Publications

Research Papers (2005-2018)

2017-2018

1. Ogiwara H, Takahashi K, Sasaki M, Kuroda T, Watanabe R, Yoshida H, Maruyama A, Makinoshima H, Chiwaki F, Sasaki H, Kato T, Okamoto A, Kohno T. Targeting Vulnerability of Glutathione Metabolic Pathway in ARID1A-Deficient Cancers. Cancer Cell. 2019 Jan 16. pii: S1535-6108(18)30581-6. doi: 10.1016/j.ccell.2018.12.009.

2. Kamei R, Yoshimura K, Yoshino S, Inoue M, Asao T, Fuse M, Wada S, Kuramasu A, Furuya-Kondo T, Oga A, Iizuka N, Suzuki N, Maeda N, Watanabe Y, Matsukuma S, Iida M, Takeda S, Ueno T, Yamamoto N, Fukagawa T, Katai H, Sasaki H, Hazama S, Oka M, Nagano H.Expression levels of UL16 binding protein 1 and natural killer group 2 member D affect overall survival in patients with gastric cancer following gastrectomy. Oncol Lett. 2018 Jan;15(1):747-754. doi: 10.3892/ol.2017.7354.

3. Tamaoki M, Komatsuzaki R, Komatsu M, Minashi K, Aoyagi K, Nishimura T, Chiwaki F, Hiroki T, Daiko H, Morishita K, Sakai Y, Seno H, Chiba T, Muto M, Yoshida T, Sasaki H. Multiple roles of single-minded 2 in esophageal squamous cell carcinoma and its clinical implications. Cancer Sci., 2018 Apr;109(4):1121-1134. doi: 10.1111/cas.13531. PMID: 29427302

4. Saeki N, Saito A, Sugaya Y, Amemiya M, Ono H, Komatsuzaki R, Yanagihara K, Sasaki H. Chromatin immunoprecipitation and DNA sequencing identified a LIMS1/ILK pathway regulated by LMO1 in neuroblastoma. Cancer Genomics Proteomics. 2018 May-Jun;15(3):165-174.PMID: 29695398

5. Tanabe S, Aoyagi K, Yokozaki H, Sasaki H. PTCH1 pathway network model in diffuse-type gastric cancer and epithelial-mesenchymal transition. Journal of Stem Cell Research and Medicine, 3, 1-15, 2018.

6. Tanabe S, Aoyagi K, Yokozaki H, Sasaki H. Molecular network pathway of ERBB in diffuse-type gastric cancer, mesenchymal stem cells and epithelial-mesenchymal transition. Journal of Clinical Epigenetics, 4, 2:13, 2018.

7. Saeki N, Saito A, Sugaya Y, Amemiya M, Sasaki H. Indirect Down-regulation of Tumor-suppressive let-7 Family MicroRNAs by LMO1 in Neuroblastoma.　Cancer Genomics Proteomics. 2018 Sep-Oct;15(5):413-420. doi: 10.21873/cgp.20100. PMID: 30194082

8. Tanabe S, Aoyagi K, Yokozak Ki, Sasaki H. Molecular pathway network of EFNA1 in cancer and mesenchymal stem cells. AIMS Cell and Tissue Engineering, 2, 58-77, 2018.

9. Nagasato M, Rin Y, Yamamoto Y, Henmi M, Hiraoka N, Chiwaki F, Matsusaki K, Tagawa M, Sasaki H, Aoki K. A tumor-targeting adenovirus with high gene-transduction efficiency for primary pancreatic cancer and ascites cells. Anticancer Res, 37: 3599-3605, 2017.

10. Nakamura K, Komatsu M, Chiwaki F, Takeda T, Kobayashi Y, Banno K, Aoki D, Yoshida T, Sasaki H. SIM2l attenuates resistance to hypoxia and tumor growth by transcriptional suppression of HIF1A in uterine cervical squamous cell carcinoma. Scientific Rep, 7: 14574, doi: 10.1038/s41598-017-15261-4, 2017.

