トップページ > 2014年の刊行論文

2014年の刊行論文

List of Papers Published in 2014


Group for Cancer Development: 1. Division of Molecular Pathology; 2. Division of Genetics; 3. Division of Familial Cancer Research; 4. Division of Multistep Carcinogenesis; 5. Division of Virology; 6. Division of Cancer Development System

Group for Research of Molecular Functions and Targets: 7. Division of Metastasis and Invasion Signaling; 8. Division of Molecular and Cellular Medicine; 9. Division of Cancer Biology; 10. Division of Cancer Differentiation; 11. Division of Hematological Malignancy

Group for Development of Molecular diagnostics and Individualized Therapy: 12. Division of Pharmacogenomics; 13. Division of Pharmacoproteomics; 14. Division of Epigenomics; 15. Division of Genome Biology; 16. Division of Cancer Genomics

Group for Translational Research: 17. Division of Cancer Pathophysiology; 18. Division of Cancer Stem Cell; 19. Division of Gene and Immune Medicine; 20. Division of Genome Stability Research; 21. Division of Chemotherapy and Clinical Research

Core Facilities for Research and Innovative Medicine: 22. Central Animal Division; 23. Central Radioisotope Division; 24. Core Facility Division

Project Group: 25. Division of Refractory Cancer Research; 26. Division of Cancer Prevention Research; 27. Division of Integrative Omics and Bioinformatics; 28. Division of Brain Tumor Translational Research

Group for Translational Research Support Core: 29. Department of Biobank Support Core; 30. Department of Clinical Pharmacology; 31. Department of Translational Research Seeds Evaluation; 32. Department of Clinical Genomics; 33. Department of Translational Oncology; 34. Department of Biomarker Evaluation; 35. Department of Bioinformatics

1. Division of Molecular Pathology

2. Division of Genetics

1. Oue N, Anami K, Schetter AJ, Moehler M, Okayama H, Khan MA, Bowman ED, Mueller A, Schad A, Shimomura M, Hinoi T, Aoyagi K, Sasaki H, Okajima M, Ohdan H, Galle PR, Yasui W, Harris CC. High miR-21 expression from FFPE tissues is associated with poor survival and response to adjuvant chemotherapy in colon cancer. Int J Cancer, 134:1926-1934, 2014

2. Oue N, Naito Y, Hayashi T, Takigahira M, Kawano-Nagatsuma A, Sentani K, Sakamoto N, Zarni Oo H, Uraoka N, Yanagihara K, Ochiai A, Sasaki H, Yasui W. Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-α secretion in gastric cancer. Oncogene, 33:3918-3926, 2014

3. Division of Familial Cancer Research

4. Division of Multistep Carcinogenesis

5. Division of Virology

6. Division of Cancer Development System

3. Igarashi M, Hippo Y, Ochiai M, Fukuda H, Nakagama H. AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats. Biochem Biophys Res Commun, 443:852-857, 2014

4. Iwasaki M, Mukai T, Takachi R, Ishihara J, Totsuka Y, Tsugane S. Validity of a self-administered food frequency questionnaire in the estimation of heterocyclic aromatic amines. Cancer Causes Control, 25:1015-1028, 2014

5. Kikuchi R, Ohata H, Ohoka N, Kawabata A, Naito M. APOLLON protein promotes early mitotic CYCLIN　A degradation independent of the spindle assembly checkpoint. J Biol Chem, 289:3457-3467, 2014

6. Komiya M, Fujii G, Takahashi M, Shimura M, Noma N, Shimizu S, Onuma W, Mutoh M. Bi-directional regulation between adiponectin and plasminogen activator-inhibitor-1 in 3T3-L1 cells. In Vivo, 28:13-19, 2014

7. Mikawa T, Maruyama T, Okamoto K, Nakagama H, Lleonart ME, Tsusaka T, Hori K, Murakami I, Izumi T, Takaori-Kondo A, Yokode M, Peters G, Beach D, Kondoh H. Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2. J Cell Biol, 204:729-745, 2014

8. Mutoh M, Takahashi M, Wakabayashi K. Chemoprevention of colorectal cancer by anti-inflammatory agents. In: Hiraku Y, Kawanishi S, Ohshima H (eds), Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects. Chichester, John Wiley & Sons, Inc, pp 285-299, 2014

9. Ochiai M, Hippo Y, Izumiya M, Watanabe M, Nakagama H. Newly defined aberrant crypt foci as a marker for dysplasia in the rat colon. Cancer Sci, 105:943-950, 2014

10. Sakai H, Sato A, Aihara Y, Ikarashi Y, Midorikawa Y, Kracht M, Nakagama H, Okamoto K. MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells. Cancer Sci, 105:425-430, 2014

11. Terasaki M, Mutoh M, Fujii G, Takahashi M, Ishigamori R, Masuda S. Potential ability of xanthophylls to prevent obesity-associated cancer. World J Pharmacol, 3:140-152, 2014

12. Totsuka Y, Watanabe T, Coulibaly S, Kobayashi S, Nishizaki M, Okazaki M, Hasei T, Wakabayashi K, Nakagama H. In vivo genotoxicity of a novel heterocyclic amine, aminobenzoazepinoquinolinone-derivative (ABAQ), produced by the Maillard reaction between glucose and l-tryptophan. Mutat Res, 760:48-55, 2014

13. Yamamoto N, Okano K, Kushida Y, Deguchi A, Yachida S, Suzuki Y. Clinicopathology of recurrent hepatocellular carcinomas after radiofrequency ablation treated with salvage surgery. Hepatol Res, 44:1062-1071, 2014

7. Division of Metastasis and Invasion Signaling

14. Yamaguchi H, Yoshida N, Takanashi M, Ito Y, Fukami K, Yanagihara K, Yashiro M, Sakai R. Stromal fibroblasts mediate extracellular matrix remodeling and invasion of scirrhous gastric carcinoma cells. PLoS One, 9:e85485, 2014

