研究について

治療方法の開発を行うため、院内のみでなく多施設共同研究グループに参加し、臨床試験を行っています。また、放射線治療の質の向上や放射線治療の新たな装置の開発に関する研究を行っています。

放射線治療に関する研究では、標準的治療の確立に向けた研究やよりよいQOLを目的とした臨床研究を行っています。

放射線治療に関する研究のみでなく、手術や薬物療法との併用療法の一部としての放射線治療について多くの臨床試験に参加し、治療計画の立案より実施内容の検証まで幅広く関与しています。

論文業績【共著含む】

2023年度

1. Eguchi K, Omura G, Shimoi T, Kageyama D, Igaki H, Abe Y, Watanabe T, Aihara Y, Sakai A, Matsumoto Y, Sakai T, Yonemori K, Mori T, Yoshida A, Yoshimoto S. BCOR-CCNB3 sarcoma arising in the pharynx. Auris Nasus Larynx. 2023 Aug;50(4):618-22. PubMed PMID: 35545465. Epub 20220508. eng.
2. Matsumura A, Asano T, Hirose K, Igaki H, Kawabata S, Kumada H. Initiatives Toward Clinical Boron Neutron Capture Therapy in Japan. Cancer Biother Radiopharm. 2023 Apr;38(3):201-7. PubMed PMID: 36374236. Pubmed Central PMCID: PMC10122211. Epub 20221114. eng.
3. Nakaichi T, Okamoto H, Kon M, Takaso K, Aikawa A, Nakamura S, Ijima K, Chiba T, Nakayama H, Takemori M, Mikasa S, Fujii K, Urago Y, Goka T, Shimizu Y, Igaki H. Commissioning and performance evaluation of commercially available mobile imager for image guided total body irradiation. J Appl Clin Med Phys. 2023 Apr;24(4):e13865. PubMed PMID: 36573258. Pubmed Central PMCID: PMC10113699. Epub 20221226. eng.
4. Murakami N, Watanabe M, Uno T, Sekii S, Tsujino K, Kasamatsu T, Machitori Y, Aoshika T, Kato S, Hirowatari H, Kaneyasu Y, Nakagawa T, Ikushima H, Ando K, Murata M, Yoshida K, Yoshioka H, Murata K, Ohno T, Okonogi N, Saito AI, Ichikawa M, Okuda T, Tsuchida K, Sakurai H, Yoshimura R, Yoshioka Y, Yorozu A, Kunitake N, Okamoto H, Inaba K, Kato T, Igaki H, Itami J. Phase I/II prospective clinical trial for the hybrid of intracavitary and interstitial brachytherapy for locally advanced uterine cervical cancer. J Gynecol Oncol. 2023 May;34(3):e24. PubMed PMID: 36603849. Pubmed Central PMCID: PMC10157336. Epub 20221221. eng.
5. Murakami N, Masui K, Yoshida K, Noda SE, Watanabe M, Takenaka T, Ii N, Atsumi K, Umezawa R, Inaba K, Iijima K, Kubo A, Igaki H, Shikama N, Ikushima H. Hands-on seminar for image-guided adaptive brachytherapy and intracavitary/interstitial brachytherapy for uterine cervical cancer. Jpn J Clin Oncol. 2023 Jun 1;53(6):508-13. PubMed PMID: 36810684. eng.
6. Nakayama H, Okamoto H, Nakamura S, Iijima K, Chiba T, Takemori M, Nakaichi T, Mikasa S, Fujii K, Sakasai T, Kuwahara J, Miura Y, Fujiyama D, Tsunoda Y, Hanzawa T, Igaki H, Chang W. Film measurement and analytical approach for assessing treatment accuracy and latency in a magnetic resonance-guided radiotherapy system. J Appl Clin Med Phys. 2023 May;24(5):e13915. PubMed PMID: 36934441. Pubmed Central PMCID: PMC10161048. Epub 20230319. eng.
7. Okamoto H, Murakami N, Isohashi F, Kasamatsu T, Hasumi Y, Kobayashi H, Ishikawa M, Nakamura M, Nishio T, Igaki H, Ishikura S, Yaegashi N, Mizowaki T, Nishimura Y, Toita T. Plan quality association between dummy run and individual case review in a prospective multi-institutional clinical trial of postoperative cervical cancer patients treated with intensity-modulated radiotherapy: Japan clinical Oncology Group study (JCOG1402). Radiother Oncol. 2023 Jun;183:109630. PubMed PMID: 36934892. Epub 20230318. eng.
