Molecular analyses of Head and Neck cancer and melanoma

A large sample of about 89 cases of oral, esophageal, and colorectal second solid tumors (post bone marrow transplantation cancer) linked to clinicopathological information was collected from multiple centers in Japan. Although some specimens were deficient due to qualitative evaluation, whole exome sequencing (WES) was completed for a total of 174 specimens from 79 cases. The number of cases included 31 oral cancer cases (69 specimens), 30 esophageal cancer cases (70 specimens), and 18 colorectal cancer cases (35 specimens). In addition, 79 age- and sex-matched primary solid tumors (31 oral cancer cases, 29 esophageal cancer cases, and 19 colorectal cancer cases) were collected from our biobank as a control group. A clinical-pathological database was established for these cases after detailed patient information (medical history, treatment, HLA match, serum data, drugs used, duration, etc.) and pathological analysis (site, multiplicity and spread, histological type, immunohistochemical staining, presence of viral infection, etc.) were performed.

Figure 3  Function of TP53 gene mutation in squamous cell carcinoma of head and neck and its relation to cancer progression and treatment.