8. Division of Molecular and Cellular Medicine

15. Chen AK, Sengupta P, Waki K, Van Engelenburg SB, Ochiya T, Ablan SD, Freed EO, Lippincott-Schwartz J. MicroRNA binding to the HIV-1 Gag protein inhibits Gag assembly and virus production. Proc Natl Acad Sci U S A, 111:E2676-E2683, 2014

16. Fujita Y, Kuwano K, Ochiya T. Challenges and strategies for pulmonary delivery of microRNA-based therapeutics. In: Babashah S (ed), MicroRNAs: Key Regulators of Oncogenesis. Switzerland, Springer, pp 413-428, 2014

17. Fujita Y, Kuwano K, Ochiya T. The potential role of MicroRNA-based therapy for lung cancer stem cells. In: Sarkar FH (ed), MicroRNA Targeted Cancer Therapy. Switzerland, Springer International Publishing, pp 83-98, 2014

18. Fujita Y, Kuwano K, Ochiya T, Takeshita F. The impact of extracellular vesicle-encapsulated circulating microRNAs in lung cancer research. Biomed Res Int, 2014:486413, 2014

19. Fujita Y, Yoshioka Y, Ito S, Araya J, Kuwano K, Ochiya T. Intercellular communication by extracellular vesicles and their microRNAs in asthma. Clin Ther, 36:873-881, 2014

20. Fujiwara T, Katsuda T, Hagiwara K, Kosaka N, Yoshioka Y, Takahashi RU, Takeshita F, Kubota D, Kondo T, Ichikawa H, Yoshida A, Kobayashi E, Kawai Akira, Ozaki T, Ochiya T. Clinical relevance and therapeutic significance of microRNA-133a expression profiles and functions in malignant osteosarcoma-initiating cells. Stem Cells, 32:959–973, 2014

21. Fujiwara T, Kawai A, Nezu Y, Fujita Y, Kosaka N, Ozaki T, Ochiya T. Circulating microRNAs in sarcoma: potential biomarkers for diagnosis and targets for therapy. Chemotherapy, 3:1000123, 2014

22. Fujiwara T, Kunisada T, Takeda K, Uotani K, Yoshida A, Ochiya T, Ozaki T. MicroRNAs in soft tissue sarcomas: overview of the accumulating evidence and importance as novel biomarkers. Biomed Res Int, 2014:592868, 2014

23. Fujiwara T, Takahashi RU, Kosaka N, Nezu Y, Kawai A, Ozaki T, Ochiya T. RPN2 gene confers osteosarcoma cell malignant phenotypes and determines clinical prognosis. Mol Ther Nucleic Acids, 3:e189, 2014

24. Hagiwara K, Ochiya T, Kosaka N. A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications. Drug Deliv Transl Res, 4:31-37, 2014

25. Haldrup C, Kosaka N, Ochiya T, Borre M, Høyer S, Orntoft TF, Sorensen KD. Profiling of circulating microRNAs for prostate cancer biomarker discovery. Drug Deliv Transl Res, 4:19-30, 2014

26. Izumi H, Kosaka N, Shimizu T, Sekine K, Ochiya T, Takase M. Time-dependent expression profiles of microRNAs and mRNAs in rat milk whey. PLoS One, 9:e88843, 2014

27. Katsuda T, Ikeda S, Yoshioka Y, Kosaka N, Kawamata M, Ochiya T. Physiological and pathological relevance of secretory microRNAs and a perspective on their clinical application. Biol Chem, 395:365-373, 2014

28. Katsuda T, Kosaka N, Ochiya T. The roles of extracellular vesicles in cancer biology: toward the development of novel cancer biomarkers. Proteomics, 14:412-425, 2014

29. Katsuda T, Kurata H, Tamai R, Banas A, Ishii T, Ishikawa S, Ochiya T. The in vivo evaluation of the therapeutic potential of human adipose tissue-derived mesenchymal stem cells for acute liver disease. Methods Mol Biol, 1213:57-67, 2014

30. Kosaka N, Yoshioka Y, Tominaga N, Hagiwara K, Katsuda T, Ochiya T. Dark side of the exosome: the role of the exosome in cancer metastasis and targeting the exosome as a strategy for cancer therapy. Future Oncol, 10:671-681, 2014

31. Kurata H, Tamai R, Katsuda T, Ishikawa S, Ishii T, Ochiya T. Adipose tissue-derived mesenchymal stem cells in regenerative medicine treatment for liver cirrhosis - focused on efficacy and safety in preclinical and clinical studies. JSM Regen Med, 2:1012, 2014

32. Ochiya T, Takenaga K, Endo H. Silencing of S100A4, a metastasis-associated protein, in endothelial cells inhibits tumor angiogenesis and growth. Angiogenesis, 17:17-26, 2014

33. Ono M, Kosaka N, Tominaga N, Yoshioka Y, Takeshita F, Takahashi RU, Yoshida M, Tsuda H, Tamura K, Ochiya T. Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells. Sci Signal, 7:ra63, 2014

34. Osaki M, Kosaka N, Okada F, Ochiya T. Circulating microRNAs in drug safety assessment for hepatic and cardiovascular toxicity: the latest biomarker frontier? Mol Diagn Ther, 18:121-126, 2014

35. Otsuka K, Ochiya T. Genetic networks lead and follow tumor development: microRNA regulation of cell cycle and apoptosis in the p53 pathways. Biomed Res Int, 2014:749724, 2014

36. Seino S, Takeshita F, Asari A, Masuda Y, Kunou M, Ochiya T. No influence of exogenous hyaluronan on the behavior of human cancer cells or endothelial cell capillary formation. J Food Sci, 79:T1469-T1475, 2014

37. Takahashi RU, Miyazaki H, Ochiya T. The role of microRNAs in the regulation of cancer stem cells. Front Genet, 4:1-11, 2014