8. Yoshida K, Kotsuma T, Takaoka Y, Tamenaga S, Yamazaki H, Nose T, Murakami N, Inaba K, Akiyama H, Masui K, Takenaka T, Kubota H, Tselis N, Masuda N, Yasojima H, Takeda M, Mano M, Nakamura S, Utsunomiya K, Tanigawa N, Tanaka E. HDR-brachytherapy for accelerated partial breast irradiation: Long-term experience from a Japanese institution. J Contemp Brachytherapy. 2023 Feb;15(1):1-8. PubMed PMID: 36970436. Pubmed Central PMCID: PMC10034731. Epub 20230228.
9. Doi Y, Nagata Y, Matsumoto Y, Numata K, Sasaki R, Yamada T, Igaki H, Imagumbai T, Katoh N, Yoshitake T, Shimizuguchi T, Fujioka D, Inoue M, Koide Y, Kimura T, Ito Y. Multicenter retrospective study of stereotactic body radiotherapy for patients with previously untreated initial small hepatocellular carcinoma. Hepatol Res. 2023 Aug;53(8):749-60. PubMed PMID: 37036153. Epub 20230425. eng.
10. Nakamura M, Zhou D, Minemura T, Kito S, Okamoto H, Tohyama N, Kurooka M, Kumazaki Y, Ishikawa M, Clark CH, Miles E, Lehmann J, Andratschke N, Kry S, Ishikura S, Mizowaki T, Nishio T. A virtual audit system for intensity-modulated radiation therapy credentialing in Japan Clinical Oncology Group clinical trials: A pilot study. J Appl Clin Med Phys. 2023 Jun;24(6):e14040. PubMed PMID: 37191875. Pubmed Central PMCID: PMC10243313. Epub 20230516.
11. Yoshioka Y, Sasamura K, Ito M, Kaneko M, Takahashi T, Anno W, Shimoyachi N, Suzuki J, Okuda T, Kashihara T, Inaba K, Igaki H, Itami J. Treatment planning comparison of high-dose-rate brachytherapy vs. robotic and conventional stereotactic body radiotherapy for ultrahypofractionated treatment of prostate cancer. Phys Imaging Radiat Oncol. 2023 Apr;26:100445. PubMed PMID: 37197153. Pubmed Central PMCID: PMC10183665. Epub 20230504. eng.
12. Imaizumi J, Shida D, Boku N, Igaki H, Itami J, Miyakita Y, Narita Y, Takashima A, Kanemitsu Y. Prognostic factors associated with the transition in treatment methods for brain metastases from colorectal cancer. Int J Clin Oncol. 2023 Aug;28(8):1043-53. PubMed PMID: 37208499. Pubmed Central PMCID: PMC10390364. Epub 20230519. eng.
13. Nakamura S, Imamichi S, Shimada K, Takemori M, Kanai Y, Iijima K, Chiba T, Nakayama H, Nakaichi T, Mikasa S, Urago Y, Kashihara T, Takahashi K, Nishio T, Okamoto H, Itami J, Ishiai M, Suzuki M, Igaki H, Masutani M. Relative biological effectiveness for epithermal neutron beam contaminated with fast neutrons in the linear accelerator-based boron neutron capture therapy system coupled to a solid-state lithium target. J Radiat Res. 2023 Jul 18;64(4):661-7. PubMed PMID: 37295954. Pubmed Central PMCID: PMC10354855. eng.
14. Murakami N, Nakatani F, Takahashi K, Nakamura S, Igaki H, Shikama N. Salvage high-dose rate brachytherapy for myxofibrosarcoma of the brachium: a technical report. J Radiat Res. 2023 Jul 18;64(4):746-9. PubMed PMID: 37301983. Pubmed Central PMCID: PMC10354856. eng.
15. Kishigami Y, Nakamura M, Nakao M, Okamoto H, Takahashi A, Igaki H. Three-dimensional assessment of interfractional cervical and uterine motions using daily magnetic resonance images to determine margins and timing of replanning. J Appl Clin Med Phys. 2023 Oct;24(10):e14073. PubMed PMID: 37317937. Pubmed Central PMCID: PMC10562032. Epub 20230615. eng.
16. Adachi M, Matsumoto Y, Furuse H, Uchimura K, Imabayashi T, Yotsukura M, Yoshida Y, Nakagawa K, Igaki H, Watanabe SI, Tsuchida T. Utility of the endobronchial Watanabe spigot for intractable cancer-related pneumothorax: a retrospective observational study. Jpn J Clin Oncol. 2023 Aug 30;53(9):829-36. PubMed PMID: 37340759. Pubmed Central PMCID: PMC10473273. eng.