11. Fukuoka S, Kojima T, Koga Y, Yamauchi M, Komatsu M, Komatsuzaki R, Sasaki H, Yasunaga M, Matsumura Y, Doi T, Ohtsu A. Preclinical efficacy of Sym004, novel anti-EGFR antibody mixture, in esophageal squamous cell carcinoma cell lines. Oncotarget, 8: 11020-11029, 2017. PMID: 28038457 PMCID: PMC5355242 DOI: 10.18632/oncotarget.14209

12. Nishimura T, Tamaoki M, Komatsuzaki R, Oue N, Taniguchi H, Komatsu M, Aoyagi A, Minashi K, Chiwaki F, Shinohara H, Tachimori Y, Yasui W, Muto M, Yoshida T, Sakai Y, Sasaki H. SIX1 maintains tumor basal cells via TGF-β pathway and associates with poor prognosis in esophageal cancer. Cancer Sci, 108: 216-225, 2017. PMID: 27987372 PMCID: PMC5329162 DOI: 10.1111/cas.13135

2016

13. Kurashige J, Hasegawa T, Niida A, Deng N, Mima K, Uchi R, Sawada G, Takahashi Y, Eguchi H, Sugimachi K, Inomata M, Kitano S, Fukagawa T, Sasako M, Sasaki H, Saya H, Mori M, Yanagihara K, Baba H, Miyano S, Tan P, Mimori K. Integrated molecular profiling of human gastric cancer identifies DDR2 as a potential regulator of peritoneal dissemination. Scientific Reports, 6: 22371, 2016. PMID:26934957 PMCID: PMC4776110 DOI: 10.1038/srep22371

14. Hidema S, Fukuda T, Date S, Tokitake Y, Matsui Y, Sasaki H, Nishimori K. Transgenic expression of telomerase reverse transcriptase (Tert) improbes cell proliferation of primary cells and enhances reprogramming efficiency into the induced pluripotent stem cell. Biosci Biotechnol Biochem, 80: 1925-1933, 2016. PMID: 27297181 DOI: 10.1080/09168451.2016.1191330

15. Tanabe S, Aoyagi K, Yokozaki H, Sasaki H. Regulation of CTNNB1 signaling in gastric cancer and stem cells. World J Gastrointest Oncol, 8: 592-598, 2016. PMID: 27574551 PMCID: PMC4980649 DOI:10.4251/wjgo.v8.i8.59

2015

16. Tanabe S, Aoyagi K, Yokozaki H, Sasaki H. Regulated genes in mesenchymal stem cells and gastric cancer. W. J. Stem Cells, 7: 208-222, 2015. PMID: 25621121 PMCID: PMC4300932 DOI:10.4252/wjsc.v7.i1.208

17. Saeki N, Ono H, Yanagihara K, Aoyagi K, Sasaki H, Sakamoto H, Yoshida T. rs2294008T, a risk allele for gastric and gallbladder cancers, suppresses the PSCA promoter by recruiting the transcription factor YY1. Genes Cells, 20: 382-391, 2015. PMID: 25727947 DOI: 10.1111/gtc.12228

18. Yamanoi K, Arai E, Tian Y, Takahashi Y, Miyata S, Sasaki H, Chiwaki F, Ichikawa H, Sakamoto H, Kushima R, Katai H, Yoshida T, Sakamoto M, Kanai Y. Epigenetic clustering of gastric carcinomas based on DNA methylation profiles at the precancerous stage: its correlation with tumor aggressiveness and patient outcome. Carcinogenesis, 36: 509-520, 2015. PMID: 25740824 PMCID: PMC4417340 DOI:10.1093/carcin/bgv013

19. Saeki N, Komatsuzaki R, Chiwaki F, Yanagihara K, Sasaki H. A GSDMB enhancer-driven HSV thymidine kinase-expressing vector for controlling occult peritoneal dissemination of gastric cancer. BMC Cancer, 15: 439-447, 2015. PMID: 26016667 PMCID: PMC4446855 DOI: 10.1186/s12885-015-1436-1

20. Higuchi Y, Kojima M, Ishii G, Aoyagi K, Sasaki H, Ochiai A. Gastrointestinal fibroblasts have specialized, diverse transcriptional phenotypes: a comprehensive gene expression analysis of human fibroblasts. PLoS One, 10(6): e0129241, 2015. PMID: 26046848 PMCID: PMC4457624 DOI:10.1371/journal.pone.0129241

21. Suzuki M, Chiwaki F, Sawada Y, Ashikawa M, Aoyagi K, Fujita T, Yanagihara K, Komatsu M, Narita M, Suzuki T, Nagase H, Kushima R, Sakamoto H, Fukagawa T, Katai H, Nakagama H, Yoshida T, Uezono Y, Sasaki H. Peripheral opioid antagonist enhances the effect of anti-tumor drug by blocking a cell growth-suppressive pathway in vivo. PLoS One, 10(4): e0123407, 2015. PMID: 25853862 PMCID: PMC4390307 DOI: 10.1371/journal.pone.0123407

22. Fujita T, Chiwaki F, Takahashi R, Aoyagi K, Yanagihara K, Nishimura T, Tamaoki M, Komatsu M, Komatsuzaki R, Matsusaki K, Ichikawa H, Sakamoto H, Yamada Y, Fukagawa T, Katai H, Konno H, Ochiya T, Yoshida T, Sasaki H. Identification and characterization of CXCR4-positive gastric cancer stem cells. PLoS One, 10(6): e0130808, 2015. PMID: 26110809 PMCID: PMC4481351 DOI:10.1371/journal.pone.0130808

23. Tanabe S, Komatsu M, Aoyagi K, Yokozaki H, Sasaki H. Implications of epithelial-mesenchymal transition in gastric cancer. Transl. Gastrointest. Cancer, 4: 258-264, 2015.