38. Takahashi RU, Ochiya T. RPN2: a promising therapeutic target for breast cancer? J Stem Cells Res, Rev & Rep, 1:2, 2014

39. Thirion M, Kanda T, Murakami Y, Ochiya T, Iizasa H. MicroRNAs and oncogenic human viruses. In: Babashah S (ed), MicroRNAs: Key Regulators of Oncogenesis. Switzerland, Springer, pp 155-182, 2014

40. Tominaga N, Hagiwara K, Kosaka N, Honma K, Nakagama H, Ochiya T. RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy. Mol Cancer, 13:134, 2014

41. Yoshioka Y, Kosaka N, Konishi Y, Ohta H, Okamoto H, Sonoda H, Nonaka R, Yamamoto H, Ishii H, Mori M, Furuta K, Nakajima T, Hayashi H, Sugisaki H, Higashimoto H, Kato T, Takeshita F, Ochiya T. Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen. Nat Commun, 5:3591, 2014

9. Division of Cancer Biology

10. Division of Cancer Differentiation

11. Division of Hematological Malignancy

12. Division of Pharmacogenomics

13. Division of Pharmacoproteomics

42. Hosoya N, Sakumoto M, Tomita Y, Kondo T. Approach to spot overlapping problem in 2D-PAGE revealed clinical and functional significance of RKIP and MnSOD in renal cell carcinoma. EuPA Open Proteomics, 4:129-139, 2014

43. Ito M, Hagiyama M, Mimae T, Inoue T, Kato T, Yoneshige A, Nakanishi J, Kondo T, Okada M, Ito A. α-Parvin, a pseudopodial constituent, promotes cell motility and is associated with lymph node metastasis of lobular breast carcinoma. Breast Cancer Res Treat, 144:59-69, 2014

44. Kondo T. Casting doubt on the traditional approach of cancer biomarker discovery through proteomics. Expert Rev Proteomics, 11:9-12, 2014

45. Kondo T. Inconvenient truth: cancer biomarker development by using proteomics. Biochim Biophys Acta, 1844:861-865, 2014

46. Kondoa T, Kawai A. A proteomics approach for the development of sarcoma biomarkers. EuPA Open Proteomics, 4:121-128, 2014

47. Kubota D, Yoshida A, Kawai A, Kondo T. Proteomics identified overexpression of SET oncogene product and possible therapeutic utility of protein phosphatase 2A in alveolar soft part sarcoma. J Proteome Res, 13:2250-2261, 2014

48. Kubota D, Yoshida A, Kikuta K, Saito T, Suehara Y, Gotoh M, Kawai A, Kondo T. Proteomic approach to gastrointestinal stromal tumor identified prognostic biomarkers. J Proteomics Bioinform, 7:10-16, 2014

49. Mimae T, Ito A, Hagiyama M, Nakanishi J, Hosokawa Y, Okada M, Murakami Y, Kondo T. A novel approach to pseudopodia proteomics: excimer laser etching, two-dimensional difference gel electrophoresis, and confocal imaging. Protoc exch, 2014:1-23, 2014

50. Mukaihara K, Kubota D, Yoshida A, Asano N, Suehara Y, Kaneko K, Kawai A, Kondo T. Proteomic profile of epithelioid sarcoma. J Proteomics Bioinform, 7:158-165, 2014

51. Suehara Y, Kohsaka S, Kubota D, Mukaihara K, Akaike K, Mineki R, Fujimura T, Kaneko K, Ladanyi M, Saito T, Kondo T. Proteomic technologies to develop biomarkers and functional analyses for bone and soft tissue tumors. J Proteomics Bioinform, pp 1-13, 2014

52. Tani Y, Tajima T, Kawai A, Unuma Y, Kinoshita H, Kondo T. Evaluation of a novel automated machine, the auto2D, for two-dimensional gel electrophoresis. J Proteomics Bioinform, 7:108-111, 2014

53. Uemura N, Kondo T. Current status of predictive biomarkers for neoadjuvant therapy in esophageal cancer. World J Gastrointest Pathophysiol, 5:322-334, 2014

14. Division of Epigenomics

54. Brücher BL, Lyman G, van Hillegersberg R, Pollock RE, Lordick F, Yang HK, Ushijima T, Yeoh KG, Skricka T, Polkowski W, Wallner G, Verwaal V, Garofalo A, D'Ugo D, Roviello F, Steinau HU, Wallace TJ, Daumer M, Maihle N, Reid TJ 3rd, Ducreux M, Kitagawa Y, Knuth A, Zilberstein B, Steele SR, Jamall IS. Imagine a world without cancer. BMC Cancer, 14:186, 2014

55. Hattori N, Ushijima T. Compendium of aberrant DNA methylation and histone modifications in cancer. Biochem Biophys Res Commun, 455:3-9, 2014

56. Imaoka T, Nishimura M, Doi K, Tani S, Ishikawa K, Yamashita S, Ushijima T, Imai T, Shimada Y. Molecular characterization of cancer reveals interactions between ionizing radiation and chemicals on rat mammary carcinogenesis. Int J Cancer, 134:1529-1538, 2014

57. Liu Z, Zhang J, Gao Y, Pei L, Zhou J, Gu L, Zhang L, Zhu B, Hattori N, Ji J, Yuasa Y, Kim W, Ushijima T, Shi H, Deng D. Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis. Clin Cancer Res, 20:4598-4612, 2014

58. Okochi-Takada E, Hattori N, Tsukamoto T, Miyamoto K, Ando T, Ito S, Yamamura Y, Wakabayashi M, Nobeyama Y, Ushijima T. ANGPTL4 is a secreted tumor suppressor that inhibits angiogenesis. Oncogene, 33:2273-2278, 2014

