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業績論文

  1. Otomo K, Omura T, Nozawa Y, Edwards SJ, Sato Y, Saito Y, Yagishita S, Uchida H, Watakabe Y, Naitou K, Yanai R, Sahara N, Takagi S, Katayama　R, Iwata Y, Toshiro Shiokawa, Hayakawa Y, Otsuka K, Watanabe-Takano H, Haneda Y, Fukuhara S, Fujiwara M, Nii T, Meno C, Takeshita N, Yashiro K, Rocabado JMR, Kaku M, Yamada T, Oishi Y, Koike H, Cheng Y, Sekine K, Koga JI, Sugiyama K, Kimura K, Karube F, Kim H, Manabe I, Nemoto T, Tainaka K, Hamada A, Brismar H and Susaki EA.
    descSPIM:an affordable and easy-to-build light-sheet microscope optimozed for tissue cleaning techniques
    Nature Communications(15):4941. (2024) doi: https://doi.org/10.1038/s41467-024-49131-1
  2. Kometani T, Kamo K, Kido T, Hiraoka N, Chibazakura T, Unno K, Sekine K.Development of a novel co-culture system using human pancreatic cancer cells and human iPSC-derived stellate cells to mimic the characteristics of pancreatic ductal adenocarcinoma in vitroBiochem. Biophys. Res. Commun. 658: 1-9 (2023) doi: 10.1016/j.bbrc.2023.03.061
  3. Krumm J, Sekine K, Samaras P, Brazovskaja A, Breunig M, Yasui R, Kleger A, Taniguchi H, Wilhelm M, Treutlein B, Camp JG, Kuster B
    High temporal resolution proteome and phosphoproteome profiling of stem cell-derived hepatocyte development
    Cell Reports. 38(13):110604. (2022) doi: 10.1016/j.celrep.2022.110604
  4. Yasui R, Sekine K*, Kiyoshi Yamaguchi, Yoichi Furukawa, Taniguchi H*.
    Robust parameter design of human iPSC differentiation protocols defines lineage-specific induction of anterior–posterior gut tube endodermal cells. *corresponding author
    Stem Cells 39(4):429-442. (2021) doi: 10.1002/stem.3326. Epub 2021 Jan 15.
  5. Sekine K, Ogawa S, Tsuzuki S, Kobayashi T, Ikeda K, Nakanishi N, Takeuchi K, Kanai E, Otake Y, Okamoto S, Kobayashi T, Takebe T, Taniguchi H
    Generation of human induced pluripotent stem cell-derived liver buds with chemically defined and animal origin-free media
    Scientific Reports 10(1):17937. (2020) doi: 10.1038/s41598-020-73908-1.
  6. Sekine K*, Tsuzuki S, Yasui R, Kobayashi T, Ikeda K, Hamada Y, Kanai E, Camp JG, Treutlein B, Ueno Y, Okamoto S, Taniguchi H*. corresponding authors.
    Robust detection of undifferentiated iPSC among differentiated cells
    Scientific Reports 10, Article number: 10293 (2020)
  7. Takada K, Aizawa Y, Sano D, Okuda R, Sekine K, Ueno Y, Shoji Nakayama S, Jun Aoyama J, Sato K, Kuwahara T, Hatano T, Takahashi H, Arai Y, Nishimura G, Taniguchi H, Oridate N
    Establishment of PDX-derived salivary adenoid cystic carcinoma cell lines using organoid culture method
    International Journal of Cancer (2020) in press.
  8. Takahashi Y, Sekine K, Kin T, Takebe T, Taniguchi H
    Self-Condensation Culture Enables Vascularization Of Tissue Fragments For Efficient Therapeutic Transplantation
    Cell Reports. 23時16分20-1629. (2018)
  9. Nie YZ, Zheng YW, Miyakawa K, Murata S, Zhang RR, Sekine K, Ueno Y, Takebe T, Wakita T, Ryo A, Taniguchi H.
    Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells.
    EBioMedicine. 35: 114-123. (2018)
  10. Ayabe H, Anada T, Kaomoya T, Sato T, Kimura M, Yoshizawa E, Kikuchi S, Ueno Y, Sekine K, Camp JG, Treutlein B, Ferguson A, Suzuki O, Takebe T, Taniguchi H.
    Optimal Hypoxia Regulates Human iPSC-Derived Liver Bud Differentiation Through Intercellular TGFB Signaling.