24. Naito Y, Oue N, Pham T.T.B, Yamamoto M, Fujihara M, Ishida T, Mukai S, Sentani K, Sakamoto N, Hida E, Sasaki H, Yasui W. Characteristic miR-24 expression in gastric cancers among atomic bomb survivors, Pathobiol., 82: 68-75, 2015. PMID: 26045155 DOI: 10.1159/000398809

25. Tanaka Y, Aoyagi K, Minashi K, Komatsuzaki R, Komatsu M, Chiwaki F, Tamaoki M, Nishimura T, Takahashi Y, Oda I, Tachimori Y, Arao T, Nishio K, Kitano S, Narumi K, Aoki K, Fujii S, Ochiai A, Yoshida T, Muto M, Yamada Y, Sasaki H. Discovery of a good responder subtype of esophageal squamous cell carcinoma with cytotoxic T-lymphocyte signatures activated by chemoradiotherapy. PLoS One, 10(12): e0143804, 2015. PMID: 26625258 PMCID: PMC4666638 DOI:10.1371/journal.pone.0143804

2014

26. Oue N, Anami K, Schetter AJ, Moehler M, Okayama H, Khan MA, Bowman ED, Mueller A, Schad A, Shimomura M, Hinoi T, Aoyagi K, Sasaki H, Okajima M, Ohdan H, Galle PR, Yasui W, Harris CC. High miR-21 expression from FFPE tissues is associated with poor survival and response to adjyuvant chemotherapy in colon cancer. Int. J. Cancer, 134: 1926-1934, 2014. PMID: 24122631 PMCID:PMC3947446 DOI: 10.1002/ijc.28522

27. Sakamoto N, Naito Y, Oue N, Sentani K, Uraoka N, Zarni Oo H, Yanagihara K, Aoyagi K, Sasaki H, Yasui W. MicroRNA-148a is downregulated in gastric cancer, targets MMP7, and indicates tumor invasiveness and poor prognosis. Cancer Sci., 105: 236-243, 2014. PMID: 24283384 PMCID: PMC4317816 DOI: 10.1111/cas.12330

28. Maeda R, Ishii G, Neri S, Aoyagi K, Haga H, Sasaki H, Nagai K, Ochiai A. Circulating CD14+CD204+ cells predict postoperative recurrence in non-small-cell lung cancer patients. J. Thorac. Oncol., 9: 179-188, 2014. PMID: 24419414 DOI: 10.1097/JTO.0000000000000044

29. Kojima M, Higuchi Y, Yokota M, Ishii G, Saito N, Aoyagi K, Sasaki H, Ochiai A. Human subperitoneal fibroblast and cancer cell interaction creates microenvironment that enhances tumor progression and metastasis. PLoS One, 9(2), e88018, 2014. PMID: 24505356 PMCID: PMC3913740 DOI:10.1371/journal.pone.0088018

30. Oue N, Naito Y, Hayashi T, Takigahira M, Kawano-Nagatsuma A, Sentani K, Sakamoto N, Zarni Oo H, Uraoka N, Yanagihara K, Ochiai A, Sasaki H, Yasi W. Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-a secretion in gastric cancer. Oncogene, 33:3918-3926, 2014. PMID: 23995782 DOI: 10.1038/onc.2013.364

31. Tanabe S, Aoyagi K, Yokozaki H, Sasaki H. Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition. Int. J. Oncol., 44: 1955-1970, 2014. PMID:24728500 DOI: 10.3892/ijo.2014.2387

32. Komatsu M, Sasaki H. DNA methylation is a key factor in understanding differentiation phenotype in esophageal squamous cell carcinoma. Epigenomics, 6: 567-569, 2014. PMID: 25531249 DOI:10.2217/epi.14.56

33. Tanabe S, Aoyagi K, Yokozaki H, Sasaki H. Gastric-related markers and their significance in cancer. J. Med. Genomics Biomark., 44: 1955-1970, 2014.