59. Ueda Y, Ando T, Nanjo S, Ushijima T, Sugiyama T. DNA methylation of microRNA-124a is a potential risk marker of colitis-associated cancer in patients with ulcerative colitis. Dig Dis Sci, 59:2444-5451, 2014

60. Ushijima T. Cancer epigenetics: now harvesting fruit and seeding for common diseases. Biochem Biophys Res Commun, 455:1-2, 2014

61. Yamada M, Fukagawa T, Nakajima T, Asada K, Sekine S, Yamashita S, Okochi-Takada E, Taniguchi H, Kushima R, Oda I, Saito Y, Ushijima T, Katai H. Hereditary diffuse gastric cancer in a Japanese family with a large deletion involving CDH1. Gastric Cancer, 17:750-756, 2014

62. Yoshida T, Kato J, Inoue I, Yoshimura N, Deguchi H, Mukoubayashi C, Oka M, Watanabe M, Enomoto S, Niwa T, Maekita T, Iguchi M, Tamai H, Utsunomiya H, Yamamichi N, Fujishiro M, Iwane M, Takeshita T, Ushijima T, Ichinose M. Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer. Int J Cancer, 134:1445-1457, 2014

15. Division of Genome Biology

63. Kato K, Nakajima K, Ui A, Muto-Terao Y, Ogiwara H, Nakada S. Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice. Mol Cell, 53:617-630, 2014

64. Kinno T, Tsuta K, Shiraishi K, Mizukami T, Suzuki M, Yoshida A, Suzuki K, Asamura H, Furuta K, Kohno T, Kushima R. Clinicopathological features of nonsmall cell lung carcinomas with BRAF mutations. Ann Oncol, 25:138-142, 2014

65. Kohno T, Tsuchihara K, Ogiwara H, Ichikawa H. RET and other genes: therapeutic targets in lung adenocarcinoma. Lung Cancer Manag, 3:219-226, 2014

66. Kurioka D, Takeshita F, Tsuta K, Sakamoto H, Watanabe S, Matsumoto K, Watanabe M, Nakagama H, Ochiya T, Yokota J, Kohno T, Tsuchiya N. NEK9-dependent proliferation of cancer cells lacking functional p53. Sci Rep, 4:6111, 2014

67. Mizukami T, Shiraishi K, Shimada Y, Ogiwara H, Tsuta K, Ichikawa H, Sakamoto H, Kato M, Shibata T, Nakano T, Kohno T. Molecular mechanisms underlying oncogenic RET fusion in lung adenocarcinoma. J Thorac Oncol, 9:622-630, 2014

68. Nakaoku T, Tsuta K, Ichikawa H. Druggable oncogene fusions in invasive mucinous lung adenocarcinoma. Clin Cancer Res , 20:3087-3093, 2014

69. Ogata-Kawata H, Izumiya M, Kurioka D, Honma Y, Yamada Y, Furuta K, Gunji T, Ohta H, Okamoto H, Sonoda H, Watanabe M, Nakagama H, Yokota J, Kohno T, Tsuchiya N. Circulating exosomal microRNAs as biomarkers of colon cancer. PLoS One, 9:e92921, 2014

70. Oike T, Komachi M, Ogiwara H, Amornwichet N, Saitoh Y, Torikai K, Kubo N, Nakano T, Kohno T. C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe. Radiother Oncol, 111:222-227, 2014

71. Oike T, Ogiwara H, Amornwichet N, Nakano T, Kohno T. Chromatin-regulating proteins as targets for cancer therapy. J Radiat Res, 55:613-628, 2014

72. Oike T, Ogiwara H, Nakano T, Kohno T. Proposal for a synthetic lethality therapy using the paralog dependence of cancer cells--response. Cancer Res, 74:4948-4949, 2014

73. Romero OA, Torres-Diz M, Pros E, Savola S, Gomez A, Moran S, Saez C, Iwakawa R, Villanueva A, Montuenga LM, Kohno T, Yokota J, Sanchez-Cespedes M. MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1. Cancer Discov, 4:292-303, 2014

74. Saito M, Ishigame T, Tsuta K, Kumamoto K, Imai T, Kohno T. A mouse model of KIF5B-RET fusion-dependent lung tumorigenesis. Carcinogenesis, 35:2452-2456, 2014

75. Saito M, Shiraishi K, Matsumoto K, Schetter AJ, Ogata-Kawata H, Tsuchiya N, Kunitoh H, Nokihara H, Watanabe S, Tsuta K, Kumamoto K, Takenoshita S, Yokota J, Harris CC, Kohno T. A three-microRNA signature predicts responses to platinum-based doublet chemotherapy in patients with Lung adenocarcinoma. Clin Cancer Res, 20:4784-4793, 2014

76. Shiraishi K, Kohno T. Genetic susceptibility to lung adenocarcinoma. Genes Environ, 36:160-166, 2014

77. Tsuta K, Kohno T, Yoshida A, Shimada Y, Asamura H, Furuta K, Kushima R. RET-rearranged non-small-cell lung carcinoma: a clinicopathological and molecular analysis. Br J Cancer, 110:1571-1578, 2014

78. Ui A, Ogiwara H, Nakajima S, Kanno S, Watanabe R, Harata M, Okayama H, Harris CC, Yokota J, Yasui A, Kohno T. Possible involvement of LKB1-AMPK signaling in non-homologous end joining. Oncogene, 33:1640-1648, 2014

