原著論文

1. Fujiwara Y., Takahashi R., Saito M., Umakoshi M., Shimada Y., Koyama K., Yatabe Y., Watanabe S., Koyota S., Minamiya Y., Tahara H., Kono K., Shiraishi K., Kohno T., Goto A., Tsuchiya N. “Oncofetal IGF2BP3-mediated control of microRNA structural diversity in the malignancy of early-stage lung adenocarcinoma.” Proc Natl Acad Sci USA. 121(36): e2407016121, 2024. doi : 10.1073/pnas.2407016121

 

2. Matsuzaki J, Kato K, Oono K, Tsuchiya N, Sudo K, Shimomura A, Tamura K, Shiino S, Kinoshita T, Daiko H, Wada T, Katai H, Ochiai H, Kanemitsu Y, Takamaru H, Abe S, Saito Y, Boku N, Kondo S, Ueno H, Okusaka T, Shimada K, Ohe Y, Asakura K, Yoshida Y, Watanabe SI, Asano N, Kawai A, Ohno M, Narita Y, Ishikawa M, Kato T, Fujimoto H, Niida S, Sakamoto H, Takizawa S, Akiba T, Okanohara D, Shiraishi K, Kohno T, Takeshita F, Nakagama H, Ota N, Ochiya T. “ Project Team for Development and Diagnostic Technology for Detection of miRNA in Body Fluids. Prediction of tissue-of-origin of early stage cancers using serum miRNomes. ” JNCI Cancer Spectr. 3;7(1):pkac080, 2023

 

3. Asano N., Matsuzaki J., Ichikawa M., Kawauchi J., Takizawa S., Aoki Y., Sakamoto H., Yoshida A., Kobayashi E., Tanzawa Y., Nakayama R., Morioka H., Matsumoto M., Nakamura M., Kondo T., Kato K., Tsuchiya N., Kawai A., Ochiya T. “ A serum microRNA classifier for the diagnosis of bone and soft tissue sarcomas of various histological subtypes.” Nat. Commun. 10(1):1299, 2019

 

4. Fujiwara Y., Saito M., Robles AI., Nishida M., Takeshita F., Watanabe M., Ochiya T., Yokota J., Kohno T., Harris CC., Tsuchiya N. “ A nucleolar stress-specific p53-miR-101 molecular circuit functions as an intrinsic tumor-suppressor network.” EBioMedicine. 33: 33-48, 2018

 

5. Robles AI., Kanai Y., Mathé E., Okayama H., Schetter A., Brown D., Petersen D., Bowman ED., Noro R., Welsh J., Edelman D., Stevenson H., Tsuchiya N., Kohno T., Skaug V., Mollerup S., Haugen A., Meltzer P., Yokota J., Harris CC. “ An Integrated Prognostic Classifier for Stage I Lung Adenocarcinoma based on mRNA, microRNA and Methylation Biomarkers.” J. Thoraic Oncol. 10(7):1037-1048, 2015

 

6. Saito M., Shiraishi K., Matsumoto K., Schetter AJ., Ogata-Kawata H., Tsuchiya N., Kunitoh H., Nokihara H., Watanabe S., Tsuta K., Kumamoto K., Takenoshita S., Yokota J., Harris CC., Kohno T. “ A three-microRNA signature predicts responses to platinum-based doublet chemotherapy in patients with lung adenocarcinoma.” Clin. Can. Res. 20, 4784-4793, 2014

 

7. Kurioka D, Takeshita F, Tsuta K, Sakamoto H, Watanabe S, Matsumoto K, Watanabe M, Nakagama H, Ochiya T, Yokota J, Kohno T, Tsuchiya N. “ NEK9-dependent proliferation of cancer cells lacking functional p53.” Sci Rep. 4:6111, 2014

 

8. Ogata-Kawata H, Izumiya M, Kurioka D, Honma Y, Yamada Y, Furuta K, Gunji T, Ohta H, Okamoto H, Sonoda H, Watanabe M, Nakagama H, Yokota J, Kohno T, Tsuchiya N. “ Circulating exosomal microRNAs as biomarkers of colon cancer. “ PLoS One. 9:e92921, 2014

 

9. Okamoto K, Ishiguro T, Midorikawa Y, Ohata H, Izumiya M, Tsuchiya N, Sato A, Sakai H, Nakagama H. “ miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver.” EMBO J. 28:1752-63, 2012

 

10. Tsuchiya N, Izumiya M, Ogata-Kawata H, Okamoto K, Fujiwara Y, Nakai M, Okabe A, Schetter AJ, Bowman ED, Midorikawa Y, Sugiyama Y, Aburatani H, Harris CC, Nakagama H. “ Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21.” Cancer Res. 71(13):4628-4639, 2011

 

11. Izumiya M, Tsuchiya N, Okamoto K, Nakagama H. “ Systematic exploration of cancer-associated microRNA through functional screening assays.” Cancer Sci. 102(9):1615-1621, 2011

 

12. Izumiya M, Okamoto K, Tsuchiya N, Nakagama H. “ Functional screening using a microRNA virus library and microarrays: a new high-throughput assay to identify tumor-suppressive microRNAs.” Carcinogenesis. 31:1354-9, 2010

 

13. Tsuchiya N, Nakagama H. “ MicroRNA, SND1, and alterations in translational regulation in colon carcinogenesis.” Mutat Res. 693:94-100, 2010

 

14. Tsuchiya N, Ochiai M, Nakashima K, Ubagai T, Sugimura T, Nakagama H. “ SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis.” Cancer Res. 67:9568-76, 2007

 

15. Tazawa H, Tsuchiya N, Izumiya M, Nakagama H. “ Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells.” Proc Natl Acad Sci USA. 104(39):15472-15477, 2007.

雑誌論文（和文）

1. 土屋直人. “野生型・変異型p53とマイクロRNA - ネットワーク理解とがん分子標的の同定”医学のあゆみ 269(5): 390-396, 2019.
2. 土屋直人. “血清エクソソームmiRNAと大腸がん病態との関連：あらたな診断法開発の可能性” 医学のあゆみ 255(3):221-225, 2015
3. 土屋直人. “血清エクソソームmiRNAsによる大腸がん診断バイオマーカー” 日本分子腫瘍マーカー研究会誌 31(0), 60-61,2015
4. 緒方(川田)広子, 土屋直人. “血中エクソソーム中のmicroRNAによるがんの診断” 細胞工学 vol.32 No.1 85-90, 2013
5. 土屋直人, 中釜斉. “がん抑制的 miRNAs - 効率な単離法から機能解析まで” 遺伝子医学MOOK 23時12分6-132, 2012
6. 泉谷昌志, 土屋直人. “マイクロRNAの機能スクリーニング” 細胞 42（6）, 229-231,2010
7. 土屋直人, 中釜斉. “microRNAの機能異常と大腸発がん” ゲノム医学 9（1）: 37-41, 2009.
8. 土屋直人, 中釜斉. “miR-34aの細胞増殖抑制機構と大腸発癌における役割” 実験医学 27（8）: 1213-1217, 2009.
9. 土屋直人. “マイクロRNAの機能異常とがん” 最新医学 64(9月増刊): 1936-1945, 2009.