2013

34. Fujita T, Yanagihara K, Takeshita F, Aoyagi K, Takigahira M, Chiwaki F, Fukagawa T, Katai H, Ochiya T, Sakamoto H, Konno H, Yoshida T, Sasaki H. Intraperitoneal delivery of a small interfering RNA targeting NEDD1 prolongs the survival of scirrhous gastric cancer model mice. Cancer Sci. 104: 214-222, 2013. PMID: 23106787 DOI: 10.1111/cas.12054

35. Aoyagi K, Tamaoki M, Nishimura T, Sasaki H. Technical consideration for analyzing EMT-MET data from surgical samples. Cancer Lett., 341: 105-110, 2013. PMID: 23933174 DOI:10.1016/j.canlet.2013.08.001

36. Ono H, Chihara D, Chiwaki F, Yanagihara K, Sasaki H, Sakamoto H, Tanaka H, Yoshida T, Saeki N, Matsuo K. Missense allele of a single nucleotide polymorphism rs2294008 attenuated antitumor effects of prostate stem cell antigen in gallbladder cancer cells. J. Carcinogenesis, 12:4, 2013. PMID:23599686 PMCID: PMC3622366 DOI: 10.4103/1477-3163.109030

37. Ichikawa H, Kanda T, Kosugi S, Kawachi Y, Sasaki H, Wakai T, Kondo T. Laser microdissection and two-dimensional difference gel electrophoresis reveal the role of a novel macrophahge-capping ptotein in lymph node metastasis in gastric cancer. J Proteome Res., 12: 3780-3791, 2013. PMID: 23782053 DOI: 10.1021/pr400439m

38. Ishii H, Sasaki H, Aoyagi K, Yamazaki T. Classification of gastric cancer subtypes using ICA, MLR and Bayesian network. Stud. Health Technol. Inform., 192: 1014, 2013. PMID: 23920788

2012

39. Ono H, Hiraoka N, Lee Y-S, Woo SM, Lee WJ, Choi IJ, Saito A, Yanagihara K, Kanai Y, Ohnami S, Sakamoto H, Chiwaki F, Sasaki H, Yoshida T, Saeki N. Prostate stem cell antigen, a presumable organ-dependent tumor suppressor gene, is down-regulated in gallbladder carcinogenesis. Genes Chromosomes Cancer, 51:30-41, 2012. PMID: 21936014 DOI: 10.1002/gcc.20928

40. Satoh Y, Mori K, Kitano K, Kitayama J, Yokota H, Sasaki H, Uozaki H, Fukayama M, Seto M, Nagawa H, Yatomi Y, Takai D. Analysis for thecombination expression of CK20, FABP1, and MUC2 is sensitive for the prediction of peritoneal recurrence in gastric cancer. Jpn. J. Clin. Oncol., 42: 148-152, 2012. PMID: 22172348 DOI: 10.1093/jjco/hyr179

41. Saeki N, Sasaki H. Gasdermin superfamily: a novel gene family fuctioning in epithelial cells. In Endothelium and Epithelium: Composition and Functions. Carrasco J and Mota M (edits) Nova Science (2012)

42. Oue N, Noguchi T, Anami K, Kitano S, Sakamoto N, Sentani K, Uraoka N, Aoyagi K, Yoshida T, Sasaki H, Yasui W. Cytokewratin 7 is a predictive marker for survival in patients with esophageal squamous cell carcinoma. Ann. Surg. Oncol. 19: 1902-1910, 2012. PMID: 22203179 DOI: 10.1245/s10434-011-2175-4

43. Matsumoto K, Arao T, Hamaguchi T, Shimada Y, Kato K, Oda I, Taniguchi H, Koizumi F, Yanagihara K, Sasaki H, Nishio K, Yamada Y. FGFR2 gene amplification and clinicopathological features in gastric cancer. Br. J. Cancer 106: 727-732, 2012. PMID: 22240789 PMCID: PMC3322955 DOI:10.1038/bjc.2011.603

44. Sentani K, Oue N, Naito Y, Sakamoto N, Anami K, Oo HZ, Uraoka N, Aoyagi K, Sasaki H, Yasui W. Upregulation of HOXA10 in gastric cancer with intestinal mucin phenotype: reduction during tumor progression and favorable prognosis. Carcinogenesis 33: 1081-1088, 2012. PMID: 22411957 DOI:10.1093/carcin/bgs121

45. Nishimura K, Semba S, Aoyagi K, Sasaki H, Yokozaki H. Mesenchymal stem cells provide an advantageous tumor microenvironment for the restoration of cancer stem cells. Pathobiology 79: 290-306, 2012. PMID: 22688186 DOI: 10.1159/000337296