79. Wang Z, Zhu B, Zhang M, Parikh H, Jia J, Chung CC, Sampson JN, Hoskins JW, Hutchinson A, Burdette L, Ibrahim A, Hautman C, Raj PS, Abnet CC, Adjei AA, Ahlbom A, Albanes D, Allen NE, Ambrosone CB, Aldrich M, Amiano P, Amos C, Andersson U, Andriole GJ, Andrulis IL, Arici C, Arslan AA, Austin MA, Baris D, Barkauskas DA, Bassig BA, Beane Freeman LE, Berg CD, Berndt SI, Bertazzi PA, Biritwum RB, Black A, Blot W, Boeing H, Boffetta P, Bolton K, Boutron-Ruault MC, Bracci PM, Brennan P, Brinton LA, Brotzman M, Bueno-de-Mesquita HB, Buring JE, Butler MA, Cai Q, Cancel-Tassin G, Canzian F, Cao G, Caporaso NE, Carrato A, Carreon T, Carta A, Chang GC, Chang IS, Chang-Claude J, Che X, Chen CJ, Chen CY, Chen CH, Chen C, Chen KY, Chen YM, Chokkalingam AP, Chu LW, Clavel-Chapelon F, Colditz GA, Colt JS, Conti D, Cook MB, Cortessis VK, Crawford ED, Cussenot O, Davis FG, De Vivo I, Deng X, Ding T, Dinney CP, Di Stefano AL, Diver WR, Duell EJ, Elena JW, Fan JH, Feigelson HS, Feychting M, Figueroa JD, Flanagan AM, Fraumeni JFJ, Freedman ND, Fridley BL, Fuchs CS, Gago-Dominguez M, Gallinger S, Gao YT, Gapstur SM, Garcia-Closas M, Garcia-Closas R, Gastier-Foster JM, Gaziano JM, Gerhard DS, Giffen CA, Giles GG, Gillanders EM, Giovannucci EL, Goggins M, Gokgoz N, Goldstein AM, Gonzalez C, Gorlick R, Greene MH, Gross M, Grossman HB, Grubb R, Gu J, Guan P, Haiman CA, Hallmans G, Hankinson SE, Harris CC, Hartge P, Hattinger C, Hayes RB, He Q, Helman L, Henderson BE, Henriksson R, Hoffman-Bolton J, Hohensee C, Holly EA, Hong YC, Hoover RN, Hosgood HD, Hsiao CF, Hsing AW, Hsiung CA, Hu N, Hu W, Hu Z, Huang MS, Hunter DJ, Inskip PD, Ito H, Jacobs EJ, Jacobs KB, Jenab M, Ji BT, Johansen C, Johansson M, Johnson A, Kaaks R, Kamat AM, Kamineni A, Karagas M, Khanna C, Khaw KT, Kim C, Kim IS, Kim JH, Kim YH, Kim YC, Kim YT, Kang CH, Jung YJ, Kitahara CM, Klein AP, Klein R, Kogevinas M, Koh WP, Kohno T, Kolonel LN, Kooperberg C, Kratz CP, Krogh V, Kunitoh H, Kurtz RC, Kurucu N, Lan Q, Lathrop M, Lau CC, Lecanda F, Lee KM, Lee MP, Le Marchand L, Lerner SP, Li D, Liao LM, Lim WY, Lin D, Lin J, Lindstrom S, Linet MS, Lissowska J, Liu J, Ljungberg B, Lloreta J, Lu D, Ma J, Malats N, Mannisto S, Marina N, Mastrangelo G, Matsuo K, McGlynn KA, McKean-Cowdin R, McNeill LH, McWilliams RR, Melin BS, Meltzer PS, Mensah JE, Miao X, Michaud DS, Mondul AM, Moore LE, Muir K, Niwa S, Olson SH, Orr N, Panico S, Park JY, Patel AV, Patino-Garcia A, Pavanello S, Peeters PHM, Peplonska B, Peters U, Petersen GM, Picci P, Pike MC, Porru S, Prescott J, Pu X, Purdue MP, Qiao YL, Rajaraman P, Riboli E, Risch HA, Rodabough RJ, Rothman N, Ruder AM, Ryu JS, Sanson M, Schned A, Schumacher FR, Schwartz AG, Schwartz KL, Schwenn M, Scotlandi K, Seow A, Serra C, Serra M, Sesso HD, Severi G, Shen H, Shen M, Shete S, Shiraishi K, Shu XO, Siddiq A, Sierrasesumaga L, Sierri S, Loon Sihoe AD, Silverman DT, Simon M, Southey MC, Spector L, Spitz M, Stampfer M, Stattin P, Stern MC, Stevens VL, Stolzenberg-Solomon RZ, Stram DO, Strom SS, Su WC, Sund M, Sung SW, Swerdlow A, Tan W, Tanaka H, Tang W, Tang ZZ, Tardon A, Tay E, Taylor PR, Tettey Y, Thomas DM, Tirabosco R, Tjonneland A, Tobias GS, Toro JR, Travis RC, Trichopoulos D, Troisi R, Truelove A, Tsai YH, Tucker MA, Tumino R, Van Den Berg D, Van Den Eeden SK, Vermeulen R, Vineis P, Visvanathan K, Vogel U, Wang C, Wang C, Wang J, Wang SS, Weiderpass E, Weinstein SJ, Wentzensen N, Wheeler W, White E, Wiencke JK, Wolk A, Wolpin BM, Wong MP, Wrensch M, Wu C, Wu T, Wu X, Wu YL, Wunder JS, Xiang YB, Xu J, Yang HP, Yang PC, Yatabe Y, Ye Y, Yeboah ED, Yin Z, Ying C, Yu CJ, Yu K, Yuan JM, Zanetti KA, Zeleniuch-Jacquotte A, Zheng W, Zhou B, Mirabello L, Savage SA, Kraft P, Chanock SJ, Yeager M, Landi MT, Shi J, Chatterjee N, Amundadottir LT. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33. Hum Mol Genet, 23:6616-6633, 2014

80. Watanabe R, Ui A, Kanno SI, Ogiwara H, Nagase T, Kohno T, Yasui A. SWI/SNF factors required for cellular resistance to DNA damage include ARID1A and ARID1B and show interdependent protein stability. Cancer Res, 74:2465-2475, 2014

16. Division of Cancer Genomics

81. Arai Y, Totoki Y, Hosoda F, Shirota T, Hama N, Nakamura H, Ojima H, Furuta K, Shimada K, Okusaka T, Kosuge T, Shibata T. Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma. Hepatology, 59:1427-1434, 2014

