Naoya Sakamoto, M.D., Ph. D.

I am currently focusing on the molecular biology of cancer stem cell in the gastro-intestinal cancer organoids. Considering the correlation between histopathology and genetic-molecular abnormalities, we would like to expand the unique cancer research as a pathologist.

Official Title

• Division Head in pathology

Speciality

• Gastrointestinal pathology

キーワード

• Pahtology
• Gastric cancer
• Colorectal cancer
• Organoid
• Resistance against anti-cancer drugs

Current research

• Omics analysis using cancer organoids

Potential collaboration

• Identification of biomarkers using cancer organoids
• Mechanisms of acquisition of drug resistance in the cancer stem cells

Email

naosakam●east.ncc.go.jp（Replace ● to ＠）

Career history

• Hiroshima University School of Medicine (2005)
• Graduate School of Biomedical and Health Sciences,
  Hiroshima University (2010)
• Post-doctoral Fellow, University of Michigan,
  Comprehensive Cancer Center (2013-2016)
• Assistant professor, Graduate School of Biomedical and
  Health Sciences, Hiroshima University (2016-2020)
• Current position (2020-)

Affiliated societies

• Japanese Association of Pathology
• Japanese Cancer Association
• Japanese Cytology Association
• Japanese Gastric Cancer Association
• American Association for Cancer Research

Publications

1. Sakamoto N, Sekino Y, Fukada K, Pham QT, Honma R, Taniyama D, Ukai S, Takashima T, Hattori T, Naka K, Tanabe K, Ohdan H, Yasui W.: Uc.63+ contributes to gastric cancer progression through regulation of NF-kB signaling. Gastric Cancer. 2020, in press.
2. Takashima T, Sakamoto N, Murai J, Taniyama D, Honma R, Ukai S, Maruyama R, Kuraoka K, Rajapakse VN, Pommier Y, Yasui W.: Immunohistochemical analysis of SLFN11 expression uncovers potential non-responders to DNA-damaging agaents overlooked by tissue RNA-seq. Virchows Arch. 2020, in press.
3. Sekino Y, Sakamoto N, Ishikawa A, Honma R, Shigematsu Y, Hayashi T, Sentani K, Oue N, Teishima J, Matsubara A and Yasui W: Transcribed ultraconserved region Uc.63+ promotes resistance to cisplatin through regulation of androgen receptor signaling in bladder cancer. Oncol Rep 41(5):3111-3118, 2019
4. Sakamoto N, Feng Y, Stolfi C, Kurosu Y, Green M, Lin J, Green ME, Sentani K, Yasui W, Mcmahon M, Hardiman KM, Spence JR, Horita N, Greenson JK, Kuick R, Cho KR and Fearon ER: BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis. eLIFE 6:e20331, 2017
5. Sekino Y, Sakamoto N, Goto K, Honma R, Shigematsu Y, Sentani K, Oue N, Teishima J, Matsubara A and Yasui W: Transcribed ultraconserved region Uc.63+ promotes resistance to docetaxel through regulation of androgen receptor signaling in prostate cancer. Oncotarget 8(55): 94259-94270. 2017
6. Feng Y, Sakamoto N, Wu R, Liu JY, Wiese A, Green ME, Green M, Akyol A, Roy BC, Zhai Y, Cho KR, Fearon ER: Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium. PLoS Genet. 11(11). 2015