46. Suzuki M, Narita M, Ashikawa M, Furuta S, Matoba M, Sasaki H, Yanagihara K, Terawaki K Suzuki T, Uezono Y. Changes in the melanocortin receptors in the hypothalamus of a rat model of cancer cachexia. Synapse 66: 747-751, 2012. PMID: 22460823 DOI: 10.1002/syn.21559

47. Suzuki M, Narita M, Hasegawa M, Furuta S, Kawamata T, Miyano K, Yanagihara K, Chiwaki F, Ochiya T, Suzuki T, Matoba M, Sasaki H, Uezono Y. Sensation of abdominal pain induced by peritoneal carcinomatosis is accompanied by changes in the expression of substance P and m-opioid receptors in the spinal cord of mice. Anesthesiology 117: 847-856, 2012. PMID: 22913923 DOI:10.1097/ALN.0b013e31826a4ac8

48. Imoto A, Mitsunaga S, Inagaki M, Aoyagi K, Sasaki H, Ikeda M, Nakachi K, Higuchi K, Ochiai A. Neural invasion induces cachexia via astrocytic activation of neural route in pancreatic cancer. Int J Cancer 131:2795-2807, 2012. PMID: 22511317 DOI: 10.1002/ijc.27594

49. Sakamoto N, Oue N, Sentani K, Anami K, Uraoka N, Naito Y, Oo HZ, Ohdan H, Yanagihara K, Aoyagi K, SasakiH, Yasui W. Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer. Cancer Sci. 103:1744-1750, 2012. PMID: 22676223 DOI:10.1111/j.1349-7006.2012.02353.x

50. Naito Y, Oue N, Hinoi T, Sakamoto N, Sentani K, Ohdan H, Yanagihara K, Sasaki H, Yasui W. RegIV is a direct target of intestinal transcription factor CDX2 in gastric cancer PLoS One 7(11): e47545, 2012. PMID: 23133598 PMCID: PMC3487720 DOI: 10.1371/journal.pone.0047545

2011

51. Wang K, Diskin SJ, Attiyeh EF, Winter C, Schnepp RW, Diamond M, Zhang H, Hou C, Bosse K, Mayes P, Glessner J, Kim C, Frackelton E, Garris M, Wang Q, Glaberson W, Chiavacci R, Nguyen L, Saeki N, Sasaki H, Grant SFA, Mosse YP, Iolascon A, Hannenhalli S, Li H, Devoto M, McGrady PW, London WB, Capasso M, Rahman N, Hakonarson H, Maris JM. Integrative genomics identifies LMO1 as a neuroblastoma oncogene. Nature, 469: 216-220, 2011. PMID: 21124317 PMCID: PMC3320515 DOI: 10.1038/nature09609

52. Saeki N, Saito A, Choi JI, Matsuno K, Ohnami S, Totsuka H, Chiku S, Kuchiba A, Lee Y-S, Yoon K-A, Kook M-C, Park SR, Kim Y-W, Tanaka H, Tajima K, Hirose H, Tanioka F, Matsuno Y, Sugimura H, Kato S, Nakamura T, Nishina T, Yasui W, Aoyagi K, Sasaki H, Yanagihara K, Katai H, Shimoda T, Yoshida T, Nakamura Y, Hirohashi S, Sakamoto H. Chromosome 1q22 is a susceptibility locus of diffuse-type gastric cancer, harboring a functional SNP of MUC1. Gastroenterology, 140: 892-902, 2011. PMID: 21070779 DOI: 10.1053/j.gastro.2010.10.058

53. Aoyagi K, Minashi K, Igaki H, Tachimori Y, Nishimura T, Hokamura N, Ashida A, Daiko H, Ochiai A, Muto M, Ohtsu A, Yoshida T, Sasaki H. Artificially induced epithelial-mesenchymal transition in surgicasl subjects: its implications in clinical and basic cancer research. PLoS One, 6(4):e18196, 2011. PMID: 21533028 PMCID: PMC3080870 DOI: 10.1371/journal.pone.0018196

54. Oue N, Noguchi T, Anami K, Sentani K, Sakamoto N, Uraoka N, Wakamatsu Y, Sasaki H, Yasui W. Serum concentration and expression of Reg IV in patients with esophageal cancer: age-related elevation of serum Reg IV concentration. Oncol Lett, 2: 235-239, 2011. PMID: 22866070 PMCID: PMC3410574 DOI: 10.3892/ol.2011.239