    Stem Cell Reports. 11(2):306-316.(2018)
  11. Zhang RR, Koido M, Tadokoro T, Ouchi R, Matsuno T, Ueno Y, Sekine K, Takebe T, Taniguchi H.
    Human iPSC-Derived Posterior Gut Progenitors Are Expandable and Capable of Forming Gut and Liver Organoids.
    Stem Cell Reports.;10(3):780-793.(2018)
  12. Sekine K†*, Camp JG†, Gerber T, Loeffler-Wirth H, Binder H, Gac M, Kanton S, Kageyama J, Damm G, Seehofer D, Belicova L, Bickle M, Barsacchi R, Okuda R, Yoshizawa E, Kimura M, Ayabe H, Taniguchi H, Takebe T*, Treutlein B* † equal contribution., * corresponding authors.
    Multilineage communication regulates human liver bud development from pluripotency
    Nature. 546:533-538. (2017)
  13. Takebe T, Sekine K, Kimura M, Yoshizawa E, Ayano S, Koido M, Funayama S, Nakanishi N, Hisai T, Kobayashi T, Kasai T, Kitada R, Mori A, Ayabe H, Ejiri Y, Amimoto N, Yamazaki Y, Ogawa S, Ishikawa M, Kiyota Y, Sato Y, Nozawa K, Okamoto S, Ueno Y, Taniguchi H.
    Massive and reproducible production of liver buds entirely from human pluripotent stem cells
    Cell Reports 21(10):2661-2670. (2017)
  14. Chang PH, Sekine K, Chao HM, Hsu S, Chern E
    Chitosan promotes cancer progression and stem cell properties through Wnt signaling in colon and hepatocellular carcinoma cells
    Scientific Reports. 8, Article number: 45751 (2017)
  15. Koike H, Zhang RR, Ueno Y, Sekine K, Zheng YW, Takebe T, Taniguchi H
    Nutritional modulation of mouse and human liver bud growth through a branched-amino acid metabolism.
    Development. 144(6):1018-1024. (2017)
  16. Koike H, Ouchi R, Ueno Y, Nakata S, Obana Y, Sekine K, Zheng YW, Takebe T, Isono K, Koseki H,Taniguchi H.
    Polycomb group protein Ezh2 regulates hepatic progenitor cell proliferation and differentiation in murine embryonic liver.
    PLoS One. 9(8):e104776. (2014)
  17. Zhang R, Takebe T, Sekine K, Koike H, Zheng Y, Taniguchi H.
    Identification of proliferating human hepatic cells from human induced pluripotent stem cells.
    Transplant Proc. 46(4):1201-4. (2014)
  18. Tsuchida T, Zheng YW, Zhang RR, Takebe T, Ueno Y, Sekine K, Taniguchi H.
    The development of humanized liver with Rag1 knockout rats.
    Transplant Proc. 46(4):1191-3. (2014)
  19. Zheng YW, Nie YZ, Tsuchida T, Zhang RR, Aoki K, Sekine K, Ogawa M, Takebe T, Ueno Y, Sakakibara H, Hirahara F, Taniguchi H.
    Evidence of a sophisticatedly heterogeneous population of human umbilical vein endothelial cells.
    Transplant Proc. 46(4):1251-3. (2014)
  20. Takahashi Y, Takebe T, Enomura M, Koike N, Lee S, Nemeno JG, Sekine K, Lee JI, Taniguchi H.
    High-resolution intravital imaging for monitoring the transplanted islets in mice.
    Transplant Proc. 46(4):1166-8. (2014)
  21. Okuda R, Sekine K, Hisamatsu D, Ueno Y, Takebe T, Zheng YW, Taniguchi H.
    Tropism of cancer stem cells to a specific distant organ.
    In Vivo 28(3):361-5. (2014)
  22. Zheng YW, Tsuchida T, Shimao T, Li B, Takebe T, Zhang RR, Sakurai Y, Ueno Y, Sekine K, Ishibashi N, Imajima M, Tanaka T, Taniguchi H.
    The CD133+CD44+ Precancerous Subpopulation of Oval Cells is a Therapeutic Target for Hepatocellular Carcinoma
    Stem Cells D6v. 2014 Sep 15;23(18):2237-49. (2014)
  23. Sekine K, Takebe T, Taniguchi H.
    Fluorescent labeling and visualization of human induced pluripotent stem cells with the use of transcription activatore like effector nucleases
    Transplant Proc, 46(4):1205-7. (2014)
  24. Takebe T, Zhang RR, Koike H, Kimura M, Yoshizawa E, Enomura M, Koike N, Sekine K, Taniguchi H
    Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant.