82. Katsurada Y, Yoshida M, Maeshima AM, Ikeda K, Shibata T, Kinoshita T, Matsubara O, Tsuda H. Wide local extension and higher proliferation indices are characteristic features of symptomatic lobular neoplasias (LNs) and LNs with early invasive component. Histopathology, 64:994-1003, 2014

83. Murakami S, Chishima S, Uemoto H, Sakamoto E, Sato T, Kurabe N, Kawasaki Y, Shibata T, Akiyama H, Tashiro F. The male-specific factor Sry harbors an oncogenic function. Oncogene, 33:2978-2986, 2014

84. Shibata T, Aburatani H. Exploration of liver cancer genomes. Nat Rev Gastroenterol Hepatol, 11:340-349, 2014

85. Suenaga Y, Islam SMR, Alagu J, Kaneko Y, Kato M, Tanaka Y, Kawana H, Hossain S, Matsumoto D, Yamamoto M, Shoji W, Itami M, Shibata T, Nakamura Y, Ohira M, Haraguchi S, Takatori A, Nakagawara A. NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas. PLoS Genet, 10:e1003996, 2014

86. Sugita S, Arai Y, Tonooka A, Hama N, Totoki Y, Fujii T, Aoyama T, Asanuma H, Tsukahara T, Kaya M, Shibata T, Hasegawa T. A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of ewing-like sarcoma. Am J Surg Pathol, 38:1571-1576, 2014

87. Takahashi H, Ojima H, Shimizu H, Furuse J, Furukawa H, Shibata T. Axitinib (AG-013736), an oral specific VEGFR TKI, shows potential therapeutic utility against cholangiocarcinoma. Jpn J Clin Oncol, 44:570-578, 2014

88. Totoki Y, Yoshida A, Hosoda F, Nakamura H, Hama N, Ogura K, Yoshida A, Fujiwara T, Arai Y, Toguchida J, Tsuda H, Miyano S, Kawai A, Shibata T. Unique mutation portraits and frequent COL2A1 gene alteration in chondrosarcoma. Genome Res, 24:1411-1420, 2014

89. Yoshida A, Tsuta K, Wakai S, Arai Y, Asamura H, Shibata T, Furuta K, Kohno T, Kushima R. Immunohistochemical detection of ROS1 is useful for identifying ROS1 rearrangements in lung cancers. Mod Pathol, 27:711-720, 2014

17. Division of Cancer Pathophysiology

90. Fujii H, Hayashida K, Saitoh A, Yokoyama A, Hirayama S, Iwai T, Nakata E, Nemoto T, Sudo Y, Uezono Y, Yamada M, Nagase H. Novel delta opioid receptor agonists with oxazatricyclodecane structure. ACS Med Chem Lett, 5:368-372, 2014

91. Fujitsuka N, Uezono Y. Rikkunshito, a ghrelin potentiator, ameliorates anorexia–cachexia syndrome. Front Pharmacol, 5:271, 2014

92. Harayama N, Kayano T, Moriya T, Kitamura N, Shibuya I, Tanaka-Yamamoto K, Uezono Y, Ueta Y, Sata T. Analysis of G-protein-activated inward rectifying K⁺ (GIRK) channel currents upon GABA_B receptor activation in rat supraoptic neurons. Brain Res, 1591:1-13, 2014

93. Horishita T, Yanagihara N, Ueno S, Sudo Y, Uezono Y, Okura D, Minami T, Kawasaki T, Sata T. Neurosteroids allopregnanolone sulfate and pregnanolone sulfate have diverse effect on the α subunit of the neuronal voltage-gated sodium channels Na_v1.2, Na_v1.6, Na_v1.7, and Na_v1.8 expressed in Xenopus oocytes. Anesthesiology, 121:620-631, 2014

94. Ishikawa S, Takeda A, Akimoto M, Kounoike N, Uchinuma E, Uezono Y. Effects of neuropeptides and their local administration to cutaneous wounds in sensory-impaired areas. J Plast Surg Hand Surg, 48:143-147, 2014

95. Kono T, Kaneko A, Matsumoto C, Miyagi C, Ohbuchi K, Mizuhara Y, Miyano K, Uezono Y. Multitargeted effects of hangeshashinto for treatment of chemotherapy-induced oral mucositis on inducible prostaglandin E2 production in human oral keratinocytes. Integr Cancer Ther, 13:435-445, 2014

96. Kono T, Takeda H, Shimada M, Kase Y, Uezono Y. Novel therapeutics for adverse effects of antitumor therapy: the promise of multicomponent, traditional Japanese herbal remedies. J Carcinog Mutagen, S8:7, 2014

97. Miyano K, Sudo Y, Yokoyama A, Hisaoka-Nakashima K, Morioka N, Takebayashi M, Nakata Y, Higami Y, Uezono Y. History of the G protein-coupled receptor (GPCR) assays from traditional to a state-of-the-art biosensor assay. J Pharmacol Sci, 126:302-309, 2014

98. Mizuno K, Kono T, Suzuki Y, Miyagi C, Omiya Y, Miyano K, Kase Y, Uezono Y. Goshajinkigan, a traditional Japanese medicine, prevents oxaliplatin-induced acute peripheral neuropathy by suppressing functional alteration of TRP channels in rat. J Pharmacol Sci, 125:91-98, 2014

99. Morita K, Shiraishi S, Motoyama N, Kitayama T, Kanematsu T, Uezono Y, Dohi T. Palliation of bone cancer pain by antagonists of platelet-activating factor receptors. PLoS One, 9:e91746, 2014

100. Motoyama N, Morita K, Shiraishi S, Kitayama T, Kanematsu T, Uezono Y, Dohi T. Relief of cancer pain by glycine transporter inhibitors. Anesth Analg, 119:988-995, 2014