55. Hoshino A, Ishii G, Aoyagi K, Ohtaki Y, Nagai K, Sasaki H, Ochiai A. Podoplanin-positive fibroblasts enriched at perivasucular region enhance lung adenocarcinoma tumor formation Cancer Res., 71: 4769-4779, 2011. PMID: 21610106 DOI: 10.1158/0008-5472.CAN-10-3228

56. Shibata T, Kokubo A, Saito S, Narisawa-Saito M, Sasaki H, Aoyagi K, Yoshimastu Y, Katai H, Kushima R, Kiyono T, Yamamoto M, Hirohashi S. Molecular signatures of NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer. Neoplasia, 13: 864-873, 2011. PMID: 21969819 PMCID: PMC3182278

2010

57. Sano M, Aoyagi K, Takahashi H, Kawamura T, Mabuchi T, Igaki H, Tachimori Y, Kato H, Ochiai A, Honda H, Nimura Y, Nagino M, Yoshida T, Sasaki H. Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamouse cell carcinomas with extensive lymph node metastasis. Int. J. Oncol., 36: 321-330, 2010. PMID: 20043065

58. Ueda T, Volinia S, Okumura H, Shimizu M, Taccioli C, Rossi S, Alder H, Liu CG, Oue N, Yasui W, Yoshida K, Sasaki H, Nomura S, Seto M, Kaminishi M, Calin GA, Croce CM. Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. Lancet Oncol., 11: 136-146, 2010. PMID: 20022810 PMCID: PMC4299826 DOI: 10.1016/S1470-2045(09)70343-2

59. Mitsunaga S, Fujii S, Ishii G, Kinoshita T, Hasebe T, Aoyagi K, Sasaki H, Ochiai A. Nerve invasion distance is dependent on laminin l2 in tumors of pancreatic cancer. Int. J. Cancer, 127: 805-819, 2010.

60. Sentani K, Oue N, Sakamoto N, Aoyagi K, Sasaki H, Yasui W. Up-regulation of connexin 30 in intestinal phenotype gastric cancer and its reduction during tumor progression. Pathobiology, 77: 241-248, 2010. PMID: 21116114 DOI: 10.1159/000314966

2009

61. Oue N, Sentani K, Sakamoto N, Motoshita J, Nishisaka T, Fukuhara T, Matsuura H, Sasaki H, Nakachi K, Yasui W. Characteristic gene expression in stromal cells of gastric cancers among atomic-bomb survivors. Int. J. Cancer, 124: 1112-1121, 2009. PMID: 19058179 DOI: 10.1002/ijc.24060

62. Saeki N, Usui T, Aoyagi K, Kim D-H, Sato M, Mabuchi T, Yanagihara K, Ogawa K, Sakamoto H, Yoshida T, Sasaki H. Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium. Genes Chromosomes Cancer, 48: 261-271, 2009. PMID: 19051310 DOI: 10.1002/gcc.20636

63. Ohta H, Aoyagi K, Fukaya M, Danjoh I, Isohata N, Saeki N, Taniguchi H, Sakamoto H, ShimodaT, Tani T, Yoshida T, Sasaki H. Cross talk between hedgehog and epithelial-mesencymal transition pathways in gastric pit cells and in diffuse-type gastric cancers. Br. J. Cancer, 100: 389-398, 2009. PMID: 19107131 PMCID: PMC2634717 DOI: 10.1038/sj.bjc.6604846

64. Isohata N, Aoyagi K, Mabuchi T, Daiko H, Fukaya M, Ohta H, Ogawa K, Yoshida T, Sasaki H. Hedgehog and epithelial-mesenchymal transition signaling in normal and malignant epithelial cells of the esophagus. Int. J. Cancer, 125: 1212-1221, 2009. PMID: 19431210 DOI: 10.1002/ijc.24400

2008

65. Sentani K, Oue N, Sakamoto N, Aoyagi K, Sasaki H, Yasui W. Gene expression profiling using microarray and SAGE identifies PLUNC as a marker for hepatoid adenocarcinoma of the stomach. Mod. Pathol., 21: 464-475, 2008. PMID: 18204429 DOI: 10.1038/modpathol.3801050

66. The Study Group of Millennium Genome Project for Cancer: Sakamoto H, Yoshimura K, Saeki N, Katai H, Shimoda T, Matsuno Y, Saito D, Sugimura H, Tanioka F, Kato S, Matsukura N, Matsuda N, Nakamura T, Hyodo I, Nishina T, Yasui W, Hirose H, Hayashi M, Toshiro E, Ohnami S, Sekine A, Sato Y, Totsuka H, Ando M, Takemura R, Takahashi Y, Ohdaira M, Aoki K, Honmyo I, Chiku S, Aoyagi K, Sasaki H, Ohnami S, Yanagihara K, Yoon KA, Kook MC, Lee YS, Park SR, Kim CG, Choi IJ, Yoshida T, Nakamura Y, Hirohashi S. Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer. Nat. Genet., 40:730-740, 2008. PMID: 18488030 DOI: 10.1038/ng.152