17. Eguchi K, Omura G, Murakami N, Honma Y, Yokoyama K, Watanabe T, Aihara Y, Sakai A, Matsumoto Y, Sakai T, Kobayashi K, Igaki H, Yoshimoto S. Comparison of Survival Outcomes Between Larynx-Preserving Open Partial Pharyngectomy and Radiotherapy or Chemoradiotherapy in Patients with Hypopharyngeal Squamous Cell Carcinoma: A Single-Center Retrospective Analysis with Inverse Probability of Treatment Weighting Adjustments. Ann Surg Oncol. 2023 Oct;30(11):6867-74. PubMed PMID: 37452169. Epub 20230714. eng.
18. Kawauchi D, Ohno M, Miyakita Y, Takahashi M, Yanagisawa S, Omura T, Yoshida A, Kubo Y, Igaki H, Ichimura K, Narita Y. Consulting a neurosurgeon upon initial medical assessment reduces the time to the first surgery and potentially contributes to improved prognosis for glioblastoma patients. Jpn J Clin Oncol. 2023 Nov 5;53(11):1027-33. PubMed PMID: 37534529. eng.
19. Murakami N, Kojima K, Okuma K, Kashihara T, Nakamura S, Shimizu W, Suda R, Igaki H, Shikama N. Non-operative management involving chemoradiation therapy combined with high-dose-rate brachytherapy for T3 rectal cancer using a vaginal shielded cylindrical applicator: a technical report. Jpn J Clin Oncol. 2023 Nov 5;53(11):1082-6. PubMed PMID: 37554048. eng.
20. Egashira M, Arimura H, Kobayashi K, Moriyama K, Kodama T, Tokuda T, Ninomiya K, Okamoto H, Igaki H. Magnetic resonance-based imaging biopsy with signatures including topological Betti number features for prediction of primary brain metastatic sites. Phys Eng Sci Med. 2023 Dec;46(4):1411-26. PubMed PMID: 37603131. Epub 20230821. eng.
21. Tohyama N, Okamoto H, Shimomura K, Kurooka M, Kawamorita R, Ota S, Kojima T, Hayashi N, Okumura M, Nakamura M, Nakamura M, Myojoyama A, Onishi H. A national survey on the medical physics workload of external beam radiotherapy in Japandagger. J Radiat Res. 2023 Nov 21;64(6):911-25. PubMed PMID: 37816672. Pubmed Central PMCID: PMC10665301.
22. Nagao A, Okamoto H, Nakayama H, Chiba T, Fujiyama D, Kuwahara J, Sakasai T, Kashihara T, Kaneda T, Inaba K, Okuma K, Murakami N, Igaki H. Assessment of intrafractional motion of the cervix-uterus by MR-guided radiotherapy system†. J Radiat Res. 2023 Nov 21;64(6):967-72. PubMed PMID: 37816679. Pubmed Central PMCID: PMC10665310. eng.
23. Kashihara T, Mori T, Nakaichi T, Nakamura S, Ito K, Kurihara H, Kusumoto M, Itami J, Yoshimoto S, Igaki H. Correlation between L-amino acid transporter 1 expression and 4-borono-2-(18) F-fluoro-phenylalanine accumulation in humans. Cancer Med. 2023 Nov;12(21):20564-72. PubMed PMID: 37881128. Pubmed Central PMCID: PMC10660410. Epub 20231025. eng.
24. Igaki H, Nakamura S, Yamazaki N, Kaneda T, Takemori M, Kashihara T, Murakami N, Namikawa K, Nakaichi T, Okamoto H, Iijima K, Chiba T, Nakayama H, Nagao A, Sakuramachi M, Takahashi K, Inaba K, Okuma K, Nakayama Y, Shimada K, Nakagama H, Itami J. Acral cutaneous malignant melanoma treated with linear accelerator-based boron neutron capture therapy system: a case report of first patient. Front Oncol. 2023;13時12分72507. PubMed PMID: 37901311. Pubmed Central PMCID: PMC10613025. Epub 20231013. eng.
25. Kishigami Y, Nakamura M, Okamoto H, Takahashi A, Iramina H, Sasaki M, Kawata K, Igaki H. Organ-contour-driven auto-matching algorithm in image-guided radiotherapy. J Appl Clin Med Phys. 2024 Jan;25(1):e14220. PubMed PMID: 37994694. Pubmed Central PMCID: PMC10795436. Epub 20231123. eng.