101. Nagamura Y, Terawaki K, Uezono Y, Tsukada T. Enhancement of catecholamine release from PC12 cells by the traditional Japanese medicine, rikkunshito. BMC Complement Altern Med, 14:256, 2014

102. Okura D, Horishita T, Ueno S, Yanagihara N, Sudo Y, Uezono Y, Sata T. The endocannabinoid anandamide inhibits voltage-gated sodium channels Na_v1.2, Na_v1.6, Na_v1.7, and Na_v1.8 in Xenopus oocytes. Anesth Analg, 118:554-562, 2014

103. Terawaki K, Sawada Y, Kashiwase Y, Hashimoto H, Yoshimura M, Suzuki M, Miyano K, Sudo Y, Shiraishi S, Higami Y, Yanagihara K, Kase Y, Ueta Y, Uezono Y. New cancer cachexia rat model generated by implantation of a peritoneal dissemination-derived human stomach cancer cell line. Am J Physiol Endocrinol Metab, 306:E373-387, 2014

104. Yokoyama T, Minami K, Terawaki K, Miyano K, Ogata J, Maruyama T, Takeuchi M, Uezono Y, Ueta Y. Kisspeptin-10 potentiates miniature excitatory postsynaptic currents in the rat supraoptic nucleus. Brain Res, 1583:45-54, 2014

105. Yoshimura M, Hagimoto M, Matsuura T, Ohkubo J, Ohno M, Maruyama T, Ishikura T, Hashimoto H, Kakuma T, Yoshimatsu H, Terawaki K, Uezono Y, Toyohira Y, Yanagihara N, Ueta Y. Effects of food deprivation on the hypothalamic feeding-regulating peptides gene expressions in serotonin depleted rats. J Physiol Sci, 64:97-104, 2014

18. Division of Cancer Stem Cell

19. Division of Gene and Immune Medicine

106. Aida K, Miyakawa R, Suzuki K, Narumi K, Udagawa T, Yamamoto Y, Chikaraishi T, Yoshida T, Aoki K. Suppression of Tregs by anti-glucocorticoid induced TNF receptor antibody enhances the antitumor immunity of interferon-α gene therapy for pancreatic cancer. Cancer Sci, 105:159-167, 2014

107. Hashimoto H, Ueda R, Narumi K, Heike Y, Yoshida T, Aoki K. Type I IFN gene delivery suppresses regulatory T cells within tumors. Cancer Gene Ther, 21:532-541, 2014

108. Yamamoto Y, Goto N, Miura K, Narumi K, Ohnami S, Uchida H, Miura Y, Yamamoto M, Aoki K. Development of a novel efficient method to construct an adenovirus library displaying random peptides on the fiber knob. Mol Pharm, 11:1069-1074, 2014

109. Yamamoto Y, Hiraoka N, Goto N, Rin Y, Miura K, Narumi K, Uchida H, Tagawa M, Aoki K. A targeting ligand enhances infectivity and cytotoxicity of an oncolytic adenovirus in human pancreatic cancer tissues. J Control Release, 192:284-293, 2014

20. Division of Genome Stability Research

21. Division of Chemotherapy and Clinical Research

110. Fujimori H, Hirai T, Inoue K, Koizumi F, Masutani M. The distinctive properties of parp and parg as a cancer therapeutic target. JSM Clin Oncol Res, 2:1033, 2014

22. Central Animal Division

111. Imai T, Kitahashi T. A 13-week toxicity study of acrylamide administered in drinking water to hamsters. J Appl Toxicol, 34:57-65, 2014

23. Central Radioisotope Division

24. Core Facility Division

25. Division of Refractory Cancer Research

26. Division of Cancer Prevention Research

27. Division of Integrative Omics and Bioinformatics

112. Katoh M. WNT signaling in neoplasia. In: Gelmann EP, Sawyers CL, Rauscher FJ III (eds), Molecular Oncology. U.K., Cambridge University Press, pp 243-257, 2014

113. Katoh M. Cardio-miRNAs and onco-miRNAs: circulating miRNA-based diagnostics for non-cancerous and cancerous diseases. Front Cell Dev Biol, 2:61, 2014

114. Katoh M, Nakagama H. FGF Receptors: Cancer Biology and Therapeutics. Med Res Rev, 34:280-300, 2014

28. Division of Brain Tumor Translational Research

115. Fukushima S, Narita Y, Yonezawa M, Ohno M, Arita H, Miyakita Y, Ichimura K, Yoshida A, Shibui S. Short communication: sclerosing meningioma in the deep sylvian fissure. Brain Tumor Pathol, 31:289-292, 2014

116. Fukushima S, Otsuka A, Suzuki T, Yanagisawa T, Mishima K, Mukasa A, Saito N, Kumabe T, Kanamori M, Tominaga T, Narita Y, Shibui S, Kato M, Shibata T, Matsutani M, Nishikawa R, Ichimura K. Mutually exclusive mutations of KIT and RAS are associated with KIT mRNA expression and chromosomal instability in primary intracranial pure germinomas. Acta Neuropathol, 127:911-925, 2014

117. Kwiecinska A, Ichimura K, Berglund M, Dinets A, Sulaiman L, Collins VP, Larsson C, Porwit A, Lagercrantz SB. Amplification of 2p as a genomic marker for transformation in lymphoma. Genes Chromosomes Cancer, 53:750-768, 2014

118. Quillien V, Lavenu A, Sanson M, Legrain M, Dubus P, Karayan-Tapon L, Mosser J, Ichimura K, Figarella-Branger D. Outcome-based determination of optimal pyrosequencing assay for MGMT methylation detection in glioblastoma patients. J Neurooncol, 116:487-496, 2014

119. Shimizu K, Mineharu Y, Imamura H, Asai K, Imai Y, Ichimura K, Sakai N. Intracranial germinomas in a father and his son. Childs Nerv Syst, 30:2143-2146, 2014