67. Chiba H, Ishii G, Ito TK, Aoyagi K, Sasaki H, Nagai K, Ochiai A. CD105 positive cells in pulmonary arterial blood of adult human lung cancer patients include mesenchymal progenitors. Stem Cells, 26: 2523-2530, 2008. PMID: 18669913 DOI: 10.1634/stemcells.2008-0037

68. Yamada A, Sasaki H, Aoyagi K, Sano M, Fujii S, Daiko H, Nishimura M, Yoshida T, Chiba T, Ochiai A. Expression of cytokeratin 7 predicts survival in stages I/IIA/IIB squamous cell carcinoma of the esophagus. Oncol. Rep., 20: 1021-1027, 2008. PMID: 18949396

2007

69. Furuhata S, Ando K, Oki M, Aoki K, Ohnishi S, Aoyagi K, Sasaki H, Sakamoto H, Yoshida T, Ohnami S. Gene expression profiles of endothelial progenitor cells by ologonucleotide microarray analysis. Mol. Cell. Biochem., 298: 125-138, 2007. PMID: 17203242 DOI: 10.1007/s11010-006-9359-4

70. Mori K, Suzuki T, Uozaki H, Nakanishi H, Ueda T, Matsuno Y, Kodera Y, Sakamoto H, Yamomoto N, Sasako M, Kaminishi M, Sasaki H. Detection of minimal gastric cancer cells in peritoneal washings by focused microarray analysis with multiple markers: Clinical implications. Ann. Surg. Oncol., 14: 1694-1702, 2007. PMID: 17294072 DOI: 10.1245/s10434-006-9321-4

71. Takeda M, Arao T, Yokote H, Yanagihara K, Sasaki H, Yamada Y, Tamura T, Fukuoka K, Kimura H, Saijo N, Nishio K. AZD2171 shows potent antitumor activity against gastric cancer over-expressing FGFR2/KGFR. Cli. Cancer Res., 13: 3051-3057, 2007.　 PMID: 17505008 DOI: 10.1158/1078-0432.CCR-06-2743

72. Ishii G, Ito T-K, Aoyagi K, Fujimoto H, Chiba H, Hasebe T, Fujii S, Nagai K, Sasaki H, Ochiai A. Presence of human circulating progenitor cells for cancer atromal fibroblasts in the blood of lung cancer patients. Stem Cells, 25: 1469-1477, 2007. PMID: 17379768 DOI: 10.1634/stemcells.2006-0449

73. Saeki N, Kim D-H, Usui T, Aoyagi K, Tatsuta T, Aoki K, Yanagihara　K, Tamura M,　Mizushima H, Sakamoto H, Ogawa K, Ohki M, Shiroishi T, Yoshida T, Sasaki H. GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-b dependent apoptotic signalling. Oncogene, 26: 6488-6498, 2007. PMID: 17471240 DOI: 10.1038/sj.onc.1210475

74. Yajima S, Ishii M, Matsushita H, Aoyagi K, Yoshimatsu K, Kaneko H, Yamamoto N, Teramoto T, Yoshida T, Matsumura Y, Sasaki H. Expression profiling of fecal colonocytes for RNA-based screening of colorectal cancer. Int. J. Oncol., 31: 1029-1037, 2007. PMID: 17912428

2006

75. Takahashi K, Kohno T, Ajima R, Sasaki H, Minna,JD, Fujiwara T, Tanaka N, Yokota J. Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer. Int. J. Oncol., 28: 321-328, 2006. PMID: 16391785

76. Nakamura N, Kobayashi K, Nakamoto M, Kohno T, Sasaki H, Matsuno Y, Yokota J. Identification of tumor markers and differentiation markers for molecular diagnosis of lung adenocarcinoma. Oncogene, 25: 4245-4255, 2006. PMID: 16491115 DOI: 10.1038/sj.onc.1209442

77. Ashida A, Boku N, Aoyagi K, Sato H, Tsubosa Y, Minashi K, Muto M, Ohtsu A, Ochiai A, Yoshida T, Yoshida S, Sasaki H. Expression profiling of esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy: clinical implications. Int. J. Oncol., 28: 1345-1352, 2006. PMID: 16685435