26. Nakahara M, Murakami N, Chiba T, Nagao A, Okuma K, Kashihara T, Kaneda T, Takahashi K, Inaba K, Nakayama Y, Kato T, Igaki H. Gynecological technical notes for appropriate spacer injections. Brachytherapy. 2024 Jan-Feb;23(1):45-51. PubMed PMID: 38040606. Epub 20231130. eng.
27. Wada S, Ogata D, Kashihara T, Okuma K, Eto H, Nakano E, Takahashi A, Namikawa K, Igaki H, Yamazaki N. A single-center retrospective analysis of prognoses in patients with melanoma brain metastases and effectiveness of treatment in Japan. Cancer Med. 2023 Dec;12(24):21933-43. PubMed PMID: 38083908. Pubmed Central PMCID: PMC10757137. Epub 20231211. eng.
28. Kobayashi K, Gu L, Hataya R, Mizuno T, Miyake M, Watanabe H, Takahashi M, Takamizawa Y, Yoshida Y, Nakamura S, Kouno N, Bolatkan A, Kurose Y, Harada T, Hamamoto R. Sketch-based semantic retrieval of medical images. Med Image Anal. 2024 Feb;92:103060. PubMed PMID: 38104401. Epub 20231208.
29. Nakao M, Ozawa S, Miura H, Yamada K, Hayata M, Hayashi K, Kawahara D, Nakashima T, Ochi Y, Okumura T, Kunimoto H, Kawakubo A, Kusaba H, Nozaki H, Habara K, Tohyama N, Nishio T, Nakamura M, Minemura T, Okamoto H, Ishikawa M, Kurooka M, Shimizu H, Hotta K, Saito M, Nakano M, Tsuneda M, Nagata Y. CT number calibration audit in photon radiation therapy. Med Phys. 2024 Mar;51(3):1571-82. PubMed PMID: 38112216. Epub 20231219.
30. Kito S, Suda Y, Tanabe S, Takizawa T, Nagahata T, Tohyama N, Okamoto H, Kodama T, Fujita Y, Miyashita H, Shinoda K, Kurooka M, Shimizu H, Ohno T, Sakamoto M. Radiological imaging protection: a study on imaging dose used while planning computed tomography for external radiotherapy in Japan. J Radiat Res. 2024 Mar 22;65(2):159-67. PubMed PMID: 38151953. Pubmed Central PMCID: PMC10959444.
31. Sakuramachi M, Murakami N, Nagao A, Kojima K, Miyata Y, Kashihara T, Kaneda T, Takahashi K, Inaba K, Okuma K, Nakayama Y, Okamoto H, Ishikawa M, Igaki H. Hydrogel spacer injection to the meso-sigmoid to protect the sigmoid colon in cervical cancer brachytherapy: A technical report. J Contemp Brachytherapy. 2023 Dec;15(6):465-9. PubMed PMID: 38230404. Pubmed Central PMCID: PMC10789158. Epub 20231229. eng.
32. Murakami Y, Kawahara D, Soyano T, Kozuka T, Takahashi Y, Miyake K, Kashihara K, Kashihara T, Kamima T, Oguchi M, Murakami Y, Yoshioka Y, Nagata Y. Dosiomics for intensity-modulated radiotherapy in patients with prostate cancer: survival analysis stratified by baseline prostate-specific antigen and Gleason grade group in a 2-institutional retrospective study. Br J Radiol. 2024 Jan 23;97(1153):142-9. PubMed PMID: 38263831.
33. Cho H, Abe S, Nonaka S, Suzuki H, Yoshinaga S, Okuma K, Yamamoto S, Daiko H, Kato K, Sekine S, Boku N, Saito Y. Long-term outcomes after non-curative endoscopic resection for esophageal squamous cell carcinoma followed by additional chemoradiotherapy. Dis Esophagus. 2024 Jan 23. PubMed PMID: 38266034. Epub 20240123.
34. Okamoto H, Wakita A, Tani K, Kito S, Kurooka M, Kodama T, Tohyama N, Fujita Y, Nakamura S, Iijima K, Chiba T, Nakayama H, Murata M, Goka T, Igaki H. Plan complexity metrics for head and neck VMAT competition plans. Med Dosim. 2024 Feb 16. PubMed PMID: 38368182. Epub 20240216. eng.
35. Nishioka S, Okamoto H, Chiba T, Kito S, Ishihara Y, Isono M, Ono T, Mizoguchi A, Mizuno N, Tohyama N, Kurooka M, Ota S, Shimizu D. Technical note: A universal worksheet for failure mode and effects analysis-A project of the Japanese College of Medical Physics. Med Phys. 2024 Mar 20. PubMed PMID: 38507277. Epub 20240320.