    Nature Protocols 9, 396–409 (2014)
  25. Koike H, Ueno Y, Naito T, Shiina T, Nakata S, Ouchi R, Obana Y, Sekine K, Zheng YW,Takebe T, Isono KI, Koseki H, Taniguchi H.
    Ring1B promotes hepatic stem/ progenitor cell expansion via simultaneous suppression of Cdkn1a and Cdkn2a.
    Hepatology. Jul;60(1):323-33. (2014)
  26. Takebe T, Koike N, Sekine K, Fujiwara R, Amiya T, Zheng YW, Taniguchi H.
    Engineering of human hepatic tissue with functional vascular networks.
    Organogenesis. Apr-Jun;10(2):260-7. (2014)
  27. Takebe T, Sekine K, Enomura M, Koike H, Kimura M, Ogaeri T, Zhang RR, Ueno Y, Zheng YW, Koike N, Aoyama S, Adachi Y, Taniguchi H
    Vascularized and functional human liver tissue from an induced pluripotent stem cell-derived organ bud transplant.
    Nature 499(7459):481-484. (2013)
  28. Sekine K†, Tanaka H†, Tanaka S†, Kita S, Okamura A, Takebe T, Zheng YW, Ueno Y, Tanaka J and Taniguchi H. †equal contribution.
    The generation of pancreatic β-cell spheroids in a simulated microgravity culture system.
    Biomaterials 34( 23), 5785–5791. (2013)
  29. Yamamoto Y, Yoshizawa T, Fukuda T, Shirode-Fukuda Y, Yu T, Sekine K, Sato T, Kawano H, Aihara KI, Nakamichi Y, Watanabe T, Shindo M, Inoue K, Inoue E, Tsuji N, Hoshino M, Karsenty G, Metzger D, Chambon P, Kato S, Imai Y.
    Vitamin D Receptor in osteoblasts Is a negative regulator of bone mass control.
    Endocrinology. 154(3):1008-1020. (2013)
  30. Sekine K†, Koike H†, Kubota K†, Takebe T, Zheng YW, Ueno Y, Tanigawa N, Taniguchi H. †equal contribution.
    Establishment of Automated Culture System for Induced Pluripotent Stem Cells
    BMC Biotechnol., 12:81 (2012)
  31. Hirose Y, Saijou E, Sugano Y, Takeshita F, Nishimura S, Nonaka H, Chen YR, Sekine K, Kido T, Nakamura T, Kato S, Kanke T, Nakamura K, Nagai R, Ochiya T, Miyajima A.
    Inhibition of Stabilin-2 elevates the circulating hyaluronic acid level and prevents tumor metastasis
    Proc Natl Acad Sci U S A., 109 (11) 4263-4268. (2012)
  32. Sekine K, Takebe T, Enomura M, Matsui C, Tanaka H, Taniguchi H.
    Regenerative medicine approach as an alternative treatment to islet transplantation.
    Transplant Proc, 44 (4), 1104-1106. (2012)
  33. Sekine K, Takebe T, Suzuki Y, Kamiya A, Nakauchi H, Taniguchi H.
    Highly efficient generation of definitive endoderm lineage from human induced pluripotent cells.
    Transplant Proc, 44 (4), 1127-1129. (2012)
  34. Takebe T, Sekine K, Suzuki Y, Enomura M, Tanaka S, Ueno Y, Zheng YW, Taniguchi H.
    Self-organization of human hepatic organoid by recapitulating organogenesis in vitro.
    Transplant Proc, 44 (4) 1018-1020. (2012)
  35. Takebe T, Koike N, Sekine K, Enomura M, Ueno Y, Zheng YW, Taniguchi H.
    Generation of human vascular network in vitro.
    Transplant Proc, 44 (4), 1130-1133. (2012)
  36. Sekine K†, Ishikawa M†, Okamura A, Zheng YW, Ueno Y, Koike N, Tanaka J and Taniguchi H.
    Reconstitution of hepatic tissue architectures from fetal liver cells obtained from a three-dimensional culture with a rotating wall vessel bioreactor. †equal contribution.
    J Biosci Bioeng. 111, 711-718. (2011)
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