units for raft organization and function. Nat. Chem. Biol. 8: 774-783
  2. Cho KJ, Kasai RS, Park JH, Chigurupati S, Heidorn SJ, van der Hoeven D, Plowman SJ, Kusumi A, Marais R#, Hancock JF#. Raf inhibitors target ras spatiotemporal dynamics. Curr. Biol. 22: 945-955
  3. Kusumi A#, Fujiwara TK, Chadda R, Xie M, Tsunoyama TA, Kalay Z, Kasai RS, Suzuki KGN. Dynamic organizing principles of the plasma membrane that regulate signal transduction: commemorating the fortieth anniversary of Singer and Nicolson's fluid-mosaic model. Annu. Rev. Cell Dev. Biol. 28: 215-250
  4. Kusumi A#, Fujiwara TK, Morone N, Yoshida KJ, Chadda R, Xie M, Kasai RS, Suzuki KGN. Membrane mechanisms for signal transduction: the coupling of the meso-scale raft domains to membrane-skeleton-induced compartments and dynamic protein complexes. Semin. Cell Dev. Biol. 23: 126-144

2011

  1. Kasai RS, Suzuki KGN, Prossnitz ER, Koyama-Honda I, Nakada C, Fujiwara TK, Kusumi A#. Full Characterization of GPCR Monomer-Dimer Dynamic Equilibrium by Single Molecule Imaging. J. Cell Biol. 192: 463-480
  2. Kusumi A#, Suzuki KG, Kasai RS, Ritchie K, Fujiwara TK. Hierarchical mesoscale domain organization of the plasma membrane. Trends Biochem. Sci. 36: 604-615

Before 2010

  1. Morone N, Fujiwara T, Murase K, Kasai RS, Ike H, Yuasa S, Usukura J, Kusumi A#. Three-dimensional reconstruction of the membrane skeleton at the plasma membrane interface by electron tomography. J. Cell Biol. 174: 851-862 (2006)
  2. Koyama-Honda I, Ritchie K, Fujiwara T, Iino R, Murakoshi H, Kasai RS, Kusumi A#. Fluorescence Imaging for Monitoring the Colocalization of Two Single Molecules in Living Cells. Biophys. J. 88: 2126-2136 (2005)
  3. Kusumi A#, Nakada C, Ritchie K, Murase K, Suzuki K, Murakoshi H, Kasai RS, Kondo J, Fujiwara T. Paradigm Shift of the Plasma Membrane Concept from the Two-Dimensional Continuum Fluid to the Partitioned Fluid: High-Speed Single-Molecules Tracking of Membrane Molecules. Annu. Rev. Biophys. Biomol. Struc. 34: 351-378 (2005)
  4. Nakada C, Ritchie K, Oba Y, Nakamura M, Hotta Y, Iino R, Kasai RS, Yamaguchi K, Fujiwara T, Kusumi A#. Accumulation of anchored proteins forms membrane diffusion barriers during neuronal polarization. Nat. Cell Biol. 5: 626-632 (2003)
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