78. Fukaya M, Isohata N, Ohta H, Aoyagi K, Ochiya T, Saeki N, Yanagihara K, Nakanishi Y, Taniguchi H, Sakamoto H, Shimoda T, Nimura Y, Yoshida T, Sasaki H. Hedgehog signal activation in gastric pit cell and in diffuse type gastric cancer. Gastroenterology, 131: 14-29, 2006. PMID: 16831586 DOI: 10.1053/j.gastro.2006.05.008

79. Takahashi H, Aoyagi K, Nakanishi Y, Sasaki H, Yoshida T, Honda H. Classification of intramural metastases and lymph node metastases for esophageal cancer from gene expression by using boosting and projective adaptive resonance theory. J. Biosci. Bioeng., 102: 46-52, 2006. PMID: 16952836 DOI: 10.1263/jbb.102.46

80. Usui T, Aoyagi K, Saeki N, Nakanishi Y, Kanai Y, Ohki M, Ogawa K, Yoshida T, Sasaki H. Expression status of RUNX1/AML1 in normal gastric epithelium and its mutational analysis in microdissected gastric cancer cells. Int. J. Oncol., 29: 779-784, 2006. PMID: 16964375

81. Kim D-H, Muto M, Kuwahara Y, Nakanishi Y, Watanabe H, Aoyagi K, Ogawa K, Yoshida T, Sasaki H. Array-based comparative genomic hybridization of circulating esophageal tumor cells. Oncology Rep., 16: 1053-1059, 2006. PMID: 17016592

82. Daiko H, Isohata N, Sano M, Aoyagi K, Ogawa K, Kameoka S, Yoshida T, Sasaki H. Molecular profiles of the mouse postnatal development of the esophageal epithelium showing delayed growth start. Int. J. Mol. Med., 18: 1057-1066, 2006. PMID: 17089008

2005

83. Kishimoto M, Kohno T, Okudela K, Otsuka A, Sasaki H, Tanabe C, Sakiyama T, Hirama C, Kitabayashi I, Minna JD, Tekenoshita S, Yokota J. Mutations and deletions of the CBP gene in human lung cancer. Cli. Cancer Res., 11: 512-519, 2005.　 PMID: 15701835

84. Nishigaki M, Aoyagi K, Danjoh I, Fukaya M, Yanagihara K, Sakamoto H, Yoshida T, Sasaki H. Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays. Cancer Res., 65: 2115-2124, 2005.　 PMID: 15781621 DOI: 10.1158/0008-5472.CAN-04-3340

85. Teratani T, Yamamoto H, Aoyagi K, Sasaki H, Quinn G., Sasaki H, Terada M, Ochiya T. Direct hepatic fate specification from embryonic stem cell. Hepatology, 41: 836-846, 2005.　 PMID: 15742390 DOI: 10.1002/hep.20629

86. Sangai T, Ishii G, Kodama K, Miyamoto S, Aoyagi Y, Ito T, Magae J, Sasaki H, Nagashima T, Miyazaki M, Ochiai A. Effect of differences in cancer cells and tumor growth sites on recruiting bone marrow-derived endothelial cells and myofibroblasts in cancer-induced stroma. Int. J. Cancer, 115: 885-892, 2005. PMID: 15729726 DOI: 10.1002/ijc.20969

87. Ishii H, Inagaki T, Mimori K, Saito T, Sasaki H, Isobe M, Mori M, Croce CM, Huebner K, Ozawa K, Furukawa Y. Frag 1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Proc. Natl, Acad, Sci. USA., 102: 9655-9660, 2005. PMID: 15983387 PMCID: PMC1172282 DOI: 10.1073/pnas.0504222102

88. Sato M, Sasaki H, Kazui T, Yokota J, Kohno T. Probing the chromosome 9p21 region susceptible to DNA double strand breaks in human cells in vivo by restriction enzyme transfer. Oncogene, 24: 6108-6118, 2005. PMID: 16007206 DOI: 10.1038/sj.onc.1208750

89. Ishii G., Sangai T, Ito T, Hasebe T, Endoh Y, Sasaki H, Harigaya K, Ochiai A. In vivo and in vitro characterization of human fibroblasts recruited selectively into human cancer stroma. Int. J. Cancer, 117: 212-220, 2005

90. Morita E, Narikiyo M, Yokoyama A, Yano A, Kamoi K, Toshikawa E, Yamaguchi T, Igaki H, Tachimori Y, Kato H, Saito D, Hanada N, Sasaki H. Predominant presence of Streptococcus anginosus in the saliva of alcoholics. Oral Microbiol. Immunol., 20: 362-365, 2005. PMID: 15900602 DOI: 10.1002/ijc.21199