29. Department of Biobank Support Core

30. Department of Clinical Pharmacology

120. Yatsuga C, Toyohisa D, Fujisawa TX, Nishitani S, Shinohara K, Matsuura N, Ikeda S, Muramatsu M, Hamada A, Tomoda A. No association between catechol-O-methyltransferase (COMT) genotype and attention deficit hyperactivity disorder (ADHD) in Japanese children. Brain Dev, 36:620-625, 2014

31. Department of Translational Research Seeds Evaluation

121. Katsui-Taniyama T, Nokihara H, Tsuta K, Horinouchi H, Kanda S, Fujiwara Y, Yamamoto N, Koizumi F, Yunokawa M, Tamura T. Clinicopathological features in young patients treated for small-cell lung cancer: significance of immunohistological and molecular analyses. Clin Lung Cancer, 15:244-247, 2014

122. Murakami A, Takahashi F, Nurwidya F, Kobayashi I, Minakata K, Hashimoto M, Nara T, Kato M, Tajima K, Shimada N, Iwakami SI, Moriyama M, Moriyama H, Koizumi F, Takahashi K. Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor. PLoS One, 9:e86459, 2014

123. Nakadate Y, Kodera Y, Kitamura Y, Shirasawa S, Tachibana T, Tamura T, Koizumi F. KRAS mutation confers resistance to antibody-dependent cellular cytotoxicity of cetuximab against human colorectal cancer cells. Int J Cancer, 134:2146-2155, 2014

124. Watanabe M, Uehara Y, Yamashita N, Fujimura Y, Nishio K, Sawada T, Takeda K, Koizumi F, Koh Y. Multicolor detection of rare tumor cells in blood using a novel flow cytometry-based system. Cytometry A, 85:206-213, 2014

32. Department of Clinical Genomics

33. Department of Translational Oncology

125. Oue N, Anami K, Schetter AJ, Moehler M, Okayama H, Khan MA, Bowman ED, Mueller A, Schad A, Shimomura M, Hinoi T, Aoyagi K, Sasaki H, Okajima M, Ohdan H, Galle PR, Yasui W, Harris CC. High miR-21 expression from FFPE tissues is associated with poor survival and response to adjuvant chemotherapy in colon cancer. Int J Cancer, 134:1926-1934, 2014

126. Oue N, Naito Y, Hayashi T, Takigahira M, Kawano-Nagatsuma A, Sentani K, Sakamoto N, Zarni Oo H, Uraoka N, Yanagihara K, Ochiai A, Sasaki H, Yasui W. Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-α secretion in gastric cancer. Oncogene, 33:3918-3926, 2014

34. Department of Biomarker Evaluation

35. Department of Bioinformatics

127. Yasushi Totoki, Kenji Tatsuno, Kyle R Covington, Hiroki Ueda, Chad J Creighton, Mamoru Kato, Shingo Tsuji, Lawrence A Donehower, Betty L Slagle, Hiromi Nakamura, Shogo Yamamoto, Eve Shinbrot, Natsuko Hama, Megan Lehmkuhl, Fumie Hosoda, Yasuhito Arai, Kim Walker, Mahmoud Dahdouli, Kengo Gotoh, Genta Nagae, Marie-Claude Gingras, Donna M Muzny, Hidenori Ojima, Kazuaki Shimada, Yutaka Midorikawa, John A Goss, Ronald Cotton, Akimasa Hayashi, Junji Shibahara, Shumpei Ishikawa, Jacfranz Guiteau, Mariko Tanaka, Tomoko Urushidate, Shoko Ohashi, Naoko Okada, Harsha Doddapaneni, Min Wang, Yiming Zhu, Huyen Dinh, Takuji Okusaka, Norihiro Kokudo, Tomoo Kosuge, Tadatoshi Takayama, Masashi Fukayama, Richard A Gibbs, David A Wheeler, Hiroyuki Aburatani & Tatsuhiro Shibata
Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.
Nature Genetics, 2014, 46, 1267-1273.

128. Tatsuji Mizukami, Kouya Shiraishi, Yoko Shimada, Hideaki Ogiwara, Koji Tsuta, Hitoshi Ichikawa, Hiromi Sakamoto, Mamoru Kato, Tatsuhiro Shibata, Takashi Nakano, Takashi Kohno,
Molecular mechanisms underlying oncogenic RET fusion in lung adenocarcinoma.
Journal of Thoracic Oncology, 2014, 9, 622-630.

129. Shintaro Fukushima, Ayaka Otsuka, Tomonari Suzuki, Takaaki Yanagisawa, Kazuhiko Mishima, Akitake Mukasa, Nobuhito Saito, Toshihiro Kumabe, Masayuki Kanamori, Teiji Tominaga, Yoshitaka Narita, Soichiro Shibui, Mamoru Kato, Tatsuhiro Shibata, Masao Matsutani, Ryo Nishikawa, Koichi Ichimura, On behalf of the Intracranial Germ Cell Tumor Genome Analysis Consortium (iGCT Consortium)
Mutually exclusive mutations of KIT and RAS are associated with KIT mRNA expression and chromosomal instability in primary intracranial pure germinomas
Acta Neuropathologica, 2014, 127, 911-925

130. Yusuke Suenaga, S. M. Rafiqul Islam, Jennifer Alagu, Yoshiki Kaneko, Mamoru Kato, Yukichi Tanaka, Hidetada Kawana, Shamim Hossain, Daisuke Matsumoto, Mami Yamamoto, Wataru Shoji, Makiko Itami, Tatsuhiro Shibata, Yohko Nakamura, Miki Ohira, Seiki Haraguchi, Atsushi Takatori, Akira Nakagawara.
NCYM, a de novo evolved protein, stabilizes MYCN and characterizes human neuroblastoma.
PLoS Genetics, 2014, 10, e1003996.1-14